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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 38, pp. 25593 - 25601
Glucocorticoids are important regulators of lipid homeostasis, and chronically elevated glucocorticoid levels induce hypertriglyceridemia, hepatic steatosis, and visceral obesity... 
OBESITY | PLASMA | GENE | CHROMATIN | ANGIOGENESIS | DIET | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPERLIPIDEMIA | MICE | TRANSCRIPTIONAL REGULATION | PROTEIN-4 | Transcription, Genetic - drug effects | Hypertriglyceridemia - genetics | Humans | Dexamethasone - adverse effects | Receptors, Glucocorticoid - metabolism | Hepatocytes - metabolism | Fatty Liver - chemically induced | Adipose Tissue - metabolism | Angiopoietin-like 4 Protein | Dexamethasone - pharmacology | Glucocorticoids - genetics | Glucocorticoids - metabolism | Response Elements - genetics | Lipoprotein Lipase - metabolism | Glucocorticoids - adverse effects | Fatty Liver - genetics | Angiopoietins - metabolism | Fatty Liver - metabolism | Lipoprotein Lipase - genetics | Liver - metabolism | Rats | Hypertriglyceridemia - metabolism | Mice, Knockout | Triglycerides - metabolism | Adipose Tissue, White | Hypertriglyceridemia - chemically induced | Animals | Receptors, Glucocorticoid - genetics | Cell Line, Tumor | Dexamethasone - metabolism | Glucocorticoids - pharmacology | Mice | Transcription, Genetic - genetics | Triglycerides - genetics | Angiopoietins - genetics | Index Medicus | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling | Transcription | Dermatologi och venereologi | Dermatology and Venereal Diseases | Dexamethasone/adverse effects/metabolism/pharmacology | Hypertriglyceridemia/chemically induced/genetics/metabolism | Receptors | Adipose Tissue/metabolism | Liver/metabolism | Tumor | Adipose Tissue | Cell Line | Fatty Liver/chemically induced/genetics/metabolism | Triglycerides/genetics/ metabolism | Response Elements/genetics | Angiopoietins/genetics/ metabolism | Knockout | Lipoprotein Lipase/genetics/metabolism | White | Hepatocytes/metabolism | Genetic/drug effects/genetics | Glucocorticoids/adverse effects/genetics/ metabolism/pharmacology | Glucocorticoid/genetics/ metabolism
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2009, Volume 373, Issue 9678, pp. 1905 - 1917
Summary Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several common inflammatory diseases... 
Internal Medicine | RHEUMATOID-ARTHRITIS | MEDICINE, GENERAL & INTERNAL | OBSTRUCTIVE PULMONARY-DISEASE | HISTONE DEACETYLASE ACTIVITY | MIGRATION INHIBITORY FACTOR | ULCERATIVE-COLITIS | REGULATORY T-CELLS | RECEPTOR-BETA | RELATIVE CORTICOSTEROID INSENSITIVITY | BLOOD MONONUCLEAR-CELLS | RESPIRATORY-DISTRESS-SYNDROME | Transcription Factor AP-1 - drug effects | Glucocorticoids - therapeutic use | Transcriptional Activation - genetics | Transcription Factor AP-1 - genetics | Humans | Macrophage Migration-Inhibitory Factors - immunology | Transcriptional Activation - drug effects | Transcription Factor AP-1 - immunology | Histone Deacetylases - immunology | Transcriptional Activation - immunology | ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects | Calcineurin Inhibitors | Macrophage Migration-Inhibitory Factors - genetics | Inflammation - drug therapy | Phosphodiesterase 4 Inhibitors | Anti-Inflammatory Agents - therapeutic use | Mitogen-Activated Protein Kinases - immunology | Genetic Predisposition to Disease - genetics | NF-kappa B - antagonists & inhibitors | Histone Deacetylases - genetics | Macrophage Migration-Inhibitory Factors - drug effects | Repressor Proteins - genetics | Histone Deacetylase 2 | Drug Resistance - drug effects | Inflammation - immunology | Asthma - drug therapy | ATP-Binding Cassette, Sub-Family B, Member 1 - immunology | Drug Resistance - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Drug Resistance - immunology | Repressor Proteins - immunology | Histone Deacetylases - drug effects | Mitogen-Activated Protein Kinases - genetics | Repressor Proteins - drug effects | Mitogen-Activated Protein Kinases - drug effects | Pulmonary Disease, Chronic Obstructive - drug therapy | Corticosteroids | Dosage and administration | Inflammation | Research | Drug resistance | Drug therapy | Health aspects | Complications and side effects | Risk factors | Inflammatory bowel disease | Proteins | Respiratory distress syndrome | Asthma | Steroids
Journal Article
Journal Article
The journal of clinical endocrinology and metabolism, ISSN 1945-7197, 2005, Volume 90, Issue 10, pp. 5804 - 5810
Journal Article
American journal of physiology: endocrinology and metabolism, ISSN 1522-1555, 2012, Volume 302, Issue 10, pp. E1210 - E1220
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 22, pp. 19297 - 19310
Journal Article
Nature medicine, ISSN 1546-170X, 2008, Volume 15, Issue 1, pp. 50 - 58
.... Here we show that combination therapy with GSIs plus glucocorticoids can improve the antileukemic effects of GSIs and reduce their gut toxicity in vivo... 
MEDICINE, RESEARCH & EXPERIMENTAL | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR EXPRESSION | CYCLE ARREST | SRG3 | CELL BIOLOGY | NOTCH1 CONFERS | GOBLET CELLS | GENE | LINE | DIFFERENTIATION | PROMOTER | Glucocorticoids - administration & dosage | Glucocorticoids - therapeutic use | Cyclins - genetics | Receptors, Glucocorticoid - metabolism | Cyclin D2 | Enzyme Inhibitors - administration & dosage | Bcl-2-Like Protein 11 | Membrane Proteins - physiology | Apoptosis Regulatory Proteins - genetics | Female | Homeostasis - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Dexamethasone - administration & dosage | Membrane Proteins - genetics | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Leukemic - drug effects | Proto-Oncogene Proteins - genetics | Mice, SCID | Mice, Knockout | Dexamethasone - therapeutic use | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Models, Biological | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Homeostasis - physiology | Proto-Oncogene Proteins - physiology | Receptors, Glucocorticoid - genetics | Apoptosis Regulatory Proteins - physiology | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Receptors, Glucocorticoid - physiology | Receptor, Notch1 - physiology | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article