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Nature (London), ISSN 1476-4687, 09/2015, Volume 526, Issue 7572, pp. 263 - 267
.... In late-stage colorectal cancer, the most commonly used targeted therapies are the monoclonal antibodies cetuximab and panitumumab, which prevent epidermal growth factor receptor (EGFR) activation(1... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-2 - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Genomics | Humans | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Cetuximab - therapeutic use | Molecular Targeted Therapy | Receptor, Fibroblast Growth Factor, Type 1 - genetics | MAP Kinase Kinase 1 - genetics | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Insulin Receptor Substrate Proteins - genetics | Colorectal Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Cetuximab - pharmacology | DNA Copy Number Variations - genetics | Mutation - genetics | Genome, Human - genetics | Receptor, Epidermal Growth Factor - chemistry | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Exome - genetics | Animals | Receptor, Platelet-Derived Growth Factor alpha - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Colorectal cancer | Drug metabolism | Genetic aspects | Identification and classification | Health aspects | Proteins | Epidermal growth factor | Genes | Clinical trials | Mutation | Kinases | Cancer therapies | Tumors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2010, Volume 107, Issue 6, pp. 2425 - 2430
Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation through activation of three receptor tyrosine kinases, VEGFR-1, -2, and -3... 
Proteins | Angiogenesis | Receptors | Vascular endothelial growth factors | Endothelial growth factors | Ligands | Dimers | Chimeras | Monomers | Crystal structure | Vascular endothelial growth factor receptor-2 | Lymphangiogenesis | Vascular endothelial growth factor C | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Crystallography, X-Ray | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Recombinant Fusion Proteins - metabolism | Spodoptera | Vascular Endothelial Growth Factor Receptor-2 - genetics | Vascular Endothelial Growth Factor A - chemistry | Vascular Endothelial Growth Factor C - chemistry | Vascular Endothelial Growth Factor Receptor-1 - genetics | Protein Structure, Tertiary | Cell Line | Cell Survival | Models, Molecular | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Binding Sites - genetics | Recombinant Fusion Proteins - chemistry | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Vascular Endothelial Growth Factor C - genetics | Vascular Endothelial Growth Factor Receptor-3 - chemistry | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Hydrogen Bonding | Vascular Endothelial Growth Factor C - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Protein Conformation | Kinetics | Mutation | Vascular Endothelial Growth Factor Receptor-3 - genetics | Development and progression | Research | Growth factor receptors | Neovascularization | Properties | Vascular endothelial growth factor | Protein binding | Lymphangioma | Signal transduction | Immunoglobulins | Membranes | Biochemistry | Kinases | Binding sites | Index Medicus | lymphangiogenesis | Biological Sciences | vascular endothelial growth factor receptor-2 | angiogenesis | vascular endothelial growth factor C
Journal Article
PloS one, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e61426 - e61426
.... Platelets can stimulate angiogenesis and promote gastric ulcer healing. We compared the expressions of proangiogenic growth factors and their receptors in the gastric... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Demography | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Middle Aged | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Platelet-Derived Growth Factor beta - genetics | Vascular Endothelial Growth Factor A - genetics | Platelet-Derived Growth Factor - genetics | Intercellular Signaling Peptides and Proteins - blood | Vascular Endothelial Growth Factor Receptor-2 - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Stomach Ulcer - complications | Angiogenesis Inducing Agents - metabolism | Fibroblast Growth Factor 2 - metabolism | Female | Stomach Ulcer - genetics | Liver Cirrhosis - genetics | Receptor, Platelet-Derived Growth Factor beta - metabolism | Vascular Endothelial Growth Factor Receptor-1 - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Liver Cirrhosis - complications | RNA, Messenger - genetics | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Receptors, Cell Surface - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Platelet-Derived Growth Factor - metabolism | Platelet Count | Stomach Ulcer - blood | Fibroblast Growth Factor 2 - genetics | Receptor, Platelet-Derived Growth Factor alpha - genetics | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Receptors, Cell Surface - genetics | RNA | Peptic ulcer | Comparative analysis | Vascular endothelial growth factor | Health aspects | Liver cirrhosis | Growth factors | Fibroblast growth factor | Platelet-derived growth factor | Pathogenesis | Mucosa | mRNA | Angiogenesis | Receptors | Blood platelets | Rodents | Gastroenterology | Nonsteroidal anti-inflammatory drugs | Endoscopy | Fibroblast growth factor receptor 1 | Fibroblast growth factor receptor 2 | Deoxyribonucleic acid--DNA | Fibroblast growth factor 2 | Thrombocytopenia | Liver diseases | Patients | Medicine | Hospitals | Biopsy | Ulcers | Platelets | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 03/2010, Volume 65, Issue 5, pp. 597 - 611
To investigate the role of microRNAs in regulating oligodendrocyte (OL) differentiation and myelination, we utilized transgenic mice in which microRNA... 
DEVBIO | MOLNEURO | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Central Nervous System - metabolism | MicroRNAs - metabolism | Green Fluorescent Proteins - genetics | S100 Proteins - genetics | Oligodendroglia - drug effects | Basic Helix-Loop-Helix Transcription Factors - metabolism | Animals, Newborn | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | S100 Calcium Binding Protein beta Subunit | Oligonucleotide Array Sequence Analysis - methods | Rats | Mice, Transgenic | Oligodendrocyte Transcription Factor 2 | Myelin Proteins - genetics | Rats, Sprague-Dawley | Nerve Growth Factors - genetics | Mice | MicroRNAs - genetics | Myelin Proteins - metabolism | SOXD Transcription Factors - genetics | Optic Nerve - metabolism | Age Factors | SOXD Transcription Factors - metabolism | Gene Expression Regulation, Developmental - genetics | Sciatic Nerve - growth & development | Myelin Sheath - metabolism | Central Nervous System - growth & development | DNA-Binding Proteins - metabolism | Sciatic Nerve - metabolism | Oligodendroglia - physiology | Transfection | DEAD-box RNA Helicases - metabolism | Cell Differentiation - physiology | Optic Nerve - growth & development | Brain - cytology | 2',3'-Cyclic-Nucleotide Phosphodiesterases - genetics | Ribonuclease III - genetics | Ribonuclease III - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Profiling - methods | Transcription Factors - genetics | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | DEAD-box RNA Helicases - genetics | Animals | Cell Differentiation - drug effects | Receptor, Platelet-Derived Growth Factor alpha - genetics | Stem Cells - drug effects | Stem Cells - physiology | Proteins | Genotype & phenotype | Gene expression | Experiments | Rodents | Cell cycle | Index Medicus
Journal Article