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Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7605, pp. 55 - 62
Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly... 
PATHWAYS | HETEROGENEITY | PIK3CA MUTATIONS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GENES | BIOLOGY | RECEPTOR | EXPRESSION | SIGNATURE | REVEALS | Protein Kinases - metabolism | Focal Adhesion Kinase 1 - genetics | Receptor, Epidermal Growth Factor - genetics | Protein Kinases - genetics | Cyclin-Dependent Kinases - metabolism | Receptor, ErbB-2 - genetics | Receptors, G-Protein-Coupled - metabolism | Genomics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Phosphoproteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Breast Neoplasms - enzymology | Receptor, Epidermal Growth Factor - metabolism | Phosphoproteins - analysis | Mass Spectrometry | src-Family Kinases - metabolism | Female | Cyclin-Dependent Kinases - genetics | Focal Adhesion Kinase 1 - metabolism | Chromosomes, Human, Pair 5 - genetics | Breast Neoplasms - classification | Chromosome Deletion | p21-Activated Kinases - genetics | Signal Transduction | Molecular Sequence Annotation | Calcium-Binding Proteins - deficiency | Phosphoproteins - genetics | Mutation - genetics | S-Phase Kinase-Associated Proteins - metabolism | p21-Activated Kinases - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Proteomics | S-Phase Kinase-Associated Proteins - genetics | Receptors, G-Protein-Coupled - genetics | src-Family Kinases - genetics | Calcium-Binding Proteins - genetics | Breast cancer | Genetic aspects | Research | Oncology, Experimental | Cancer | Physiological aspects | Methods | Mutation (Biology) | Proteins | Gene amplification | Peptides | Protein expression | Genomes | Mutation | Kinases | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 08/2015, Volume 11, Issue 8, pp. 611 - 617
The current predominant therapeutic paradigm is based on maximizing drug-receptor occupancy to achieve clinical benefit. This strategy, however, generally... 
CHIMERIC MOLECULES | CHEMICAL PROTEOMICS | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESTROGEN-RECEPTOR-ALPHA | KINASE INHIBITORS | CARD15 MUTATIONS | BLAU-SYNDROME | ABSOLUTE QUANTIFICATION | LIGASE COMPLEX | CELL-DEATH | Neoplasm Transplantation | Small Molecule Libraries - pharmacology | Receptors, Estrogen - metabolism | Humans | Ubiquitin - metabolism | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Ubiquitination | MCF-7 Cells | Proteolysis | Female | Antineoplastic Agents - pharmacology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Neoplasm Proteins - genetics | Binding Sites | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Biocatalysis | Receptors, Estrogen - genetics | Models, Molecular | Receptors, Estrogen - antagonists & inhibitors | Ubiquitin - genetics | Breast Neoplasms - drug therapy | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Protein Binding | Mice | Proteasome Endopeptidase Complex - metabolism | Proteins | Molecular biology | Biocatalysts | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 2013, Volume 14, Issue 5, pp. 480 - 488
NOD2 receptor and the cytosolic protein kinase RIPK2 regulate NF-kappaB and MAP kinase signaling during bacterial infections, but the role of this immune axis... 
LISTERIA-MONOCYTOGENES | IMMUNE-RESPONSE | 1918 INFLUENZA-VIRUS | DOUBLE-STRANDED-RNA | IFN-GAMMA PRODUCTION | DENDRITIC CELLS | IL-1-BETA PRODUCTION | INNATE | AUTOPHAGY | IMMUNOLOGY | CD8(+) T-CELLS | Immune response | Influenza | Physiological aspects | Causes of | Genetic aspects | Cellular signal transduction | Research | Protein kinases | Index Medicus | mitophagy | autophagy | RIPK2 | NLR | inflammasome | IL-18 | Caspase-1
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2012, Volume 46, Issue 6, pp. 746 - 758
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14524 - 14529
NOD1 and NOD2 are members of the NOD-like receptor (NLR) protein family that are involved in sensing the presence of pathogens and are a component of the... 
Proteins | HEK293 cells | HCT116 cells | Plasmids | Cell lines | Antibodies | Reporter genes | Ligands | Immunoblotting | Apoptosis | CYTOCHROME-C | NEGATIVE BACTERIAL-INFECTION | ACTIVATION | HOST RECOGNITION | MULTIDISCIPLINARY SCIENCES | ALPHA-DEPENDENT APOPTOSIS | IAP | CELL-SURVIVAL | PROTEIN XIAP | NF-KAPPA-B | DROSOPHILA INHIBITOR | RNA, Small Interfering - genetics | Immunoprecipitation | Luciferases - metabolism | Humans | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Green Fluorescent Proteins - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Nod1 Signaling Adaptor Protein - metabolism | Recombinant Fusion Proteins - metabolism | Luciferases - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Transfection | Interleukin-8 - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | Gene Expression | Enzyme-Linked Immunosorbent Assay | Signal Transduction | HCT116 Cells | Reverse Transcriptase Polymerase Chain Reaction | X-Linked Inhibitor of Apoptosis Protein - genetics | NF-kappa B - genetics | Nod2 Signaling Adaptor Protein - metabolism | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Mutation | Nod1 Signaling Adaptor Protein - genetics | Research | Immunity | Bacteria | Peptides | Kinases | Immune system | Index Medicus | Biological Sciences
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 05/2014, Volume 15, Issue 5, pp. 623 - 635
Journal Article
Developmental and Comparative Immunology, ISSN 0145-305X, 01/2015, Volume 48, Issue 1, pp. 76 - 85
We report on the functional characterization of RIP2 of the goldfish. Quantitative expression analysis of goldfish RIP2 revealed the greatest mRNA levels in... 
Fish | Macrophages | Gene expression | NLR | Mycobacteria | RIP2 | ANTIMICROBIAL RESPONSES | KAPPA-B ACTIVATION | SIGNALING PATHWAYS | VIRUS-INFECTION | PROTEIN | NOD2 | IMMUNOLOGY | IDENTIFICATION | MYCOBACTERIUM-MARINUM | CELL-DEATH | ZOOLOGY | IMMUNE-RESPONSES | Monocytes - metabolism | NF-kappa B - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - immunology | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Nod1 Signaling Adaptor Protein - metabolism | Antibodies - immunology | Interleukin-1beta - biosynthesis | Macrophages - immunology | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Poly I-C - pharmacology | Neutrophils - immunology | Imidazoles - pharmacology | Inflammation - immunology | Recombinant Proteins - genetics | Spleen - cytology | Goldfish - immunology | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Aeromonas salmonicida - immunology | Animals | Mycobacterium marinum - immunology | Nod2 Signaling Adaptor Protein - metabolism | Recombinant Proteins - immunology | Spleen - metabolism | Inflammasomes - immunology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Pyridines - pharmacology | Peptidoglycan - pharmacology | Tumor Necrosis Factor-alpha - biosynthesis | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2012, Volume 287, Issue 30, pp. 25565 - 25576
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2011, Volume 43, Issue 12, pp. 1247 - 1251
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10, pp. e0206244 - e0206244
RIP2, one of the RIP kinases, interacts with p75 neurotrophin receptor, regulating the neuron survival, and with NOD1 and NOD2 proteins, causing the innate... 
MULTIDISCIPLINARY SCIENCES | DISEASE | N-15 | RELAXATION | COUPLINGS | NOD2 | CELL-DEATH | Amino Acid Sequence | Nod1 Signaling Adaptor Protein - chemistry | Magnetic Resonance Spectroscopy - methods | Nod2 Signaling Adaptor Protein - chemistry | Protein Multimerization | Protein Refolding | Models, Molecular | Nod2 Signaling Adaptor Protein - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Static Electricity | Nod1 Signaling Adaptor Protein - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Sequence Homology, Amino Acid | Nod2 Signaling Adaptor Protein - metabolism | Solutions | Receptor-Interacting Protein Serine-Threonine Kinase 2 - chemistry | Protein Binding | Caspase Activation and Recruitment Domain | Hydrogen-Ion Concentration | Nod1 Signaling Adaptor Protein - genetics | Physiological aspects | Genetic aspects | Research | Properties | Structure | Protein kinases | Protein-protein interactions | Gram-positive bacteria | Homology | Drug development | Kinases | pH effects | Neurogenesis | Inflammatory diseases | Magnetic resonance spectroscopy | Proteins | Oligomers | Protein folding | Neurodegeneration | Nod1 protein | NOD2 protein | Immune system | Cell survival | Oligomerization | Immune response | Caspase | Electrostatic properties | Physics | Domains | Chemistry | Protein expression | Protein interaction | NMR spectroscopy | Protein structure | Index Medicus | Immune systems
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 04/2012, Volume 11, Issue 4, pp. 337 - 351
is an enteropathogenic bacteria that disrupts the intestinal barrier and invades its host through gut-associated lymphoid tissue and Peyer's patches (PP). We... 
CROHNS-DISEASE | IL-1-BETA SECRETION | PERMEABILITY | PEYERS-PATCHES | MICROBIOLOGY | NOD2 | INFLAMMATORY-BOWEL-DISEASE | VIROLOGY | MURAMYL DIPEPTIDE | MICE | NF-KAPPA-B | PARASITOLOGY | III SECRETION SYSTEM | Humans | Caspase 1 - metabolism | Male | Nod2 Signaling Adaptor Protein - genetics | Intestines - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Female | Yersinia pseudotuberculosis Infections - metabolism | Yersinia pseudotuberculosis Infections - genetics | Cell Line | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Mice, Inbred C57BL | Bacterial Proteins - genetics | MAP Kinase Kinase Kinases - metabolism | Yersinia pseudotuberculosis - genetics | Animals | Intestines - microbiology | Nod2 Signaling Adaptor Protein - metabolism | Yersinia pseudotuberculosis - metabolism | Caspase 1 - genetics | Yersinia pseudotuberculosis Infections - enzymology | Yersinia pseudotuberculosis Infections - microbiology | Bacterial Proteins - metabolism | Mice | Intestines - enzymology | Bacteria | Phosphotransferases | Permeability | Index Medicus | Life Sciences | Biochemistry, Molecular Biology | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article