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EUROPEAN RESPIRATORY JOURNAL, ISSN 0903-1936, 09/2004, Volume 24, Issue 3, pp. 353 - 359
The efficacy and safety of combining bosentan, an orally active dual endothelin receptor antagonist and epoprostenol, a continuously infused prostaglandin, in... 
SURVIVAL | CHRONIC HEART-FAILURE | epoprostenol | scleroderma | PROSTACYCLIN | TERM | CONTINUOUS INTRAVENOUS EPOPROSTENOL | SYSTEMIC-SCLEROSIS | EXCRETION | endothelin receptors | Bosentan | THERAPY | RESPIRATORY SYSTEM | ENDOTHELIN-RECEPTOR ANTAGONIST | pulmonary arterial hypertension | EXPRESSION
Journal Article
Transplantation, ISSN 0041-1337, 04/2018, Volume 102, Issue 4, pp. 601 - 608
Journal Article
Journal of Heart and Lung Transplantation, ISSN 1053-2498, 2012, Volume 31, Issue 2, pp. 150 - 158
Journal Article
Chest, ISSN 0012-3692, 2012, Volume 142, Issue 6, pp. 1383 - 1390
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2016, Volume 197, Issue 5, pp. 1577 - 1586
Journal Article
CEPHALALGIA, ISSN 0333-1024, 02/2010, Volume 30, Issue 2, pp. 179 - 190
Prostacyclin [prostaglandin I-2 (PGI(2))] activates and sensitizes meningeal sensory afferents. In healthy subjects PGI(2) triggers headache in healthy... 
MIDDLE CEREBRAL-ARTERY | CUTANEOUS ALLODYNIA | CENTRAL SENSITIZATION | GENE-RELATED PEPTIDE | BLOOD-FLOW-VELOCITY | prostacyclin | Migraine | PROTEIN-KINASE | nociception | MENINGEAL NOCICEPTORS | NEUROSCIENCES | CLINICAL NEUROLOGY | prostaglandin I-2 | NITRIC-OXIDE | sensitization | HUMAN PROSTACYCLIN RECEPTOR | PREMONITORY SYMPTOMS
Journal Article
Science, ISSN 0036-8075, 12/2004, Volume 306, Issue 5703, pp. 1954 - 1957
Female gender affords relative protection from cardiovascular disease until the menopause. We report that estrogen acts on estrogen receptor subtype alpha to... 
Antioxidants | Oxidative stress | Excretion | Estrogens | Atherosclerosis | Lipids | Reports | Biosynthesis | Mice | Lesions | High fat diet | SUPEROXIDE | CYCLOOXYGENASE-2 | ROLES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | APOE-DEFICIENT MICE | NITRIC-OXIDE | ATHEROSCLEROSIS | RECEPTOR | THROMBOXANE A | 17-BETA-ESTRADIOL | Epoprostenol - metabolism | Muscle, Smooth, Vascular - metabolism | Oxidative Stress | Epoprostenol - biosynthesis | Antioxidants - metabolism | Cyclooxygenase 2 | Sulfones - adverse effects | Male | Sulfones - pharmacology | Lactones - pharmacology | Epoprostenol - physiology | Isoenzymes - metabolism | Receptors, Epoprostenol - physiology | Estrogen Receptor alpha - metabolism | Female | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Estradiol - pharmacology | Muscle, Smooth, Vascular - drug effects | Receptors, LDL - genetics | Ovariectomy | Mice, Inbred C57BL | Cells, Cultured | Hydrogen Peroxide - pharmacology | Lactones - adverse effects | Sex Characteristics | Cyclooxygenase Inhibitors - pharmacology | Mice, Knockout | Arteriosclerosis - prevention & control | Receptors, Epoprostenol - genetics | Animals | Cyclooxygenase 2 Inhibitors | Platelet Activation | Prostaglandin-Endoperoxide Synthases - metabolism | Arteriosclerosis - metabolism | Cardiovascular Diseases - chemically induced | Receptors, LDL - physiology | Lipid Peroxidation | Arteriosclerosis - pathology | Cyclooxygenase Inhibitors - adverse effects | Physiological aspects | Cardiovascular diseases | Research | Clinical trials | Cardiovascular disease | Females | Rodents | Menopause | Estrogen | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2017, Volume 363, Issue 3, pp. 348 - 357
This article describes the preclinical pharmacology and pharmacokinetics (PK) of hexadecyl-treprostinil (C16TR), a prodrug of treprostinil (TRE), formulated in... 
PROSTACYCLIN RECEPTOR | EP4 RECEPTOR | ANALOGS | ARTERIAL-HYPERTENSION | PHARMACOLOGY & PHARMACY | BINDING | ILOPROST | Antihypertensive Agents - pharmacology | Nanoparticles - chemistry | Vasodilator Agents - pharmacokinetics | Phosphatidylethanolamines - adverse effects | Humans | Excipients - adverse effects | Male | Polyethylene Glycols - chemistry | Squalene - analogs & derivatives | Drug Compounding | Hypertension, Pulmonary - drug therapy | Epoprostenol - pharmacokinetics | Guinea Pigs | Squalene - adverse effects | Antihypertensive Agents - therapeutic use | Excipients - administration & dosage | Rats, Sprague-Dawley | Epoprostenol - analogs & derivatives | Lung - drug effects | Vasodilation - drug effects | Phosphatidylethanolamines - chemistry | Drug Delivery Systems - adverse effects | Epoprostenol - administration & dosage | Prodrugs - administration & dosage | Epoprostenol - metabolism | Vasodilator Agents - therapeutic use | Antihypertensive Agents - administration & dosage | Polyethylene Glycols - adverse effects | Hypertension, Pulmonary - blood | Nanoparticles - adverse effects | Dose-Response Relationship, Drug | Epoprostenol - therapeutic use | Excipients - chemistry | Epoprostenol - pharmacology | Female | Lung - metabolism | Platelet Aggregation - drug effects | Drug Evaluation, Preclinical | Squalene - chemistry | Vasodilator Agents - pharmacology | Administration, Inhalation | Phosphatidylethanolamines - administration & dosage | Squalene - administration & dosage | Antihypertensive Agents - pharmacokinetics | Polyethylene Glycols - administration & dosage | Animals | Prodrugs - pharmacokinetics | Dogs | Nanoparticles - administration & dosage | Prodrugs - therapeutic use | Lung - blood supply | Prodrugs - pharmacology | Vasodilator Agents - administration & dosage | Index Medicus
Journal Article
European Respiratory Journal, ISSN 0903-1936, 10/2011, Volume 38, Issue 4, pp. 851 - 860
Endothelin receptor antagonists are used to treat idiopathic pulmonary arterial hypertension (IPAH), but human pulmonary arterial endothelin receptor... 
Paediatric idiopathic pulmonary arterial hypertension | Endothelin receptor antagonists | Peripheral pulmonary arteries | Endothelin receptor A and B | Endothelium | endothelium | PROTEIN | peripheral pulmonary arteries | B RECEPTOR | endothelin receptor A and B | CANCER | paediatric idiopathic pulmonary arterial hypertension | CHILDREN | MESSENGER-RNA | RESPIRATORY SYSTEM | IN-VIVO | NITRIC-OXIDE | SMOOTH-MUSCLE-CELLS | CONTINUOUS-INFUSION | ETA-RECEPTORS | Sulfones - therapeutic use | Muscle, Smooth, Vascular - metabolism | Vasodilator Agents - therapeutic use | Humans | Child, Preschool | Endothelium, Vascular - drug effects | Male | Sildenafil Citrate | Epoprostenol - therapeutic use | Pulmonary Artery - metabolism | Nifedipine - therapeutic use | Endothelin A Receptor Antagonists | Female | Hypertension, Pulmonary - drug therapy | Purines - therapeutic use | Nitric Oxide Synthase Type III - metabolism | Drug Therapy, Combination | Child | Muscle, Smooth, Vascular - drug effects | Hypertension, Pulmonary - mortality | Familial Primary Pulmonary Hypertension | Endothelin B Receptor Antagonists | Hypertension, Pulmonary - metabolism | Piperazines - therapeutic use | Pulmonary Artery - drug effects | Antihypertensive Agents - therapeutic use | Sulfonamides - therapeutic use | Endothelium, Vascular - metabolism | Adolescent | Receptor, Endothelin A - metabolism | Receptor, Endothelin B - metabolism | Index Medicus
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 05/2018, Volume 32, Issue 5, pp. 2354 - 2365
Journal Article