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Pharmacology and Therapeutics, ISSN 0163-7258, 2007, Volume 113, Issue 3, pp. 523 - 536
Journal Article
Circulation Research, ISSN 0009-7330, 05/2012, Volume 110, Issue 11, pp. 1454 - 1464
Journal Article
Circulation Research, ISSN 0009-7330, 02/2013, Volume 112, Issue 3, pp. 498 - 509
RATIONALE:In the failing heart, persistent β-adrenergic receptor activation is thought to induce myocyte death by protein kinase A (PKA)-dependent and... 
apoptosis | cAMP | exchange protein directly activated by cAMP | protein kinase A inhibition | Ca2+/calmodulin-dependent protein kinase II | extracellular signal-regulated kinases 1/2 | BETA-ADRENERGIC STIMULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | C-EPSILON | MYOCARDIAL-INFARCTION | HEART-FAILURE | INHIBITION PROTECTS | VENTRICULAR MYOCYTES | CELL APOPTOSIS | A-INDEPENDENT ACTIVATION | RAT CARDIAC MYOCYTES | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | CALMODULIN KINASE-II | Calcium - metabolism | Heart Failure - enzymology | Heart Failure - physiopathology | rac GTP-Binding Proteins - metabolism | Cardiomegaly - pathology | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Isoproterenol | Recombinant Fusion Proteins - metabolism | Dose-Response Relationship, Drug | Heart Failure - prevention & control | Myocytes, Cardiac - enzymology | Adrenergic beta-Antagonists - pharmacology | Transfection | Time Factors | Sarcoplasmic Reticulum - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Receptors, Adrenergic, beta - drug effects | Receptors, Adrenergic, beta - metabolism | Cyclic AMP - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Green Fluorescent Proteins - metabolism | rap1 GTP-Binding Proteins - metabolism | Cats | Signal Transduction | Cells, Cultured | Mice, Transgenic | Cardiomegaly - enzymology | Heart Failure - pathology | Stroke Volume | Myocytes, Cardiac - pathology | Animals | Cardiomegaly - prevention & control | Myocytes, Cardiac - drug effects | Fibrosis | Cytosol - metabolism | Mice | Enzyme Activation | Heart Failure - chemically induced | Apoptosis | Index Medicus | dependent protein kinase II | ERK2 | Ca2 | EPAC
Journal Article
Circulation research, ISSN 0009-7330, 04/2015, Volume 116, Issue 8, pp. 1304 - 1311
Rationale: Cyclic nucleotides are second messengers that regulate cardiomyocyte function through compartmentalized signaling in discrete subcellular... 
phosphodiesterase 3 inhibitors | membrane microdomains | 3',5'-cyclic-AMP phosphodiesterases | hypertrophy | atrial natriuretic factor | receptors, adrenergic | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | ATRIAL-NATRIURETIC-PEPTIDE | MYOCYTES | HEART-FAILURE | RECEPTOR | CARDIOMYOCYTES | 3 ',5 '-cyclic-AMP phosphodiesterases | PERIPHERAL VASCULAR DISEASE | MICE | GUANYLYL CYCLASE-A | HEMATOLOGY | COMPARTMENTATION | CAMP | Myocardial Contraction - drug effects | Cardiomegaly - pathology | Receptors, Adrenergic, beta-2 - drug effects | Myocytes, Cardiac - enzymology | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Fluorescence Resonance Energy Transfer | Female | Receptors, Adrenergic, beta-1 - drug effects | Atrial Natriuretic Factor - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Receptors, Adrenergic, beta - drug effects | Receptors, Adrenergic, beta - metabolism | Disease Models, Animal | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Second Messenger Systems - drug effects | Membrane Microdomains - enzymology | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Adrenergic beta-Agonists - pharmacology | Cardiomegaly - physiopathology | Mice, Transgenic | Receptors, Adrenergic, beta-1 - metabolism | Cardiomegaly - enzymology | Receptors, Adrenergic, beta-2 - metabolism | Protein Transport | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Cyclic GMP - metabolism | Membrane Microdomains - drug effects | Isoproterenol - pharmacology | Biosensing Techniques | Mice | Enzyme Activation | Receptor Cross-Talk - drug effects | Index Medicus
Journal Article
Depression and Anxiety, ISSN 1091-4269, 03/2011, Volume 28, Issue 3, pp. 186 - 193
Background: Posttraumatic stress disorder (PTSD) is associated with enhanced noradrenergic activity. Animal and human studies demonstrate that noradrenergic... 
norepinephrine | amygdala | fear conditioning | exposure therapy | isoproterenol | reconsolidation | β‐adrenergic receptor | posttraumatic stress disorder | PTSD | anxiety | extinction | late‐onset PTSD | propranolol | fear | Late-onset ptsd | Amygdala | Extinction | Posttraumatic stress disorder | Isoproterenol | Exposure therapy | Fear conditioning | Fear | Reconsolidation | β-adrenergic receptor | Anxiety | Norepinephrine | Propranolol | late-onset PTSD | POSTTRAUMATIC-STRESS-DISORDER | PSYCHIATRY | PSYCHOLOGY, CLINICAL | PROTEIN-SYNTHESIS | RETRIEVAL | PSYCHOLOGY | PATHOPHYSIOLOGY | beta-adrenergic receptor | CONSOLIDATION | ANIMAL-MODELS | NEUROBIOLOGY | Amygdala - physiopathology | Amygdala - drug effects | Norepinephrine - physiology | Humans | Retention (Psychology) - drug effects | Extinction, Psychological - drug effects | Fear - drug effects | Male | Stress Disorders, Post-Traumatic - physiopathology | Fear - physiology | Retention (Psychology) - physiology | Implosive Therapy | Adrenergic beta-Antagonists - pharmacology | Propranolol - pharmacology | Receptors, Adrenergic, beta - drug effects | Extinction, Psychological - physiology | Cues | Conditioning, Classical - drug effects | Acoustic Stimulation | Adrenergic beta-Agonists - pharmacology | Rats | Receptors, Adrenergic, beta - physiology | Conditioning, Classical - physiology | Rats, Sprague-Dawley | Animals | Isoproterenol - pharmacology | Signal Transduction - physiology | Learning | Memory | Post-traumatic stress disorder | Depression | Neurotransmitters | PTSD (DSM-IV) | Conditioned Emotional Responses | Animal Models | Stressors
Journal Article
Circulation Research, ISSN 0009-7330, 02/2007, Volume 100, Issue 3, pp. 391 - 398
Enhanced cardiac diastolic Ca leak from the sarcoplasmic reticulum (SR) ryanodine receptor may reduce SR Ca content and contribute to arrhythmogenesis. We... 
Excitation-contraction coupling | Sarcoplasmic reticulum | Ryanodine receptor | RYANODINE RECEPTOR PHOSPHORYLATION | BETA-ADRENERGIC STIMULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | CONTRACTILITY | HEART-FAILURE | RELEASE CHANNEL | FAILING HEARTS | sarcoplasmic reticulum | MOUSE VENTRICULAR MYOCYTES | SR CA2+ LOAD | II PHOSPHORYLATION | PERIPHERAL VASCULAR DISEASE | RABBIT | ryanodine receptor | HEMATOLOGY | excitation-contraction coupling | Phosphorylation | Diastole | Calcium - metabolism | Calcium Signaling - physiology | Myocardial Contraction - physiology | Myocardial Contraction - drug effects | Ryanodine Receptor Calcium Release Channel - metabolism | Tetracaine - pharmacology | Isoquinolines - pharmacology | Myocardium - metabolism | Sarcoplasmic Reticulum - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Receptors, Adrenergic, beta - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | Heart Failure - etiology | Calcium-Calmodulin-Dependent Protein Kinases - physiology | Rabbits | Cells, Cultured - drug effects | Colforsin - pharmacology | Adrenergic beta-Agonists - pharmacology | Calcium Channels, L-Type - physiology | Receptors, Adrenergic, beta - physiology | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Sulfonamides - pharmacology | Protein Processing, Post-Translational - physiology | Peptides - pharmacology | Calmodulin - physiology | Cyclic AMP-Dependent Protein Kinases - physiology | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Calcium Signaling - drug effects | Isoproterenol - pharmacology | Myocytes, Cardiac - metabolism | Signal Transduction - physiology | Cells, Cultured - metabolism | Benzylamines - pharmacology
Journal Article
Circulation research, ISSN 0009-7330, 2014, Volume 114, Issue 2, pp. 283 - 294
Journal Article