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Toxicology and applied pharmacology, ISSN 0041-008X, 04/2014, Volume 276, Issue 1, pp. 73 - 81
.... However, the effects of PPAR agonists on steatosis that is a common pathology associated with NAFLD, remain largely controversial... 
Fatty acid oxidation | Hepatocytes | Non-alcoholic steatohepatitis | Hepatotoxicity | Fatty acid overload | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Glycine - analogs & derivatives | Humans | Oleic Acid - adverse effects | Orphan Nuclear Receptors - metabolism | PPAR gamma - metabolism | Liver - drug effects | Liver X Receptors | Non-alcoholic Fatty Liver Disease | Drug Evaluation, Preclinical | Fatty Acids, Nonesterified - adverse effects | Peroxisome Proliferator-Activated Receptors - agonists | Cell Line | Fatty Liver - metabolism | Oxidation-Reduction | Liver - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Orphan Nuclear Receptors - genetics | Fatty Liver - drug therapy | Triglycerides - metabolism | Gene Expression Regulation - drug effects | Orphan Nuclear Receptors - antagonists & inhibitors | Glycine - pharmacology | Lipogenesis - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Lipid Metabolism - drug effects | PPAR gamma - agonists | Peroxisome Proliferator-Activated Receptors - metabolism | Lipotropic Agents - pharmacology | PPAR alpha - agonists | Oxazoles - pharmacology | PPAR alpha - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Monounsaturated fatty acids | Triglycerides | Index Medicus | Oleic Acid | Liver | Gene Expression Regulation | PPAR alpha | Lipid Metabolism | Pharmacology | Glycine | PPAR gamma | Receptors, Cytoplasmic and Nuclear | Fatty Liver | Life Sciences | Oxazoles | Peroxisome Proliferator-Activated Receptors | Fatty Acids, Nonesterified | Lipotropic Agents | Orphan Nuclear Receptors | Lipogenesis | Pharmaceutical sciences | OXIDATION | TRIGLYCERIDES | IN VIVO | PATHOLOGY | 60 APPLIED LIFE SCIENCES | OLEIC ACID | DISEASES | METABOLISM | IN VITRO | GENES | LIVER | LIVER CELLS | RECEPTORS
Journal Article
Environmental health perspectives, ISSN 0091-6765, 8/2009, Volume 117, Issue 8, pp. 1210 - 1218
...: Our aim was to characterize and compare the agonistic and antagonistic activities of principle PBDE congeners and their HO and MeO metabolites against human nuclear hormone receptors. Methods... 
Hormone receptors | Hormone metabolism | Receptors | Dose response relationship | Cellular metabolism | Halogenated diphenyl ethers | Plasmids | Congeners | Flame retardants | Research | Ethers | Estrogen receptor | Androgen receptor | Glucocorticoid receptor | Reporter gene assay | Brominated diphenyl ether | Thyroid hormone receptor | Chinese hamster ovary cells | Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Androgen Receptor Antagonists | Cricetinae | Receptors, Glucocorticoid - antagonists & inhibitors | Cricetulus | Humans | Thyroid Hormone Receptors beta - antagonists & inhibitors | Estrogen Receptor alpha - antagonists & inhibitors | Thyroid Hormone Receptors alpha - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - agonists | Halogenated Diphenyl Ethers - chemistry | Receptors, Glucocorticoid - agonists | Halogenated Diphenyl Ethers - metabolism | Androgens | Animals | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Thyroid Hormone Receptors beta - agonists | Molecular Structure | Thyroid Hormone Receptors alpha - agonists | Estrogen Receptor beta - antagonists & inhibitors | CHO Cells | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Metabolites | Health aspects | Polybrominated biphenyls | Index Medicus | glucocorticoid receptor | androgen receptor | thyroid hormone receptor | estrogen receptor | brominated diphenyl ether | reporter gene assay
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 02/2006, Volume 103, Issue 10, pp. 3920 - 3925
.... Here we show that the farnesoid X receptor (FXR), a nuclear receptor for bile acids, induces genes involved in enteroprotection and inhibits bacterial overgrowth and mucosal injury in ileum caused by bile duct ligation... 
Edema | Receptors | Bile acids | Messenger RNA | RNA | Bacteria | Gene expression regulation | Epithelium | Ileum | Small intestine | Barrier | Biliary obstruction | Epithelial | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Intestinal Mucosa - metabolism | Intestine, Small - pathology | Receptors, Cytoplasmic and Nuclear - deficiency | Humans | Transcription Factors - deficiency | Male | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | DNA-Binding Proteins - agonists | Steroid Hydroxylases - genetics | Intestine, Small - microbiology | Bile Acids and Salts - metabolism | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Intestinal Mucosa - microbiology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Microscopy, Electron | Mice, Knockout | Gene Expression Regulation - drug effects | Isoxazoles - pharmacology | Transcription Factors - metabolism | Animals | Steroid Hydroxylases - deficiency | Cholestanetriol 26-Monooxygenase | Mice | Intestine, Small - metabolism | Transcription Factors - agonists | Intestinal Mucosa - pathology | Receptors, Cytoplasmic and Nuclear - metabolism | Research | Intestine, Small | Antibacterial agents | Bile acid metabolism | Index Medicus | ileum | Biological Sciences | bacteria | epithelial barrier | biliary obstruction
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