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Cancer, ISSN 0008-543X, 10/2014, Volume 120, Issue 19, pp. 2980 - 2985
Simultaneous targeting of the IGF‐1R and EGFR signaling pathways for more effective downstream inhibition of proliferation and survival did not improve... 
pancreatic cancer | erlotinib signaling | randomized phase II | IGF‐1R | cixutumumab | EGFR | targeted treatment | Erlotinib signaling | Targeted treatment | Randomized phase II | Pancreatic cancer | Cixutumumab | IGF-1R | CARCINOMA-CELLS | DUCTAL ADENOCARCINOMA | MONOCLONAL-ANTIBODY | SINGLE-AGENT CETUXIMAB | BREAST-CANCER | INHIBITION | K-RAS | ONCOLOGY | THERAPEUTIC TARGET | C-MET | RESISTANCE | Erlotinib Hydrochloride | Pancreatic Neoplasms - metabolism | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Receptor, Epidermal Growth Factor - drug effects | Male | Insulin-Like Growth Factor I - drug effects | Pancreatic Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - metabolism | Adenocarcinoma - metabolism | Adult | Deoxycytidine - adverse effects | Female | Quinazolines - administration & dosage | Drug Administration Schedule | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Kaplan-Meier Estimate | Treatment Outcome | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Disease-Free Survival | Signal Transduction - drug effects | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Quinazolines - adverse effects | Aged | Deoxycytidine - analogs & derivatives | Insulin-Like Growth Factor I - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Hepatology, ISSN 0270-9139, 04/2014, Volume 59, Issue 4, pp. 1577 - 1590
Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer‐related mortality in the United States. Because of the lack of viable treatment... 
FUNCTIONAL POLYMORPHISM | HEPATIC STELLATE CELLS | MODELS | GENE-EXPRESSION | TARGETS | RISK | MECHANISMS | CYP2E1 | GASTROENTEROLOGY & HEPATOLOGY | ERLOTINIB | HEPATOCARCINOGENESIS | Erlotinib Hydrochloride | Prognosis | Rats, Wistar | Carcinoma, Hepatocellular - prevention & control | Humans | Transcriptome | Hepatic Stellate Cells - metabolism | Receptor, Epidermal Growth Factor - drug effects | Hepatocytes - pathology | Male | Receptor, Epidermal Growth Factor - metabolism | Diethylnitrosamine - adverse effects | Liver Neoplasms - pathology | Phosphorylation - drug effects | Liver Cirrhosis - genetics | Hepatic Stellate Cells - pathology | Hepatocytes - drug effects | Disease Models, Animal | Hepatic Stellate Cells - drug effects | Liver Neoplasms - prevention & control | Liver Cirrhosis - etiology | Liver Cirrhosis - prevention & control | Carbon Tetrachloride - adverse effects | Cells, Cultured | Bile Ducts - physiopathology | Rats | Mice, Inbred Strains | Disease Progression | Animals | Quinazolines - therapeutic use | Carcinoma, Hepatocellular - pathology | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Ligation - adverse effects | Quinazolines - pharmacology | Liver cancer | Epidermal growth factor | Rodents | Mortality | Hepatology | Gene expression | Liver cirrhosis | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2008, Volume 14, Issue 16, pp. 5069 - 5080
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 04/2011, Volume 103, Issue 8, pp. 645 - 661
Background Ionizing radiation (IR) is effectively used in cancer therapy. However, in subsets of patients, a few radioresistant cancer cells survive and cause... 
STEM-CELLS | IN-VITRO | ONCOLOGY | TYROSINE KINASE | HGF | CELL INVASION | RECEPTOR | EPITHELIAL-MESENCHYMAL TRANSITIONS | NF-KAPPA-B | SCATTER-FACTOR | PROTOONCOGENE | Humans | Neoplasm Invasiveness - prevention & control | Radiation Tolerance | Receptors, Growth Factor - antagonists & inhibitors | NF-kappa B - metabolism | RNA, Messenger - metabolism | NF-kappa B - radiation effects | Receptors, Growth Factor - genetics | Proto-Oncogene Proteins c-met - radiation effects | Signal Transduction - radiation effects | Protein-Serine-Threonine Kinases - metabolism | Radiation, Ionizing | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - radiation effects | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Cell Cycle Proteins - radiation effects | Receptors, Growth Factor - radiation effects | Proto-Oncogene Proteins c-met - drug effects | Ataxia Telangiectasia Mutated Proteins | Phosphorylation - radiation effects | Cell Line, Tumor | Mice | RNA, Small Interfering | Tumor Suppressor Proteins - radiation effects | Receptors, Growth Factor - metabolism | Neoplasms - metabolism | Proto-Oncogene Proteins c-met - metabolism | Apoptosis - radiation effects | Up-Regulation - radiation effects | Transcription, Genetic - radiation effects | Transplantation, Heterologous | Sulfones - pharmacology | DNA-Binding Proteins - metabolism | Chromatin Immunoprecipitation | Protein-Serine-Threonine Kinases - radiation effects | Tumor Suppressor Proteins - genetics | Polymerase Chain Reaction | Cell Cycle Proteins - genetics | Indoles - pharmacology | Neoplasms - radiotherapy | Gene Expression Regulation, Neoplastic - drug effects | In Situ Nick-End Labeling | Enzyme-Linked Immunosorbent Assay | Radiation-Sensitizing Agents - pharmacology | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | DNA-Binding Proteins - genetics | Cell Survival - radiation effects | Cell Movement - radiation effects | Proto-Oncogene Proteins c-met - genetics | Blotting, Northern | Animals | NF-kappa B - genetics | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Receptors, Growth Factor - drug effects | DNA Damage - radiation effects | Mitogen-Activated Protein Kinases - metabolism | Ionizing radiation | Physiological aspects | Genetic aspects | Cancer invasiveness | Research | Gene expression | Radiotherapy | Health aspects | Oncology | Radiation therapy | Kinases | Index Medicus
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 7/2009, Volume 58, Issue 7, pp. 1033 - 1045
Lenalidomide (Revlimid®; CC-5013) and pomalidomide (CC-4047) are IMiDs® proprietary drugs having immunomodulatory properties that have both shown activity in... 
Immunomodulatory drugs | Biomedicine | Immunology | Lenalidomide | T regulatory cells | Cancer Research | Oncology | Pomalidomide | IMiDs | MULTIPLE-MYELOMA | DENILEUKIN DIFTITOX | THERAPEUTIC IMPLICATIONS | IMiDs (R) | PERIPHERAL-BLOOD | IMMUNOLOGY | TUMOR-INFILTRATING LYMPHOCYTES | CANCER-PATIENTS | ONCOLOGY | IN-VIVO | THALIDOMIDE ANALOG | ANTITUMOR IMMUNITY | Forkhead Transcription Factors - immunology | Receptors, Nerve Growth Factor - immunology | Receptors, Transforming Growth Factor beta - immunology | Receptors, Nerve Growth Factor - drug effects | Humans | Receptors, Nerve Growth Factor - metabolism | Thalidomide - pharmacology | Colonic Neoplasms - metabolism | Receptors, OX40 - immunology | T-Lymphocytes, Regulatory - immunology | Thalidomide - analogs & derivatives | Receptors, OX40 - metabolism | Transforming Growth Factor beta - drug effects | Colonic Neoplasms - immunology | Forkhead Transcription Factors - metabolism | Interleukin-10 - metabolism | Female | Antineoplastic Agents - pharmacology | Forkhead Transcription Factors - antagonists & inhibitors | Immunosuppressive Agents - pharmacology | Receptors, Tumor Necrosis Factor - metabolism | Transforming Growth Factor beta - immunology | Glucocorticoid-Induced TNFR-Related Protein | T-Lymphocytes, Regulatory - drug effects | Animals | Receptors, Transforming Growth Factor beta - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Receptors, Tumor Necrosis Factor - immunology | Interleukin-10 - immunology | Transforming Growth Factor beta - metabolism | Receptors, Tumor Necrosis Factor - drug effects | Receptors, OX40 - antagonists & inhibitors | Care and treatment | Dexamethasone | Multiple myeloma | Angiogenesis inhibitors | Transforming growth factors | T cells | Cancer | Index Medicus
Journal Article
Respiratory Research, ISSN 1465-9921, 12/2014, Volume 15, Issue 1, pp. 157 - 157
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. The kinase inhibitor nintedanib specific for vascular... 
Fibroblasts | In vitro model | Kinase inhibitor | Lung fibrosis | CELLS | TGF-BETA | EFFICACY | BLEOMYCIN | THERAPY | GENE | RESPIRATORY SYSTEM | PDGF | EXPRESSION | IMATINIB MESYLATE | ENDOTHELIAL GROWTH-FACTOR | Receptors, Fibroblast Growth Factor - drug effects | Fibroblasts - enzymology | Phosphorylation | Humans | Fibroblast Growth Factor 2 - pharmacology | Extracellular Matrix - metabolism | Receptors, Vascular Endothelial Growth Factor - drug effects | Case-Control Studies | Lung - enzymology | Dose-Response Relationship, Drug | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Receptors, Vascular Endothelial Growth Factor - metabolism | Gelatinases - metabolism | Indoles - pharmacology | Proto-Oncogene Proteins c-sis - pharmacology | Vascular Endothelial Growth Factor A - pharmacology | Lung - pathology | Cells, Cultured | Fibroblasts - pathology | Enzyme Precursors - metabolism | Receptors, Platelet-Derived Growth Factor - metabolism | Fibroblasts - drug effects | Lung - drug effects | Receptors, Fibroblast Growth Factor - metabolism | Idiopathic Pulmonary Fibrosis - pathology | Cell Proliferation - drug effects | Idiopathic Pulmonary Fibrosis - enzymology | Protein Kinase Inhibitors - pharmacology | Receptors, Platelet-Derived Growth Factor - drug effects | Development and progression | Pulmonary fibrosis | Prognosis | Computer software industry | Analysis | Studies | Enzymes | Thoracic surgery | Hospitals | Pathogenesis | Rodents | Kinases | Vascular endothelial growth factor | Binding sites | Index Medicus | Research
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2006, Volume 12, Issue 21, pp. 6494 - 6501
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 03/2003, Volume 95, Issue 6, pp. 437 - 448
Background: Interferon alpha (IFN-alpha) has antiangiogenic activity, although the underlying mechanism of action is unclear. Because human neuroendocrine (NE)... 
CELLS | INHIBITION | THERAPY | ONCOLOGY | SP1 | CLINICAL-APPLICATIONS | PROTEIN-KINASE | DOWN-REGULATION | EXPRESSION | CANCER | BINDING | Immunohistochemistry | Interferon-alpha - pharmacology | Transcription, Genetic - drug effects | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Luciferases - metabolism | Vascular Endothelial Growth Factors | Receptors, Vascular Endothelial Growth Factor - drug effects | Transplantation, Heterologous | Pregnancy Proteins - metabolism | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Biomarkers, Tumor | Intercellular Signaling Peptides and Proteins - metabolism | Lymphokines - genetics | Receptors, Vascular Endothelial Growth Factor - metabolism | Time Factors | Lymphokines - metabolism | Antineoplastic Agents - pharmacology | Electrophoretic Mobility Shift Assay | Gene Expression Regulation, Neoplastic - drug effects | Receptors, Vascular Endothelial Growth Factor - genetics | Tumor Cells, Cultured | Lymphokines - drug effects | Enzyme-Linked Immunosorbent Assay | Neuroendocrine Tumors - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Angiogenesis Inhibitors - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Animals | Mice, Nude | Neovascularization, Pathologic - drug therapy | Endothelial Growth Factors - genetics | Neuroendocrine Tumors - drug therapy | Genes, Reporter - drug effects | Mice | Neovascularization, Pathologic - metabolism | Neuroendocrine Tumors - blood supply | Receptors, Immunologic - metabolism | Measurement | Physiological aspects | Vascular endothelial growth factor | Interferon alpha | Blood vessels | Therapy | Genes | Tumors | Index Medicus | Interferon-alpha/pharmacology | Endothelial Growth Factors/genetics/metabolism | Tumor Cells; Cultured | Tumor Markers; Biological | Neuroendocrine Tumors/blood supply/drug therapy/metabolism | Antineoplastic Agents/pharmacology | Pregnancy Proteins/metabolism | Luciferases/metabolism | Promoter Regions (Genetics)/drug effects | Research Support; Non-U.S. Gov't | Genes; Reporter/drug effects | Mice; Nude | Gene Expression Regulation; Neoplastic/drug effects | RNA; Messenger/metabolism | Receptors; Vascular Endothelial Growth Factor/drug effects/genetics/metabolism | Receptors; Immunologic/metabolism | Intercellular Signaling Peptides and Proteins/genetics/metabolism | Neovascularization; Pathologic/drug therapy/metabolism | Angiogenesis Inhibitors/pharmacology | Lymphokines/drug effects/genetics/metabolism | Transcription; Genetic/drug effects | Transplantation; Heterologous
Journal Article
Journal Article