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Journal Article
Molecular Pharmacology, ISSN 0026-895X, 03/2008, Volume 73, Issue 3, pp. 789 - 800
In addition to being an important receptor in leukocyte activation and mobilization, CCR5 is the essential coreceptor for human immunodeficiency virus (HIV). A... 
AMINO-TERMINAL DOMAIN | PROTEIN | ENTRY | CORECEPTOR | RECEPTOR ANTAGONISTS | IMMUNODEFICIENCY-VIRUS TYPE-1 | ANTI-HIV-1 ACTIVITY | PHARMACOLOGY & PHARMACY | HIGHLY POTENT | INHIBITOR | BINDING | Anti-HIV Agents - pharmacology | Benzoates - metabolism | Humans | Receptors, CCR5 - genetics | Piperazines - chemistry | Pyrimidines - metabolism | Receptors, CCR5 - metabolism | Piperidines - pharmacology | Amides - metabolism | Anti-HIV Agents - metabolism | Radioligand Assay | Binding Sites | Amides - pharmacology | Anti-HIV Agents - classification | Amino Acid Sequence | Piperidines - metabolism | Models, Molecular | Pyrimidines - pharmacology | HIV Fusion Inhibitors - pharmacology | Piperazines - pharmacology | Triazoles - metabolism | Anti-HIV Agents - chemistry | Amides - chemistry | Benzoates - pharmacology | Hydrophobic and Hydrophilic Interactions | Receptors, CCR5 - chemistry | Quaternary Ammonium Compounds - pharmacology | Cricetulus | Triazoles - chemistry | Benzoates - chemistry | Cyclohexanes - pharmacology | Molecular Sequence Data | Piperazines - metabolism | Quaternary Ammonium Compounds - chemistry | Pyrimidines - chemistry | Cyclohexanes - metabolism | Transfection | Inhibitory Concentration 50 | Cyclohexanes - chemistry | Molecular Structure | Membrane Fusion - drug effects | Spiro Compounds - chemistry | CCR5 Receptor Antagonists | CHO Cells | Protein Structure, Tertiary | Cricetinae | Piperidines - chemistry | Mutagenesis, Site-Directed | Protein Structure, Secondary | HIV-1 - drug effects | Static Electricity | Sequence Homology, Amino Acid | Triazoles - pharmacology | Animals | Quaternary Ammonium Compounds - metabolism | Spiro Compounds - pharmacology | Spiro Compounds - metabolism
Journal Article
Science, ISSN 0036-8075, 9/2007, Volume 317, Issue 5846, pp. 1930 - 1934
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Journal Article
Immunity, ISSN 1074-7613, 06/2017, Volume 46, Issue 6, pp. 1005 - 1017.e5
CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5 ligands inhibit infection by blocking CCR5 engagement with HIV gp120.... 
maraviroc | V3 loop | CCL5/RANTES | G protein-coupled receptor (GPCR) | Chemokine antagonist | CCR5-gp120 interaction | viral mimicry | membrane protein structure | two-site model | HIV entry inhibitor | CCR5 Receptor Antagonists - chemistry | CCR5 Receptor Antagonists - pharmacology | Triazoles - chemistry | Cyclohexanes - pharmacology | HIV Fusion Inhibitors - chemistry | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Virus Internalization - drug effects | HIV Envelope Protein gp120 - metabolism | Spodoptera | Chemokine CCL5 - chemistry | HIV Infections - immunology | Molecular Mimicry | Receptors, CCR5 - metabolism | Sf9 Cells | HIV-1 - physiology | Cloning, Molecular | Cyclohexanes - chemistry | Chemokine CCL5 - metabolism | HIV Envelope Protein gp120 - chemistry | Models, Molecular | Triazoles - pharmacology | Animals | Protein Binding | Receptors, CCR5 - chemistry | HIV Infections - drug therapy | Protein Conformation | Hydrogen | Analysis | Pharmacy | Therapeutics | Drugstores | HIV (Viruses) | Drug approval | Homeopathy | Materia medica and therapeutics | G proteins | Membrane proteins | Similarity | Molecular structure | Infections | Leukocytes | Hydrogen bonding | Mimicry | Exploitation | Proteins | Hydrogen bonds | Design improvements | Human immunodeficiency virus--HIV | Plasticity | Chemical bonds | Modelling | Binding | CCR5 protein | Diseases | Molecular modelling | Inhibitors | Ligands | Determinants | Plastic properties | Molecular biology | Chemokines | Glycoprotein gp120 | Recognition | Cancer | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | RANTES | CCL5
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