2001, Handbook of experimental pharmacology, ISBN 3540676163, Volume 150., xxi, 413
Book
Physiological Reviews, ISSN 0031-9333, 10/2004, Volume 84, Issue 4, pp. 1051 - 1095
The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine receptor family of ligand-gated ion channels. Functional receptors of...
RAT SPINAL-CORD | RETINAL GANGLION-CELLS | PROTEIN-KINASE-C | BRAIN-STEM MOTONEURONS | PHYSIOLOGY | NICOTINIC ACETYLCHOLINE-RECEPTOR | GATED ION CHANNELS | CENTRAL-NERVOUS-SYSTEM | GAMMA-AMINOBUTYRIC-ACID | MEMBRANE-SPANNING SEGMENT | VENTRAL TEGMENTAL AREA | Central Nervous System - physiology | Animals | Chloride Channels - chemistry | Receptors, Glycine - physiology | Humans | Neurons - physiology | Receptors, Glycine - chemistry | Molecular Structure | Protein Subunits - chemistry | Protein Subunits - physiology | Chloride Channels - physiology | Physiological aspects | Chloride channels | Research | Glycine
RAT SPINAL-CORD | RETINAL GANGLION-CELLS | PROTEIN-KINASE-C | BRAIN-STEM MOTONEURONS | PHYSIOLOGY | NICOTINIC ACETYLCHOLINE-RECEPTOR | GATED ION CHANNELS | CENTRAL-NERVOUS-SYSTEM | GAMMA-AMINOBUTYRIC-ACID | MEMBRANE-SPANNING SEGMENT | VENTRAL TEGMENTAL AREA | Central Nervous System - physiology | Animals | Chloride Channels - chemistry | Receptors, Glycine - physiology | Humans | Neurons - physiology | Receptors, Glycine - chemistry | Molecular Structure | Protein Subunits - chemistry | Protein Subunits - physiology | Chloride Channels - physiology | Physiological aspects | Chloride channels | Research | Glycine
Journal Article
Neuropharmacology, ISSN 0028-3908, 01/2009, Volume 56, Issue 1, pp. 303 - 309
The glycine receptor chloride channel (GlyR), a member of the pentameric Cys-loop ion channel receptor family, mediates inhibitory neurotransmission in the...
Chloride channel | Cys-loop receptor | Ligand-gated ion channel | Inhibitory synaptic transmission | RAT SPINAL-CORD | MOLECULAR DETERMINANTS | ALPHA-1 SUBUNIT | NEUROSCIENCES | VENTRAL TEGMENTAL AREA | AUDITORY BRAIN-STEM | PHARMACOLOGY & PHARMACY | GATED ION CHANNELS | CENTRAL-NERVOUS-SYSTEM | XENOPUS OOCYTES | BETA-SUBUNIT | Animals | Receptors, Glycine - physiology | Humans | Receptors, Glycine - classification | Physiological aspects | Lead compounds | Cytochemistry | Glycine
Chloride channel | Cys-loop receptor | Ligand-gated ion channel | Inhibitory synaptic transmission | RAT SPINAL-CORD | MOLECULAR DETERMINANTS | ALPHA-1 SUBUNIT | NEUROSCIENCES | VENTRAL TEGMENTAL AREA | AUDITORY BRAIN-STEM | PHARMACOLOGY & PHARMACY | GATED ION CHANNELS | CENTRAL-NERVOUS-SYSTEM | XENOPUS OOCYTES | BETA-SUBUNIT | Animals | Receptors, Glycine - physiology | Humans | Receptors, Glycine - classification | Physiological aspects | Lead compounds | Cytochemistry | Glycine
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 11/2013, Volume 12, Issue 11, pp. 866 - 885
Glycine transporters are endogenous regulators of the dual functions of glycine, which acts as a classical inhibitory neurotransmitter at glycinergic synapses...
ADD-ON TREATMENT | N-METHYLGLYCINE SARCOSINE | POSITRON-EMISSION-TOMOGRAPHY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SELECTIVE GLYT1 INHIBITORS | EXTRASYNAPTIC NMDA RECEPTORS | SOCIAL ANXIETY DISORDER | PHARMACOLOGY & PHARMACY | PLACEBO-CONTROLLED TRIAL | D-ASPARTATE RECEPTOR | OBSESSIVE-COMPULSIVE DISORDER | RAT NUCLEUS-ACCUMBENS | Schizophrenia - metabolism | Drugs, Investigational - pharmacology | Synaptic Transmission - physiology | Humans | Drugs, Investigational - therapeutic use | Pain - metabolism | Animals | Glycine - physiology | Pain - drug therapy | Alcoholism - metabolism | Synaptic Transmission - drug effects | Alcoholism - drug therapy | Models, Neurological | Schizophrenia - drug therapy | Glycine Plasma Membrane Transport Proteins - antagonists & inhibitors | Molecular Targeted Therapy - methods | Brain | Carrier proteins | Observations | Biological transport | Localization of functions | Testing | Cognitive ability
ADD-ON TREATMENT | N-METHYLGLYCINE SARCOSINE | POSITRON-EMISSION-TOMOGRAPHY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SELECTIVE GLYT1 INHIBITORS | EXTRASYNAPTIC NMDA RECEPTORS | SOCIAL ANXIETY DISORDER | PHARMACOLOGY & PHARMACY | PLACEBO-CONTROLLED TRIAL | D-ASPARTATE RECEPTOR | OBSESSIVE-COMPULSIVE DISORDER | RAT NUCLEUS-ACCUMBENS | Schizophrenia - metabolism | Drugs, Investigational - pharmacology | Synaptic Transmission - physiology | Humans | Drugs, Investigational - therapeutic use | Pain - metabolism | Animals | Glycine - physiology | Pain - drug therapy | Alcoholism - metabolism | Synaptic Transmission - drug effects | Alcoholism - drug therapy | Models, Neurological | Schizophrenia - drug therapy | Glycine Plasma Membrane Transport Proteins - antagonists & inhibitors | Molecular Targeted Therapy - methods | Brain | Carrier proteins | Observations | Biological transport | Localization of functions | Testing | Cognitive ability
Journal Article
Physiological Reviews, ISSN 0031-9333, 01/2012, Volume 92, Issue 1, pp. 193 - 235
Zeilhofer HU, Wildner H, Yevenes GE. Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control. Physiol Rev 92: 193-235, 2012; doi:...
GABA(A) RECEPTOR SUBUNIT | PERIPHERAL-NERVE INJURY | SUBSTANTIA-GELATINOSA NEURONS | LAMINA-I NEURONS | GREEN FLUORESCENT PROTEIN | PHYSIOLOGY | SUBUNIT MESSENGER-RNAS | GLYCINE-LIKE IMMUNOREACTIVITY | NEUROKININ 1 RECEPTOR | SUPERFICIAL DORSAL-HORN | GAMMA-AMINOBUTYRIC-ACID | Interneurons - physiology | Animals | Synaptic Transmission - physiology | Glycine - physiology | Sensory Receptor Cells - physiology | Pain - physiopathology | Humans | Posterior Horn Cells - physiology | Neurotransmitter Agents - physiology | gamma-Aminobutyric Acid - physiology | Physiological aspects | Causes of | Neural transmission | Research | Chronic pain | Central nervous system
GABA(A) RECEPTOR SUBUNIT | PERIPHERAL-NERVE INJURY | SUBSTANTIA-GELATINOSA NEURONS | LAMINA-I NEURONS | GREEN FLUORESCENT PROTEIN | PHYSIOLOGY | SUBUNIT MESSENGER-RNAS | GLYCINE-LIKE IMMUNOREACTIVITY | NEUROKININ 1 RECEPTOR | SUPERFICIAL DORSAL-HORN | GAMMA-AMINOBUTYRIC-ACID | Interneurons - physiology | Animals | Synaptic Transmission - physiology | Glycine - physiology | Sensory Receptor Cells - physiology | Pain - physiopathology | Humans | Posterior Horn Cells - physiology | Neurotransmitter Agents - physiology | gamma-Aminobutyric Acid - physiology | Physiological aspects | Causes of | Neural transmission | Research | Chronic pain | Central nervous system
Journal Article
Schizophrenia Bulletin, ISSN 0586-7614, 09/2012, Volume 38, Issue 5, pp. 958 - 966
Over the last 20 years, glutamatergic models of schizophrenia have become increasingly accepted as etiopathological models of schizophrenia, based on the...
cognition | glycine | negative symptoms | glycine transport inhibitors | schizophrenia | neurophysiology | NMDA receptors | HIGH-DOSE GLYCINE | PSYCHIATRY | MISMATCH NEGATIVITY GENERATION | N-ACETYL-CYSTEINE | RODENT PREFRONTAL CORTEX | PHENCYCLIDINE | GLUTATHIONE PRECURSOR | D-SERINE | DOUBLE-BLIND | NMDA RECEPTOR ANTAGONIST | DOPAMINERGIC DYSREGULATION | Phencyclidine - pharmacology | Synaptic Transmission - physiology | Humans | Perception - physiology | Hippocampus - drug effects | Cerebral Cortex - physiopathology | Psychoses, Substance-Induced - physiopathology | Antipsychotic Agents - therapeutic use | Schizophrenia - physiopathology | Synaptic Transmission - drug effects | Cerebral Cortex - drug effects | Disease Models, Animal | Cognition Disorders - physiopathology | Receptors, N-Methyl-D-Aspartate - drug effects | Brain - physiopathology | Cognition Disorders - drug therapy | Receptors, N-Methyl-D-Aspartate - physiology | Perception - drug effects | Brain - drug effects | Drug Synergism | Animals | Glycine - physiology | Contingent Negative Variation - drug effects | Contingent Negative Variation - physiology | Receptors, Dopamine D2 | Brain Mapping | Antipsychotic Agents - pharmacology | Schizophrenia - drug therapy | Ketamine - pharmacology | Hippocampus - physiopathology | Invited Themed
cognition | glycine | negative symptoms | glycine transport inhibitors | schizophrenia | neurophysiology | NMDA receptors | HIGH-DOSE GLYCINE | PSYCHIATRY | MISMATCH NEGATIVITY GENERATION | N-ACETYL-CYSTEINE | RODENT PREFRONTAL CORTEX | PHENCYCLIDINE | GLUTATHIONE PRECURSOR | D-SERINE | DOUBLE-BLIND | NMDA RECEPTOR ANTAGONIST | DOPAMINERGIC DYSREGULATION | Phencyclidine - pharmacology | Synaptic Transmission - physiology | Humans | Perception - physiology | Hippocampus - drug effects | Cerebral Cortex - physiopathology | Psychoses, Substance-Induced - physiopathology | Antipsychotic Agents - therapeutic use | Schizophrenia - physiopathology | Synaptic Transmission - drug effects | Cerebral Cortex - drug effects | Disease Models, Animal | Cognition Disorders - physiopathology | Receptors, N-Methyl-D-Aspartate - drug effects | Brain - physiopathology | Cognition Disorders - drug therapy | Receptors, N-Methyl-D-Aspartate - physiology | Perception - drug effects | Brain - drug effects | Drug Synergism | Animals | Glycine - physiology | Contingent Negative Variation - drug effects | Contingent Negative Variation - physiology | Receptors, Dopamine D2 | Brain Mapping | Antipsychotic Agents - pharmacology | Schizophrenia - drug therapy | Ketamine - pharmacology | Hippocampus - physiopathology | Invited Themed
Journal Article
Progress in Neurobiology, ISSN 0301-0082, 2010, Volume 91, Issue 4, pp. 349 - 361
Glycine is a primary inhibitory neurotransmitter in the spinal cord and brainstem. It acts at glycine receptor (GlyR)-chloride channels, as well as a...
Glycine | NMDA receptor | Homeostatic regulation | Glycine receptor | Hippocampus | PROTEIN-KINASE-C | TRANSPORTER SUBTYPE 1B | ACTIVATED CHLORIDE CURRENTS | D-ASPARTATE RECEPTOR | NEUROSCIENCES | SPINAL-CORD NEURONS | SUBUNIT MESSENGER-RNAS | D-SERINE | DORSAL COMMISSURAL NEURONS | RAT HIPPOCAMPAL | Glycine - metabolism | Receptors, Glycine - physiology | RNA Editing - genetics | Hippocampus - drug effects | Hippocampus - cytology | Mutation - genetics | Animals | Glycine - pharmacology | Signal Transduction - drug effects | Neurons - physiology | Receptors, Glycine - chemistry | Signal Transduction - physiology | Neurons - drug effects | Receptors, Glycine - genetics | Oxidases | Neurosciences | Nervous system diseases | Neurons | Depression, Mental | Prostaglandins E | GABA | Amino acids | Protein kinases
Glycine | NMDA receptor | Homeostatic regulation | Glycine receptor | Hippocampus | PROTEIN-KINASE-C | TRANSPORTER SUBTYPE 1B | ACTIVATED CHLORIDE CURRENTS | D-ASPARTATE RECEPTOR | NEUROSCIENCES | SPINAL-CORD NEURONS | SUBUNIT MESSENGER-RNAS | D-SERINE | DORSAL COMMISSURAL NEURONS | RAT HIPPOCAMPAL | Glycine - metabolism | Receptors, Glycine - physiology | RNA Editing - genetics | Hippocampus - drug effects | Hippocampus - cytology | Mutation - genetics | Animals | Glycine - pharmacology | Signal Transduction - drug effects | Neurons - physiology | Receptors, Glycine - chemistry | Signal Transduction - physiology | Neurons - drug effects | Receptors, Glycine - genetics | Oxidases | Neurosciences | Nervous system diseases | Neurons | Depression, Mental | Prostaglandins E | GABA | Amino acids | Protein kinases
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 08/2011, Volume 36, Issue 9, pp. 1948 - 1958
Glycine in the hippocampus can exert its effect on both synaptic NMDA receptors (NMDARs) and extrasynaptic functional glycine receptors (GlyRs) via distinct...
LTP | glycine receptor | synaptic plasticity | NMDA receptor | glycine | LTD | SITE | ACTIVATION | TRANSPORT INHIBITOR SARCOSINE | RAT | INDUCED SYNAPTIC POTENTIATION | PSYCHIATRY | NEUROSCIENCES | AMPA RECEPTORS | AMINO-ACIDS | PHARMACOLOGY & PHARMACY | BRAIN | PLASTICITY | Synaptic Transmission - physiology | Male | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Receptors, Glycine - antagonists & inhibitors | CA1 Region, Hippocampal - drug effects | Excitatory Postsynaptic Potentials - physiology | Neural Inhibition - physiology | Receptors, Glycine - agonists | Pyramidal Cells - physiology | Synaptic Transmission - drug effects | Pyramidal Cells - drug effects | Glycine Plasma Membrane Transport Proteins - physiology | Organ Culture Techniques | Long-Term Synaptic Depression - physiology | CA1 Region, Hippocampal - physiology | Receptors, Glycine - physiology | Rats | Strychnine - pharmacology | Rats, Sprague-Dawley | Animals | Glycine - pharmacology | Glycine - physiology | Neural Inhibition - drug effects | Glycine Plasma Membrane Transport Proteins - antagonists & inhibitors | molecular & cellular neurobiology | neuropharmacology | neurophysiology | Original | glutamate
LTP | glycine receptor | synaptic plasticity | NMDA receptor | glycine | LTD | SITE | ACTIVATION | TRANSPORT INHIBITOR SARCOSINE | RAT | INDUCED SYNAPTIC POTENTIATION | PSYCHIATRY | NEUROSCIENCES | AMPA RECEPTORS | AMINO-ACIDS | PHARMACOLOGY & PHARMACY | BRAIN | PLASTICITY | Synaptic Transmission - physiology | Male | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Receptors, Glycine - antagonists & inhibitors | CA1 Region, Hippocampal - drug effects | Excitatory Postsynaptic Potentials - physiology | Neural Inhibition - physiology | Receptors, Glycine - agonists | Pyramidal Cells - physiology | Synaptic Transmission - drug effects | Pyramidal Cells - drug effects | Glycine Plasma Membrane Transport Proteins - physiology | Organ Culture Techniques | Long-Term Synaptic Depression - physiology | CA1 Region, Hippocampal - physiology | Receptors, Glycine - physiology | Rats | Strychnine - pharmacology | Rats, Sprague-Dawley | Animals | Glycine - pharmacology | Glycine - physiology | Neural Inhibition - drug effects | Glycine Plasma Membrane Transport Proteins - antagonists & inhibitors | molecular & cellular neurobiology | neuropharmacology | neurophysiology | Original | glutamate
Journal Article