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Nature, ISSN 0028-0836, 04/2016, Volume 533, Issue 7602, pp. 274 - 277
Journal Article
Diabetes Care, ISSN 0149-5992, 07/2016, Volume 39, Issue 7, pp. 1075 - 1077
Journal Article
Journal Article
Vnitrni lekarstvi, ISSN 0042-773X, 2016, Volume 62, Issue 7-8, p. 661
Excessive hepatic glucose production resulting from dysregulated glucagon secretion associated with inappropriate fasting and postprandial hyperglucagonemia is... 
Hypoglycemic Agents - therapeutic use | Receptors, Glucagon - antagonists & inhibitors | Humans | Diabetes Mellitus, Type 2 - drug therapy | Glucagon - antagonists & inhibitors
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 15, pp. 1974 - 1980
A novel series of indazole/indole derivatives were discovered as glucagon receptor (GCGR) antagonists through scaffold hopping based on two literature leads:... 
Glucagon | Glucagon receptor antagonist | Indole | Diabetes mellitus | Indazole | CHEMISTRY, MEDICINAL | SERIES | CLINICAL-TRIALS | CHEMISTRY, ORGANIC | IDENTIFICATION | DISCOVERY | Diabetes
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2015, Volume 25, Issue 19, pp. 4057 - 4064
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 06/2016, Volume 15, Issue 6, pp. 384 - 384
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2018, Volume 26, Issue 21, pp. 5701 - 5710
The hormone glucagon increases blood glucose levels through increasing hepatic glucose output. In diabetic patients, dysregulation of glucagon secretion... 
Type 2 diabetes | Glucagon receptor antagonist | Phenylpyrimidine | INSULIN | CHEMISTRY, MEDICINAL | PROTEIN-KINASE | GLUCOSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | Diabetics | Hyperglycemia | Pyrimidines | Glucagon | Blood sugar | Analysis
Journal Article
Journal Article
Diabetes Care, ISSN 0149-5992, 01/2011, Volume 34, Issue 1, pp. 90 - 95
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2019, Volume 29, Issue 20, p. 126668
Type 2 diabetes mellitus (T2DM) is characterized by chronically elevated plasma glucose levels. The inhibition of glucagon-induced hepatic glucose output via... 
Glucagon receptor antagonist | Molecular modeling | Diabetes mellitus | Indazole | GENERALIZED BORN MODEL | CHEMISTRY, MEDICINAL | SERIES | CHEMISTRY, ORGANIC | BETA-CELL | IDENTIFICATION | DERIVATIVES | GLUCOSE-PRODUCTION
Journal Article