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Environmental health perspectives, ISSN 0091-6765, 8/2009, Volume 117, Issue 8, pp. 1210 - 1218
...: Our aim was to characterize and compare the agonistic and antagonistic activities of principle PBDE congeners and their HO and MeO metabolites against human nuclear hormone receptors. Methods... 
Hormone receptors | Hormone metabolism | Receptors | Dose response relationship | Cellular metabolism | Halogenated diphenyl ethers | Plasmids | Congeners | Flame retardants | Research | Ethers | Estrogen receptor | Androgen receptor | Glucocorticoid receptor | Reporter gene assay | Brominated diphenyl ether | Thyroid hormone receptor | Chinese hamster ovary cells | Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Androgen Receptor Antagonists | Cricetinae | Receptors, Glucocorticoid - antagonists & inhibitors | Cricetulus | Humans | Thyroid Hormone Receptors beta - antagonists & inhibitors | Estrogen Receptor alpha - antagonists & inhibitors | Thyroid Hormone Receptors alpha - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - agonists | Halogenated Diphenyl Ethers - chemistry | Receptors, Glucocorticoid - agonists | Halogenated Diphenyl Ethers - metabolism | Androgens | Animals | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Thyroid Hormone Receptors beta - agonists | Molecular Structure | Thyroid Hormone Receptors alpha - agonists | Estrogen Receptor beta - antagonists & inhibitors | CHO Cells | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Metabolites | Health aspects | Polybrominated biphenyls | Index Medicus | glucocorticoid receptor | androgen receptor | thyroid hormone receptor | estrogen receptor | brominated diphenyl ether | reporter gene assay
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19888 - 19899
Farnesoid X receptor alpha (FXR alpha) as a bile acid sensor plays potent roles in multiple metabolic processes, and its antagonist has recently revealed special interests in the treatment of metabolic disorders, although the underlying... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Glucose-6-Phosphatase - genetics | Receptors, Leptin - genetics | Humans | Phosphoenolpyruvate Carboxykinase (ATP) - antagonists & inhibitors | Crystallography, X-Ray | Male | Hepatocytes - metabolism | Hepatocytes - cytology | Protein Isoforms - metabolism | ATP-Binding Cassette Transporters - genetics | Protein Isoforms - agonists | Receptors, Cytoplasmic and Nuclear - chemistry | ATP-Binding Cassette Transporters - metabolism | Benzamides - pharmacology | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | Hepatocytes - drug effects | Benzamides - chemistry | Recombinant Proteins - metabolism | Signal Transduction | Isoxazoles - antagonists & inhibitors | Gene Expression Regulation | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Recombinant Proteins - genetics | Glucose-6-Phosphatase - metabolism | Hep G2 Cells | Mice, Knockout | Isoxazoles - pharmacology | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Receptors, Leptin - deficiency | Animals | ATP Binding Cassette Subfamily B Member 11 | Retinoid X Receptors - agonists | Glucose-6-Phosphatase - antagonists & inhibitors | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Mice | Molecular Docking Simulation | Mutation | Primary Cell Culture | Protein Isoforms - antagonists & inhibitors | ATP-Binding Cassette Transporters - antagonists & inhibitors | Protein Isoforms - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Protein Structure and Folding | FXR | homodimerization | molecular pharmacology | crystal structure | nuclear receptor | transcription target gene | metabolic disease | antagonist
Journal Article
Cell metabolism, ISSN 1550-4131, 02/2013, Volume 17, Issue 2, pp. 225 - 235
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1303 - 1308
The polyketide natural product Leptomycin B inhibits nuclear export mediated by the karyopherin protein chromosomal region maintenance 1 (CRM1). Here, we present 1.8-to 2.0-Å... 
Hydrolysis | Polyketides | Databases | Molecular structure | Electrostatics | Carbon | Carboxylates | Exports | Lactones | Crystal structure | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Nuclear Export Signals - genetics | Triazoles - chemistry | Humans | Crystallography, X-Ray | Acrylates - pharmacology | Receptors, Cytoplasmic and Nuclear - chemistry | Models, Anatomic | Mutagenesis, Site-Directed | Acrylates - chemistry | Karyopherins - chemistry | Fatty Acids, Unsaturated - pharmacology | Receptors, Cytoplasmic and Nuclear - genetics | Fatty Acids, Unsaturated - metabolism | Saccharomyces cerevisiae Proteins - genetics | Static Electricity | Triazoles - pharmacology | Karyopherins - metabolism | Fatty Acids, Unsaturated - chemistry | Active Transport, Cell Nucleus - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Saccharomyces cerevisiae Proteins - metabolism | Karyopherins - genetics | Protein Conformation | Karyopherins - antagonists & inhibitors | Amino Acid Substitution | Receptors, Cytoplasmic and Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Physiological aspects | Metabolites | Health aspects | Index Medicus | lactone hydrolysis | Michael addition | Biological Sciences | KPT inhibitor | exportin-1 | Xpo-1
Journal Article
PloS one, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0137210 - e0137210
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by the aberrant expression of several growth-regulating, oncogenic effectors.... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cyclin D1 - metabolism | Transcription, Genetic - drug effects | Humans | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins c-pim-1 - metabolism | Elongation Factor 2 Kinase - metabolism | Ribosomes - metabolism | Tumor Suppressor Protein p53 - genetics | Elongation Factor 2 Kinase - genetics | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Organelle Biogenesis | Proto-Oncogene Proteins c-bcl-2 - metabolism | Acrylates - pharmacology | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Peptide Elongation Factor 1 - genetics | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | HSP70 Heat-Shock Proteins - genetics | Proto-Oncogene Proteins - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Proto-Oncogene Proteins c-myc - metabolism | HSP70 Heat-Shock Proteins - metabolism | Transcription Factors - metabolism | Triazoles - pharmacology | B-Lymphocytes - drug effects | Karyopherins - metabolism | Cyclin D1 - genetics | Active Transport, Cell Nucleus - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Ribosomes - drug effects | Cell Line, Tumor | Karyopherins - genetics | Proto-Oncogene Proteins c-pim-1 - genetics | Protein Biosynthesis - drug effects | Proto-Oncogene Proteins c-myc - genetics | Karyopherins - antagonists & inhibitors | Peptide Elongation Factor 1 - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Genetic aspects | Research | Biological transport | Cell cycle | Ribosomes | Transcription factors | Biomedical research | Transcription | Bcl-2 protein | Laboratories | p53 Protein | Leukemia | c-Myc protein | Multiple myeloma | Immunoblotting | Biosynthesis | Myc protein | Glucose | Cyclin D1 | Cancer therapies | Anticancer properties | Heat shock factors | Proteins | Ribosomal subunits | Cell growth | Translation | Cell survival | Hematology | Hsp70 protein | Gene expression | Lymphoma | Nuclear transport | Molecular chains | Medicine | Molecular modelling | Lymphocytes B | Medical prognosis | Proteomics | Mantle cell lymphoma | Lymphomas | Viability | Heat shock | Apoptosis | Tumors | B-cell lymphoma | Index Medicus
Journal Article
Nature immunology, ISSN 1529-2916, 09/2010, Volume 11, Issue 10, pp. 897 - 904
Journal Article