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1. Full Text The obestatin/ghrelin ratio and ghrelin genetics in adult celiac patients before and after a gluten-free diet, in irritable bowel syndrome patients and healthy individuals
by Russo, Francesco and Chimienti, Guglielmina and Linsalata, Michele and Clemente, Caterina and Orlando, Antonella and Riezzo, Giuseppe
European Journal of Gastroenterology & Hepatology, ISSN 0954-691X, 02/2017, Volume 29, Issue 2, pp. 160 - 168
BACKGROUNDGhrelin levels and obestatin/ghrelin ratio have been proposed as activity markers in ulcerative colitis, but no data are available in celiac disease... 
Gluten-free diet | Celiac disease | GHRL | Ghrelin | Irritable bowel syndrome | Obestatin | gluten-free diet | CROHNS-DISEASE | PERMEABILITY | irritable bowel syndrome | SENSITIVITY | obestatin | RECEPTOR | PREVALENCE | PATHOGENESIS | PLASMA GHRELIN | ghrelin | POLYMORPHISMS | FUNCTIONAL DYSPEPSIA | celiac disease | IBS | GASTROENTEROLOGY & HEPATOLOGY | Lactulose - metabolism | Humans | Male | Intestines - metabolism | Healthy Volunteers | Diarrhea - blood | Mannitol - metabolism | Celiac Disease - blood | Adult | Female | Diet, Gluten-Free | Genetic Predisposition to Disease | Irritable Bowel Syndrome - metabolism | Celiac Disease - genetics | Ghrelin - genetics | Genotype | Permeability | Irritable Bowel Syndrome - genetics | Ghrelin - blood | Lactulose - urine | Diarrhea - genetics | Irritable Bowel Syndrome - blood | Polymorphism, Single Nucleotide | Mannitol - urine | Celiac Disease - diet therapy | Celiac Disease - metabolism
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2. Full Text Des‐Acyl Ghrelin Directly Targets the Arcuate Nucleus in a Ghrelin‐Receptor Independent Manner and Impairs the Orexigenic Effect of Ghrelin
by Fernandez, G and Cabral, A and Cornejo, M. P and De Francesco, P. N and Garcia‐Romero, G and Reynaldo, M and Perello, M
Journal of Neuroendocrinology, ISSN 0953-8194, 02/2016, Volume 28, Issue 2, pp. 1 - n/a
Ghrelin is a stomach‐derived octanoylated peptide hormone that plays a variety of well‐established biological roles acting via its specific receptor known as... 
des‐acyl ghrelin receptor | acyl‐ghrelin | hypothalamus | food intake | Acyl-ghrelin | Hypothalamus | Food intake | Des-acyl ghrelin receptor | RAT | FOOD-INTAKE | NEUROSCIENCES | NEUROPEPTIDE-Y | PERIPHERAL GHRELIN | GROWTH | ENDOCRINOLOGY & METABOLISM | NEURONS | CENTRAL-NERVOUS-SYSTEM | HORMONE SECRETAGOGUE RECEPTOR | des-acyl ghrelin receptor | DESACYL-GHRELIN | BRAIN | acyl-ghrelin | Ghrelin - administration & dosage | Ghrelin - physiology | Arcuate Nucleus of Hypothalamus - metabolism | Ghrelin - pharmacology | Receptors, Ghrelin - physiology | Receptors, Ghrelin - genetics | Eating - physiology | Mice, Knockout | Ghrelin - antagonists & inhibitors | Eating - drug effects | Animals | Injections, Subcutaneous | Neurons - metabolism | Infusions, Intraventricular | Neurons - drug effects | Neuropeptide Y | Physiological aspects | Somatotropin
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3. Full Text Role of ghrelin in food reward: impact of ghrelin on sucrose self‐administration and mesolimbic dopamine and acetylcholine receptor gene expression
by Skibicka, Karolina P and Hansson, Caroline and Egecioglu, Emil and Dickson, Suzanne L and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Institute of Neuroscience and Physiology, Department of Physiology and Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi and Sahlgrenska Academy
Addiction Biology, ISSN 1355-6215, 01/2012, Volume 17, Issue 1, pp. 95 - 107
ABSTRACT The decision to eat is strongly influenced by non‐homeostatic factors such as food palatability. Indeed, the rewarding and motivational value of food... 
GHS‐R1A | ghrelin | Acetylcholine | food motivation | dopamine | operant conditioning | GHS-R1A | BIOCHEMISTRY & MOLECULAR BIOLOGY | STIMULATES LOCOMOTOR-ACTIVITY | GROWTH-HORMONE-SECRETION | SUBSTANCE ABUSE | DIET-INDUCED OBESITY | ARCUATE NUCLEUS | VENTRAL TEGMENTAL AREA | NUCLEUS-ACCUMBENS | NEUROPEPTIDE-Y | MOTIVATED BEHAVIOR | INDUCED INCREASES | BRAIN | Sucrose - administration & dosage | Gene Expression - drug effects | Receptors, Cholinergic - metabolism | Gene Expression - genetics | Receptors, Cholinergic - drug effects | Ghrelin - genetics | Dopamine - genetics | Rats | Ghrelin - pharmacology | Male | Rats, Sprague-Dawley | Feeding Behavior - drug effects | Brain - drug effects | Brain - metabolism | Ghrelin - metabolism | Animals | Conditioning, Operant | Reward | Self Administration - statistics & numerical data | Sweetening Agents - administration & dosage | Dopamine - metabolism | Food | Receptors, Cholinergic - genetics | Physiological aspects | Phenols | Gene expression | Genes | Preclinical Studies | Physiology | Fysiologi
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4. Full Text Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism
by Andrews, Zane B and Erion, Derek and Beiler, Rudolph and Liu, Zhong-Wu and Abizaid, Alfonso and Zigman, Jeffrey and Elsworth, John D and Savitt, Joseph M and DiMarchi, Richard and Tschop, Matthias and Roth, Robert H and Gao, Xiao-Bing and Horvath, Tamas L
Journal of Neuroscience, ISSN 0270-6474, 11/2009, Volume 29, Issue 45, pp. 14057 - 14065
Ghrelin targets the hypothalamus to regulate food intake and adiposity. Endogenous ghrelin receptors [growth hormone secretagogue receptor (GHSR)] are also... 
MOUSE SUBSTANTIA-NIGRA | CIRCULATING GHRELIN | BRAIN REWARD | NEURONS | STIMULATES LOCOMOTOR-ACTIVITY | UNCOUPLING PROTEIN-2 | DEFICIENT MICE | DIET-INDUCED OBESITY | NEUROSCIENCES | PARKINSONS-DISEASE | CALORIE RESTRICTION | Tyrosine 3-Monooxygenase - metabolism | Ion Channels - genetics | Mitochondrial Proteins - genetics | RNA, Messenger - metabolism | Receptors, Ghrelin - genetics | Mitochondrial Proteins - metabolism | Receptors, Ghrelin - metabolism | Acyl Coenzyme A - metabolism | Dopamine - metabolism | MPTP Poisoning | Mice, Inbred C57BL | Ghrelin - genetics | Mice, Transgenic | Mitochondria - drug effects | Mice, Knockout | Ghrelin - metabolism | Substantia Nigra - drug effects | Animals | Cell Death - physiology | Ion Channels - metabolism | Corpus Striatum - drug effects | Corpus Striatum - physiology | Mice | Uncoupling Protein 2 | Mitochondria - physiology | Substantia Nigra - physiology | Index Medicus
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5. Full Text Neuronal deletion of ghrelin receptor almost completely prevents diet-induced obesity
by Lee, Jong Han and Lin, Ligen and Xu, Pingwen and Saito, Kenji and Wei, Qiong and Meadows, Adelina G and Bongmba, Odelia Y.N and Pradhan, Geetali and Zheng, Hui and Xu, Yong and Sun, Yuxiang
Diabetes, ISSN 0012-1797, 08/2016, Volume 65, Issue 8, pp. 2169 - 2178
Ghrelin signaling has major effects on energy and glucose homeostasis, but it is unknown whether ghrelin's functions are centrally and/or peripherally... 
THERMOGENESIS | ENERGY-EXPENDITURE | MESSENGER-RNA | ENDOCRINOLOGY & METABOLISM | MICE | BROWN ADIPOSE-TISSUE | HORMONE SECRETAGOGUE RECEPTOR | SPONTANEOUS LOCOMOTOR-ACTIVITY | HYPOTHALAMIC NEURONS | DOPAMINE TRANSPORTER | EXPRESSION | Thermogenesis - genetics | Diet, High-Fat - adverse effects | Male | Obesity - genetics | Receptors, Ghrelin - genetics | Synapsins - genetics | Synapsins - metabolism | Eating - physiology | Brain - metabolism | Thermogenesis - physiology | Insulin Resistance - physiology | Mice, Mutant Strains | Receptors, Ghrelin - metabolism | Female | Neurons - metabolism | Energy Metabolism - genetics | Energy Metabolism - physiology | Real-Time Polymerase Chain Reaction | Glucose Tolerance Test | Calorimetry, Indirect | Eating - genetics | Obesity - metabolism | Animals | Hypothalamus - metabolism | Obesity - prevention & control | Insulin Resistance - genetics | Mice | Prevention | Obesity | Cellular signal transduction | Research | Ghrelin | Metabolism
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6. Full Text Neonatal ghrelin programs development of hypothalamic feeding circuits
by Steculorum, Sophie M and Collden, Gustav and Coupe, Berengere and Croizier, Sophie and Lockie, Sarah and Andrews, Zane B and Jarosch, Florian and Klussmann, Sven and Bouret, Sebastien G
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 846 - 858
A complex neural network regulates body weight and energy balance, and dysfunction in the communication between the gut and this neural network is associated... 
ENERGY-BALANCE | MEDICINE, RESEARCH & EXPERIMENTAL | POSTNATAL LEPTIN SURGE | MESSENGER-RNA | FOOD-INTAKE | PROOPIOMELANOCORTIN NEURONS | GROWTH | MICE | HORMONE SECRETAGOGUE RECEPTOR | DIET-INDUCED OBESITY | ARCUATE NUCLEUS | Arcuate Nucleus of Hypothalamus - metabolism | Leptin - metabolism | Ghrelin - genetics | Axons - metabolism | Arcuate Nucleus of Hypothalamus - cytology | Leptin - genetics | Adipocytes - pathology | Feeding Behavior - physiology | Mice, Knockout | Ghrelin - metabolism | Animals | Adipocytes - metabolism | Signal Transduction - physiology | Mice | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Infants (Newborn) | Obesity | Neural circuitry | Ghrelin | Physiological aspects | Food and nutrition | Properties | Weight control | Hypotheses | Physiology | Nutrition | Rodents | Metabolic disorders
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7. Full Text Ghrelin and glucose homeostasis
by Delhanty, P.J.D and van der Lely, A.J
Peptides, ISSN 0196-9781, 11/2011, Volume 32, Issue 11, pp. 2309 - 2318
► Ghrelin has direct effects on pancreatic islet function. ► Available data indicate the potential of ghrelin blockade as a means to prevent its diabetogenic... 
Obesity | Diabetes | Metabolism | Ghrelin | POLYCYSTIC-OVARY-SYNDROME | BODY-WEIGHT GAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DES-ACYL GHRELIN | HEALTHY-YOUNG MEN | ENERGY-BALANCE | GROWTH-HORMONE SECRETAGOGUE | UNACYLATED GHRELIN | RECEPTOR KNOCKOUT MICE | ENDOCRINOLOGY & METABOLISM | PHARMACOLOGY & PHARMACY | PITUITARY-ADRENAL AXIS | STIMULATES INSULIN-SECRETION | Acyltransferases - antagonists & inhibitors | Islets of Langerhans - drug effects | Obesity - drug therapy | Humans | Insulin-Like Growth Factor I - genetics | Diabetes Mellitus, Type 2 - metabolism | Acyltransferases - metabolism | Receptors, Ghrelin - genetics | Islets of Langerhans - metabolism | Receptors, Ghrelin - metabolism | Acylation | Gene Expression | Signal Transduction | Liver - metabolism | Enzyme Inhibitors - pharmacology | Ghrelin - genetics | Insulin Resistance | Rats | Receptors, Ghrelin - antagonists & inhibitors | Ghrelin - pharmacology | Enzyme Inhibitors - therapeutic use | Obesity - metabolism | Peptides - pharmacology | Ghrelin - antagonists & inhibitors | Ghrelin - blood | Insulin - metabolism | Animals | Glucose - metabolism | Mice | Diabetes Mellitus, Type 2 - drug therapy | Energy Metabolism - drug effects | Insulin-Like Growth Factor I - metabolism | Peptides - therapeutic use | Glucose | Peptides | Dextrose | Reserves | Goats | Blocking | Secretions | Physiological responses | Insulin
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8. Full Text Ghrelin mediates stress-induced food-reward behavior in mice
by Chuang, Jen-Chieh and Perello, Mario and Sakata, Ichiro and Osborne-Lawrence, Sherri and Savitt, Joseph M and Lutter, Michael and Zigman, Jeffrey M
Journal of Clinical Investigation, ISSN 0021-9738, 07/2011, Volume 121, Issue 7, pp. 2684 - 2692
The popular media and personal anecdotes are rich with examples of stress-induced eating of calorically dense "comfort foods." Such behavioral reactions likely... 
MEDICINE, RESEARCH & EXPERIMENTAL | PLASMA GHRELIN | MESSENGER-RNA | BRAIN REWARD | CONDITIONED PLACE PREFERENCE | SYSTEMIC GHRELIN | SOCIAL DEFEAT | STIMULATES LOCOMOTOR-ACTIVITY | HORMONE SECRETAGOGUE RECEPTOR | INDUCED OBESITY | NUCLEUS-ACCUMBENS | Humans | Mice, Inbred C57BL | Behavior, Animal - physiology | Male | Social Dominance | Receptors, Ghrelin - genetics | Feeding Behavior - physiology | Eating - physiology | Mice, Knockout | Ghrelin - metabolism | Animals | Conditioning (Psychology) | Receptors, Ghrelin - metabolism | Stress, Psychological | Mice | Neurons - metabolism | Reward | Food | Physiological aspects | Research | Stress (Psychology) | Ghrelin | Food habits | Depressive Disorders | PTSD | Eating Disorders | Etiology | Neuropeptides | Animal Models | Stressors
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9. Full Text Characterization of Adult Ghrelin and Ghrelin Receptor Knockout Mice under Positive and Negative Energy Balance
by Sun, Yuxiang and Butte, Nancy F and Garcia, Jose M and Smith, Roy G
Endocrinology, ISSN 0013-7227, 02/2008, Volume 149, Issue 2, pp. 843 - 850
Ghrelin and the ghrelin receptor (GH secretagogue receptor, GHS-R), are believed to have important roles in energy homeostasis. We describe results from the... 
GASTRIC BYPASS-SURGERY | OBESITY | STIMULATION | METABOLISM | INSULIN-RESISTANCE | FOOD-INTAKE | ENDOCRINOLOGY & METABOLISM | WEIGHT | EXPRESSION | PREFERENCE | ADIPOSE-TISSUE | Age Factors | Caloric Restriction | Ghrelin - genetics | Genotype | Male | Weight Gain - physiology | Body Temperature - physiology | Receptors, Ghrelin - genetics | Mice, Knockout | Ghrelin - metabolism | Phenotype | Animals | Dietary Fats - pharmacology | Weight Loss - physiology | Receptors, Ghrelin - metabolism | Mice | Mice, Congenic | Energy Metabolism - physiology
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10. Full Text Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet
by McFarlane, Matthew R and Brown, Michael S and Goldstein, Joseph L and Zhao, Tong-Jin
Cell Metabolism, ISSN 1550-4131, 07/2014, Volume 20, Issue 1, pp. 54 - 60
Injection of the peptide hormone ghrelin stimulates food intake in mice and humans. However, mice born without ghrelin demonstrate no significant loss of... 
ACYLTRANSFERASE | GASTRIC BYPASS | ENDOCRINE | ENDOCRINOLOGY & METABOLISM | HUMANS | RELEASE | HORMONE SECRETAGOGUE RECEPTOR | APPETITE | STRESS | PEPTIDE | DELETION | CELL BIOLOGY | Heparin-binding EGF-like Growth Factor - genetics | Caloric Restriction | Ghrelin - genetics | Body Weight - drug effects | Mice, Transgenic | Diphtheria Toxin - toxicity | Hypoglycemia - metabolism | RNA, Messenger - metabolism | Ghrelin - metabolism | Heparin-binding EGF-like Growth Factor - metabolism | Eating - drug effects | Ghrelin - blood | Animals | Hypoglycemia - etiology | Signal Transduction - drug effects | Diet, High-Fat | Mice | Chorionic gonadotropin | Peptides | Molecular genetics | Blood sugar | Body weight | Genetic engineering | Famines
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11. Full Text Lean mean fat reducing "ghrelin" machine: Hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity
by Schellekens, Harriët and Dinan, Timothy G and Cryan, John F
Neuropharmacology, ISSN 0028-3908, 01/2010, Volume 58, Issue 1, pp. 2 - 16
Obesity has reached epidemic proportions not only in Western societies but also in the developing world. Current pharmacological treatments for obesity are... 
Growth hormone secretagogue receptor | CB1 | Hypothalamus | Food intake | Heterodimerisation | PROTEIN-COUPLED RECEPTORS | DIET-INDUCED OBESITY | ARCUATE NUCLEUS | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | DES-ACYL GHRELIN | APPETITE-STIMULATING PEPTIDE | GASTRIC BYPASS-SURGERY | GROWTH-HORMONE | PHARMACOLOGY & PHARMACY | HORMONE SECRETAGOGUE RECEPTOR | PRADER-WILLI-SYNDROME | Ghrelin - metabolism | Animals | Hypothalamus - metabolism | Energy Metabolism | Humans | Ghrelin - genetics | Obesity - therapy | Receptors, Ghrelin - metabolism | Receptors, Ghrelin - genetics | Obesity - pathology
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12. Full Text In Situ Localization and Rhythmic Expression of Ghrelin and ghs-r1 Ghrelin Receptor in the Brain and Gastrointestinal Tract of Goldfish
by Sanchez-Bretano, A and Blanco, AM and Unniappan, S and Kah, O and Gueguen, MM and Bertucci, JI and Alonso-Gomez, AL and Valenciano, AI and Isorna, E and Delgado, MJ
PLOS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, p. e0141043
Ghrelin is a gut-brain peptide hormone, which binds to the growth hormone secretagogue receptor (GHS-R) to regulate a wide variety of biological processes in... 
CELLS | ACYLATED PEPTIDE | RAINBOW-TROUT | MESSENGER-RNA EXPRESSION | FOOD-INTAKE | TISSUE DISTRIBUTION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | HORMONE SECRETAGOGUE RECEPTOR | COMPLEMENTARY DEOXYRIBONUCLEIC-ACID | CLOCK | Pituitary Gland - metabolism | Circadian Rhythm - genetics | Gene Expression Regulation | Ghrelin - genetics | Ghrelin - biosynthesis | Receptors, Ghrelin - genetics | Gastrointestinal Tract - metabolism | Brain - metabolism | Ghrelin - metabolism | Goldfish - genetics | Animals | Receptors, Ghrelin - biosynthesis | Receptors, Ghrelin - metabolism | Immunohistochemistry | Usage | Analysis | Physiological aspects | Influence | Cholecystokinin | Research | Goldfish | Gene expression | Cerebellum | Brain | Gene regulation | Mucosa | Reverse transcription | Mapping | Hypothalamus | Tissues | Ghrelin | Fish | Localization | Circadian rhythms | Trout | Pineal gland | Brain mapping | Telencephalon | Zebrafish | Gastrointestinal tract | Rhythms | Circadian rhythm | Epithelium | Biological activity | Pituitary | Growth hormone | Life Sciences
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13. Full Text A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear
by Meyer, R.M and Burgos-Robles, A and Liu, E and Correia, S.S and Goosens, K.A
Molecular Psychiatry, ISSN 1359-4184, 12/2014, Volume 19, Issue 12, pp. 1284 - 1294
Hormones in the hypothalamus-pituitary-adrenal (HPA) axis mediate many of the bodily responses to stressors, yet there is no clear relationship between the... 
stress | trauma-related anxiety disorders | ACYLATED PEPTIDE | PANIC DISORDER | PSYCHIATRY | SECRETAGOGUE RECEPTOR | BASOLATERAL AMYGDALA | BIOCHEMISTRY & MOLECULAR BIOLOGY | HPA axi