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Journal Article
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 11/2015, Volume 20, Issue 11, pp. 1373 - 1385
Hetero-oligomers of G-protein-coupled receptors have become the subject of intense investigation, because their purported potential to manifest signaling and... 
RAT STRIATUM | PSYCHIATRY | BASAL GANGLIA | COMPARTMENTAL ORGANIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPASE-C | BAC TRANSGENIC MICE | NEUROSCIENCES | NUCLEUS-ACCUMBENS | GENE-EXPRESSION | MEDIUM SPINY NEURONS | PHOSPHOINOSITIDE HYDROLYSIS | ADENYLATE-CYCLASE | Humans | Nucleus Accumbens - metabolism | Motor Activity - drug effects | Male | Receptors, Dopamine D2 - metabolism | Corpus Striatum - metabolism | Receptors, Dopamine D1 - metabolism | Protein Multimerization - physiology | HEK293 Cells | Phosphorylation - drug effects | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Protein Structure, Tertiary | Dopamine Agonists - pharmacology | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Mice, Inbred C57BL | Grooming - drug effects | Models, Molecular | 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - analogs & derivatives | Receptors, Dopamine D2 - genetics | Mice, Knockout | Motor Activity - genetics | Animals | Dopamine Antagonists - pharmacology | 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology | Corpus Striatum - drug effects | Luminescent Proteins - genetics | Mice | Nucleus Accumbens - drug effects | Protein Multimerization - drug effects | Luminescent Proteins - metabolism | Receptors, Dopamine D1 - genetics | Oligomers | Depression, Mental | Schizophrenia | Physiological aspects | Research | Risk factors | Dopamine receptors | Index Medicus | BRET | striatum | Gαq | hetero-oligomer | proximity ligation assay | biased agonism | dopamine
Journal Article
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7695, pp. 269 - 273
Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward, addiction, control of coordinated movement, metabolism and hormonal... 
LIGANDS | CLONING | CRYSTAL-STRUCTURE | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | CHARGES | RHODOPSIN | MODEL | BETA-ADRENERGIC RECEPTOR | DISCOVERY | AGONIST | Receptors, Dopamine D4 - chemistry | Humans | Receptors, Dopamine D3 - chemistry | Receptors, Dopamine D3 - metabolism | Mutant Proteins - genetics | Models, Molecular | Crystallography, X-Ray | Mutant Proteins - metabolism | Risperidone - chemistry | Receptors, Dopamine D2 - metabolism | Receptors, Dopamine D2 - genetics | Antipsychotic Agents - chemistry | Mutant Proteins - chemistry | Drug Design | Hydrophobic and Hydrophilic Interactions | Receptors, Dopamine D2 - chemistry | Antipsychotic Agents - metabolism | Ligands | Receptors, Dopamine D4 - metabolism | Risperidone - metabolism | Kinetics | Mutation | Binding Sites | Pharmacology, Experimental | Drug interactions | Physiological aspects | Research | Risperidone | Structure | Dopamine receptors | Drugs | Attention deficit disorder | Neuroleptics | Parkinson's disease | Molecular structure | Mental disorders | Parkinsons disease | Schizophrenia | Mental depression | Proteins | Psychotropic drugs | Receptors | Vomiting | Reinforcement | Dopamine D2 receptors | Movement disorders | Crystal structure | Dopamine | Neurodegenerative diseases | Secretion | Attention deficit hyperactivity disorder | Nausea | Metabolism | Side effects | Addiction | Structure-function relationships | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2012, Volume 32, Issue 26, pp. 9023 - 9024
Dysfunctions of dopaminergic homeostasis leading to either low or high dopamine (DA) levels are causally linked to Parkinson's disease, schizophrenia, and... 
MICE LACKING DOPAMINE-D-2 | TYROSINE-HYDROXYLASE ACTIVITY | KNOCK-OUT MICE | STRIATAL SYNAPTOSOMES | BASAL GANGLIA | IN-VIVO | CORTICOSTRIATAL TERMINALS | INHIBITORY CONTROL | DEFICIENT MICE | NEUROSCIENCES | NUCLEUS-ACCUMBENS | Tyrosine 3-Monooxygenase - metabolism | Chromatography, High Pressure Liquid - methods | Male | Neurons - cytology | Ventral Tegmental Area - cytology | RNA, Messenger - metabolism | Receptors, Dopamine D2 - metabolism | Excitatory Postsynaptic Potentials - drug effects | Substantia Nigra - cytology | Dose-Response Relationship, Drug | Phosphorylation - genetics | Synapses - metabolism | Dopamine Agents - pharmacology | Neurons - physiology | Phosphorylation - drug effects | Neurons - drug effects | Electric Stimulation - methods | Dopamine - metabolism | Excitatory Postsynaptic Potentials - genetics | Synapses - drug effects | Ventral Tegmental Area - drug effects | 3,4-Dihydroxyphenylacetic Acid - metabolism | Electrochemical Techniques | Presynaptic Terminals - drug effects | Mice, Inbred C57BL | Mice, Transgenic | Biophysics | Reaction Time - genetics | Mutation - genetics | Receptors, Dopamine D2 - genetics | Motor Activity - genetics | Patch-Clamp Techniques | Substantia Nigra - drug effects | Animals | Homovanillic Acid - metabolism | Analysis of Variance | Presynaptic Terminals - metabolism | Mice | Quinpirole - pharmacology | In Vitro Techniques | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 10, pp. 2726 - 2731
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 09/2012, Volume 134, Issue 36, pp. 14890 - 14896
The recently published crystal structure of the D3 dopamine receptor shows a tightly packed region of aromatic residues on helices 5 and 6 in the space... 
Oocytes - metabolism | Humans | Oocytes - chemistry | Xenopus laevis | Models, Molecular | Amino Acids - genetics | Receptors, Dopamine D2 - metabolism | Receptors, Dopamine D2 - genetics | Hydrocarbons, Aromatic - chemistry | Animals | Mutagenesis | Receptors, Dopamine D2 - chemistry | Mutation | Sulfur - chemistry | Index Medicus
Journal Article