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The Journal of clinical investigation, ISSN 1558-8238, 2016, Volume 126, Issue 5, pp. 1704 - 1716
... through beta-adrenergic receptor (beta ARs) and protein kinase A (PKA) signaling. Here, we have shown that a key hub in the insulin signaling pathway, activation of p70 ribosomal S6 kinase (S6K1... 
MEDICINE, RESEARCH & EXPERIMENTAL | UNCOUPLING PROTEIN-1 GENE | WHITE FAT | GLUCOSE-HOMEOSTASIS | CYCLIC-AMP | ADIPOCYTE PROLIFERATION | INITIATION-FACTOR 4E | SMOOTH-MUSCLE-CELLS | ADULT HUMANS | DIET-INDUCED OBESITY | INSULIN SENSITIVITY | TOR Serine-Threonine Kinases - metabolism | Humans | Adipose Tissue, White - metabolism | Multiprotein Complexes - genetics | Uncoupling Protein 1 - biosynthesis | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Adipose Tissue, White - cytology | Cyclic AMP-Dependent Protein Kinases - genetics | TOR Serine-Threonine Kinases - genetics | HEK293 Cells | Regulatory-Associated Protein of mTOR | Insulin - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Uncoupling Protein 1 - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - genetics | 3T3-L1 Cells | Mice, Knockout | Adipose Tissue, Brown - cytology | Insulin - metabolism | Animals | Receptors, Adrenergic, beta - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Adipose Tissue, Brown - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 05/2015, Volume 55, Issue 5, pp. 1045 - 1061
...) derived from all ligand-bound β-adrenergic crystal structure monomers to post-process the docking poses of known β1R... 
Adrenergic beta-2 Receptor Antagonists | Humans | Computational Biology | Library and Information Sciences | Chemistry(all) | Crystallography, X-Ray | Receptors, Adrenergic, beta-2 | Adrenergic beta-2 Receptor Agonists | Journal Article | Adrenergic beta-1 Receptor Antagonists | Animals | Computer Science Applications | Research Support, Non-U.S. Gov't | Receptors, Adrenergic, beta-1 | Adrenergic beta-1 Receptor Agonists | Chemical Engineering(all) | Ligands | Protein Conformation | Medicine(all) | Molecular Docking Simulation | Drug Evaluation, Preclinical | CHEMISTRY, MEDICINAL | CRYSTAL-STRUCTURE | COMPUTER SCIENCE, INFORMATION SYSTEMS | HUMAN P2Y RECEPTOR | ADRENERGIC-RECEPTOR | 2 SERINE RESIDUES | CHEMISTRY, MULTIDISCIPLINARY | A(2A) ADENOSINE RECEPTOR | MOLECULAR INTERACTION FINGERPRINTS | MUSCARINIC ACETYLCHOLINE-RECEPTOR | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | STRUCTURE-BASED DISCOVERY | BETA-ADRENERGIC RECEPTOR | PARTIAL AGONIST ACTIVITY | Computational Biology - methods | Adrenergic beta-1 Receptor Antagonists - pharmacology | Adrenergic beta-2 Receptor Agonists - metabolism | Receptors, Adrenergic, beta-1 - metabolism | Receptors, Adrenergic, beta-1 - chemistry | Adrenergic beta-1 Receptor Agonists - pharmacology | Receptors, Adrenergic, beta-2 - metabolism | Adrenergic beta-2 Receptor Agonists - pharmacology | Receptors, Adrenergic, beta-2 - chemistry | Adrenergic beta-2 Receptor Antagonists - metabolism | Adrenergic beta-1 Receptor Antagonists - metabolism | Adrenergic beta-1 Receptor Agonists - metabolism | Adrenergic beta-2 Receptor Antagonists - pharmacology
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 03/2012, Volume 18, Issue 5, pp. 1201 - 1206
Journal Article
Circulation Research, ISSN 0009-7330, 02/2013, Volume 112, Issue 3, pp. 498 - 509
RATIONALE:In the failing heart, persistent β-adrenergic receptor activation is thought to induce myocyte death by protein kinase A (PKA... 
apoptosis | cAMP | exchange protein directly activated by cAMP | protein kinase A inhibition | Ca2+/calmodulin-dependent protein kinase II | extracellular signal-regulated kinases 1/2 | BETA-ADRENERGIC STIMULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | C-EPSILON | MYOCARDIAL-INFARCTION | HEART-FAILURE | INHIBITION PROTECTS | VENTRICULAR MYOCYTES | CELL APOPTOSIS | A-INDEPENDENT ACTIVATION | RAT CARDIAC MYOCYTES | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | CALMODULIN KINASE-II | Calcium - metabolism | Heart Failure - enzymology | Heart Failure - physiopathology | rac GTP-Binding Proteins - metabolism | Cardiomegaly - pathology | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Isoproterenol | Recombinant Fusion Proteins - metabolism | Dose-Response Relationship, Drug | Heart Failure - prevention & control | Myocytes, Cardiac - enzymology | Adrenergic beta-Antagonists - pharmacology | Transfection | Time Factors | Sarcoplasmic Reticulum - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Receptors, Adrenergic, beta - drug effects | Receptors, Adrenergic, beta - metabolism | Cyclic AMP - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Green Fluorescent Proteins - metabolism | rap1 GTP-Binding Proteins - metabolism | Cats | Signal Transduction | Cells, Cultured | Mice, Transgenic | Cardiomegaly - enzymology | Heart Failure - pathology | Stroke Volume | Myocytes, Cardiac - pathology | Animals | Cardiomegaly - prevention & control | Myocytes, Cardiac - drug effects | Fibrosis | Cytosol - metabolism | Mice | Enzyme Activation | Heart Failure - chemically induced | Apoptosis | Index Medicus | dependent protein kinase II | ERK2 | Ca2 | EPAC
Journal Article
Circulation Research, ISSN 0009-7330, 03/2017, Volume 120, Issue 7, pp. 1103 - 1115
Journal Article
PLoS biology, ISSN 1545-7885, 2019, Volume 17, Issue 8, p. e3000412
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2011, Volume 31, Issue 17, pp. 6277 - 6288
.... Here we show that repeated social defeat in mice increased c-Fos staining in brain regions associated with fear and threat appraisal and promoted anxiety-like behavior in a beta-adrenergic receptor-dependent manner... 
INDUCED GLUCOCORTICOID RESISTANCE | CYTOKINE RESPONSES | AUTOIMMUNE DEMYELINATING DISEASE | IN-VIVO | ANIMAL-MODELS | RAT HIPPOCAMPUS | AGED MICE | STRESS | NEUROSCIENCES | EXPERIMENTAL-MODELS | BRAIN | Inflammation - pathology | Flow Cytometry - methods | Male | Tacrolimus Binding Proteins - metabolism | RNA, Messenger - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | Prefrontal Cortex - pathology | Dose-Response Relationship, Drug | Inflammation - metabolism | Anxiety Disorders - pathology | Propranolol - administration & dosage | Receptors, Interleukin-1 - deficiency | Social Behavior | Behavior, Animal - drug effects | Adrenergic beta-Antagonists - administration & dosage | Cytokines - blood | Microglia - drug effects | Mice, Inbred C57BL | Cells, Cultured | Proto-Oncogene Proteins c-fos - metabolism | Transcription Factors - genetics | Anxiety Disorders - etiology | Inflammation - etiology | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Tacrolimus Binding Proteins - genetics | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Anxiety Disorders - prevention & control | Animals | Analysis of Variance | Lipopolysaccharides - pharmacology | Proto-Oncogene Proteins c-fos - genetics | Mice | Stress, Psychological - complications
Journal Article
Cancer immunology, immunotherapy, ISSN 1432-0851, 2018, Volume 68, Issue 1, pp. 11 - 22
.... Norepinephrine, the primary neurotransmitter secreted by post-ganglionic sympathetic neurons, binds toand activates -adrenergic receptors expressed on the surface of immune cells and regulates... 
T-cell suppression | Adrenergic signaling | CD8 | Tumor immunology | Glycolysis | Metabolic reprogramming | T-cell activation | PATHWAYS | DRIVER | RECEPTOR | IMMUNOLOGY | ONCOLOGY | SUPPRESSES | MICE | EXPRESSION | CD8(+) T-cell suppression | TUMOR MICROENVIRONMENT | MODULATION | CD8-Positive T-Lymphocytes - cytology | Glucose - immunology | Receptors, Adrenergic, beta-2 - genetics | Mice, Inbred C57BL | Cells, Cultured | Adrenergic beta-Agonists - pharmacology | Receptors, Adrenergic, beta-2 - immunology | Receptors, Adrenergic, beta-2 - metabolism | Mice, Knockout | Adrenergic beta-Antagonists - pharmacology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Propranolol - pharmacology | Animals | Signal Transduction - drug effects | Immune Tolerance - immunology | Lymphocyte Activation - drug effects | Isoproterenol - pharmacology | CD8-Positive T-Lymphocytes - metabolism | Glucose - metabolism | Female | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Immune Tolerance - drug effects | Glucose transporter | Metabolic rate | Memory cells | Immunological memory | CD8 antigen | Effector cells | T cell receptors | Lymphocytes T | Glucose | Isoproterenol | Metabolism | Immunosuppression | Mitochondria | Cell activation | Autonomic nervous system | Sympathetic nerves | Adrenergic receptors | Norepinephrine | Propranolol | CD8+ T-cell suppression | Original
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 02/2013, Volume 112, Issue 3, pp. 476 - 486
RATIONALE:Short-term β-adrenergic stimulation promotes contractility in response to stress but is ultimately detrimental in the failing heart because of accrual of cardiomyocyte death... 
heart failure | cardiac progenitor cells | adrenergic regulation | adrenergic receptors | adult stem cells | PROTEIN-KINASE-A | CHRONIC HEART-FAILURE | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | DILATED CARDIOMYOPATHY | LEFT-VENTRICULAR DYSFUNCTION | FAILING HEART | GENE-EXPRESSION | MEDIATED DNA-SYNTHESIS | PERIPHERAL VASCULAR DISEASE | CYCLE PROGRESSION | BETA-ADRENERGIC RECEPTORS | HEMATOLOGY | Cyclin D1 - metabolism | Phosphorylation | Coculture Techniques | Humans | Male | G-Protein-Coupled Receptor Kinase 2 - metabolism | Receptors, Adrenergic, beta-2 - drug effects | Proto-Oncogene Proteins c-kit - metabolism | Stem Cells - metabolism | Adrenergic beta-2 Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Stem Cell Transplantation | Transfection | RNA Interference | Time Factors | Myocardial Infarction - pathology | Cell Death | Receptors, Adrenergic, beta-1 - drug effects | Nitric Oxide Synthase Type III - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Adrenergic beta-2 Receptor Antagonists - pharmacology | Disease Models, Animal | Myocardial Infarction - surgery | Cell Survival | Receptors, Adrenergic, beta-2 - genetics | Cells, Cultured | Receptors, Adrenergic, beta-1 - metabolism | Myocardial Infarction - metabolism | Receptors, Adrenergic, beta-2 - metabolism | Myocytes, Cardiac - pathology | Myocytes, Cardiac - transplantation | Animals | Myocytes, Cardiac - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Myocytes, Cardiac - metabolism | Stem Cells - drug effects | Stem Cells - pathology | Receptors, Adrenergic, beta-1 - genetics | Cell Proliferation - drug effects | Mice | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article