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Journal Article
Cancer Research, ISSN 0008-5472, 10/2006, Volume 66, Issue 20, pp. 10073 - 10082
Journal Article
Human Gene Therapy, ISSN 1043-0342, 02/2013, Volume 24, Issue 2, pp. 189 - 202
Mutations in GUCY2D are associated with recessive Leber congenital amaurosis-1 (LCA1). GUCY2D encodes photoreceptor-specific, retinal guanylate cyclase-1... 
Research Articles | OCULAR SUBRETINAL INJECTION | RETINAL DEGENERATION | MEDICINE, RESEARCH & EXPERIMENTAL | LINKED JUVENILE RETINOSCHISIS | OPTICAL COHERENCE TOMOGRAPHY | RHODOPSIN KINASE PROMOTER | LONG-TERM PRESERVATION | ADENOASSOCIATED VIRAL VECTORS | CONE-ROD DYSTROPHY | VISUAL FUNCTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | PHOTORECEPTOR DEGENERATION | Leber Congenital Amaurosis - pathology | Dependovirus - genetics | Genetic Vectors - administration & dosage | Humans | Retinal Cone Photoreceptor Cells - enzymology | Retina - enzymology | G-Protein-Coupled Receptor Kinase 1 - metabolism | Retinal Cone Photoreceptor Cells - pathology | Retinal Rod Photoreceptor Cells - enzymology | Receptors, Cell Surface - administration & dosage | Leber Congenital Amaurosis - therapy | Guanylate Cyclase - administration & dosage | Gene Transfer Techniques | Promoter Regions, Genetic | Dependovirus - metabolism | Tomography, Optical Coherence | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Guanylate Cyclase - metabolism | Mice, Knockout | Animals | Maze Learning | G-Protein-Coupled Receptor Kinase 1 - genetics | Guanylate Cyclase - genetics | Mice | Enzyme Activation | Retina - pathology | Retinal Rod Photoreceptor Cells - pathology | Genetic Therapy - methods | Receptors, Cell Surface - genetics
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 04/2013, Volume 9, Issue 4, pp. 250 - 256
Targeted delivery of antigens to dendritic cells (DCs) is a promising vaccination strategy. However, to ensure immunity, the approach depends on... 
EXPRESSED PROTEIN LIGATION | DEC-205 RECEPTOR | SENSITIVE ANTIGEN-DETECTION | RNA | RECOGNITION | HIV-GAG | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | CYTOSOLIC DNA | ANTIBODY | MHC-I | Antigens, CD - immunology | Lectins, C-Type - administration & dosage | Adjuvants, Immunologic - administration & dosage | Minor Histocompatibility Antigens | Dendritic Cells - immunology | Humans | Lectins, C-Type - immunology | Interferon Type I - immunology | Immunoconjugates - administration & dosage | Lectins, C-Type - chemistry | Drug Delivery Systems | Antigens - administration & dosage | Immunoconjugates - immunology | Interferon Type I - biosynthesis | Adjuvants, Immunologic - chemistry | Poly dA-dT - immunology | Dendritic Cells - drug effects | Receptors, Cell Surface - chemistry | Antigens, CD - chemistry | Receptors, Cell Surface - administration & dosage | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Antigens, CD - administration & dosage | Immunity, Innate - drug effects | Poly dA-dT - chemistry | Mice, Inbred C57BL | Immunoconjugates - chemistry | Receptors, Cell Surface - immunology | Antigens - chemistry | Adaptive Immunity - drug effects | Animals | Antibodies, Monoclonal - administration & dosage | Plasmids | Antigens - immunology | Mice | Poly dA-dT - administration & dosage | Genetic Vectors | Antigens | Drug delivery systems | Vaccines | Cells
Journal Article
Human Gene Therapy, ISSN 1043-0342, 10/2011, Volume 22, Issue 10, pp. 1179 - 1190
Leber congenital amaurosis (LCA) is a severe retinal dystrophy manifesting from early infancy as poor vision or blindness. Loss-of-function mutations in GUCY2D... 
Research Articles | ARRESTIN TRANSLOCATION | MEDICINE, RESEARCH & EXPERIMENTAL | ROD | LIGHT | ADENOASSOCIATED-VIRUS | MURINE MODEL | CHILDHOOD BLINDNESS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RESTORES VISION | GENETICS & HEREDITY | PHOTORECEPTOR DEGENERATION | EXPRESSION | VECTORS | Immunohistochemistry | Genetic Vectors - administration & dosage | Photoreceptor Cells, Vertebrate - drug effects | DNA Primers - genetics | Vision, Ocular - drug effects | Dose-Response Relationship, Drug | Guanylate Cyclase - pharmacology | Receptors, Cell Surface - administration & dosage | Leber Congenital Amaurosis - therapy | Real-Time Polymerase Chain Reaction | Guanylate Cyclase - administration & dosage | Electroretinography | Photoreceptor Cells, Vertebrate - cytology | Leber Congenital Amaurosis - genetics | Dependovirus | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Genetic Vectors - genetics | Mice, Knockout | Guanylate Cyclase - deficiency | Leber Congenital Amaurosis - enzymology | Animals | Analysis of Variance | Genetic Vectors - pharmacology | Receptors, Cell Surface - deficiency | Guanylate Cyclase - genetics | Mice | Genetic Therapy - methods | Receptors, Cell Surface - genetics | Care and treatment | Rhodopsin | Physiological aspects | Research | Leber's congenital amaurosis | Gene therapy | Guanylate cyclase | Health aspects | Risk factors
Journal Article
Vaccine, ISSN 0264-410X, 2014, Volume 33, Issue 1, pp. 133 - 140
Highlights • Tag-free recombinant dog ZP3 produced as fusion protein with T-cell epitope of TT in fermentor. • E. coli -expressed recombinant protein is... 
Allergy and Immunology | Recombinant protein produced in fermentor | Zona pellucida glycoprotein-3 | Adjuvant | Immunocontraception | CpG motif | MEDICINE, RESEARCH & EXPERIMENTAL | POSSUM TRICHOSURUS-VULPECULA | VACCINE | POTENT ENHANCER | B SURFACE-ANTIGEN | IMMUNOLOGY | CPG DNA | WHITE-TAILED DEER | IMMUNE-RESPONSES | MICE | MONOCLONAL-ANTIBODIES | BACTERIAL-DNA | Adjuvants, Immunologic - administration & dosage | Immunoglobulin G - blood | Vaccines, Contraceptive - isolation & purification | Recombinant Proteins - isolation & purification | Fertility | Cloning, Molecular | Female | Escherichia coli - growth & development | Membrane Glycoproteins - immunology | Receptors, Cell Surface - administration & dosage | Receptors, Cell Surface - isolation & purification | Litter Size | Zona Pellucida Glycoproteins | Gene Expression | Membrane Glycoproteins - isolation & purification | Vaccines, Contraceptive - immunology | Immunization - methods | Treatment Outcome | Vaccines, Contraceptive - administration & dosage | Receptors, Cell Surface - immunology | Recombinant Proteins - administration & dosage | Membrane Glycoproteins - administration & dosage | Animals | Egg Proteins - administration & dosage | Recombinant Proteins - immunology | Escherichia coli - genetics | Dogs | Egg Proteins - immunology | Antibodies - blood | Mice | Egg Proteins - isolation & purification | Immunization | Contraceptives | T cells | Recombinant proteins | Cells | Antigenic determinants | Vaccines | Rodents | Bacteriology
Journal Article
Laboratory Investigation, ISSN 0023-6837, 2014, Volume 94, Issue 8, pp. 881 - 892
Vascular endothelial cells (ECs) are ideal gene therapy targets as they provide widespread tissue access and are the first contact surfaces following... 
MEDICINE, RESEARCH & EXPERIMENTAL | CAPSID-MODIFIED ADENOVIRUS | THERAPY | VEGF121 CDNA | IN-VIVO | FOLLOW-UP | CYSTIC-FIBROSIS | PATHOLOGY | ALPHA-1-ANTITRYPSIN DEFICIENCY | LIVER TROPISM | VIRAL VECTORS | CORONARY-ARTERY-DISEASE | Endothelium, Vascular - cytology | Myeloid Cells - cytology | Injections, Intravenous | Genetic Vectors - administration & dosage | Humans | Green Fluorescent Proteins - genetics | Hepatocytes - metabolism | Recombinant Fusion Proteins - metabolism | Viral Proteins - metabolism | Peptides - administration & dosage | Hepatocytes - cytology | Peptides - metabolism | Green Fluorescent Proteins - administration & dosage | HEK293 Cells | Adenoviridae - genetics | Viral Proteins - administration & dosage | Receptors, Cell Surface - administration & dosage | Viral Tropism | Recombinant Fusion Proteins - administration & dosage | Cytomegalovirus - genetics | Gene Transfer Techniques | Green Fluorescent Proteins - metabolism | Promoter Regions, Genetic | Mice, Inbred C57BL | Virion - physiology | Receptors, Cell Surface - metabolism | Viral Proteins - genetics | Adenoviridae - physiology | Myeloid Cells - virology | Animals | Endothelium, Vascular - metabolism | Endothelium, Vascular - virology | Hepatocytes - virology | Myeloid Cells - metabolism | Genetic Vectors - physiology | Mice | Receptors, Cell Surface - genetics | adenovirus vector | gene therapy | gene transfer | endothelial cell
Journal Article
Veterinary Microbiology, ISSN 0378-1135, 06/2018, Volume 219, pp. 1 - 7
Porcine reproductive and respiratory syndrome (PRRS) is one of the most important swine diseases affecting pig industry worldwide. Sialoadehesin (Sn) and CD163... 
Protective effect | Soluble viral receptors | Recombinant adenoviruses | PRRSV | PROTEIN | COXSACKIEVIRUS | ENTRY | SWINE | MICROBIOLOGY | IDENTIFICATION | IN-VITRO | MOUTH-DISEASE | ALVEOLAR MACROPHAGES | VETERINARY SCIENCES | VACCINOLOGY | Antigens, CD - immunology | Viremia | Sialic Acid Binding Ig-like Lectin 1 - immunology | Antigens, CD - genetics | Viral Load | Sialic Acid Binding Ig-like Lectin 1 - genetics | Porcine Reproductive and Respiratory Syndrome - virology | Lung - virology | Swine | Adenoviridae - genetics | Receptors, Cell Surface - administration & dosage | Porcine Reproductive and Respiratory Syndrome - immunology | Antigens, Differentiation, Myelomonocytic - immunology | Disease Models, Animal | Macrophages, Alveolar - virology | Lung - pathology | Porcine Reproductive and Respiratory Syndrome - prevention & control | Antigens, CD - administration & dosage | Enzyme-Linked Immunosorbent Assay | Porcine respiratory and reproductive syndrome virus - immunology | Antibodies, Viral | Receptors, Cell Surface - immunology | Antigens, Differentiation, Myelomonocytic - genetics | Animals | Antigens, Differentiation, Myelomonocytic - administration & dosage | Sialic Acid Binding Ig-like Lectin 1 - administration & dosage | Porcine respiratory and reproductive syndrome virus - pathogenicity | Genetic Vectors | Lung - immunology | Receptors, Cell Surface - genetics | Virus diseases | Biological products | Viral proteins | Analysis | Adenoviruses | Zoonoses
Journal Article