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Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 23, pp. 4621 - 4634
The nuclear export protein XPO1 is overexpressed in cancer, leading to the cytoplasmic mislocalization of multiple tumor suppressor proteins. Existing... 
ANTICANCER ACTIVITY | APOPTOSIS | TRANSPORT | PROTEIN | MECHANISM | RITUXIMAB | DRUG-RESISTANCE | CELL-SURVIVAL | CRM1 | HEMATOLOGY | EXPRESSION | Triazoles - chemistry | Humans | Crystallography, X-Ray | Immunoblotting | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Antineoplastic Agents - metabolism | RNA Interference | T-Lymphocytes - metabolism | Acrylates - metabolism | T-Lymphocytes - drug effects | Acrylates - pharmacology | Receptors, Cytoplasmic and Nuclear - chemistry | Interleukin-10 - metabolism | Antineoplastic Agents - pharmacology | Molecular Structure | Interleukin-6 - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Acrylates - chemistry | Karyopherins - chemistry | Cells, Cultured | Models, Molecular | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Triazoles - pharmacology | Microscopy, Confocal | Triazoles - metabolism | Animals | Karyopherins - metabolism | Active Transport, Cell Nucleus - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Cell Line, Tumor | Karyopherins - genetics | Protein Binding | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Journal Article
Nature, ISSN 0028-0836, 06/2015, Volume 522, Issue 7556, pp. 359 - 362
Journal Article
Nature, ISSN 0028-0836, 01/2007, Volume 445, Issue 7124, pp. 219 - 223
The liver has a central role in glucose homeostasis, as it has the distinctive ability to produce and consume glucose. On feeding, glucose influx triggers gene... 
HOMEOSTASIS | METABOLISM | LIPOGENESIS | MULTIDISCIPLINARY SCIENCES | ELEMENT-BINDING PROTEIN-1C | LIVER | TRANSCRIPTION | ALPHA | X-RECEPTOR | MICE | DEFICIENCY | Transcription, Genetic - drug effects | Humans | DNA-Binding Proteins - metabolism | DNA-Binding Proteins - agonists | Liver - drug effects | Liver X Receptors | Receptors, Cytoplasmic and Nuclear - chemistry | Response Elements - genetics | Orphan Nuclear Receptors | Fatty Acids - metabolism | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | Fasting | Gene Expression Regulation - genetics | Liver - metabolism | Glucose-6-Phosphate - pharmacology | Retinoid X Receptors - chemistry | Glucose - pharmacology | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Cholesterol - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Gene Expression Regulation - drug effects | Animals | Lipid Metabolism - drug effects | Benzoates - pharmacology | Cell Line, Tumor | Glucose - metabolism | Ligands | Mice | Transcription, Genetic - genetics | Benzylamines - pharmacology | Glucose-6-Phosphate - metabolism | Homeostasis - genetics | Fatty Acids - biosynthesis | Receptors, Cytoplasmic and Nuclear - metabolism | Medical research | Glucose | Gene expression | Insulin | Liver | Binding sites | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1303 - 1308
The polyketide natural product Leptomycin B inhibits nuclear export mediated by the karyopherin protein chromosomal region maintenance 1 (CRM1). Here, we... 
Hydrolysis | Polyketides | Databases | Molecular structure | Electrostatics | Carbon | Carboxylates | Exports | Lactones | Crystal structure | lactone hydrolysis | Michael addition | LOCALIZATION | RANGTP | COMPLEX | ACID | KPT inhibitor | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | Xpo-1 | SIGNALS | exportin-1 | Nuclear Export Signals - genetics | Triazoles - chemistry | Humans | Crystallography, X-Ray | Acrylates - pharmacology | Receptors, Cytoplasmic and Nuclear - chemistry | Models, Anatomic | Mutagenesis, Site-Directed | Acrylates - chemistry | Karyopherins - chemistry | Fatty Acids, Unsaturated - pharmacology | Receptors, Cytoplasmic and Nuclear - genetics | Fatty Acids, Unsaturated - metabolism | Saccharomyces cerevisiae Proteins - genetics | Static Electricity | Triazoles - pharmacology | Karyopherins - metabolism | Fatty Acids, Unsaturated - chemistry | Active Transport, Cell Nucleus - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Saccharomyces cerevisiae Proteins - metabolism | Karyopherins - genetics | Protein Conformation | Karyopherins - antagonists & inhibitors | Amino Acid Substitution | Receptors, Cytoplasmic and Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Physiological aspects | Metabolites | Health aspects | Mutagenesis | Chromosomes | Binding sites | Index Medicus | Biological Sciences
Journal Article
Cell, ISSN 0092-8674, 04/2018, Volume 173, Issue 3, pp. 677 - 692.e20
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2013, Volume 288, Issue 27, pp. 19830 - 19844
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 11/2010, Volume 17, Issue 11, pp. 1367 - 1376
Journal Article
Leukemia, ISSN 0887-6924, 01/2013, Volume 27, Issue 1, pp. 66 - 74
Journal Article