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Journal Article
Cancer Research, ISSN 0008-5472, 07/2014, Volume 74, Issue 18, pp. 5057 - 5069
Cancer immunotherapy generally offers limited clinical benefit without coordinated strategies to mitigate the immunosuppressive nature of the tumor... 
ACTIVATION | INHIBITION | MICROENVIRONMENT | ONCOLOGY | ADENOCARCINOMA | INFLAMMATION | KINASE | CSF | POLARIZATION | IPILIMUMAB | PROGRESSION | Receptor, Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Immunotherapy - methods | Receptor, Macrophage Colony-Stimulating Factor - immunology | Adenocarcinoma - pathology | Macrophage Colony-Stimulating Factor - biosynthesis | Mannose-Binding Lectins - biosynthesis | Tissue Array Analysis | Humans | Lectins, C-Type - immunology | Tumor Microenvironment | Deoxycytidine - pharmacology | Lectins, C-Type - biosynthesis | Female | Receptors, Cell Surface - biosynthesis | Carcinoma, Pancreatic Ductal - immunology | Macrophages - immunology | Signal Transduction | Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Adenocarcinoma - immunology | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - therapy | Random Allocation | Carcinoma, Pancreatic Ductal - pathology | Receptors, Cell Surface - immunology | Macrophage Colony-Stimulating Factor - immunology | Animals | Mannose-Binding Lectins - immunology | Pancreatic Neoplasms - immunology | T-Lymphocytes - immunology | Mice | Deoxycytidine - analogs & derivatives | Cohort Studies | Pancreatic Neoplasms - therapy | macrophage | chemoresistance | pancreatic cancer | cytokines | innate immunity | immune checkpoint
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2012, Volume 18, Issue 3, pp. 869 - 881
Purpose: Within heterogeneous tumors, subpopulations often labeled cancer stem cells (CSC) have been identified that have enhanced tumorigenicity and... 
ONCOLOGY | ALDEHYDE DEHYDROGENASE | THERAPEUTIC TARGET | ANTIBODY | DEFINES | DRUG-RESISTANCE | GROWTH-FACTOR | EXPRESSION | CARCINOMA | HEDGEHOG | ENDOGLIN CD105 | Immunohistochemistry | Adenocarcinoma - pathology | Aldehyde Dehydrogenase - analysis | Antigens, CD - biosynthesis | Humans | Zinc Finger Protein Gli2 | Aldehyde Dehydrogenase - biosynthesis | Ovarian Neoplasms - pathology | Laser Capture Microdissection | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Antigens, CD - genetics | Antigens, CD - analysis | Ovarian Neoplasms - genetics | Endoglin | Adenocarcinoma - metabolism | Neoplastic Stem Cells - metabolism | Nuclear Proteins - biosynthesis | Neoplastic Stem Cells - pathology | Female | Adenocarcinoma - genetics | Ovarian Neoplasms - metabolism | Receptors, Cell Surface - biosynthesis | Nuclear Proteins - genetics | Kruppel-Like Transcription Factors - biosynthesis | Neoplasm Recurrence, Local - metabolism | Hyaluronan Receptors - biosynthesis | Reverse Transcriptase Polymerase Chain Reaction | AC133 Antigen | Blotting, Western | Glycoproteins - biosynthesis | Hyaluronan Receptors - analysis | Signal Transduction - physiology | Glycoproteins - analysis | Drug Resistance, Neoplasm - physiology | Kruppel-Like Transcription Factors - genetics | Peptides - analysis | Receptors, Cell Surface - genetics | aldehyde dehydrogenase | cancer stem cell | ovarian cancer | ALDH1A1 | CD105 | endoglin | gli1 | CD44 | gli2 | CD133
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 08/2005, Volume 175, Issue 3, pp. 1551 - 1557
TLRs are involved in innate cell activation by conserved structures expressed by microorganisms. Human T cells express the mRNA encoding most of TLRs.... 
SIGNALING PATHWAYS | ACTIVATION | DENDRITIC CELLS | RECOGNITION | TOLL-LIKE RECEPTORS | INNATE IMMUNE-RESPONSE | BACTERIAL FLAGELLIN | KAPPA-B | IMMUNOLOGY | LYMPHOCYTES | RESIQUIMOD | T-Lymphocyte Subsets - immunology | Toll-Like Receptor 3 | Toll-Like Receptor 4 | Membrane Glycoproteins - metabolism | Humans | Membrane Glycoproteins - biosynthesis | Leukocyte Common Antigens - biosynthesis | Immunologic Memory - drug effects | Toll-Like Receptor 5 | Toll-Like Receptor 7 | CD4-Positive T-Lymphocytes - immunology | Flagellin - pharmacology | RNA, Messenger - biosynthesis | Toll-Like Receptors | Lymphocyte Activation - immunology | Membrane Glycoproteins - physiology | T-Lymphocyte Subsets - drug effects | Flagellin - metabolism | Receptors, Cell Surface - biosynthesis | Receptors, Cell Surface - physiology | Imidazoles - metabolism | Interleukin-8 - biosynthesis | Receptors, CCR7 | Receptors, Chemokine - metabolism | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Receptors, Cell Surface - metabolism | Imidazoles - pharmacology | Membrane Glycoproteins - genetics | Up-Regulation - drug effects | Up-Regulation - immunology | Lymphocyte Activation - drug effects | T-Lymphocyte Subsets - metabolism | Interleukin-10 - biosynthesis | Ligands | Cell Proliferation - drug effects | Interleukin-2 - biosynthesis | CD4-Positive T-Lymphocytes - drug effects | Interferon-gamma - biosynthesis | Receptors, Cell Surface - genetics
Journal Article
The Journal of Immunology, ISSN 0022-1767, 09/2004, Volume 173, Issue 6, pp. 3916 - 3924
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2016, Volume 36, Issue 15, pp. 4182 - 4195
Stroke is a leading cause of disability and currently lacks effective therapy enabling long-term functional recovery. Ischemic brain injury causes local... 
Neuroinflammation | Stroke | Monocyte | Macrophage | Microglia | FOCAL CEREBRAL-ISCHEMIA | macrophage | RECEPTOR | MICROGLIAL CELLS | stroke | NEUROSCIENCES | IMMUNE-SYSTEM | neuroinflammation | INFLAMMATORY CELLS | STAIRCASE TEST | monocyte | CENTRAL-NERVOUS-SYSTEM | CHEMOATTRACTANT PROTEIN-1 | RAT-BRAIN | microglia | ALTERNATIVE ACTIVATION | Infarction, Middle Cerebral Artery - physiopathology | Inflammation - pathology | Recovery of Function - drug effects | Antigens, CD - biosynthesis | Male | Antibodies, Blocking - pharmacology | Antigens, CD - genetics | Lectins - biosynthesis | Stroke - physiopathology | Transforming Growth Factor beta - biosynthesis | Receptors, CCR2 - antagonists & inhibitors | Stroke - pathology | Neuronal Plasticity - physiology | Monocytes - pathology | Behavior, Animal - drug effects | Receptors, Cell Surface - biosynthesis | beta-N-Acetylhexosaminidases - genetics | Antigens, Differentiation, Myelomonocytic - biosynthesis | Macrophages - pathology | Mice, Inbred C57BL | Psychomotor Performance - drug effects | Functional Laterality | beta-N-Acetylhexosaminidases - biosynthesis | Antigens, Differentiation, Myelomonocytic - genetics | Animals | Transforming Growth Factor beta - genetics | Lectins - genetics | Mice | Chimera | Receptors, Cell Surface - genetics | Neurologi | Clinical Medicine | Neurology | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
Journal Article
Journal Article
Cellular Immunology, ISSN 0008-8749, 01/2013, Volume 281, Issue 1, pp. 51 - 61
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e36814
Cardiac tissue macrophages (cTMs) are a previously uncharacterised cell type that we have identified and characterise here as an abundant GFP(+) population... 
GROWTH FACTOR-I | GENE SIGNATURE | STEM-CELLS | MUSCLE REGENERATION | FRACTALKINE RECEPTOR | MONOCYTE | DENDRITIC CELLS | VIVO | MULTIDISCIPLINARY SCIENCES | DIET-INDUCED OBESITY | ADIPOSE-TISSUE | Antigens, CD - biosynthesis | Leukocyte Common Antigens - biosynthesis | Brain - metabolism | Myocardium - metabolism | Receptors, Cell Surface - biosynthesis | Macrophage Activation - physiology | Antigens, Differentiation, Myelomonocytic - biosynthesis | Brain - cytology | Insulin-Like Growth Factor I - biosynthesis | Myocytes, Cardiac - cytology | Endothelial Cells - metabolism | Mice, Transgenic | Spleen - cytology | Macrophages - cytology | Myocardium - cytology | Glycoproteins - biosynthesis | Antigens, Differentiation - biosynthesis | Macrophages - metabolism | Animals | Spleen - metabolism | Endothelial Cells - cytology | Homeostasis - physiology | Myocytes, Cardiac - metabolism | Mice | CD11b Antigen - biosynthesis | Macrophages | Gene expression | Analysis | Heart | Brain | Flow cytometry | Heart attacks | Laboratories | Insulin-like growth factor I | Homeostasis | Insulin-like growth factors | Blood | CD45 antigen | Ethics | Immunology | Transgenic animals | Bone marrow | Trends | Heart diseases | Spleen | Antigens | Enzymes | CD11b antigen | Immunomodulation | Secretion | Markers | Cardiomyocytes | Inflammation | Endothelial cells | Medicine | CD163 antigen | Cytometry | Stem cells | Myocardium | Molecular biology
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 06/2005, Volume 174, Issue 11, pp. 6592 - 6597
We demonstrate that functional and phenotypic equivalents of mouse splenic CD8(+) and CD8(-) conventional dendritic cell (cDC) subsets can be generated in... 
SPLEEN | COLONY-STIMULATING FACTOR | SUBTYPES | SOLUBLE-ANTIGEN | MOUSE | SUBSETS | ANTIGEN PRESENTATION | IMMUNOLOGY | FLT3 LIGAND | DIFFERENTIAL PRODUCTION | IFN-ALPHA | Interferon Regulatory Factors | Spleen - immunology | Dendritic Cells - immunology | Membrane Glycoproteins - biosynthesis | fms-Like Tyrosine Kinase 3 | Repressor Proteins - physiology | Cell Differentiation - genetics | Toll-Like Receptors | Bone Marrow Cells - immunology | Cystatin C | Receptors, Chemokine - biosynthesis | Cross-Priming - genetics | Membrane Proteins - metabolism | Receptors, Cell Surface - biosynthesis | Dendritic Cells - metabolism | CD4 Antigens - genetics | Proto-Oncogene Proteins - metabolism | Chemokines - biosynthesis | Bone Marrow Cells - cytology | Mice, Inbred C57BL | Cells, Cultured | Repressor Proteins - genetics | Antigen Presentation - genetics | CD8 Antigens - biosynthesis | Immunophenotyping | Mice, Transgenic | Spleen - cytology | Antigen Presentation - immunology | Receptor Protein-Tyrosine Kinases - metabolism | Mice, Knockout | Cell Differentiation - immunology | Animals | Repressor Proteins - biosynthesis | Cross-Priming - immunology | Spleen - metabolism | CD8 Antigens - genetics | Cystatins - biosynthesis | Ligands | Dendritic Cells - cytology | Mice | CD4 Antigens - biosynthesis | Bone Marrow Cells - metabolism | Cytokines - biosynthesis
Journal Article
Journal Article