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1. Full Text Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain‐death induced immunological injury post–lung transplant
by Cheng, Qi and Patel, Kunal and Lei, Biao and Rucker, Lindsay and Allen, D. Patterson and Zhu, Peng and Vasu, Chentha and Martins, Paulo N and Goddard, Martin and Nadig, Satish N and Atkinson, Carl
American journal of transplantation, ISSN 1600-6135, 10/2018, Volume 18, Issue 10, pp. 2417 - 2428
animal models: murine | complement biology | immunosuppression/immune modulation | lung transplantation/pulmonology | immunobiology | ischemia reperfusion injury (IRI) | basic (laboratory) research/science | Transplantation | Life Sciences & Biomedicine | Surgery | Science & Technology | Reperfusion Injury - etiology | Receptors, Complement - antagonists & inhibitors | Graft Rejection - prevention & control | Mice, Inbred C57BL | Administration, Inhalation | Brain Death - physiopathology | Graft Rejection - etiology | Lung Transplantation - adverse effects | Animals | Reperfusion Injury - prevention & control | Mice | Mice, Inbred BALB C | Tissue Donors | Transplantation of organs, tissues, etc | Analysis | Complement receptors | Complement activation | Complement component C3a | Reperfusion | Transplants & implants | Donors | Lungs | Ischemia | Syngeneic grafts | Lung transplantation | Brain injury | Graft rejection | Index Medicus
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2. Full Text Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo
by Das, Rituparna and Verma, Rakesh and Sznol, Mario and Boddupalli, Chandra Sekhar and Gettinger, Scott N and Kluger, Harriet and Callahan, Margaret and Wolchok, Jedd D and Halaban, Ruth and Dhodapkar, Madhav V and Dhodapkar, Kavita M
The Journal of immunology (1950), ISSN 0022-1767, 02/2015, Volume 194, Issue 3, pp. 950 - 959
Life Sciences & Biomedicine | Immunology | Science & Technology | Neoplasms - metabolism | T-Lymphocyte Subsets - immunology | Signal Transduction | Antibodies, Monoclonal - pharmacology | Humans | Ipilimumab | Antibodies, Monoclonal - therapeutic use | Immunophenotyping | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Gene Expression Profiling | Neoplasms - drug therapy | Neoplasms - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoplasms - immunology | T-Lymphocyte Subsets - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Antigens, Surface | Gene Expression Regulation, Neoplastic - drug effects | CTLA-4 Antigen - antagonists & inhibitors | Cytokines - blood | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus | Abridged Index Medicus
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3. Full Text Stimulation of CD25 + CD4 + regulatory T cells through GITR breaks immunological self-tolerance
by Yamazaki, Sayuri and Ishida, Yasumasa and Sakaguchi, Shimon and Shimizu, Jun and Takahashi, Takeshi
Nature immunology, ISSN 1529-2908, 02/2002, Volume 3, Issue 2, pp. 135 - 142
T-Lymphocyte Subsets - immunology | Receptors, Nerve Growth Factor - immunology | Spleen - immunology | Rats, Wistar | Glycoproteins - metabolism | Receptors, Nerve Growth Factor - metabolism | Autoimmune Diseases - etiology | CD4-Positive T-Lymphocytes - immunology | Immune Tolerance - immunology | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | Dimerization | Receptors, Nerve Growth Factor - antagonists & inhibitors | Receptors, Tumor Necrosis Factor - metabolism | Signal Transduction | Glucocorticoid-Induced TNFR-Related Protein | Glycoproteins - antagonists & inhibitors | Rats | Lymph Nodes - immunology | Receptors, Interleukin-2 - isolation & purification | Glycoproteins - immunology | Animals | CD4 Antigens - isolation & purification | Mice | Mice, Inbred BALB C | Receptors, Tumor Necrosis Factor - immunology | Index Medicus
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4. Full Text Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
by Furman, David and Chang, Junlei and Lartigue, Lydia and Bolen, Christopher R and Haddad, François and Gaudilliere, Brice and Ganio, Edward A and Fragiadakis, Gabriela K and Spitzer, Matthew H and Douchet, Isabelle and Daburon, Sophie and Moreau, Jean-François and Nolan, Garry P and Blanco, Patrick and Déchanet-Merville, Julie and Dekker, Cornelia L and Jojic, Vladimir and Kuo, Calvin J and Davis, Mark M and Faustin, Benjamin
Nature medicine, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 174 - 184
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Toll-Like Receptor 5 - genetics | Humans | Middle Aged | Oxidative Stress - immunology | Transcriptome | Immunoblotting | Male | Purinergic P1 Receptor Antagonists - pharmacology | Young Adult | Toll-Like Receptor 8 - immunology | Aging - immunology | Toll-Like Receptor 6 - immunology | Aging - genetics | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | Aged, 80 and over | Caffeine - pharmacology | Hypertension - genetics | Intracellular Signaling Peptides and Proteins - genetics | Interleukin 1 Receptor Antagonist Protein - immunology | Carotid Intima-Media Thickness | Mortality | Neutrophils - drug effects | Hypertension - immunology | Nucleotides - metabolism | Toll-Like Receptor 5 - immunology | Monocytes - drug effects | Regression Analysis | Phenotype | Mice | Calcium-Binding Proteins - genetics | Metabolomics | Pulse Wave Analysis | Neutrophil Activation - drug effects | Cytidine - pharmacology | Interleukin 1 Receptor Antagonist Protein - genetics | Intracellular Signaling Peptides and Proteins - immunology | Cytidine - analogs & derivatives | CARD Signaling Adaptor Proteins - genetics | Toll-Like Receptor 6 - genetics | Adult | Female | Blood Pressure - drug effects | Blood Platelets - drug effects | Macrophages - immunology | Cytokines - immunology | CARD Signaling Adaptor Proteins - immunology | Cell Line | Vascular Stiffness - genetics | Cytokines - metabolism | Oxidative Stress - genetics | Interleukin-1beta - immunology | Adenine - pharmacology | Inflammation - immunology | Inflammasomes - genetics | Vascular Stiffness - immunology | Animals | Inflammasomes - immunology | Toll-Like Receptor 8 - genetics | Inflammation - genetics | Aged | Platelet Activation - drug effects | Genetic aspects | Immune response | Gene expression | Health aspects | Aging | Inflammation | Immune system | Index Medicus
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5. Full Text TIGIT and PD-1 impair tumor antigen-specific CD8 + T cells in melanoma patients
by Chauvin, Joe-Marc and Pagliano, Ornella and Fourcade, Julien and Sun, Zhaojun and Wang, Hong and Sander, Cindy and Kirkwood, John M and Chen, Tseng-Hui Timothy and Maurer, Mark and Korman, Alan J and Zarour, Hassane M
The Journal of clinical investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 2046 - 2058
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Up-Regulation | Receptors, Immunologic - physiology | Receptors, Virus - biosynthesis | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Programmed Cell Death 1 Receptor - physiology | Receptors, Virus - genetics | Receptors, Immunologic - antagonists & inhibitors | Receptors, Immunologic - biosynthesis | Programmed Cell Death 1 Receptor - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Interleukin-2 Receptor beta Subunit - genetics | Neoplasm Proteins - genetics | Antibodies, Monoclonal - immunology | Antigen-Presenting Cells - metabolism | Antigens, Neoplasm - immunology | Lymphocyte Activation | Neoplasm Proteins - biosynthesis | Antibodies, Monoclonal - pharmacology | Immunophenotyping | Interleukin-2 Receptor beta Subunit - biosynthesis | Melanoma - pathology | Antigen-Presenting Cells - immunology | Melanoma - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | Cell Line, Tumor | T-Cell Antigen Receptor Specificity | Immunologic Memory | Antigens, Differentiation, T-Lymphocyte - biosynthesis | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | Programmed Cell Death 1 Receptor - genetics | Cytokines - biosynthesis | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus | Abridged Index Medicus | Oncology | Immunology | Dermatology | Therapeutics
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6. Full Text Distinct clinical and immunological features of SARS–CoV-2–induced multisystem inflammatory syndrome in children
by Lee, Pui Y and Day-Lewis, Megan and Henderson, Lauren A and Friedman, Kevin G and Lo, Jeffrey and Roberts, Jordan E and Lo, Mindy S and Platt, Craig D and Chou, Janet and Hoyt, Kacie J and Baker, Annette L and Banzon, Tina M and Chang, Margaret H and Cohen, Ezra and de Ferranti, Sarah D and Dionne, Audrey and Habiballah, Saddiq and Halyabar, Olha and Hausmann, Jonathan S and Hazen, Melissa M and Janssen, Erin and Meidan, Esra and Nelson, Ryan W and Nguyen, Alan A and Sundel, Robert P and Dedeoglu, Fatma and Nigrovic, Peter A and Newburger, Jane W and Son, Mary Beth F
The Journal of clinical investigation, ISSN 0021-9738, 11/2020, Volume 130, Issue 11, pp. 5942 - 5950
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Interleukin 1 Receptor Antagonist Protein - administration & dosage | Fibrin Fibrinogen Degradation Products - metabolism | Humans | Child, Preschool | Immunoglobulins, Intravenous - administration & dosage | Interleukin-10 - blood | Infant | Male | Mucocutaneous Lymph Node Syndrome - immunology | Macrophage Activation Syndrome - immunology | COVID-19 | SARS-CoV-2 | Systemic Inflammatory Response Syndrome - blood | Interleukin-6 - blood | Systemic Inflammatory Response Syndrome - immunology | Female | Retrospective Studies | Mucocutaneous Lymph Node Syndrome - diagnosis | Child | Natriuretic Peptide, Brain - blood | Mucocutaneous Lymph Node Syndrome - blood | Macrophage Activation Syndrome - diagnosis | Macrophage Activation Syndrome - blood | Mucocutaneous Lymph Node Syndrome - drug therapy | Immunomodulation | Macrophage Activation Syndrome - drug therapy | Biomarkers - blood | Betacoronavirus - metabolism | Adolescent | Systemic Inflammatory Response Syndrome - diagnosis | Systemic Inflammatory Response Syndrome - drug therapy | Adrenal Cortex Hormones - administration & dosage | Infection | Medical research | Pediatrics | Medicine, Experimental | Skin diseases | Children | Comparative analysis | Natriuretic peptides | Complications and side effects | Inflammation | Diagnosis | Research | Immunodiagnosis | Pediatric research | Corticoids | Intensive care | Intravenous administration | Peptides | Laboratories | Hispanic Americans | Infections | Arthritis | Macrophages | Interleukin 6 | Cell activation | Kawasaki disease | Age | Thrombocytopenia | Brain natriuretic peptide | Immunoglobulins | Multisystem inflammatory syndrome in children | Cytokines | Interleukin 1 receptor antagonist | Mortality | Hypersensitivity | Coronaviruses | Patients | Hypotension | Children & youth | Severe acute respiratory syndrome coronavirus 2 | Infectious diseases | Globulins | Lymphopenia | Coronary vessels | Interleukin 10 | Mucocutaneous lymph node syndrome | Ejection fraction | Index Medicus | Abridged Index Medicus
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7. Full Text Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American society of clinical oncology clinical practice guideline
by Brahmer, Julie R and Lacchetti, Christina and Schneider, Bryan J and Atkins, Michael B and Brassil, Kelly J and Caterino, Jeffrey M and Chau, Ian and Ernstoff, Marc S and Gardner, Jennifer M and Ginex, Pamela and Hallmeyer, Sigrun and Chakrabarty, Jennifer Holter and Leighl, Natasha B and Mammen, Jennifer S and McDermott, David F and Naing, Aung and Nastoupil, Loretta J and Phillips, Tanyanika and Porter, Laura D and Puzanov, Igor and Reichner, Cristina A and Santomasso, Bianca D and Seigel, Carole and Spira, Alexander and Suarez-Almazor, Maria E and Wang, Yinghong and Weber, Jeffrey S and Wolchok, Jedd D and Thompson, John A and Natl Comprehensive Canc Network and National Comprehensive Cancer Network and in collaboration with the National Comprehensive Cancer Network
Journal of clinical oncology, ISSN 0732-183X, 06/2018, Volume 36, Issue 17, pp. 1714 - 1768
Life Sciences & Biomedicine | Oncology | Science & Technology | Antineoplastic Agents, Immunological - administration & dosage | Humans | Antibodies, Monoclonal - adverse effects | Programmed Cell Death 1 Receptor - antagonists & inhibitors | CTLA-4 Antigen - immunology | B7-H1 Antigen - immunology | Neoplasms - drug therapy | Antineoplastic Agents, Immunological - adverse effects | B7-H1 Antigen - antagonists & inhibitors | Antibodies, Monoclonal - administration & dosage | Antineoplastic Agents, Immunological - immunology | Neoplasms - immunology | Adult | Programmed Cell Death 1 Receptor - immunology | CTLA-4 Antigen - antagonists & inhibitors | Practice Guidelines as Topic
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8. Full Text "Velcro" engineering of high affinity CD47 Ectodomain as signal regulatory protein α (SIRPα) antagonists that enhance antibody-dependent cellular phagocytosis
by Ho, Chia Chi M and Guo, Nan and Sockolosky, Jonathan T and Ring, Aaron M and Weiskopf, Kipp and Özkan, Engin and Mori, Yasuo and Weissman, Irving L and Garcia, K. Christopher
The Journal of biological chemistry, ISSN 0021-9258, 05/2015, Volume 290, Issue 20, pp. 12650 - 12663
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Neoplasms - metabolism | Humans | Antibodies | Receptors, Immunologic - antagonists & inhibitors | Neoplasms - genetics | Immunotherapy | Protein Engineering | CD47 Antigen - pharmacology | Antigens, Differentiation - metabolism | Antineoplastic Agents - pharmacology | CD47 Antigen - genetics | Protein Structure, Tertiary | Phagocytosis - drug effects | Macrophages - pathology | CD47 Antigen - chemistry | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Macrophages - metabolism | Animals | Cell Line, Tumor | Protein Binding | Antigens, Differentiation - genetics | Mice | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Index Medicus | cancer therapy | phagocytosis | don't-eat-me signal | protein engineering | Immunology | immunotherapy | SIRPα | CD47 | directed evolution
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