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1. Full Text The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels
by Alsina‐Sanchis, Elisenda and Figueras, Agnès and Lahiguera, Álvaro and Vidal, August and Casanovas, Oriol and Graupera, Mariona and Villanueva, Alberto and Viñals, Francesc
International Journal of Cancer, ISSN 0020-7136, 10/2016, Volume 139, Issue 8, pp. 1894 - 1903
In a search for new therapeutic targets for treating epithelial ovarian cancer, we analyzed the Transforming Growth Factor Beta (TGFβ) signaling pathway in... 
TGFβ | epithelial ovarian tumors | IGF1R | Epithelial ovarian tumors | INSULIN | PATHOGENESIS | LY2109761 | TARGET | ONCOLOGY | BIOLOGY | GROWTH-FACTOR | TGF beta | EXPRESSION | Neoplasms, Glandular and Epithelial - pathology | Antibodies, Monoclonal - pharmacology | Humans | Cell Proliferation - physiology | Ovarian Neoplasms - pathology | Neoplasms, Glandular and Epithelial - metabolism | Random Allocation | Pyrroles - pharmacology | Animals | Heterografts | Signal Transduction - drug effects | Mice, Nude | Receptors, Somatomedin - metabolism | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Transforming Growth Factor beta - antagonists & inhibitors | Female | Mice | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - drug therapy | Transforming Growth Factor beta - metabolism | Pyrazoles - pharmacology | Factors de creixement | Cell proliferation | Càncer d'ovari | Proliferació cel·lular | Cèl·lules epitelials | Insulin receptors | Epithelial cells | Receptors d'insulina | Growth factors | Ovarian cancer
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2. El papel de los ácidos grasos libres en la resistencia a la insulina
by Vázquez-Jiménez, José Gustavo and Roura-Guiberna, Adriana and Jiménez-Mena, Luisa Reyna and Olivares-Reyes, Jesús Alberto
Gaceta medica de Mexico, ISSN 0016-3813, 01/2017, Volume 153, Issue 7, pp. 852 - 863
Free fatty acids are essential nutritional components and recent studies identified them as signaling molecules in various physiological processes. It has now... 
Insulin resistance | Insulin receptor | Fatty acids | Insulin receptor substrate | Protein Kinases - metabolism | Cardiovascular Diseases - etiology | Obesity | Ceramides - metabolism | Fatty Acids, Nonesterified - physiology | Insulin - physiology | Humans | Oxidative Stress - physiology | Insulin Resistance - physiology | Diabetes Mellitus, Type 2 - etiology | Toll-Like Receptors - metabolism | Dyslipidemias - etiology | Endoplasmic Reticulum Stress - physiology
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3. Síndrome de insulinorresistencia severa tipo A debido a mutación del gen del receptor de insulina
by Ros, P and Colino-Alcol, E and Grasso, V and Barbetti, F and Argente, J
Anales de pediatria (Barcelona, Spain : 2003), 01/2015, Volume 82, Issue 1, pp. e30 - e34
Insulin resistance syndromes without lipodystrophy are an infrequent and heterogeneous group of disorders with variable clinical phenotypes, associated with... 
Tyrosine kinase | Insulin receptor mutation | Mutación del receptor de insulina | Insulinorresistencia | Hiperandrogenismo | Hyperandrogenism | Insulin resistance | Acanthosis nigricans | Tirosinquinasa | Acantosis nigricans
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4. Full Text Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
by Ettcheto, Miren and Sánchez-López, Elena and Pons, Laura and Busquets, Oriol and Olloquequi, Jordi and Beas-Zarate, Carlos and Pallas, Merce and García, Maria Luisa and Auladell, Carme and Folch, Jaume and Camins, Antoni
Redox Biology, ISSN 2213-2317, 10/2017, Volume 13, Issue C, pp. 345 - 352
The aim of the present study is to elucidate the neuronal pathways associated to NSAIDs causing a reduction of the risk and progression of Alzheimer's disease.... 
APPSwe/PS1dE9 | Memory impairment | Mitochondria | Dexibuprofen | TAU | Insulin receptor | Alzheimer's disease | Hippocampus | APP/PS1 MICE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSGENIC MODEL | PATHOLOGY | PATHOGENESIS | ANTIINFLAMMATORY AGENTS | NEUROINFLAMMATION | INFLAMMATION | IN-VIVO | MOUSE MODEL | Neuroprotective Agents - therapeutic use | Tumor Necrosis Factor-alpha - metabolism | Amyloid Precursor Protein Secretases - genetics | Ibuprofen - therapeutic use | tau Proteins - metabolism | Cognition | Aspartic Acid Endopeptidases - genetics | Phosphoproteins - metabolism | Ibuprofen - analogs & derivatives | Brain - metabolism | Neuroprotective Agents - pharmacology | Cyclins - metabolism | Female | Ibuprofen - pharmacology | Signal Transduction | Mice, Inbred C57BL | Alzheimer Disease - drug therapy | Presenilin-1 - genetics | Cyclin-Dependent Kinase 5 - metabolism | Brain - drug effects | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Carrier Proteins - metabolism | Aspartic Acid Endopeptidases - metabolism | Proto-Oncogene Proteins c-abl - metabolism | Mice | Alzheimer Disease - genetics | Index Medicus | Drugs | Malaltia d'Alzheimer | Medicaments | Insulin receptors | Receptors d'insulina | Hippocampus (Brain) | Hipocamp (Cervell) | Mitocondris
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5. Full Text Characterization data of gilthead sea bream (Sparus aurata) IGF-I receptors (IGF-IRa/Rb)
by Vélez, Emilio J and Azizi, Sheida and Salmerón, Cristina and Chan, Shu Jin and Nematollahi, Mohammad Ali and Amiri, Bagher Mojazi and Navarro, Isabel and Capilla, Encarnación and Gutiérrez, Joaquim
Data in Brief, ISSN 2352-3409, 03/2016, Volume 6, pp. 507 - 513
In this data article we describe the coding sequence of two IGF-IR paralogues (IGF-IRa and IGF-IRb) obtained from gilthead sea bream embryos. The putative... 
IGF-I receptors | Gilthead sea bream | Miogènesi | Sparus aurata | Insulin receptors | Orada | Receptors d'insulina | Gene expression | Expressió gènica | Myogenesis
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6. Full Text Asociación de los polimorfismos génicos de los receptores adrenérgicos β1 y β3 con la resistencia a la insulina y los perfiles elevados de lípidos relacionados con la diabetes tipo 2 y el síndrome metabólico
by Burguete-García, Ana I and Martínez-Nava, Gabriela A and Valladares-Salgado, Adán and Bermúdez, V.H and Estrada-Velasco, Bárbara and Wacher, Niels and Peralta-Romero, Jesús and Garcia-Mena, Jaime and Parra, Esteban and Cruz, Miguel
Nutricion Hospitalaria, ISSN 0212-1611, 2014, Volume 29, Issue 6, pp. 1327 - 1334
Type 2 diabetes | Adrenergic receptors | Metabolic syndrome | Polymorphism
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7. Full Text Estimulação com insulina da fosforilação da Akt/PKB em placenta de pacientes com pré-eclâmpsia
by Ferreira, Gustavo Dias and Orcy, Rafael Bueno and Martins-Costa, Sérgio Hofmeister and Ramos, José Geraldo Lopes and Brum, Ilma Simoni and von Eye Corleta, Helena and Capp, Edison
Sao Paulo Medical Journal, ISSN 1516-3180, 12/2011, Volume 129, Issue 6, pp. 387 - 391
Placenta | Receptor | Insulin resistance | Pre-eclampsia | Proto-oncogene proteins c-akt | Insulin
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8. Efecto de la deficiencia de hierro sobre la expresión de factor de crecimiento de insulina tipo II y su receptor en células neuronales y gliales
by Morales González, E and Contreras, I and Estrada, J.A
Neurologia, ISSN 0213-4853, 2014, Volume 29, Issue 7, pp. 408 - 415
Introduction: Many studies have demonstrated that iron deficiency modifies the normal function of the central nervous system and alters cognitive abilities.... 
Cell cultures | Insulin-like growth factor II | Iron deficiency | Growth factors | Central nervous system | Specific receptor of insulin-like growth factor II
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9. Insulin receptors
by Harrison, Len C and Kahn, C. Ronald
1988, Receptor biochemistry and methodology, ISBN 9780845137994, Volume 12, 2 pt.
Insulin | Receptors | Receptors, Insulin
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10. Full Text Ilhotas pancreaśticas isoladas de camundongos com deleção do receptor adrenérgico β2 apresenta reduzida secreção de insulina em resposta a nutrientes
by Marçal, Anderson Carlos and Davel, Ana Paula Couto and Carpinelli, Angelo Rafael and Brum, Patrícia Chakur and Rossoni, Luciana Venturini and Carvalho, Carla Roberta de Oliveira
Acta Scientiarum - Biological Sciences, ISSN 1679-9283, 2013, Volume 35, Issue 3, pp. 437 - 443
Pancreatic beta cells | Adrenergic receptors | Glucose | Leucine
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11. Insulin and IGFs
by Litwack, Gerald
2009, 1st ed., Vitamins and hormones, ISBN 0123744083, Volume 80., xxii, 733 p., [16] p. of plates
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the... 
Somatomedin | Insulin
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12. Understanding insulin action
: principles and molecular mechanisms
by Espinal, J. (Joseph)
1989, Ellis Horwood books in the biological sciences. Series in biotechnology., ISBN 074580473X, 129
Insulin | Therapeutic use
Book
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13. Full Text Influence of G1359A polimorphysm of the cannabinoid receptor gene (CNR1) on insulin resistance and adipokines in patients with non alcoholic fatty liver disease Influencia del polimorfismo G1359a del gen del receptor cannabinoide (CNR1) sobre la resistencia a la insulina y adipocinas en pacientes con enfermedad hepática no alcohólica
by R. Aller and D. A. de Luis and D. Pacheco and M. C. Velasco and R. Conde and O. Izaola and M. González Sagrado
Nutrición Hospitalaria, ISSN 0212-1611, 10/2012, Volume 27, Issue 5, pp. 1637 - 1642
Background: Considering the evidence that endogenous cannabinoid system plays a role in metabolic aspects of body weight and metabolic syndrome components such... 
Esteatosis. Polimorfismo | Adipocitoquinas | Resistencia a la insulina | Cannabinoid receptor gene | Insulin resistance | Adipokines | Gen del receptor canabi-noide | Steatosis | Polymorphism
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14. Full Text mutações no gene do receptor do fator de crescimento insulina-Símile 1 (IGF1R) como causa de retardo do crescimento pré- e pós-natal
by de Castro Leal, Andréa and Canton, Ana Pinheiro Machado and Montenegro, Luciana Ribeiro and Coutinho, Débora Cabral and Arnhold, Ivo Jorge Prado and de Lima Jorge, Alexander Augusto
Arquivos Brasileiros de Endocrinologia e Metabologia, ISSN 0004-2730, 11/2011, Volume 55, Issue 8, pp. 541 - 549
Aproximadamente 10% das crianças nascidas pequenas para a idade gestacional (PIGs) não apresentam recuperação espontânea do crescimento. As causas desse... 
Mutation | Fetal growth retardation | Insulin-like growth factor I | Receptor | IGF type 1 | Growth disorders | ENDOCRINOLOGY & METABOLISM
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15. Full Text Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons
by Rodriguez-Rodriguez, Patricia and Sandebring-Matton, Anna and Merino-Serrais, Paula and Parrado-Fernandez, Cristina and Rabano, Alberto and Winblad, Bengt and Ávila, Jesús and Ferrer, Isidre and Cedazo-Minguez, Angel
Brain, ISSN 0006-8950, 12/2017, Volume 140, Issue 12, pp. 3269 - 3285
Insulin signalling deficiencies and insulin resistance have been directly linked to the progression of neurodegenerative disorders like Alzheimer's disease.... 
tau | insulin | Alzheimer's disease | oligomers | neurofibrillary tangles | RECEPTOR SUBSTRATE | ALZHEIMERS-DISEASE | NEUROSCIENCES | CLINICAL NEUROLOGY | MOUSE MODEL | IN-VIVO | A-BETA | MIDDLE-AGED ADULTS | DEGRADING ENZYME | GLUCOSE-UPTAKE | GROWTH-FACTOR EXPRESSION | BRAIN | Phosphorylation | Humans | Middle Aged | Insulin Resistance | tau Proteins - metabolism | Male | Brain - metabolism | Insulin - metabolism | Alzheimer Disease - metabolism | Aged, 80 and over | Supranuclear Palsy, Progressive - metabolism | Female | Aged | Neurons - metabolism | Malaltia d'Alzheimer | Brain | Resistència a la insulina | Neurones | Neurons | Cervell | Insulin resistance | Metabolisme | Metabolism
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16. Full Text Efficacy and Safety of IDegLira Versus Basal-Bolus Insulin Therapy in Patients With Type 2 Diabetes Uncontrolled on Metformin and Basal Insulin: The DUAL VII Randomized Clinical Trial
by Billings, LK and Doshi, A and Gouet, D and Oviedo, A and Rodbard, HW and Tentolouris, N and Gron, R and Halladin, N and Jodar, E
DIABETES CARE, ISSN 0149-5992, 05/2018, Volume 41, Issue 5, pp. 1009 - 1016
OBJECTIVE In patients with uncontrolled type 2 diabetes on basal insulin, prandial insulin may be initiated. We assessed the efficacy and safety of initiating... 
FIXED-RATIO COMBINATION | MANAGEMENT | ENDOCRINOLOGY & METABOLISM | HYPOGLYCEMIA | GLP-1 RECEPTOR AGONIST | INERTIA | LIRAGLUTIDE IDEGLIRA | DEGLUDEC | DEGLUDEC/LIRAGLUTIDE | Glycated Hemoglobin A - analysis | Humans | Middle Aged | Male | Metformin - adverse effects | Insulin Glargine - administration & dosage | Insulin Aspart - administration & dosage | Hypoglycemic Agents - administration & dosage | Adult | Female | Metformin - administration & dosage | Drug Therapy, Combination | Insulin Glargine - adverse effects | Insulin - administration & dosage | Treatment Outcome | Blood Glucose - drug effects | Insulin, Long-Acting - adverse effects | Insulin, Long-Acting - administration & dosage | Liraglutide - adverse effects | Aged | Liraglutide - administration & dosage | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Insulin - adverse effects | Insulin Aspart - adverse effects | Drug Combinations | Type 2 diabetes | Care and treatment | Control | Blood sugar | Analysis | Hemoglobin | Diagnosis | Research | Hypoglycemia | Drug therapy | Insulin
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17. Insulin signaling
: from cultured cells to animal models
by Grunberger, George and Zick, Yehiel
2002, Frontiers in animal diabetes research, ISBN 9780415271745, Volume 3, xviii, 423
With contributions from the leading researchers in the field, this volume brings together the latest studies on insulin action and signal transduction to... 
metabolism | Receptors, Insulin | Diabetes | Insulin | Cellular signal transduction
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18. Insulin
: its receptor and diabetes
by Hollenberg, Morley D
1985, ISBN 9780824773830, Volume 6., x, 318
Insulin | Receptors | Diabetes
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19. Early detection of potential diabetics
: the problems and the promise
by Grave, Gilman D
1979, ISBN 0890043019, xv, 260
Obesity | Receptors | Diabetes mellitus | Genetic aspects | Diabetes | Diagnosis | Complications and sequelae | Insulin | Prediabetic state
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20. Full Text G1359A polymorphism of the cannabinoid receptor gene (CNR1) and insulin resistance in patients with diabetes mellitus type 2 Relación del polimorfismo G1359A del receptor endocanabinoide CB1 y la resistencia a la insulina en pacientes con diabetes mellitus tipo 2
by D. A. de Luis and M. González Sagrado and R. Aller and O. Izaola and R. Conde and E. Romero
Nutrición Hospitalaria, ISSN 0212-1611, 02/2010, Volume 25, Issue 1, pp. 34 - 38
Background: A silent intragenic biallelic polymorphism (1359 G/A) (rs1049353) of the CB1 gene resulting in the substitution of the G to A at nucleotide... 
Gen del receptor cannabinoide | Diabetes mellitus | Insulin resistencia | Cannabinoid receptor gene | Insulin resistance | Polimorfismo | Polymorphism
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