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1. Full Text Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes
by Yoichi Shinkai and Shigeo Koyasu and Kei-ichi Nakayama and Kenneth M. Murphy and Dennis Y. Loh and Ellis L. Reinherz and Frederick W. Alt
Science, ISSN 0036-8075, 2/1993, Volume 259, Issue 5096, pp. 822 - 825
Introduction of TCRα transgene, TCRβ transgene, or both into RAG-2$^{-/-}$ mice differentially rescues T cell development. RAG-2$^{-/-}$ mice have small... 
T lymphocytes | Thymocytes | rev genes | Transgenic animals | Developmental biology | B lymphocytes | Cell lines | Reports | Dimers | Transgenes | T cell antigen receptors | SCID MUTATION | CHAIN | CD3-ZETA | ALPHA | MONOCLONAL-ANTIBODY | DIFFERENTIATION | IMMUNOLOGY | ANTIGEN RECEPTOR | EXPRESSION | T-Lymphocyte Subsets - immunology | Molecular Weight | Receptors, Antigen, T-Cell, alpha-beta - analysis | Molecular Sequence Data | Receptors, Antigen, T-Cell, gamma-delta - genetics | Polymerase Chain Reaction - methods | CD3 Complex - genetics | Base Sequence | DNA-Binding Proteins | Gene Expression | Oligodeoxyribonucleotides | Electrophoresis, Polyacrylamide Gel | Mice, Transgenic | Antibodies, Monoclonal | Receptors, Antigen, T-Cell, alpha-beta - genetics | CD8 Antigens - analysis | Proteins - genetics | CD3 Complex - analysis | Animals | Receptors, Antigen, T-Cell, gamma-delta - analysis | CD4 Antigens - analysis | T-Lymphocytes - immunology | Thymus Gland - immunology | Cell Membrane - immunology | Mice | Genetically modified mice | T cells | Research | MEMBRANE PROTEINS | SOMATIC CELLS 550400 -- Genetics | BASIC BIOLOGICAL SCIENCES | GENETICS | ORGANIC COMPOUNDS | GENES | BIOLOGY | CELL DIFFERENTIATION | RECEPTORS | THYMOCYTES | ANIMAL CELLS | PROTEINS
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2. Full Text Microbial Colonization Drives Expansion of IL-1 Receptor 1-Expressing and IL-17-Producing γ/δ T Cells
by Duan, Jinyou and Chung, Hachung and Troy, Erin and Kasper, Dennis L
Cell Host & Microbe, ISSN 1931-3128, 2010, Volume 7, Issue 2, pp. 140 - 150
IL-17 cytokine production by the Th17 T cell subset is regulated by intestinal commmensals. We show that microbial colonization also regulates innate IL-17... 
MOLIMMUNO | MICROBIO | GAMMA | HOST IMMUNE-SYSTEM | BACTERIA | ACTIVATION | RECOGNITION | MHCII PATHWAY | MICROBIOLOGY | INFECTION | MICE | INDUCTION | LYMPHOCYTES | T-Lymphocyte Subsets - immunology | Cell Proliferation | Mice, Inbred C57BL | Gastrointestinal Tract - microbiology | Male | Interleukin-17 - biosynthesis | Mice, Knockout | Receptors, Interleukin-1 - analysis | Bacteria - immunology | Animals | Receptors, Antigen, T-Cell, gamma-delta - analysis | Models, Biological | T-Lymphocyte Subsets - chemistry | T-Lymphocytes - chemistry | T-Lymphocytes - immunology | Mice | IL-1R1 | gamma delta | IL-23 | Bacteroides fragilis | IL-17
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3. Full Text γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ + /CD19 + lymphocytes
by Airoldi, Irma and Bertaina, Alice and Prigione, Ignazia and Zorzoli, Alessia and Pagliara, Daria and Cocco, Claudia and Meazza, Raffaella and Loiacono, Fabrizio and Lucarelli, Barbarella and Bernardo, Maria Ester and Barbarito, Giulia and Pende, Daniela and Moretta, Alessandro and Pistoia, Vito and Moretta, Lorenzo and Locatelli, Franco
Blood, ISSN 0006-4971, 04/2015, Volume 125, Issue 15, pp. 2349 - 2358
We prospectively assessed functional and phenotypic characteristics of γδ T lymphocytes up to 7 months after HLA-haploidentical hematopoietic stem cell... 
B-Lymphocytes - cytology | Cell Degranulation | Antigens, CD19 - analysis | Humans | Receptors, Antigen, T-Cell, alpha-beta - analysis | Cells, Cultured | Child, Preschool | Leukemia - therapy | Infant | Male | T-Lymphocytes - transplantation | Receptors, Antigen, T-Cell, gamma-delta - analysis | T-Lymphocytes - cytology | Adolescent | Female | Hematopoietic Stem Cell Transplantation - methods | Child | Immunobiology
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4. Full Text Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with Diverse TCR Repertoires
by Terzieva, A and Dimitrova, V and Djerov, L and Dimitrova, P and Zapryanova, S and Hristova, I and Vangelov, I and Dimova, T
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 02/2019, Volume 20, Issue 3, p. 687
Pregnancy is a state where high and stage-dependent plasticity of the maternal immune system is necessary in order to equilibrate between immunosuppression of... 
TCR repertoire diversity | CHEMOKINE RECEPTOR EXPRESSION | RECOGNITION | decidua | BIOCHEMISTRY & MOLECULAR BIOLOGY | EARLY-STAGE | SUBSETS | delta T-cell effectors | human pregnancy | CHEMISTRY, MULTIDISCIPLINARY | MHC CLASS-I | NK CELLS | MEMORY | ACCUMULATION | HUMAN ENDOMETRIUM | gamma | LYMPHOCYTES | Pregnancy | Receptors, Antigen, T-Cell, gamma-delta - analysis | Receptors, Antigen, T-Cell, gamma-delta - blood | Decidua - immunology | Lymphocyte Activation | Humans | Immune Tolerance | Female | Fetus - immunology | Receptors, Antigen, T-Cell, gamma-delta - immunology | T-Lymphocytes - immunology | gamma/delta T-cell effectors
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5. Full Text CD1-mediated γ/δ T cell maturation of dendritic cells
by Leslie, David S and Vincent, Michael S and Spada, Franca M and Das, Hiranmoy and Sugita, Masahiko and Morita, Craig T and Brenner, Michael B
Journal of Experimental Medicine, ISSN 0022-1007, 12/2002, Volume 196, Issue 12, pp. 1575 - 1584
Immature myeloid dendritic cells (DCs) express only low levels of major histocompatibility complex (MHC) class II but express high levels of CD1 a, b, and c... 
CD1 | Antigen-presenting cell | Dendritic cells | Tumor necrosis factor | T cell antigen receptors γ/δ | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | antigen-presenting cell | RECOGNITION | RECEPTOR | IMMUNOLOGY | GAMMA-DELTA LYMPHOCYTES | MOLECULES | T cell antigen receptors gamma/delta | dendritic cells | tumor necrosis factor | IN-VIVO | INFECTION | INNATE IMMUNITY | ANTIGEN | Tumor Necrosis Factor-alpha - metabolism | Membrane Glycoproteins - metabolism | T-Lymphocyte Subsets - cytology | Coculture Techniques | Humans | Dendritic Cells - physiology | Interferon-gamma - metabolism | Immunoglobulins - metabolism | CD40 Ligand - metabolism | Flow Cytometry | Antigen Presentation | Dendritic Cells - drug effects | Cell Differentiation - physiology | Antibodies, Monoclonal - immunology | Antigens, CD1 - immunology | Cells, Cultured | Interleukin-12 - metabolism | Phenotype | Receptors, Antigen, T-Cell, gamma-delta - analysis | T-Lymphocyte Subsets - metabolism | Antigens, CD1 - metabolism | Lipopolysaccharides - pharmacology | Dendritic Cells - cytology | Antibodies, Monoclonal - metabolism | Antigens, CD | T cell antigen receptors γ
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6. Full Text Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability
by Lee, Jacob S and Tato, Cristina M and Joyce-Shaikh, Barbara and Gulen, Muhammet F and Cayatte, Corinne and Chen, Yi and Blumenschein, Wendy M and Judo, Michael and Ayanoglu, Gulesi and McClanahan, Terrill K and Li, Xiaoxia and Cua, Daniel J
Immunity, ISSN 1074-7613, 10/2015, Volume 43, Issue 4, pp. 727 - 738
Whether interleukin-17A (IL-17A) has pathogenic and/or protective roles in the gut mucosa is controversial and few studies have analyzed specific cell... 
ACT1 | INFLAMMATION | PROINFLAMMATORY IL-17(+) | BARRIER FUNCTION | RECEPTOR | INNATE LYMPHOID-CELLS | IMMUNOLOGY | IL-23 | EXPRESSION | T-CELLS | TH17 CELLS | Cell Polarity | Intestinal Mucosa - physiopathology | Humans | Epithelium - physiopathology | Interleukin-17 - physiology | Interleukin-17 - pharmacology | Occludin - metabolism | Lymphocyte Subsets - metabolism | Tight Junctions - physiology | Colitis - chemically induced | Nuclear Receptor Subfamily 1, Group F, Member 3 - deficiency | Interleukin-23 - physiology | Disease Models, Animal | Acute Disease | Interleukin-17 - deficiency | Permeability | Recombinant Proteins - pharmacology | Dextran Sulfate - toxicity | Mice, Knockout | Protein Transport | Tumor Necrosis Factor-alpha - pharmacology | Adaptor Proteins, Signal Transducing - physiology | Animals | Colitis - physiopathology | Receptors, Antigen, T-Cell, gamma-delta - analysis | Adaptor Proteins, Signal Transducing - deficiency | Colonic Neoplasms - pathology | Cell Line, Tumor | Mice | Homeodomain Proteins - physiology | Interleukins | T cells | Analysis | Inflammatory bowel disease | Cytokines | Lymphocytes | Rodents | Tumor necrosis factor-TNF | Gene expression
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7. Full Text Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma
by Toro, Jorge R and Liewehr, David J and Pabby, Nina and Sorbara, Lynn and Raffeld, Mark and Steinberg, Seth M and Jaffe, Elaine S
Blood, ISSN 0006-4971, 05/2003, Volume 101, Issue 9, pp. 3407 - 3412
The importance of alphabeta versus gammadelta T-cell subset antigen expression in the classification of peripheral T-cell lymphomas is still unclear. The... 
PANNICULITIS | DISTINCT CLINICOPATHOLOGICAL ENTITY | MYCOSIS-FUNGOIDES | CLASSIFICATION | PROPOSAL | LEUKEMIA | MUCOSAL | RECEPTORS | HEMATOLOGY | EXPRESSION | LYMPHOCYTES | T-Lymphocyte Subsets - immunology | Lymph Nodes - pathology | Prognosis | Lymphoma, T-Cell, Cutaneous - immunology | Humans | Middle Aged | Neoplastic Stem Cells - immunology | Male | Life Tables | Neoplastic Stem Cells - chemistry | Skin Neoplasms - blood | Lymphoma, T-Cell, Cutaneous - blood | Skin Neoplasms - mortality | Hemorrhage - etiology | T-Lymphocyte Subsets - chemistry | Aged, 80 and over | Adult | Female | Lymphoma, T-Cell, Cutaneous - mortality | Skin Neoplasms - immunology | Proportional Hazards Models | Receptors, Antigen, T-Cell, gamma-delta - analysis | Bone Marrow - pathology | Adolescent | Survival Analysis | Neoplasm Proteins - analysis | Aged
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8. Full Text A variant of SCID with specific immune responses and predominance of gamma delta T cells
by Ehl, S and Schwarz, K and Enders, A and Duffner, U and Pannicke, U and Kuhr, J and Mascart, F and Schmitt-Graeff, A and Niemeyer, C and Fisch, P
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 11/2005, Volume 115, Issue 11, pp. 3140 - 3148
We describe here a patient with a clinical and molecular diagnosis of recombinase activating gene 1-deficient (RAG1-deficient) SCID, who produced specific... 
MEDICINE, RESEARCH & EXPERIMENTAL | Fibroblasts - virology | Amino Acid Sequence | Receptors, Antigen, T-Cell, gamma-delta - biosynthesis | Humans | Cells, Cultured | Molecular Sequence Data | Immunophenotyping | Infant | Receptors, Antigen, T-Cell, gamma-delta - genetics | Cytomegalovirus Infections - immunology | Severe Combined Immunodeficiency - immunology | Homeodomain Proteins - genetics | Cytomegalovirus - immunology | Severe Combined Immunodeficiency - genetics | Receptors, Antigen, T-Cell, gamma-delta - analysis | T-Lymphocytes - metabolism | Base Sequence | Female | Fibroblasts - immunology | T-Lymphocytes - immunology | Clone Cells
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9. Full Text Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer
by Bense, Rico D and Sotiriou, Christos and Piccart-Gebhart, Martine J and Haanen, John B. A. G and van Vugt, Marcel A. T. M and de Vries, Elisabeth G. E and Schroeder, Carolien P and Fehrmann, Rudolf S. N
Jnci-Journal of the national cancer institute, ISSN 0027-8874, 01/2017, Volume 109, Issue 1, p. djw192
Background: Not all breast cancer patients benefit from neoadjuvant or adjuvant therapy, resulting in considerable undertreatment or overtreatment. New... 
SURVIVAL | TRASTUZUMAB | ONCOLOGY | PROGNOSIS | MACROPHAGES | STROMAL MAST-CELLS | IDENTIFICATION | EXPRESSION | T-CELLS | CHEMOTHERAPY | LYMPHOCYTES | Mast Cells - immunology | Breast Neoplasms - immunology | Humans | Middle Aged | Transcriptome | Survival Rate | Receptors, Estrogen - analysis | T-Lymphocytes, Regulatory - immunology | Disease-Free Survival | Breast Neoplasms - chemistry | Breast Neoplasms - genetics | Receptors, Antigen, T-Cell, gamma-delta - analysis | Computer Simulation | Leukocytes, Mononuclear - immunology | Female | Lymphocytes, Tumor-Infiltrating - chemistry | Receptor, ErbB-2 - analysis | CD8-Positive T-Lymphocytes - immunology | Macrophages - immunology | Breast cancer | T cells | Gene expression | Analysis | Adjuvant treatment | Cancer | Index Medicus
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10. Full Text Anti‐tumour immunotherapy with Vγ9Vδ2 T lymphocytes: from the bench to the bedside
by Braza, Mounia S and Klein, Bernard
British Journal of Haematology, ISSN 0007-1048, 01/2013, Volume 160, Issue 2, pp. 123 - 132
Gamma delta (γδ) Τ cells are non‐conventional T lymphocyte effectors that can interact with and eradicate tumour cells. Several data demonstrate that these T... 
cancer | lymphocytes | gamma delta | immunotherapy | monoclonal antibodies | haematological oncology | Haematological oncology | Monoclonal antibodies | Immunotherapy | Gamma delta T lymphocytes | Cancer | T-Lymphocyte Subsets - immunology | Adjuvants, Immunologic - pharmacology | Dendritic Cells - immunology | Humans | Receptors, Antigen, T-Cell, alpha-beta - analysis | Cells, Cultured - transplantation | Receptors, Antigen, T-Cell, gamma-delta - genetics | Gene Rearrangement, delta-Chain T-Cell Antigen Receptor | Mesenchymal Stromal Cells - immunology | T-Lymphocytes, Regulatory - immunology | Neoplasms - therapy | T-Lymphocytes, Cytotoxic - transplantation | T-Lymphocyte Subsets - chemistry | Diphosphonates - therapeutic use | Killer Cells, Natural - immunology | Cells, Cultured - immunology | Tumor Escape - immunology | Adaptive Immunity | T-Lymphocytes, Cytotoxic - immunology | Cells, Cultured - drug effects | Immunotherapy, Adoptive | Antigens, Neoplasm - immunology | Translational Medical Research | Clinical Trials as Topic | Immunity, Innate | T-Lymphocyte Subsets - transplantation | Immunologic Surveillance - immunology | Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor | T-Lymphocytes, Cytotoxic - chemistry | Receptors, Antigen, T-Cell, gamma-delta - analysis | Neoplasms - immunology | CD8-Positive T-Lymphocytes - immunology | Dendritic Cells - transplantation | Diphosphonates - pharmacology | Immunologic Surveillance | Tumor Escape | Killer Cells, Natural | Dendritic Cells | T-Lymphocytes, Cytotoxic | Neoplasms | CD8-Positive T-Lymphocytes | Life Sciences | Immunology | Mesenchymal Stromal Cells | Receptors, Antigen, T-Cell, alpha-beta | T-Lymphocytes, Regulatory | T-Lymphocyte Subsets | Antigens, Neoplasm | Adjuvants, Immunologic | Cells, Cultured | Diphosphonates | Receptors, Antigen, T-Cell, gamma-delta
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11. Full Text CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5–7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses
by Neves, Patrícia C.C and Rudersdorf, Richard A and Galler, Ricardo and Bonaldo, Myrna C and Santana, Marlon Gilsepp Veloso de and Mudd, Philip A and Martins, Maurício A and Rakasz, Eva G and Wilson, Nancy A and Watkins, David I
Vaccine, ISSN 0264-410X, 2010, Volume 28, Issue 51, pp. 8183 - 8188
Abstract The yellow fever 17D (YF-17D) vaccine is one of the most efficacious vaccines developed to date. Interestingly, vaccination with YF-17D induces IFN-γ... 
Allergy and Immunology | Yellow fever vaccine | IFN-γ | Rhesus model | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | DENDRITIC CELLS | PROTECTION | 1ST-TIME VACCINATION | NILE-VIRUS-INFECTION | IMMUNOLOGY | IFN-gamma | YF ENCEPHALITIS | MICE | INNATE IMMUNITY | CD4-Positive T-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - chemistry | T-Lymphocyte Subsets - immunology | Antigens, Viral - immunology | Animals | Receptors, Antigen, T-Cell, gamma-delta - analysis | Yellow Fever Vaccine - administration & dosage | Yellow Fever Vaccine - immunology | Interferon-gamma - secretion | T-Lymphocyte Subsets - chemistry | Macaca mulatta | CD8-Positive T-Lymphocytes - immunology | Yellow Fever vaccine
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12. Full Text Statins Prevent Bisphosphonate‐Induced γ,δ‐T‐Cell Proliferation and Activation In Vitro
by Thompson, Keith and Rogers, Michael J
Journal of Bone and Mineral Research, ISSN 0884-0431, 02/2004, Volume 19, Issue 2, pp. 278 - 288
The acute phase response is the major adverse effect of intravenously administered N‐BPs. In this study we show that N‐BPs cause γ,δ‐T‐cell activation and... 
acute phase response | osteoporosis | osteoclast | farnesyl diphosphate synthase | mevalonate | Osteoporosis | Farnesyl diphosphate synthase | Osteoclast | Mevalonate | Acute phase response | BONE METASTASES | NITROGEN-CONTAINING BISPHOSPHONATES | NONPEPTIDE ANTIGENS | TUMOR-CELLS | DELTA-T-CELLS | ZOLEDRONIC ACID | ACUTE-PHASE RESPONSE | POSTMENOPAUSAL OSTEOPOROSIS | ENDOCRINOLOGY & METABOLISM | PAGETS-DISEASE | Mevalonic Acid - pharmacology | T-Lymphocytes - enzymology | Humans | Alkyl and Aryl Transferases - antagonists & inhibitors | Geranyltranstransferase | Protein Prenylation | Cell Division - drug effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Receptors, Antigen, T-Cell, gamma-delta - analysis | T-Lymphocytes - cytology | Lymphocyte Activation - drug effects | T-Lymphocytes - drug effects | T-Lymphocytes - immunology | In Vitro Techniques | Diphosphonates - pharmacology
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13. Full Text Gamma Delta T Cells Regulate Wound Myeloid CELL Activity After Burn
by Rani, Meenakshi and Zhang, Qiong and Schwacha, Martin G
Shock, ISSN 1073-2322, 08/2014, Volume 42, Issue 2, pp. 133 - 141
ABSTRACTMajor burns induce immune complications, which are associated with myeloid cell activation by ill-defined mechanisms. Although γδ T cells have been... 
macrophage | cytokines | MDSC | inflammation | Injury | SURGERY | MACROPHAGE HYPERACTIVITY | THERMAL-INJURY | MURINE MODEL | IMMUNE-SYSTEM | IMMUNOSUPPRESSION | PERIPHERAL VASCULAR DISEASE | SYSTEMIC INFLAMMATORY RESPONSE | SUPPRESSOR-CELLS | DYSFUNCTION | HEMATOLOGY | UP-REGULATION | LYMPHOCYTES | CRITICAL CARE MEDICINE | T-Lymphocyte Subsets - immunology | Cytokines - metabolism | Cell Count | Mice, Inbred C57BL | Male | Wound Healing - immunology | Cell Movement - immunology | Animals | Receptors, Antigen, T-Cell, gamma-delta - analysis | Immune Tolerance - immunology | Myeloid Cells - immunology | Inflammation Mediators - metabolism | CD11b Antigen - metabolism | Burns - immunology | Macrophages - immunology | Skin - immunology | Inflammation | Cytokines | Macrophage
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