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1. Full Text Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists
by Stahn, Cindy and Löwenberg, Mark and Hommes, Daniel W and Buttgereit, Frank
Molecular and cellular endocrinology, ISSN 0303-7207, 2007, Volume 275, Issue 1, pp. 71 - 78
Mechanisms of action | SEGRA | Non-genomic | mGCR | Glucocorticoid | cGCR | Genomic | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Animals | Anti-Inflammatory Agents - pharmacology | Humans | Glucocorticoids - pharmacology | Immunosuppressive Agents - pharmacology | Cell Membrane - drug effects | Receptors, Glucocorticoid - agonists | Index Medicus
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2. Full Text Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor
by Surjit, Milan and Ganti, Krishna Priya and Mukherji, Atish and Ye, Tao and Hua, Guoqiang and Metzger, Daniel and Li, Mei and Chambon, Pierre
Cell (Cambridge), ISSN 0092-8674, 2011, Volume 145, Issue 2, pp. 224 - 241
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Promoter Regions, Genetic | Animals | Cytokines | Response Elements | Humans | Gene Expression Regulation | Transcription, Genetic | Mice | Dermatitis, Atopic - metabolism | Repressor Proteins - metabolism | Receptors, Glucocorticoid - agonists | Corticosteroids | Steroids | Index Medicus
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3. Full Text Topical ‘dual-soft’ glucocorticoid receptor agonist for dermatology
by Dack, Kevin N and Johnson, Patrick S and Henriksson, Krister and Eirefelt, Stefan and Carnerup, Martin A and Stahlhut, Martin and Ollerstam, Anna K
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 09/2020, Volume 30, Issue 17, pp. 127402 - 127402
Soft-drug | Glucocorticoid receptor agonist | Dermatology | Non-steroidal | SEGRA | Corticosteroids | Atopic dermatitis | Liver | Formulae, receipts, prescriptions | Physiological aspects | Dermatologic agents | Skin | Index Medicus
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4. Full Text The long‐acting β2‐adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor‐mediated transcription in human airway epithelial cells in a gene‐ and agonist‐dependent manner
by Joshi, T and Johnson, M and Newton, R and Giembycz, M A
British journal of pharmacology, ISSN 0007-1188, 05/2015, Volume 172, Issue 10, pp. 2634 - 2653
Epithelial Cells - metabolism | Respiratory Mucosa - drug effects | Colforsin - pharmacology | Epithelial Cells - drug effects | Humans | Transcriptional Activation - drug effects | Cells, Cultured | Quinolones - pharmacology | Receptors, Glucocorticoid - metabolism | Adrenergic beta-2 Receptor Agonists - pharmacology | Dexamethasone - analogs & derivatives | Dexamethasone - pharmacology | Drug Interactions | Transfection | Ligands | Steroids - pharmacology | Response Elements - genetics | Respiratory Mucosa - metabolism | Benzodioxoles - pharmacology | Indans - pharmacology | Index Medicus | Research Papers
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5. Full Text MicroRNA-708 activation by glucocorticoid receptor agonists regulate breast cancer tumorigenesis and metastasis via downregulation of NF-κB signaling
by Senthil Kumar, K J and Gokila Vani, M and Hsieh, Hen-Wen and Lin, Chin-Chung and Liao, Jiunn-Wang and Chueh, Pin-Ju and Wang, Sheng-Yang
Carcinogenesis (New York), ISSN 0143-3334, 04/2019, Volume 40, Issue 2, pp. 335 - 348
Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Proliferation - genetics | Humans | Carcinogenesis - genetics | Signal Transduction - genetics | Down-Regulation - genetics | Animals | Breast Neoplasms - genetics | MCF-7 Cells | NF-kappa B - genetics | Mice, Nude | Receptors, Glucocorticoid - genetics | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Female | Mice | Mice, Inbred BALB C | MicroRNAs - genetics | Index Medicus
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6. Full Text Natural and synthetic compounds as dissociated agonists of glucocorticoid receptor
by Zhang, Tiehua and Liang, Yuan and Zhang, Jie
Pharmacological research, ISSN 1043-6618, 06/2020, Volume 156, pp. 104802 - 104802
Transrepression | Natural products | Selective glucocorticoid receptor modulators | Transactivation | Dissociated characteristics | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Index Medicus
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7. Full Text X-ray Crystal Structure of the Novel Enhanced-Affinity Glucocorticoid Agonist Fluticasone Furoate in the Glucocorticoid Receptor−Ligand Binding Domain
by Biggadike, Keith and Bledsoe, Randy K and Hassell, Anne M and Kirk, Barrie E and McLay, Iain M and Shewchuk, Lisa M and Stewart, Eugene L and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Journal of medicinal chemistry, ISSN 0022-2623, 06/2008, Volume 51, Issue 12, pp. 3349 - 3352
Hormones. Endocrine system | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Androstadienes - chemistry | Humans | Models, Molecular | Crystallography, X-Ray | Protein Conformation | Nuclear Receptor Coactivator 2 - chemistry | Binding Sites | Receptors, Glucocorticoid - chemistry | Receptors, Glucocorticoid - agonists | Index Medicus | DEXAMETHASONE | GLUCOCORTICOIDS | LIGANDS | ESTERS | CRYSTAL STRUCTURE | RECEPTORS | 60 APPLIED LIFE SCIENCES
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8. Full Text Discovery of New non-steroidal selective glucocorticoid receptor agonists
by Potamitis, Constantinos and Siakouli, Dimitra and Papavasileiou, Konstantinos D and Boulaka, Athina and Ganou, Vassiliki and Roussaki, Marina and Calogeropoulou, Theodora and Zoumpoulakis, Panagiotis and Alexis, Michael N and Zervou, Maria and Mitsiou, Dimitra J
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 02/2019, Volume 186, pp. 142 - 153
Virtual screening | MD simulations | Selective agonists | Anti-Inflammatory action | Pharmacophore model | Glucocorticoid receptor | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Benzothiazoles - pharmacology | Humans | Models, Molecular | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Receptors, Glucocorticoid - metabolism | Drug Discovery | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Receptors, Glucocorticoid - agonists | Gene Expression Regulation - drug effects | NF-kappa B - genetics | Drug Design | Benzothiazoles - chemistry | HeLa Cells | Receptors, Glucocorticoid - chemistry | NF-κB protein | Side effects | Inflammation | Antiinflammatory agents | Glucocorticoids | Benzothiazole | Index Medicus
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9. Full Text Selective glucocorticoid receptor agonists: Glucocorticoid therapy with no regrets?
by Cooper, Mark S and Zhou, Hong and Seibel, Markus J
Journal of bone and mineral research, ISSN 0884-0431, 11/2012, Volume 27, Issue 11, pp. 2238 - 2241
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Receptors, Glucocorticoid - metabolism | Animals | Bone Density | Humans | Physiological aspects | Corticosteroids | Steroids | Index Medicus | Obesity | Antiinflammatory agents | Glucocorticoids | Diabetes mellitus | Cushing's syndrome | Glucocorticoid receptors | Atrophy | Glucose tolerance | Osteoporosis | Side effects | Skin | Bone | Myopathy
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10. Full Text 2‑Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as Potent Dissociated Glucocorticoid Receptor Agonists
by Chantigny, Yves A and Murray, John C and Kleinman, Edward F and Robinson, Ralph P and Plotkin, Michael A and Reese, Matthew R and Buckbinder, Leonard and McNiff, Patricia A and Millham, Michele L and Schaefer, Jean F and Abramov, Yuriy A and Bordner, Jon
Journal of medicinal chemistry, ISSN 0022-2623, 03/2015, Volume 58, Issue 6, pp. 2658 - 2677
Cell Line | Anti-Inflammatory Agents - pharmacology | Humans | Matrix Metalloproteinase 13 - genetics | Tumor Necrosis Factor-alpha - blood | Models, Molecular | Crystallography, X-Ray | Receptors, Glucocorticoid - metabolism | Receptors, Glucocorticoid - agonists | Up-Regulation - drug effects | Phenanthrenes - chemistry | Phenanthrenes - pharmacology | Animals | Dexamethasone - pharmacology | Interleukin-1 - immunology | Tumor Necrosis Factor-alpha - immunology | Mice | Mammary Tumor Virus, Mouse - genetics | Index Medicus
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11. Full Text Non-steroidal glucocorticoid agonists—The discovery of aryl pyrazoles as A-ring mimetics
by Clackers, Margaret and Coe, Diane M and Demaine, Derek A and Hardy, George W and Humphreys, Davina and Inglis, Graham G.A and Johnston, Michael J and Jones, Haydn T and House, David and Loiseau, Richard and Minick, Doug J and Skone, Philip A and Uings, Iain and McLay, Iain M and Macdonald, Simon J.F
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2007, Volume 17, Issue 17, pp. 4737 - 4745
Aryl pyrazole | Agonist | Glucocorticoid | Non-steroidal | Dissociated | Tetrahydronaphthalene | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Chemistry, Pharmaceutical - methods | Models, Chemical | Stereoisomerism | Molecular Conformation | Receptors, Glucocorticoid - agonists | Pyrazoles - chemistry | Drug Design | Amides - chemistry | Inhibitory Concentration 50 | Drug Evaluation, Preclinical | Binding Sites | Glucocorticoids - agonists | Steroids - chemistry | Index Medicus
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