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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2006, Volume 103, Issue 31, pp. 11736 - 11741
...$), plays a key role in initiating a skin and systemic atopic dermatitis-like phenotype. We show here that topical application of the physiologically active ligand [lα,25(OH)₂D₃; calcitriol... 
T lymphocytes | Receptors | Ethanol | Vitamin D | Cytokines | Cholecalciferols | Keratinocytes | Skin | Mast cells | Inflammation | Retinoic acid receptor | Retinoid X receptor | Retinoic acid | Vitamin D receptor | retinoid X receptor | ALLERGIC INFLAMMATION | CELLS | MULTIDISCIPLINARY SCIENCES | skin | NUCLEAR RECEPTOR SUPERFAMILY | retinoic acid receptor | retinoic acid | GENE | ASTHMA | ABLATION | vitamin D receptor | 1,25-DIHYDROXYVITAMIN D-3 | MICE | ASSOCIATION | Skin - cytology | Retinoid X Receptor alpha - metabolism | Calcium - metabolism | Dermatologic Agents - administration & dosage | Humans | Calcitriol - adverse effects | Dermatologic Agents - adverse effects | Receptors, Calcitriol - genetics | Receptors, Retinoic Acid - genetics | Calcitriol - administration & dosage | Calcitriol - analogs & derivatives | Dermatitis, Atopic - chemically induced | Vitamins - immunology | Receptors, Retinoic Acid - agonists | Dermatitis, Atopic - immunology | Female | Cytokines - genetics | Dimerization | Skin - pathology | Cytokines - immunology | Retinoid X Receptor beta - metabolism | Vitamins - chemistry | Cells, Cultured | Retinoid X Receptor beta - genetics | Mice, Transgenic | Receptors, Retinoic Acid - metabolism | Keratinocytes - cytology | Receptors, Calcitriol - metabolism | Keratinocytes - immunology | Mice, Knockout | Retinoid X Receptor alpha - agonists | Vitamins - adverse effects | Animals | Retinoid X Receptor alpha - genetics | Mice | Dermatologic Agents - immunology | Administration, Topical | Retinoids - immunology | Skin - drug effects | Vitamins - administration & dosage | Calcitriol - immunology | Retinoid X Receptor beta - agonists | Physiological aspects | Causes of | Vitamin D3 | Atopic dermatitis | Tretinoin | Dermatitis, Atopic | Calcium | Calcitriol | Retinoid X Receptor alpha | Retinoids | Life Sciences | Retinoid X Receptor beta | Receptors, Retinoic Acid | Biochemistry, Molecular Biology | Vitamins | Dermatologic Agents | Receptors, Calcitriol | Molecular biology | Biological Sciences
Journal Article
Journal of Reproductive Immunology, ISSN 0165-0378, 2009, Volume 81, Issue 1, pp. 17 - 24
.... Since trophoblasts produce calcitriol, a hormone with strong immunosuppressive properties, we assessed the effects of this secosteroid on inflammatory cytokines induced in trophoblasts by challenge with TNF-α... 
Obstetrics and Gynecology | Vitamin D antagonist | CYP24A1 | CYP19 | VDR | Preeclampsia | IL-6 | VITAMIN-D | CHORIONIC-GONADOTROPIN | PREECLAMPTIC PREGNANCIES | IMMUNOLOGY | AMNIOTIC-FLUID | HUMAN SYNCYTIOTROPHOBLAST CELLS | PREMATURE RUPTURE | TUMOR-NECROSIS-FACTOR | IN-VITRO | REPRODUCTIVE BIOLOGY | 25-HYDROXYVITAMIN D-3 | GENE-TRANSCRIPTION | Tumor Necrosis Factor-alpha - metabolism | Steroid Hydroxylases - metabolism | Dose-Response Relationship, Immunologic | Progesterone Reductase - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Aromatase - metabolism | Chorionic Gonadotropin - immunology | Interferon-gamma - metabolism | Gene Expression Regulation, Developmental - immunology | Trophoblasts - drug effects | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Calcitriol - analogs & derivatives | Aromatase - genetics | Tumor Necrosis Factor-alpha - immunology | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Calcitriol - metabolism | Interferon-gamma - genetics | Interleukin-6 - metabolism | Steroid Hydroxylases - genetics | Steroid Hydroxylases - immunology | Immune Tolerance - drug effects | Receptors, Calcitriol - antagonists & inhibitors | Chorionic Gonadotropin - genetics | Trophoblasts - metabolism | Interleukin-6 - genetics | Cells, Cultured | Gene Expression Regulation, Developmental - drug effects | Vitamin D3 24-Hydroxylase | Progesterone Reductase - genetics | Placental Hormones - immunology | Chorionic Gonadotropin - metabolism | Pregnancy | Trophoblasts - immunology | Aromatase - immunology | Progesterone Reductase - immunology | Calcitriol - pharmacology | Calcitriol - immunology | Pregnancy Complications - immunology
Journal Article
Nutrients, ISSN 2072-6643, 12/2014, Volume 6, Issue 12, pp. 6048 - 6059
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 3, pp. 1514 - 1528
Muscle weakness and myopathy are observed in vitamin D deficiency and chronic renal failure, where concentrations of the active vitamin D3 metabolite,... 
Mitochondrial Dynamics | Phosphorylation | MicroRNAs - antagonists & inhibitors | Humans | Mitochondria, Muscle - metabolism | MicroRNAs - metabolism | Muscle, Skeletal - metabolism | Gene Expression Profiling | Green Fluorescent Proteins - genetics | Muscle, Skeletal - cytology | Receptors, Calcitriol - genetics | Recombinant Fusion Proteins - metabolism | Calcitriol - analogs & derivatives | RNA Interference | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - metabolism | Calcitriol - metabolism | MicroRNAs - agonists | Protein-Serine-Threonine Kinases - metabolism | Receptors, Calcitriol - antagonists & inhibitors | Green Fluorescent Proteins - metabolism | Muscle, Skeletal - enzymology | Mitochondria, Muscle - enzymology | Signal Transduction | Cells, Cultured | Gene Expression Regulation | Oxidative Phosphorylation | Protein-Serine-Threonine Kinases - genetics | Receptors, Calcitriol - metabolism | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Receptors, Calcitriol - agonists | Protein Processing, Post-Translational | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - genetics | Gene Regulation | 1,25-dihydroxyvitamin D3 | RNA-seq | WTSS | oxygen consumption | mitochondria | vitamin D | cell signaling | skeletal muscle | gene expression
Journal Article
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2013, Volume 123, Issue 11, pp. 4579 - 4594
The TGF-beta superfamily comprises pleiotropic cytokines that regulate SMAD and non-SMAD signaling. TGF-beta-SMAD signal transd.uction is known to be involved... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR-BETA | COMPLEX-FORMATION | TGF-BETA | NUCLEAR RECEPTORS | CRYSTAL-STRUCTURE | INTERSTITIAL FIBROSIS | GENE-EXPRESSION | 1,25-DIHYDROXYVITAMIN D-3 | MICE LACKING SMAD3 | EXPERIMENTAL GLOMERULONEPHRITIS | Kidney - pathology | Humans | Ureteral Obstruction - metabolism | RNA, Messenger - metabolism | Receptors, Calcitriol - genetics | Gene Knockdown Techniques | Calcitriol - analogs & derivatives | Kidney - metabolism | HEK293 Cells | Lactams - pharmacology | Ureteral Obstruction - genetics | Calcitriol - metabolism | Receptors, Calcitriol - antagonists & inhibitors | Promoter Regions, Genetic | Kidney - drug effects | Mice, Inbred C57BL | RNA, Messenger - genetics | Models, Molecular | Receptors, Calcitriol - metabolism | Drug Discovery | Animals | Signal Transduction - drug effects | Calcitriol - pharmacology | Ureteral Obstruction - pathology | Fibrosis | Ligands | Mice | Smad Proteins - metabolism | Transforming Growth Factor beta - metabolism | Care and treatment | Usage | Vitamin D | Physiological aspects | Calcifediol | Genetic aspects | Research | Alfacalcidol | Transforming growth factors | Health aspects | Kidneys | Gene expression | Experiments | Proteins | Studies | Signal transduction | Acids | Metabolites | Rodents | Collagen | Genetic engineering | Laboratory animals | Crystal structure
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2007, Volume 179, Issue 3, pp. 1634 - 1647
Journal Article
PloS one, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0169742
.... On the other hand, the most active component of the vitamin D family, calcitriol, has been shown to be tumor protective in vitro and in vivo... 
BREAST-CANCER | MORTALITY | VITAMIN-D | SPHINGOSINE-1-PHOSPHATE LYASE | MCF-7 | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | GROWTH | PLANT-EXTRACTS | LINES | Osteosarcoma - drug therapy | Lysophospholipids - metabolism | Humans | Aldehyde-Lyases - biosynthesis | Receptors, Calcitriol - genetics | Receptors, Calcitriol - biosynthesis | Calcitriol - administration & dosage | Estrogen Receptor beta - genetics | Estrogen Receptor beta - biosynthesis | Genistein - administration & dosage | Sphingosine - metabolism | Aldehyde-Lyases - genetics | Gene Expression Regulation, Neoplastic - drug effects | Phytoestrogens - administration & dosage | Osteosarcoma - metabolism | Ethanolamine - metabolism | Osteoblasts - drug effects | Drug Synergism | Sphingosine - analogs & derivatives | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Osteoblasts - metabolism | Osteosarcoma - pathology | Care and treatment | Osteosarcoma | Analysis | Calcitriol | Development and progression | Dosage and administration | Research | Genetic regulation | Health aspects | Isoflavones | Pediatrics | Energy metabolism | Phytoestrogens | Estrogens | Acidification | Metastasis | Osteoblasts | Cancer therapies | Ovarian cancer | Metastases | Cell growth | Vitamin D | Xenoestrogens | Surgery | Biocompatibility | Lipid metabolism | Enzymes | Metabolism | Osteosarcoma cells | Hospitals | Combined treatment | Comparative analysis | Cell migration | Phosphates | Cell proliferation | Metabolomics | Animal models | Genistein | Estrogen | Estrogen receptors | Amino acids | Lipids | Biology | Kinases | Synergism | Biomedical materials | Metabolites | Xenografts | Cell cycle | Ethanolamine | Secretion | Breast cancer | Bone cancer | Womens health | In vivo methods and tests | Prostate cancer | Cancer
Journal Article
Endocrine-Related Cancer, ISSN 1351-0088, 03/2010, Volume 17, Issue 1, pp. R19 - R38
Calcitriol, the hormonally active form of vitamin D, exerts multiple anti-proliferative and pro-differentiating actions including cell cycle arrest and induction of apoptosis in many malignant cells... 
C-REACTIVE PROTEIN | PROLIFERATIVE INFLAMMATORY ATROPHY | PHASE-II TRIAL | ONCOLOGY | FACTOR BINDING PROTEIN-3 | SPORADIC COLORECTAL ADENOMAS | ENDOCRINOLOGY & METABOLISM | VITAMIN-D-RECEPTOR | 1,25-DIHYDROXYVITAMIN D-3 | NF-KAPPA-B | HIGH-DOSE CALCITRIOL | ENDOTHELIAL GROWTH-FACTOR | Prostatic Neoplasms - metabolism | Adenocarcinoma - pathology | Apoptosis - drug effects | Adenocarcinoma - etiology | Humans | Prostatic Neoplasms - etiology | Male | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Cell Line, Tumor - drug effects | Receptors, Prostaglandin - biosynthesis | Calcitriol - therapeutic use | Dual-Specificity Phosphatases - biosynthesis | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 - biosynthesis | Adenocarcinoma - metabolism | Receptors, Prostaglandin - genetics | Cyclooxygenase 2 - genetics | Cyclooxygenase 2 Inhibitors - therapeutic use | Dual-Specificity Phosphatases - genetics | Angiogenesis Inhibitors - therapeutic use | Enzyme Induction - drug effects | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Prostatic Neoplasms - prevention & control | Neoplasm Proteins - genetics | Anticarcinogenic Agents - pharmacology | Prostatic Neoplasms - drug therapy | Prostatitis - complications | Anticarcinogenic Agents - therapeutic use | Prostatic Neoplasms - pathology | NF-kappa B - antagonists & inhibitors | Cyclooxygenase 2 Inhibitors - pharmacology | Neoplasm Proteins - biosynthesis | Mitogen-Activated Protein Kinase Phosphatases - biosynthesis | Angiogenesis Inhibitors - pharmacology | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Clinical Trials as Topic | Adenocarcinoma - drug therapy | Mitogen-Activated Protein Kinase Phosphatases - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Prostatitis - drug therapy | Adenocarcinoma - prevention & control | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Calcitriol - pharmacology | Prostaglandins - metabolism
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 4, p. e62040
.... Therefore we investigated the effect of the biologically active vitamin D-3 metabolite, calcitriol, on primary fetal ventral mesencephalic cultures of dopamine neurons... 
TRIAL | NEUROTROPHIC FACTOR GDNF | MULTIDISCIPLINARY SCIENCES | PROTEIN EXPRESSION | MOUSE | VITAMIN-D-RECEPTOR | PARKINSON-DISEASE | 1,25-DIHYDROXYVITAMIN D-3 | INFUSION | RAT-BRAIN | DIFFERENTIATION | Apoptosis - drug effects | Mesencephalon - metabolism | Glial Cell Line-Derived Neurotrophic Factor - genetics | Rats | Receptors, Calcitriol - metabolism | Gene Expression Regulation - drug effects | Glial Cell Line-Derived Neurotrophic Factor - metabolism | Animals | Mesencephalon - embryology | Neuroprotective Agents - pharmacology | Signal Transduction - drug effects | Cell Differentiation - drug effects | Calcitriol - pharmacology | Dopaminergic Neurons - metabolism | Dopaminergic Neurons - drug effects | Primary Cell Culture | Calcifediol | Alfacalcidol | Vitamin D | Neurons | Neuroprotection | Cell culture | Vitamin D3 | Neurosciences | Parkinson's disease | Mesencephalon | Genes | Parkinsons disease | Calcitriol | Neuronal-glial interactions | Confidence intervals | Proteins | Biological effects | Illnesses | Rodents | Life sciences | Movement disorders | Dopamine receptors | Glial cell line-derived neurotrophic factor | Cell survival | Dopamine | Neurodegenerative diseases | Fetuses | Dopamine D3 receptors | Vitamin deficiency | Biological activity | Medicine | Studies | Neurology | Signaling | Brain research | Stem cells | Culture media | Ligands | Differentiation | Apoptosis | Media (culture)
Journal Article