Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 02/2010, Volume 50, Issue 1, pp. 295 - 322
The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors that participate in the modulation of synaptic transmission and neuronal...
Neuromodulation | Allosterism | G-protein-coupled receptors | Synaptic plasticity | MESSENGER-RNA EXPRESSION | INVERSE AGONIST ACTIVITY | PROTEIN-COUPLED RECEPTORS | allosterism | MGLUR1 MUTANT MICE | neuromodulation | LONG-TERM DEPRESSION | FRAGILE-X-SYNDROME | 2ND INTRACELLULAR LOOP | POSITIVE ALLOSTERIC MODULATORS | TOXICOLOGY | synaptic plasticity | PARKINSONS-DISEASE | WORKING-MEMORY | Protein Structure, Tertiary | Receptors, Metabotropic Glutamate - drug effects | Animals | Alternative Splicing | Signal Transduction | Allosteric Regulation | Humans | Receptors, Metabotropic Glutamate - physiology | Receptors, Metabotropic Glutamate - chemistry | Receptors, Metabotropic Glutamate - therapeutic use | Neuroplasticity | Cell receptors | Care and treatment | Nervous system diseases | Physiological aspects | Research | Mental illness
Neuromodulation | Allosterism | G-protein-coupled receptors | Synaptic plasticity | MESSENGER-RNA EXPRESSION | INVERSE AGONIST ACTIVITY | PROTEIN-COUPLED RECEPTORS | allosterism | MGLUR1 MUTANT MICE | neuromodulation | LONG-TERM DEPRESSION | FRAGILE-X-SYNDROME | 2ND INTRACELLULAR LOOP | POSITIVE ALLOSTERIC MODULATORS | TOXICOLOGY | synaptic plasticity | PARKINSONS-DISEASE | WORKING-MEMORY | Protein Structure, Tertiary | Receptors, Metabotropic Glutamate - drug effects | Animals | Alternative Splicing | Signal Transduction | Allosteric Regulation | Humans | Receptors, Metabotropic Glutamate - physiology | Receptors, Metabotropic Glutamate - chemistry | Receptors, Metabotropic Glutamate - therapeutic use | Neuroplasticity | Cell receptors | Care and treatment | Nervous system diseases | Physiological aspects | Research | Mental illness
Journal Article
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 7/2010, Volume 460, Issue 2, pp. 525 - 542
Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal dysfunction and degeneration. As glutamate is a major excitatory...
TRP channel | Sodium–calcium exchange | Biomedicine | Human Physiology | Calcium | Neuroprotective drugs | Excitotoxicity | Neuronal cell death | Glutamate | NMDA receptor | Free radical | Gap junction | Sodium-calcium exchange | APOPTOSIS-INDUCING FACTOR | PRESYNAPTIC KAINATE RECEPTORS | PHYSIOLOGY | NITRIC-OXIDE SYNTHASE | ANEURYSMAL SUBARACHNOID HEMORRHAGE | FOCAL CEREBRAL-ISCHEMIA | CULTURED CORTICAL-NEURONS | INTRACELLULAR ZINC RELEASE | TRAUMATIC BRAIN-INJURY | MANGANESE-SUPEROXIDE-DISMUTASE | METHYL-D-ASPARTATE | Caspases - physiology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Receptors, Kainic Acid | Calcium - metabolism | Humans | Nerve Degeneration - physiopathology | Receptors, Metabotropic Glutamate - physiology | Calpain - physiology | Zinc - physiology | Free Radicals - metabolism | Sodium-Calcium Exchanger - therapeutic use | Free Radical Scavengers - therapeutic use | Hypothalamus - drug effects | Glutamic Acid - adverse effects | Receptors, AMPA - physiology | Glutamic Acid - physiology | Nitric Oxide - physiology | Receptors, N-Methyl-D-Aspartate - physiology | Antioxidants - therapeutic use | Animals | Neurodegenerative Diseases - physiopathology | Cell Death - physiology | Neurotoxicity Syndromes - physiopathology | Receptors, Glutamate - physiology | Receptors, AMPA - antagonists & inhibitors | Methyl aspartate | Brain | Nervous system diseases | Multiple sclerosis | Parkinson's disease | Neurons | Cell death | Physiological aspects | Injuries | Index Medicus
TRP channel | Sodium–calcium exchange | Biomedicine | Human Physiology | Calcium | Neuroprotective drugs | Excitotoxicity | Neuronal cell death | Glutamate | NMDA receptor | Free radical | Gap junction | Sodium-calcium exchange | APOPTOSIS-INDUCING FACTOR | PRESYNAPTIC KAINATE RECEPTORS | PHYSIOLOGY | NITRIC-OXIDE SYNTHASE | ANEURYSMAL SUBARACHNOID HEMORRHAGE | FOCAL CEREBRAL-ISCHEMIA | CULTURED CORTICAL-NEURONS | INTRACELLULAR ZINC RELEASE | TRAUMATIC BRAIN-INJURY | MANGANESE-SUPEROXIDE-DISMUTASE | METHYL-D-ASPARTATE | Caspases - physiology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Receptors, Kainic Acid | Calcium - metabolism | Humans | Nerve Degeneration - physiopathology | Receptors, Metabotropic Glutamate - physiology | Calpain - physiology | Zinc - physiology | Free Radicals - metabolism | Sodium-Calcium Exchanger - therapeutic use | Free Radical Scavengers - therapeutic use | Hypothalamus - drug effects | Glutamic Acid - adverse effects | Receptors, AMPA - physiology | Glutamic Acid - physiology | Nitric Oxide - physiology | Receptors, N-Methyl-D-Aspartate - physiology | Antioxidants - therapeutic use | Animals | Neurodegenerative Diseases - physiopathology | Cell Death - physiology | Neurotoxicity Syndromes - physiopathology | Receptors, Glutamate - physiology | Receptors, AMPA - antagonists & inhibitors | Methyl aspartate | Brain | Nervous system diseases | Multiple sclerosis | Parkinson's disease | Neurons | Cell death | Physiological aspects | Injuries | Index Medicus
Journal Article
Pharmacological Reviews, ISSN 0031-6997, 09/2010, Volume 62, Issue 3, pp. 405 - 496
The mammalian ionotropic glutamate receptor family encodes 18 gene products that coassemble to form ligand-gated ion channels containing an agonist recognition...
CALCIUM-PERMEABLE AMPA | SUBUNIT MESSENGER-RNAS | GLUR6 KAINATE-RECEPTOR | EXCITATORY AMINO-ACID | LONG-TERM DEPRESSION | PHARMACOLOGY & PHARMACY | LIGAND-BINDING DOMAIN | ACTIVITY-DEPENDENT REGULATION | NR2B-CONTAINING NMDA-RECEPTORS | METHYL-D-ASPARTATE | PROTEIN-KINASE-II | Gene Expression | Receptors, Glutamate - genetics | Humans | Ion Channels - genetics | Terminology as Topic | Ion Channels - physiology | Synaptic Transmission | Receptors, Glutamate - chemistry | Protein Processing, Post-Translational | Protein Subunits - chemistry | Protein Subunits - physiology | Ion Channels - chemistry | Receptors, Glutamate - physiology | Protein Subunits - genetics | Review
CALCIUM-PERMEABLE AMPA | SUBUNIT MESSENGER-RNAS | GLUR6 KAINATE-RECEPTOR | EXCITATORY AMINO-ACID | LONG-TERM DEPRESSION | PHARMACOLOGY & PHARMACY | LIGAND-BINDING DOMAIN | ACTIVITY-DEPENDENT REGULATION | NR2B-CONTAINING NMDA-RECEPTORS | METHYL-D-ASPARTATE | PROTEIN-KINASE-II | Gene Expression | Receptors, Glutamate - genetics | Humans | Ion Channels - genetics | Terminology as Topic | Ion Channels - physiology | Synaptic Transmission | Receptors, Glutamate - chemistry | Protein Processing, Post-Translational | Protein Subunits - chemistry | Protein Subunits - physiology | Ion Channels - chemistry | Receptors, Glutamate - physiology | Protein Subunits - genetics | Review
Journal Article