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1. Full Text Glucocorticoids suppress hypoxia‐induced COX‐2 and hypoxia inducible factor‐1α expression through the induction of glucocorticoid‐induced leucine zipper
by Lim, Wonchung and Park, Choa and Shim, Myeong Kuk and Lee, Yong Hee and Lee, You Mie and Lee, YoungJoo
British journal of pharmacology, ISSN 0007-1188, 02/2014, Volume 171, Issue 3, pp. 735 - 745
hypoxia | glucocorticoid receptor | hypoxia‐inducible factor‐1 | cyclooxygenase‐2 | glucocorticoid‐induced leucine zipper | glucocorticoid-induced leucine zipper | cyclooxygenase-2 | hypoxia-inducible factor-1 | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Dexamethasone - antagonists & inhibitors | Receptors, Glucocorticoid - antagonists & inhibitors | Humans | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Receptors, Glucocorticoid - metabolism | Alveolar Epithelial Cells - immunology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Receptors, Glucocorticoid - agonists | Cell Hypoxia | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Dexamethasone - pharmacology | RNA Interference | Cyclooxygenase 2 - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Cell Line | Cyclooxygenase 2 - chemistry | Transcription Factors - antagonists & inhibitors | Alveolar Epithelial Cells - metabolism | Alveolar Epithelial Cells - drug effects | Transcription Factors - genetics | Hormone Antagonists - pharmacology | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Cell Movement - drug effects | Animals | Glucocorticoids - antagonists & inhibitors | Signal Transduction - drug effects | Cyclooxygenase 2 - metabolism | Glucocorticoids - pharmacology | Genes, Reporter - drug effects | Mice | Transcription Factors - agonists | Signal transduction | Dexamethasone | Glucocorticoids | Therapeutic applications | Invasiveness | Prostaglandin E2 | Hypoxia | mRNA | Glucocorticoid receptors | Leucine zipper proteins | Index Medicus
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2. Full Text Mifepristone, a Glucocorticoid Receptor Antagonist, Produces Clinical and Metabolic Benefits in Patients with Cushing's Syndrome
by Fleseriu, Maria and Biller, Beverly M. K and Findling, James W and Molitch, Mark E and Schteingart, David E and Gross, Coleman and on behalf of the SEISMIC Study Investigators and SEISMIC Study Investigators and The SEISMIC Study Investigators include and on behalf of the SEISMIC Study Investigators
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 06/2012, Volume 97, Issue 6, pp. 2039 - 2049
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Fundamental and applied biological sciences. Psychology | Feeding. Feeding behavior | Adrenals. Adrenal axis. Renin-angiotensin system (diseases) | Non tumoral diseases. Target tissue resistance. Benign neoplasms | Vertebrates: anatomy and physiology, studies on body, several organs or systems | Vertebrates: endocrinology | Biological and medical sciences | Endocrinopathies | Medical sciences | Glucose Intolerance - metabolism | Quinolines - blood | Receptors, Glucocorticoid - antagonists & inhibitors | Humans | Middle Aged | Body Weight - drug effects | Hypertension - drug therapy | Male | Diabetes Mellitus, Type 2 - metabolism | Cushing Syndrome - metabolism | Urea - blood | Glucose Intolerance - drug therapy | Body Composition - drug effects | Urea - analogs & derivatives | Adult | Female | Blood Pressure - drug effects | Blood Pressure - physiology | Hydrocortisone - blood | Cushing Syndrome - drug therapy | Diabetes Mellitus, Type 2 - complications | Body Composition - physiology | Mifepristone - administration & dosage | Antihypertensive Agents - therapeutic use | Glucose Intolerance - complications | Hormone Antagonists - administration & dosage | Hypertension - metabolism | Blood Glucose - drug effects | Cushing Syndrome - complications | Mifepristone - adverse effects | Hypertension - complications | Quality of Life | Blood Glucose - metabolism | Body Weight - physiology | Diabetes Mellitus, Type 2 - drug therapy | Hormone Antagonists - adverse effects | Index Medicus | Abridged Index Medicus
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3. Glucocorticoid receptor antagonists
by Clark, Robin D
Current topics in medicinal chemistry, ISSN 1568-0266, 06/2008, Volume 8, Issue 9, pp. 813 - 838
Glucocorticoid receptor anatagonist | Mifepristone | Nuclear receptor | GR antagonist | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Drug Evaluation, Preclinical - methods | Hormone Antagonists - chemistry | Receptors, Glucocorticoid - antagonists & inhibitors | Humans | Drug Therapy | Protein Binding | Structure-Activity Relationship
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4. Full Text Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic
by Sherk, Andrea B and Frigo, Daniel E and Schnackenberg, Christine G and Bray, Jeffrey D and Laping, Nicholas J and Trizna, Walter and Hammond, Marlys and Patterson, Jaclyn R and Thompson, Scott K and Kazmin, Dmitri and Norris, John D and McDonnell, Donald P
Cancer research (Chicago, Ill.), ISSN 0008-5472, 09/2008, Volume 68, Issue 18, pp. 7475 - 7483
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Gynecology. Andrology. Obstetrics | Pharmacology. Drug treatments | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Antineoplastic agents | Male genital diseases | Tumors | RNA, Small Interfering - genetics | Up-Regulation | Humans | Receptors, Androgen - metabolism | Cell Growth Processes - physiology | Male | Immediate-Early Proteins - metabolism | RNA, Messenger - biosynthesis | Prostatic Neoplasms - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Metribolone - pharmacology | Prostatic Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Prostatic Neoplasms - pathology | Immediate-Early Proteins - biosynthesis | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Protein-Serine-Threonine Kinases - biosynthesis | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Immediate-Early Proteins - genetics | Benzoates - pharmacology | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Immediate-Early Proteins - antagonists & inhibitors | Index Medicus | prostate cancer | androgen receptor | serum and glucocorticoid-regulated kinase 1
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5. Full Text Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals
by Vendruscolo, Leandro F and Estey, David and Goodell, Vivian and Macshane, Lauren G and Logrip, Marian L and Schlosburg, Joel E and McGinn, M. Adrienne and Zamora-Martinez, Eva R and Belanoff, Joseph K and Hunt, Hazel J and Sanna, Pietro P and George, Olivier and Koob, George F and Edwards, Scott and Mason, Barbara J
The Journal of clinical investigation, ISSN 0021-9738, 08/2015, Volume 125, Issue 8, pp. 3193 - 3197
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Receptors, Glucocorticoid - antagonists & inhibitors | Administration, Oral | Humans | Alcohol Drinking - drug therapy | Rats | Alcohol Drinking - physiopathology | Male | Hormone Antagonists - administration & dosage | Animals | Mifepristone - adverse effects | Adult | Female | Alcoholism - drug therapy | Alcoholism - physiopathology | Hormone Antagonists - adverse effects | Mifepristone - administration & dosage | Prevention | Hormone receptors | Usage | Alcoholism | Physiological aspects | Mifepristone | Genetic aspects | Research | Drug therapy | Health aspects | Phosphorylation | Hypotheses | Brain research | Confidentiality | Rodents | FDA approval | Addictions | Laboratory animals | Multivariate analysis | Drug dosages | Alcohol use | Index Medicus | Abridged Index Medicus | Brief Report
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6. Full Text Oral Glucocorticoid–Sparing Effect of Benralizumab in Severe Asthma
by Nair, Parameswaran and Wenzel, Sally and Rabe, Klaus F and Bourdin, Arnaud and Lugogo, Njira L and Kuna, Piotr and Barker, Peter and Sproule, Stephanie and Ponnarambil, Sandhia and Goldman, Mitchell and ZONDA Trial Investigators
The New England journal of medicine, ISSN 0028-4793, 06/2017, Volume 376, Issue 25, pp. 2448 - 2458
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Anti-Asthmatic Agents - adverse effects | Antibodies, Monoclonal, Humanized - adverse effects | Glucocorticoids - administration & dosage | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Administration, Oral | Anti-Asthmatic Agents - therapeutic use | Humans | Middle Aged | Interleukin-5 Receptor alpha Subunit - antagonists & inhibitors | Male | Asthma - drug therapy | Dose-Response Relationship, Drug | Injections, Subcutaneous | Adult | Female | Anti-Asthmatic Agents - administration & dosage | Treatment outcome | Corticosteroids | Analysis | Dosage and administration | Drug therapy | Health aspects | Asthmatics | Asthma | Oral cavity | Respiratory function | Interleukin 5 | Glucocorticoids | Cytokines | Lungs | Clinical trials | Monoclonal antibodies | Eosinophilia | Index Medicus | Abridged Index Medicus | Life Sciences
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7. Full Text 11β-hydroxysteroid dehydrogenases intracellular gate-keepers of tissue glucocorticoid action
by Chapman, Karen and Holmes, Megan and Seckl, Jonathan
Physiological reviews, ISSN 0031-9333, 07/2013, Volume 93, Issue 3, pp. 1139 - 1206
Gene Expression Regulation, Enzymologic | Tissue Distribution | 11-beta-Hydroxysteroid Dehydrogenases - metabolism | Animals | Glucocorticoids - metabolism | Receptors, Mineralocorticoid - metabolism | 11-beta-Hydroxysteroid Dehydrogenases - genetics | Humans | Glucocorticoids - chemistry | Receptors, Glucocorticoid - metabolism | Index Medicus
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8. Full Text Glucocorticoid antagonists in neuropsychotic disorders
by Schatzberg, Alan F and Lindley, Steven
European journal of pharmacology, ISSN 0014-2999, 2008, Volume 583, Issue 2, pp. 358 - 364
Mifepristone | Stress psychotic major depression | Cortisol | Glucocorticoid receptors | Mineralocorticoid receptors | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Nervous system diseases | Antipsychotic drugs | Corticosteroids | Analysis | Depression, Mental | Amyloid beta-protein | Schizophrenia | Alzheimer's disease | Steroids
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9. Full Text Glucocorticoid receptor signaling in health and disease
by Kadmiel, Mahita and Cidlowski, John A
Trends in pharmacological sciences (Regular ed.), ISSN 0165-6147, 2013, Volume 34, Issue 9, pp. 518 - 530
Advanced Basic Science | nuclear receptor | stress hormones | inflammation | glucocorticoid-response element | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Receptors, Glucocorticoid - metabolism | Animals | Signal Transduction | Humans | Corticosteroids | Steroids | Index Medicus | g