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by Bailey, Peter and Chang, David K and Nones, Katia and Johns, Amber L and Patch, Ann-Marie and Gingras, Marie-Claude and Miller, David K and Christ, Angelika N and Bruxner, Tim J. C and Quinn, Michael C and Nourse, Craig and Murtaugh, L. Charles and Harliwong, Ivon and Idrisoglu, Senel and Manning, Suzanne and Nourbakhsh, Ehsan and Wani, Shivangi and Fink, Lynn and Holmes, Oliver and Chin, Venessa and Anderson, Matthew J and Kazakoff, Stephen and Leonard, Conrad and Newell, Felicity and Waddell, Nick and Wood, Scott and Xu, Qinying and Wilson, Peter J and Cloonan, Nicole and Kassahn, Karin S and Taylor, Darrin and Quek, Kelly and Robertson, Alan and Pantano, Lorena and Mincarelli, Laura and Sanchez, Luis N and Evers, Lisa and Wu, Jianmin and Pinese, Mark and Cowley, Mark J and Jones, Marc D and Colvin, Emily K and Nagrial, Adnan M and Humphrey, Emily S and Chantrill, Lorraine A and Mawson, Amanda and Humphris, Jeremy and Chou, Angela and Pajic, Marina and Scarlett, Christopher J and Pinho, Andreia V and Giry-Laterriere, Marc and Rooman, Ilse and Samra, Jaswinder S and Kench, James G and Lovell, Jessica A and Merrett, Neil D and Toon, Christopher W and Epari, Krishna and Nguyen, Nam Q and Barbour, Andrew and Zeps, Nikolajs and Moran-Jones, Kim and Jamieson, Nigel B and Graham, Janet S and Duthie, Fraser and Oien, Karin and Hair, Jane and Grützmann, Robert and Maitra, Anirban and Iacobuzio-Donahue, Christine A and Wolfgang, Christopher L and Morgan, Richard A and Lawlor, Rita T and Corbo, Vincenzo and Bassi, Claudio and Rusev, Borislav and Capelli, Paola and Salvia, Roberto and Tortora, Giampaolo and Mukhopadhyay, Debabrata and Petersen, Gloria M and Munzy, Donna M and Fisher, William E and Karim, Saadia A and Eshleman, James R and Hruban, Ralph H and Pilarsky, Christian and Morton, Jennifer P and Sansom, Owen J and Scarpa, Aldo and Musgrove, Elizabeth A and Bailey, Ulla-Maja Hagbo and Hofmann, Oliver and Sutherland, Robert L and Wheeler, David A and Gill, Anthony J and Gibbs, Richard A and Pearson, John V and Waddell, Nicola and ... and Australian Pancreatic Canc Genome and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 03/2016, Volume 531, Issue 7592, pp. 47 - 52
Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-beta,... 
PATHWAYS | METASTASIS | DUCTAL ADENOCARCINOMA | PACKAGE | MULTIDISCIPLINARY SCIENCES | TUMOR | MUTATIONS | DIFFERENTIATION | Pancreatic Neoplasms - metabolism | Prognosis | Hepatocyte Nuclear Factor 3-beta - genetics | Genomics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Hepatocyte Nuclear Factor 3-gamma - genetics | Gene Regulatory Networks | Histone Demethylases - genetics | Tumor Suppressor Protein p53 - genetics | Carcinoma, Pancreatic Ductal - genetics | DNA Methylation | Tumor Suppressor Proteins - genetics | Carcinoma, Pancreatic Ductal - classification | Trans-Activators - genetics | Pancreatic Neoplasms - classification | Transcription, Genetic | Nuclear Proteins - genetics | Carcinoma, Pancreatic Ductal - immunology | Genes, Neoplasm - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Carcinoma, Pancreatic Ductal - pathology | Genome, Human - genetics | Homeodomain Proteins - genetics | Animals | Pancreatic Neoplasms - immunology | Survival Analysis | Cell Line, Tumor | Mice | Physiological aspects | Pancreatic cancer | Methods | Genes | Genomes | Mutation | Gene expression | Tumors | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7396, pp. 123 - 127
Journal Article
Science, ISSN 0036-8075, 12/2012, Volume 338, Issue 6114, pp. 1619 - 1622
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 02/2009, Volume 11, Issue 2, pp. 197 - 203
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 23, pp. 4621 - 4634
The nuclear export protein XPO1 is overexpressed in cancer, leading to the cytoplasmic mislocalization of multiple tumor suppressor proteins. Existing... 
B-CELLS | ANTICANCER ACTIVITY | APOPTOSIS | PROTEIN | IN-VIVO | MYELOMA CELLS | DRUG-RESISTANCE | CRM1 | HEMATOLOGY | EXPRESSION | CANCER | Triazoles - chemistry | Humans | Crystallography, X-Ray | Immunoblotting | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Antineoplastic Agents - metabolism | RNA Interference | T-Lymphocytes - metabolism | Acrylates - metabolism | T-Lymphocytes - drug effects | Acrylates - pharmacology | Receptors, Cytoplasmic and Nuclear - chemistry | Interleukin-10 - metabolism | Antineoplastic Agents - pharmacology | Molecular Structure | Interleukin-6 - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Acrylates - chemistry | Karyopherins - chemistry | Cells, Cultured | Models, Molecular | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Triazoles - pharmacology | Microscopy, Confocal | Triazoles - metabolism | Animals | Karyopherins - metabolism | Active Transport, Cell Nucleus - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Cell Line, Tumor | Karyopherins - genetics | Protein Binding | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Journal Article
Nature, ISSN 0028-0836, 01/2007, Volume 445, Issue 7124, pp. 219 - 223
The liver has a central role in glucose homeostasis, as it has the distinctive ability to produce and consume glucose. On feeding, glucose influx triggers gene... 
HOMEOSTASIS | METABOLISM | LIPOGENESIS | MULTIDISCIPLINARY SCIENCES | ELEMENT-BINDING PROTEIN-1C | LIVER | TRANSCRIPTION | ALPHA | X-RECEPTOR | MICE | DEFICIENCY | Transcription, Genetic - drug effects | Humans | DNA-Binding Proteins - metabolism | DNA-Binding Proteins - agonists | Liver - drug effects | Liver X Receptors | Receptors, Cytoplasmic and Nuclear - chemistry | Response Elements - genetics | Orphan Nuclear Receptors | Fatty Acids - metabolism | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | Fasting | Gene Expression Regulation - genetics | Liver - metabolism | Glucose-6-Phosphate - pharmacology | Retinoid X Receptors - chemistry | Glucose - pharmacology | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Cholesterol - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Gene Expression Regulation - drug effects | Animals | Lipid Metabolism - drug effects | Benzoates - pharmacology | Cell Line, Tumor | Glucose - metabolism | Ligands | Mice | Transcription, Genetic - genetics | Benzylamines - pharmacology | Glucose-6-Phosphate - metabolism | Homeostasis - genetics | Fatty Acids - biosynthesis | Receptors, Cytoplasmic and Nuclear - metabolism | Medical research | Glucose | Gene expression | Insulin | Liver | Binding sites | Index Medicus
Journal Article