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1. Full Text Differential effects of D1 and D2 dopamine agonists on memory, motivation, learning and response time in non‐human primates
by Marino, Robert A and Levy, Ron
European Journal of Neuroscience, ISSN 0953-816X, 01/2019, Volume 49, Issue 2, pp. 199 - 214
Dopamine ( DA ) plays a critical role in cognition, motivation and information processing. DA action has been shown to both improve and/or impair cognition... 
CANTAB | attention | learning | reaching | memory | dopamine | TASK | D-1 | NEUROSCIENCES | PREFRONTAL CORTEX | DECISION-MAKING | DIHYDREXIDINE | MOTOR | RECEPTOR AGONIST | EFFORT-RELATED CHOICE | WORKING-MEMORY | PARKINSONS-DISEASE
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2. Full Text Duration of drug action of dopamine D2 agonists in mice with 6-hydroxydopamine-induced lesions
by Tsuchioka, Akihiro and Oana, Fumiki and Suzuki, Takayuki and Yamauchi, Yuji and Ijiro, Tomoyuki and Kaidoh, Kouichi and Hiratochi, Masahiro
NeuroReport, ISSN 0959-4965, 12/2015, Volume 26, Issue 18, pp. 1126 - 1132
Although 6-hydroxydopamine-induced (6-OHDA-induced) rats are a well-known Parkinson’s disease model, the effects of dopamine D2 agonists in mice with... 
6-hydroxydopamine | Duration of drug action | Mice | Parkinson's disease | Dopamine agonist | BEHAVIOR | RATS | dopamine agonist | mice | NEUROSCIENCES | ROTIGOTINE | D-3 RECEPTORS | INJECTION | duration of drug action | MOUSE MODEL | ANIMAL-MODELS | ANTAGONISTS | PARKINSONS-DISEASE | Apomorphine - pharmacokinetics | Parkinsonian Disorders - psychology | Receptors, Dopamine D2 - agonists | Injections, Intraventricular | Dopamine Agonists - pharmacokinetics | Motor Activity - drug effects | Tetrahydronaphthalenes - pharmacokinetics | Male | Parkinsonian Disorders - chemically induced | Benzothiazoles - pharmacokinetics | Antiparkinson Agents - pharmacokinetics | Ergolines - pharmacokinetics | Quinolines - pharmacokinetics | Thiophenes - pharmacokinetics | Animals | Oxidopamine - pharmacology | Parkinsonian Disorders - pathology | Corpus Striatum - drug effects | Indoles - pharmacokinetics | Azepines - pharmacokinetics | Corpus Striatum - pathology | Disease Models, Animal
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3. Full Text Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D2 receptor agonists
by Chen, Xin and Sassano, Maria F and Zheng, Lianyou and Setola, Vincent and Chen, Meng and Bai, Xu and Frye, Stephen V and Wetsel, William C and Roth, Bryan L and Jin, Jian
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2012, Volume 55, Issue 16, pp. 7141 - 7153
Functionally selective G protein-coupled receptor (GPCR) ligands, which differentially modulate canonical and noncanonical signaling, are extremely useful for... 
Cricetulus | Humans | Arrestins - genetics | Male | Piperazines - chemistry | Quinolones - pharmacology | Structure-Activity Relationship | Aripiprazole | Receptors, Dopamine D2 - metabolism | Arrestins - metabolism | Antipsychotic Agents - chemical synthesis | Hyperkinesis - drug therapy | Phencyclidine | Quinolones - chemistry | Quinolones - chemical synthesis | HEK293 Cells | Female | Hyperkinesis - chemically induced | Radioligand Assay | CHO Cells | Cricetinae | Receptors, Dopamine D2 - agonists | Piperazines - pharmacology | Mice, Knockout | Animals | Antipsychotic Agents - chemistry | Cyclic AMP - biosynthesis | beta-Arrestins | Ligands | Piperazines - chemical synthesis | Mice | Antipsychotic Agents - pharmacology
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4. Full Text Dopamine D2 agonist affects visuospatial working memory distractor interference depending on individual differences in baseline working memory span
by Broadway, James M and Frank, Michael J and Cavanagh, James F
Cognitive, Affective, & Behavioral Neuroscience, ISSN 1530-7026, 6/2018, Volume 18, Issue 3, pp. 509 - 520
The interplay of dopaminergic striatal D1–D2 circuits is thought to support working memory (WM) by selectively filtering information that is to be remembered... 
Neurosciences | Agonist | Basal ganglia | Dopamine | Psychology | Prefrontal cortex | Cognitive Psychology | Striatum | Capacity | Individual differences | Visuospatial working memory | Working memory | Cabergoline | Automation | Memory | Data compression | Interference | Mental task performance | Experiments | Dopamine D1 receptors | Neostriatum | Computer applications | Agonists | Short term memory | Dopamine D2 receptors | Spatial memory | Dopamine receptors
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5. Full Text Monitoring of the dopamine D2 receptor agonists hordenine and N-methyltyramine during the brewing process and in commercial beer samples
by Sommer, Thomas and Dlugash, Gelena and Hübner, Harald and Gmeiner, Peter and Pischetsrieder, Monika
Food Chemistry, ISSN 0308-8146, 03/2019, Volume 276, pp. 745 - 753
The phenethylamine alkaloid hordenine, present in germinated barley, was identified recently as a functionally selective dopamine D2 receptor agonist... 
Hordenine | N-Methyltyramine | Mashing | Dopamine D2 receptor agonist | Brewing | Fermentation | Beer | RAW-MATERIALS | FOOD SCIENCE & TECHNOLOGY | BRAIN DOPAMINE | NON-VOLATILE AMINES | CITRUS-AURANTIUM | NUTRITION & DIETETICS | LIQUID-CHROMATOGRAPHY | BARLEY | PLANT-METABOLISM | FOOD REWARD | CHEMISTRY, APPLIED | TYRAMINE METHYLPHERASE | METHYLATED DERIVATIVES | Tyramine - analysis | Beer - analysis | Cricetulus | Food Analysis - methods | Hordeum - metabolism | Humans | Receptors, Dopamine D2 - agonists | Chromatography, High Pressure Liquid | Receptors, Dopamine D2 - metabolism | Receptors, Dopamine D2 - genetics | Tandem Mass Spectrometry | Animals | Spectrometry, Mass, Electrospray Ionization | Radioligand Assay | Dopamine Agonists - analysis | Tyramine - metabolism | Dopamine Agonists - metabolism | Tyramine - analogs & derivatives | CHO Cells | Alkaloids | Pharmacy | Drugstores | Phenols | G proteins | Production processes
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6. Full Text Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists
by Chen, Xin and McCorvy, John D and Fischer, Matthew G and Butler, Kyle V and Shen, Yudao and Roth, Bryan L and Jin, Jian
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2016, Volume 59, Issue 23, pp. 10601 - 10618
Biased ligands (also known as functionally selective ligands) of G protein-coupled receptors are valuable tools for dissecting the roles of G protein-dependent... 
DRUG | RECRUITMENT | CHEMISTRY, MEDICINAL | ANTIPSYCHOTICS | LIGANDS | PHARMACOLOGY | FUNCTIONAL SELECTIVITY | SCHIZOPHRENIA | DISORDERS | ARIPIPRAZOLE | Dose-Response Relationship, Drug | Aripiprazole - pharmacology | Humans | Receptors, Dopamine D2 - agonists | HEK293 Cells | Aripiprazole - chemistry | Ligands | Aripiprazole - chemical synthesis | Molecular Structure | Structure-Activity Relationship | Drug Discovery | GTP-Binding Proteins - metabolism
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7. Function and expression differences between ergot and non-ergot dopamine D2 agonists on heart valve interstitial cells
by Oana, Fumiki and Onozuka, Hiroshi and Tsuchioka, Akihiro and Suzuki, Takayuki and Tanaka, Nobuyuki and Kaidoh, Kouichi and Hoyano, Yuji and Hiratochi, Masahiro and Kikuchi, Shinji and Takehana, Yasuo and Shibata, Nobuo
The Journal of heart valve disease, ISSN 0966-8519, 2014, Volume 23, Issue 2, pp. 246 - 252
The symptoms of Parkinson's disease are alleviated by dopamine D2 agonists, which are classified as ergot dopamine D2 agonists and non-ergot D2 agonists. Among... 
Oligonucleotide Array Sequence Analysis | Receptor, Serotonin, 5-HT2B - metabolism | Pergolide - toxicity | RNA, Messenger - metabolism | Receptors, Dopamine D2 - metabolism | Mitral Valve - metabolism | Dose-Response Relationship, Drug | Receptor, Serotonin, 5-HT2B - genetics | Receptor, Serotonin, 5-HT2B - drug effects | Mitral Valve - drug effects | Benzothiazoles - toxicity | Dopamine Agonists - toxicity | Serotonin 5-HT2 Receptor Agonists - toxicity | Real-Time Polymerase Chain Reaction | Reproducibility of Results | Receptors, Dopamine D2 - agonists | Cells, Cultured | Gene Expression Profiling - methods | Serotonin 5-HT2 Receptor Antagonists - pharmacology | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Cell Proliferation - drug effects | Mitral Valve - pathology | Protein Kinase Inhibitors - pharmacology
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8. Full Text Revision of the Classical Dopamine D2 Agonist Pharmacophore Based on an Integrated Medicinal Chemistry, Homology Modelling and Computational Docking Approach
by Krogsgaard-Larsen, N and Harpsøe, K and Kehler, J and Christoffersen, C T and Brøsen, P and Balle, T
Neurochemical Research, ISSN 0364-3190, 10/2014, Volume 39, Issue 10, pp. 1997 - 2007
The scientific advances during the 1970ies and 1980ies within the field of dopaminergic neurotransmission enabled the development of a pharmacophore that... 
Neurochemistry | Biochemistry, general | Neurosciences | GPCR docking | Dopamine D2 agonist pharmacophore | Cell Biology | Dopamine D2 agonist | Neurology | Biomedicine | Dopamine D2 receptor | Ergoline derivative | Dopamine D2 SAR | Homology modelling | Receptors, Dopamine D2 - chemistry | Molecular Docking Simulation | Structure-Activity Relationship | Humans | Receptors, Dopamine D2 - agonists | Chemistry, Pharmaceutical | Phenols | Models | Dopamine | Enantiomers | Analysis
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9. Full Text Combined use of the adenosine A(2A) antagonist KW-6002 with L-DOPA or with selective D1 or D2 dopamine agonists increases antiparkinsonian activity but not dyskinesia in MPTP-treated monkeys
by Kanda, Tomoyuki and Jackson, Michael J and Smith, Lance A and Pearce, Ronald K. B and Nakamura, Joji and Kase, Hiroshi and Kuwana, Yoshihisa and Jenner, Peter
Experimental Neurology, ISSN 0014-4886, 2000, Volume 162, Issue 2, pp. 321 - 327
The novel selective adenosine A(2A) receptor antagonist KW-6002 improves motor disability in MPTP-treated parkinsonian marmosets without provoking dyskinesia.... 
Primates | Adenosine A(2A) antagonist | MPTP | Antiparkinson | L-DOPA | Dyskinesia | adenosine A(2A) antagonist | LOCALIZATION | primates | CAFFEINE | KF17837 | DENERVATION | COMMON MARMOSETS | RELEASE | dyskinesia | NEUROSCIENCES | POTENT | antiparkinson | RECEPTOR-MEDIATED MODULATION | NEURONS | PARKINSONS-DISEASE | Purinergic P1 Receptor Antagonists | Administration, Oral | Callithrix | Receptors, Dopamine D2 - agonists | Injections, Intraperitoneal | Motor Activity - drug effects | Male | Purines - administration & dosage | Quinpirole - administration & dosage | Dyskinesia, Drug-Induced - therapy | Receptor, Adenosine A2A | Drug Synergism | Animals | Levodopa - administration & dosage | Levodopa - adverse effects | Parkinson Disease, Secondary - physiopathology | Parkinson Disease, Secondary - drug therapy | Receptors, Dopamine D1 - agonists | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Female | Parkinson Disease, Secondary - chemically induced | Drug Therapy, Combination | Carbidopa - administration & dosage | Disease Models, Animal
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10. Full Text Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade
by Kihara, Takeshi and Shimohama, Shun and Sawada, Hideyuki and Honda, Kazuhiro and Nakamizo, Tomoki and Kanki, Rie and Yamashita, Hiroshi and Akaike, Akinori
Journal of Neuroscience Research, ISSN 0360-4012, 11/2002, Volume 70, Issue 3, pp. 274 - 282
Glutamate, one of the excitatory neurotransmitters, contributes to the neuronal death associated with neurodegenerative diseases, such as Alzheimer's disease... 
dopamine D2 agonists | cortical neurons | phosphatidylinositol 3 kinase cascade | Phosphatidylinositol 3 kinase cascade | Cortical neurons | Dopamine D2 agonists | ALZHEIMERS-DISEASE | RECEPTOR MESSENGER-RNA | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | GLUTAMATE-INDUCED CYTOTOXICITY | BETA-AMYLOID TOXICITY | BROMOCRIPTINE PROTECTS | INDUCED NEUROTOXICITY | RAT-BRAIN | INSITU HYBRIDIZATION HISTOCHEMISTRY | CEREBRAL-ISCHEMIA | Protein-Serine-Threonine Kinases | Phosphatidylinositol 3-Kinases - metabolism | Receptors, Dopamine D2 - metabolism | Cerebral Cortex - metabolism | Cerebral Cortex - physiopathology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Neuroprotective Agents - pharmacology | Phosphatidylinositol 3-Kinases - drug effects | Up-Regulation - physiology | Fetus | Neurons - metabolism | Cerebral Cortex - drug effects | Nitric Oxide Donors - pharmacology | Neurons - drug effects | Cell Survival - physiology | Ionophores - pharmacology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Dopamine Agonists - pharmacology | Alzheimer Disease - physiopathology | Proto-Oncogene Proteins - drug effects | Glutamic Acid - pharmacology | Receptors, Dopamine D2 - agonists | Cells, Cultured | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Rats | Bromocriptine - pharmacology | Proto-Oncogene Proteins c-akt | Up-Regulation - drug effects | Animals | Alzheimer Disease - metabolism | Proto-Oncogene Proteins c-bcl-2 - drug effects | Glutamic Acid - metabolism | Quinpirole - pharmacology | Dopamine D2 Receptor Antagonists
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11. Full Text Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists
by Weichert, Dietmar and Stanek, Markus and Hübner, Harald and Gmeiner, Peter
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2016, Volume 24, Issue 12, pp. 2641 - 2653
Aiming to discover dual-acting β adrenergic/dopamine D receptor ligands, a structure-guided approach for the evolution of GPCR agonists that address multiple... 
G protein-coupled receptors | Dopamine receptor | Polypharmacology | Molecular probes | β2 adrenergic receptor | Neurodegenerative disorders | Parkinson’s disease | β | Parkinson's disease | adrenergic receptor | Dopamine Agonists - pharmacology | Cricetulus | Adrenergic beta-2 Receptor Agonists - chemistry | Humans | Receptors, Dopamine D2 - agonists | Models, Molecular | Parkinson Disease - drug therapy | Receptors, Dopamine D2 - metabolism | Drug Discovery | Receptors, Adrenergic, beta-2 - metabolism | Adrenergic beta-2 Receptor Agonists - pharmacology | Animals | Benzoxazines - pharmacology | HEK293 Cells | Parkinson Disease - metabolism | Dopamine Agonists - chemistry | Benzoxazines - chemistry | CHO Cells
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12. Full Text Functionally selective dopamine D2, D3 receptor partial agonists
by Möller, Dorothee and Kling, Ralf C and Skultety, Marika and Leuner, Kristina and Hübner, Harald and Gmeiner, Peter
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2014, Volume 57, Issue 11, pp. 4861 - 4875
Dopamine D2 receptor-promoted activation of Gα(o) over Gα(i) may increase synaptic plasticity and thereby might improve negative symptoms of schizophrenia.... 
Cricetulus | Pyrazoles - chemical synthesis | Stereoisomerism | Humans | Piperazines - chemistry | Structure-Activity Relationship | Arrestins - metabolism | Antipsychotic Agents - chemical synthesis | Pyrazoles - chemistry | Swine | HEK293 Cells | Radioligand Assay | CHO Cells | Pyrazoles - pharmacology | Drug Partial Agonism | Receptors, Dopamine D2 - agonists | Heterocyclic Compounds, 2-Ring - chemistry | Oximes - chemical synthesis | Piperazines - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacology | Oximes - chemistry | Receptors, Dopamine D3 - agonists | Animals | Antipsychotic Agents - chemistry | beta-Arrestin 2 | beta-Arrestins | Oximes - pharmacology | Piperazines - chemical synthesis | Mice | Molecular Docking Simulation | Antipsychotic Agents - pharmacology | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Heterocyclic Compounds, 2-Ring - chemical synthesis
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13. Full Text Effects of dopamine D2 agonist quinpirole on neuronal activity of anterior cingulate cortex and striatum in rats
by Huang, Jian-Jia and Yen, Chen-Tung and Liu, Tzu-Lan and Tsao, Hen-Wai and Hsu, Ju-Wei and Tsai, Meng-Li
Psychopharmacology, ISSN 0033-3158, 6/2013, Volume 227, Issue 3, pp. 459 - 466
The influence of acute D2 agonist quinpirole on locomotor activity has been effectively characterized. However, few studies have addressed the dynamic changes... 
Quinpirole | Striatum | Neurosciences | Biomedicine | Anterior cingulate cortex | Neuronal activity | Pharmacology/Toxicology | Psychiatry | Locomotor activity | PSYCHIATRY | BASAL GANGLIA | FRONTAL-CORTEX | CEREBRAL GLUCOSE-UTILIZATION | RECEPTOR GENE-EXPRESSION | LOCOMOTOR-ACTIVITY | NEUROSCIENCES | CHLORAL HYDRATE | NUCLEUS-ACCUMBENS | COMPULSIVE CHECKING BEHAVIOR | SENSITIZED RATS | URETHANE ANESTHESIA | PHARMACOLOGY & PHARMACY | Dopamine Agonists - pharmacology | Motor Activity - physiology | Rats, Wistar | Receptors, Dopamine D2 - agonists | Motor Activity - drug effects | Rats | Male | Excitatory Postsynaptic Potentials - drug effects | Dose-Response Relationship, Drug | Animals | Time Factors | Neurons - physiology | Corpus Striatum - drug effects | Corpus Striatum - physiology | Gyrus Cinguli - physiology | Gyrus Cinguli - drug effects | Quinpirole - pharmacology | Neurons - drug effects | Inhibitory Postsynaptic Potentials - drug effects | Dopamine | Neurons | Agonists | Corpus striatum | Research | Properties | Psychotropic drugs | Brain | Animal behavior | Rodents
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14. Full Text Repositioning dopamine D2 receptor agonist bromocriptine to enhance docetaxel chemotherapy and treat bone metastatic prostate cancer
by Yang, Yang and Mamouni, Kenza and Li, Xin and Chen, Yanhua and Kavuri, Sravan and Du, Yuhong and Fu, Haian and Kucuk, Omer and Wu, Daqing
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2018, Volume 17, Issue 9, pp. 1859 - 1870
Docetaxel resistance remains a major obstacle in the treatment of prostate cancer bone metastasis. In this study, we demonstrate that the dopamine D2 receptor... 
ANDROGEN RECEPTOR | LUNG-CANCER | CELLS | NEUROENDOCRINE TUMORS | ANTAGONIST | ONCOLOGY | THERAPEUTIC TARGET | GROWTH | ACUTE MYELOID-LEUKEMIA | EXPRESSION | CARCINOMA | Cell Survival - drug effects | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Bromocriptine - administration & dosage | Humans | Receptors, Dopamine D2 - agonists | Bone Neoplasms - secondary | Male | Drug Repositioning | Receptors, Dopamine D2 - metabolism | Bone Neoplasms - metabolism | Drug Synergism | Xenograft Model Antitumor Assays | Docetaxel - administration & dosage | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Cycle Checkpoints - drug effects | Mice, Nude | Dopamine Agonists - administration & dosage | Cell Line, Tumor | Bone Neoplasms - drug therapy | Prostatic Neoplasms - drug therapy | androgen receptor | bone metastasis | dopamine D2 receptor | bromocriptine | docetaxel | Prostate cancer
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15. Full Text Synthesis of 2-fluoro-11-hydroxy-N-propylnoraporphine: A potential dopamine D2 agonist
by Zhang, Ao and Csutoras, Csaba and Zong, Rushi and Neumeyer, John L
Organic Letters, ISSN 1523-7060, 07/2005, Volume 7, Issue 15, pp. 3239 - 3242
[structure: see text]. 2-Fluoro-11-hydroxy-N-propylnoraporphine 4 (2-F-11-OH-NPa) was synthesized from thebaine in 13 steps with an overall yield of 1.35%. The... 
Brain - drug effects | Brain - cytology | Dopamine Agonists - chemical synthesis | Thebaine - chemistry | Animals | Receptors, Dopamine D2 - agonists | Rats | Palladium - chemistry | Aporphines - chemical synthesis
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16. Full Text Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αb-crystallin
by Shao, Wei and Zhang, Shu-Zhen and Tang, Mi and Zhang, Xin-Hua and Zhou, Zheng and Yin, Yan-Qing and Zhou, Qin-Bo and Huang, Yuan-Yuan and Liu, Ying-Jun and Wawrousek, Eric and Chen, Teng and Li, Sheng-Bin and Xu, Ming and Zhou, Jiang-Ning and Hu, Gang and Zhou, Jia-Wei
Nature, ISSN 0028-0836, 02/2013, Volume 494, Issue 7435, pp. 90 - 94
Chronic neuroinflammation is a common feature of the ageing brain and some neurodegenerative disorders. However, the molecular and cellular mechanisms... 
MICROGLIA | PATHWAY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DISEASE | INNATE | HUMAN-BRAIN | MICE | Inflammation - chemically induced | alpha-Crystallin B Chain - genetics | Inflammation - pathology | Receptors, Dopamine D2 - deficiency | Male | alpha-Crystallin B Chain - metabolism | Receptors, Dopamine D2 - metabolism | Substantia Nigra - cytology | Neuroprotective Agents - metabolism | Microglia - immunology | Astrocytes - immunology | Dopaminergic Neurons - drug effects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Microglia - cytology | Astrocytes - drug effects | Immunity, Innate - drug effects | Mice, Inbred C57BL | Receptors, Dopamine D2 - agonists | Inflammation - immunology | Receptors, Dopamine D2 - genetics | Substantia Nigra - drug effects | Animals | Inflammation - genetics | Mice | Quinpirole - pharmacology | Astrocytes - metabolism | Index Medicus
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