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Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 17, pp. 7657 - 7670
The bombesin (BBN) antagonist binds with high affinity to the gastrin releasing peptide receptor (GRPr), a receptor overexpressed on many human cancers. We... 
CHEMISTRY, MEDICINAL | ANALOGS | RADIOLIGANDS | PROSTATE-CANCER DIAGNOSIS | GASTRIN-RELEASING-PEPTIDE | POSITIVE TUMORS | MODEL | GRPR | RECEPTOR TARGETED RADIOPHARMACEUTICALS | EXPRESSION | PET
Journal Article
BIOCONJUGATE CHEMISTRY, ISSN 1043-1802, 07/2013, Volume 24, Issue 7, pp. 1144 - 1153
The gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for the visualization of prostate cancer. This work focused on the development of... 
RECEPTOR ANTAGONISTS | ANALOG | BIOCHEMISTRY & MOLECULAR BIOLOGY | AFFIBODY MOLECULES | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | GASTRIN-RELEASING-PEPTIDE | CHEMISTRY, MULTIDISCIPLINARY | POSITRON-EMISSION-TOMOGRAPHY | RADIOPHARMACEUTICALS | PROSTATE-CANCER | IN-VIVO | EXPRESSION | PET
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2017, Volume 23, Issue 13, pp. 3343 - 3351
Journal Article
The Journal of Nuclear Medicine, ISSN 0161-5505, 05/2017, Volume 58, p. 262
Objectives: We aimed to develop near-infrared fluorescent (NIRF) bombesin antagonist peptides to target the gastrin releasing peptide receptors (GRPRs)... 
Nuclear medicine | Peptides | Fluorescence | Molecular weight | Receptors | Mouse devices | Rodents | Coinjection | Imaging | Piperidine | Chemical synthesis | Binding | Bombesin | Muscles | I.R. radiation | Liquid chromatography | Injection | High-performance liquid chromatography | Cells | Spacer | Gastrin | Affinity | In vivo methods and tests | Prostate cancer | Prostate | Cancer | Tumors
Journal Article
The Journal of Nuclear Medicine, ISSN 0161-5505, 05/2017, Volume 58, p. 266
Objectives: Gastrin releasing peptide receptors (GRPr) are frequently overexpressed in primary human prostate cancer with only low expression in normal... 
Nuclear medicine | Ascorbic acid | Dyes | Peptides | Hyperplasia | Fluorescence | Fluorescent dyes | Antagonists | Fluorescent indicators | Optimization | Metastases | Receptors | Synthesis | Mouse devices | Tomography | Radiolysis | Target detection | Medical imaging | Bombesin | Positron emission | Liquid chromatography | High-performance liquid chromatography | Biopsy | Spacer | Gastrin | Affinity | Ligands | Prostate cancer | Prostate | Cancer | Tumors
Journal Article
Contrast Media and Molecular Imaging, ISSN 1555-4309, 08/2017, Volume 2017, pp. 6873684 - 10
High gastrin releasing peptide receptor (GRPR) expression is associated with numerous cancers including prostate and breast cancer. The aim of the current... 
VISUALIZATION | POSITRON-EMISSION-TOMOGRAPHY | THERAPY | ANALOG | AFFINITY | RADIOLABELED PEPTIDES | PROTEINS | IN-VIVO EVALUATION | AGONISTS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | RECEPTOR-POSITIVE TUMORS | Humans | Male | Positron-Emission Tomography - methods | Receptors, Bombesin - antagonists & inhibitors | Tissue Distribution | Receptors, Bombesin - metabolism | Animals | Heterografts | Bombesin - antagonists & inhibitors | Prostatic Neoplasms - diagnostic imaging | Cobalt Radioisotopes - pharmacokinetics | Mice | Receptors, Bombesin - analysis | PET imaging | Analysis | Gastrin | Genetic aspects | Diagnosis | Properties | Prostate cancer | Methods | Cancer | Nuclear medicine | Visualization | Peptides | Xenotransplantation | Liver | Biology | Cobalt | Blood | Biological effects | Allografts | Computed tomography | Xenografts | Tomography | Labeling | Microwaves | Radioactivity | Image contrast | Binding | Stability | Medical imaging | Bombesin | Kidneys | Feasibility studies | Organs | Positron emission | Reabsorption | Breast cancer | Single photon emission computed tomography | Prostate | Tumors | In-Vivo Evaluation | Therapy | Medical and Health Sciences | Radiologi och bildbehandling | Medicin och hälsovetenskap | Klinisk medicin | Proteins | Clinical Medicine | Radiolabeled Peptides | Radiology, Nuclear Medicine and Medical Imaging | Affinity | Positron-Emission-Tomography | Receptor-Positive Tumors | Analog; Agonists
Journal Article
Journal Article
Journal Article
NUCLEAR MEDICINE AND BIOLOGY, ISSN 0969-8051, 07/2018, Volume 62-63, pp. 71 - 77
Introduction: In this study, we describe development of a true matched-pair theranostic agent that is able to target the alpha(v)beta(3) integrin and the... 
Bombesin | ANALOG | TUMORS | RGD | PEPTIDE | THERAPY | RGD-BOMBESIN HETERODIMER | RM2 | MICE | Yttrium | RECEPTORS | Prostate cancer | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
Journal Article