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Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2013, Volume 23, Issue 6, pp. 1883 - 1886
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2019, Volume 29, Issue 3, pp. 441 - 448
Exploring various cyclization strategies, using a submicromolar pyrazole HTS screening hit as a starting point, a novel indazole based CCR1 antagonist core was... 
CCR1 | Scaffold hopping | Clinical compound | Chemokine receptors | Indazole | MLN3897 | CHEMISTRY, MEDICINAL | EFFICACY | SAFETY | CHEMISTRY, ORGANIC | ARTHRITIS | DISCOVERY | PHARMACOKINETICS | PLUS METHOTREXATE | TARGETS | BLOCKADE | Medicine, Experimental | Medical research | Respiratory tract diseases | Drug discovery
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2010, Volume 10, Issue 13, pp. 1268 - 1277
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2013, Volume 23, Issue 5, pp. 1228 - 1231
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2014, Volume 57, Issue 18, pp. 7550 - 7564
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2013, Volume 23, Issue 12, pp. 3500 - 3504
Journal Article
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY, ISSN 0968-0896, 01/2014, Volume 24, Issue 1, pp. 108 - 112
A series of fused bicyclic and urea derivatives of spirocyclic compounds were designed, synthesised and evaluated in vitro as potent CCR1 antagonists. In... 
CCR1 | RHEUMATOID-ARTHRITIS | DESIGN | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | Antagonists | IDENTIFICATION | Receptor | INFLAMMATION | Spirocyclic | RECEPTORS | Chemokines
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2013, Volume 23, Issue 14, pp. 4026 - 4030
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2019, Volume 29, Issue 3, pp. 435 - 440
A HTS screen for CCR1 antagonists afforded a novel sub-micromolar hit containing a pyrazole core. In this report the design, optimization, and SAR of novel... 
CCR1 | Development candidate | HTS hit | Chemokine receptors | Pyrazole | MLN3897 | CHEMISTRY, MEDICINAL | EFFICACY | SAFETY | CHEMISTRY, ORGANIC | ARTHRITIS | POTENT | PHARMACOKINETICS | PLUS METHOTREXATE | TARGETS | BLOCKADE | Respiratory tract diseases | Amides | Drug discovery
Journal Article