X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (47022) 47022
Book Chapter (173) 173
Book / eBook (30) 30
Conference Proceeding (13) 13
Newspaper Article (11) 11
Publication (10) 10
Dissertation (7) 7
Reference (4) 4
Book Review (2) 2
Newsletter (2) 2
Transcript (2) 2
Government Document (1) 1
Magazine Article (1) 1
Web Resource (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (28201) 28201
animals (27121) 27121
index medicus (24150) 24150
mice (16270) 16270
immunology (14152) 14152
female (10083) 10083
male (8860) 8860
cell biology (8122) 8122
expression (7817) 7817
inflammation (7805) 7805
cytokines (7077) 7077
cells, cultured (7001) 7001
biochemistry & molecular biology (6701) 6701
signal transduction (6363) 6363
mice, inbred c57bl (6265) 6265
activation (5964) 5964
receptor (5098) 5098
proteins (4952) 4952
neurosciences (4807) 4807
gene expression (4758) 4758
research (4412) 4412
apoptosis (4363) 4363
mice, knockout (4320) 4320
toll-like receptors (4178) 4178
dendritic cells (4103) 4103
research article (4091) 4091
interferon-gamma (3991) 3991
cell line (3959) 3959
immune system (3798) 3798
nf-kappa-b (3680) 3680
adult (3669) 3669
interferon (3653) 3653
lymphocytes (3613) 3613
health aspects (3608) 3608
hematology (3435) 3435
multidisciplinary sciences (3427) 3427
gene-expression (3396) 3396
receptors (3350) 3350
medicine (3323) 3323
rats (3317) 3317
physiology (3314) 3314
physiological aspects (3289) 3289
cells (3286) 3286
analysis (3220) 3220
macrophages (3192) 3192
middle aged (3036) 3036
rodents (3011) 3011
immune response (2950) 2950
t-cells (2946) 2946
t cells (2781) 2781
flow cytometry (2738) 2738
in-vivo (2659) 2659
disease models, animal (2633) 2633
science (2629) 2629
innate immunity (2623) 2623
cytokines - metabolism (2591) 2591
tumor-necrosis-factor (2589) 2589
biology (2583) 2583
cancer (2575) 2575
phosphorylation (2574) 2574
oncology (2511) 2511
mice, inbred balb c (2442) 2442
signal transduction - physiology (2426) 2426
medicine, research & experimental (2415) 2415
endocrinology & metabolism (2360) 2360
infection (2351) 2351
ligands (2329) 2329
infections (2313) 2313
immunity (2266) 2266
t-lymphocytes - immunology (2243) 2243
genetic aspects (2211) 2211
kinases (2202) 2202
review (2098) 2098
interferon-gamma - pharmacology (2086) 2086
ifn-gamma (2083) 2083
in-vitro (2029) 2029
microbiology (2007) 2007
differentiation (2000) 2000
lymphocytes t (1991) 1991
rna, messenger - metabolism (1983) 1983
gene expression regulation (1976) 1976
virology (1939) 1939
viruses (1933) 1933
interferon-gamma - metabolism (1914) 1914
disease (1882) 1882
necrosis-factor-alpha (1882) 1882
infectious diseases (1844) 1844
cell line, tumor (1836) 1836
aged (1818) 1818
pathogenesis (1800) 1800
molecular sequence data (1779) 1779
antigens (1758) 1758
signal transduction - drug effects (1756) 1756
cell proliferation (1740) 1740
abridged index medicus (1728) 1728
genes (1704) 1704
lymphocyte activation (1699) 1699
induction (1690) 1690
dendritic cells - immunology (1685) 1685
pathology (1661) 1661
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (20) 20
Collection Dvlpm't (Acquisitions) - Vendor file (4) 4
Collection Dvlpm't (Acquisitions) - Closed Orders (2) 2
Online Resources - Online (2) 2
UofT at Mississauga - Stacks (2) 2
Trinity College (John W Graham) - Stacks (1) 1
UTL at Downsview - May be requested (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (47103) 47103
Japanese (175) 175
Chinese (49) 49
French (33) 33
Russian (24) 24
German (20) 20
Spanish (15) 15
Polish (7) 7
Italian (3) 3
Swedish (2) 2
Ukrainian (2) 2
Arabic (1) 1
Dutch (1) 1
Korean (1) 1
Norwegian (1) 1
Portuguese (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Cytokine and Growth Factor Reviews, ISSN 1359-6101, 2015, Volume 26, Issue 2, pp. 103 - 111
Abstract Interferons (IFN) are key cytokines with multifaceted antiviral and cell-modulatory properties... 
Advanced Basic Science | Interferon types I–III | Interferon–interferon interactions | Interferon genes and receptors | Anti-interferon strategies | Interferon types I-III | Interferon-interferon interactions | CELLS | III INTERFERONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | LAMBDA | CELL BIOLOGY | INHIBITION | INTERFERON-GAMMA | MULTIPLE-SCLEROSIS | VIRUS-REPLICATION | ANTIVIRAL ACTIVITY | BETA-INTERFERON | Cell Proliferation | Virus Diseases - immunology | Signal Transduction | Antiviral Agents - immunology | Humans | Transcriptional Activation | Interferon-gamma - physiology | Receptor, Interferon alpha-beta - physiology | Virus Diseases - virology | Interferon Type I - immunology | Interferons - immunology | Genetic Variation | Interferon Type I - genetics | Cell Differentiation | Interferon Type I - physiology | Interferons - physiology | Interferons - genetics | Virus diseases | Interferon | Biological response modifiers | Health aspects | Genetic polymorphisms | IRF, interferon regulatory factor | WNV, West Nile virus | ADAR1, adenosine deaminase acting on RNA 1 | CREB-binding protein | IPS-1, interferon promoter-stimulating factor 1 | EM, environmental mycobacteria | HSE, herpes simplex encephalitis | NEMO, nuclear factor (NF)-kB essential modulator | hCMV, human Cytomegalovirus | APCs, antigen presenting cells | NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells | IRAK-4, interleukin-1 receptor-associated kinase 4 | ds, double strand | SARS, severe acute respiratory syndrome | GAS, gamma interferon activation site | ss, single strand | IFI16, gamma-interferon-inducible protein 16 | TREX1, three prime repair exonuclease 1 | Th, lymphocytes T helper | p300 | PKR, dsRNA-dependent protein kinase | TYK2, tyrosine kinase 2 | IL, interleukin | CRF2, class II cytokine receptor family | IFNGR, interferon gamma receptor | ISGF3, interferon-stimulated gene factor 3 | CHIKV, Chickungunya virus | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | HCV, hepatitis C virus | ATF6, activating transcription factor 6 | EAE, experimental allergic encephalomyelitis | MSMD, Mendelian susceptibility to mycobacterial disease | MxA, Myxovirus Resistance Gene A | RIG-1, retinoic-acid-inducible gene 1 | CBP, chromatin remodeling associated p300 | AP-1, activator protein 1 | OAS, 2′,5′-oligo adenylate synthetase A | HSV-1, herpes simplex virus-1 | SAMHD1, SAM domain and HD domain-containing protein 1 | SARS-CoV, severe acute respiratory syndrome-associated coronavirus | STAT, Signal Transducer and Activator of Transcription | VZV, Varicella-Zoster virus | IFN, interferon | VSV, vesicular stomatitis virus | LASV, Lassa virus | cGAS, cyclic GMP-AMP synthase | ISRE, interferon stimulated response element | EMCV, encephalomyocarditis virus | IFNAR, interferon alpha receptor | BCG, bacille Calmette–Guérin | MHC, major histocompatibility complex | MS, multiple sclerosis | SNPs, single nucleotide polymorphisms | PD-L1, programmed death ligand 1 | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | MAPK, mitogen-activated protein kinases | NK, natural killer cells | PRRs, pattern-recognition receptors
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2013, Volume 339, Issue 6126, pp. 1448 - 1453
Type I interferons (IFN-α and IFN-β) are important for protection against many viral infections, whereas type II interferon (IFN-γ... 
Monocytes | Messenger RNA | Tuberculosis | Mycobacterium tuberculosis | Antimicrobials | REPORTS | Leprosy | Infections | Skin | Lesions | Gene expression | LISTERIA-MONOCYTOGENES | ACTIVATION | PROFILES | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | HUMAN TUBERCULOSIS | IL-1-BETA | INDUCTION | DEPENDENT ANTIMICROBIAL PATHWAY | SARCOIDOSIS | LEPROSY | Up-Regulation | Interferon-beta - immunology | Humans | Transcriptome | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics | Monocytes - metabolism | Monocytes - immunology | Interferon-gamma - metabolism | Antimicrobial Cationic Peptides - metabolism | RNA, Messenger - metabolism | Receptors, Calcitriol - genetics | Mycobacterium leprae - immunology | Interferon-beta - genetics | Interleukin-10 - metabolism | beta-Defensins - metabolism | Interferon-gamma - genetics | Antimicrobial Cationic Peptides - genetics | Leprosy, Lepromatous - genetics | Mycobacterium leprae - physiology | Leprosy, Tuberculoid - immunology | beta-Defensins - genetics | Leprosy, Lepromatous - immunology | RNA, Messenger - genetics | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism | Microbial Viability | Receptors, Calcitriol - metabolism | Leprosy, Tuberculoid - genetics | Tuberculosis - immunology | Leprosy, Lepromatous - metabolism | Interferon-beta - metabolism | Tuberculosis - genetics | Leprosy, Tuberculoid - metabolism | Interferon-gamma - immunology | Interleukin-10 - genetics | Interleukins | Physiological aspects | Host-parasite relationships | Anti-infective agents | Interferon | Genetic aspects | Health aspects | Antimicrobial agents | Pathogenesis | Genes | Bacteria | Human behavior | Antiinfectives and antibacterials | Digital signatures
Journal Article
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2012, Volume 188, Issue 7, pp. 2967 - 2971
The host response to Chikungunya virus is dependent on the direct action of type I IFN on infected nonhematopoietic cells. Prior studies have demonstrated that... 
PATHOGENESIS | VIRUS | PROTEIN | MODEL | IMMUNOLOGY | DISTINCT | Age Factors | Interferon Regulatory Factor-7 - genetics | Interferon Regulatory Factor-3 - genetics | Interferon Regulatory Factor-7 - physiology | Interferon-alpha - genetics | Bone Marrow Transplantation | Hematopoietic Stem Cells - virology | Fibroblasts - metabolism | Animals, Newborn | Chikungunya Fever | Fibroblasts - virology | Toll-Like Receptor 7 - genetics | Interferon-alpha - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 7 - deficiency | Hematopoietic Stem Cells - metabolism | Radiation Chimera | Alphavirus Infections - immunology | Chikungunya virus - growth & development | Chikungunya virus - immunology | Interferon Regulatory Factor-3 - physiology | Membrane Glycoproteins - genetics | Mice, Knockout | Host-Pathogen Interactions | Adaptor Proteins, Signal Transducing - physiology | Animals | Interferon Regulatory Factor-3 - deficiency | Myeloid Differentiation Factor 88 - deficiency | Interferon Regulatory Factor-7 - deficiency | Mice | Membrane Glycoproteins - deficiency | Interferon Regulatory Factor-7/deficiency | Toll-Like Receptor 7/genetics | Membrane Glycoproteins/genetics | Hematopoietic Stem Cells/metabolism | Myeloid Differentiation Factor 88/genetics | Life Sciences | Alphavirus Infections/immunology | Immunology | Fibroblasts/metabolism | Chikungunya virus/growth & development | Myeloid Differentiation Factor 88/deficiency | Toll-Like Receptor 7/deficiency | Interferon Regulatory Factor-3/physiology | Interferon Regulatory Factor-3/genetics | Interferon-alpha/biosynthesis | Adaptor Proteins, Signal Transducing/physiology | Hematopoietic Stem Cells/virology | Membrane Glycoproteins/deficiency | Interferon Regulatory Factor-3/deficiency | Chikungunya virus/immunology
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2011, Volume 34, Issue 2, pp. 213 - 223
Type I interferon (IFN) is a common therapy for autoimmune and inflammatory disorders, yet the mechanisms of action are largely unknown... 
FAMILIAL MEDITERRANEAN FEVER | MULTIPLE-SCLEROSIS | CASPASE-1 | HOST-DEFENSE | INNATE | CRYSTALS | RECOMBINANT INTERLEUKIN-1 | MICE | BACTERIAL-INFECTION | IMMUNOLOGY | RECEPTOR ANTAGONIST | Interleukin-1 - genetics | Inflammasomes - metabolism | STAT1 Transcription Factor - deficiency | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Monocytes - metabolism | Monocytes - immunology | Interleukin-10 - physiology | Interleukin-1 - biosynthesis | Interferon-beta - therapeutic use | Interferon Type I - biosynthesis | STAT3 Transcription Factor - physiology | Candida albicans - physiology | Interferon Type I - physiology | Caspase 1 - physiology | Candidiasis - immunology | Carrier Proteins - physiology | Peritonitis - etiology | STAT1 Transcription Factor - physiology | Poly I-C - pharmacology | Disease Susceptibility | Mice, Inbred C57BL | Peritonitis - immunology | STAT1 Transcription Factor - genetics | Gene Expression Regulation - drug effects | Animals | Candidiasis - etiology | Caspase 1 - genetics | Caspase 1 - deficiency | Interferon Type I - genetics | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Apoptosis Regulatory Proteins - physiology | Cells, Cultured - metabolism | Mice | Interferon Inducers - pharmacology | Multiple Sclerosis - drug therapy | Interferon | Infections | Cytokines | Viral infections | Molecular weight | Immune system
Journal Article
Nature immunology, ISSN 1529-2916, 2008, Volume 9, Issue 4, pp. 361 - 368
Journal Article
Journal of virology, ISSN 1098-5514, 2012, Volume 86, Issue 18, pp. 9888 - 9898
Chikungunya virus (CHIKV) infections can produce severe disease and mortality. Here we show that CHIKV infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7 ) is lethal... 
ANTIBODY-DEPENDENT ENHANCEMENT | VIROLOGY | IFN-ALPHA-BETA | DENDRITIC CELLS | INNATE IMMUNE-RESPONSES | NONHEMATOPOIETIC CELLS | SIGNALING PATHWAY | POSITIVE FEEDBACK | DENGUE VIRUS | HUMAN KERATINOCYTES | VIRAL-INFECTION | Interferon-alpha - pharmacology | Shock, Hemorrhagic - prevention & control | Humans | Adaptor Proteins, Vesicular Transport - deficiency | Adaptor Proteins, Vesicular Transport - genetics | Receptor, Interferon alpha-beta - physiology | Interferon Regulatory Factor-7 - genetics | Interferon Regulatory Factor-3 - genetics | Host-Pathogen Interactions - immunology | Alphavirus Infections - prevention & control | Interferon Regulatory Factor-7 - physiology | Chikungunya virus - physiology | Receptor, Interferon alpha-beta - genetics | Chikungunya virus - pathogenicity | Chikungunya Fever | Virus Replication - drug effects | Adaptor Proteins, Vesicular Transport - physiology | Interferon-alpha - biosynthesis | Receptor, Interferon alpha-beta - deficiency | Mice, Inbred C57BL | Myeloid Differentiation Factor 88 - genetics | Interferon-beta - biosynthesis | Alphavirus Infections - immunology | Chikungunya virus - immunology | Alphavirus Infections - pathology | Interferon Regulatory Factor-3 - physiology | Mice, Knockout | Animals | Interferon Regulatory Factor-3 - deficiency | Myeloid Differentiation Factor 88 - deficiency | Host-Pathogen Interactions - genetics | Interferon Regulatory Factor-7 - deficiency | Myeloid Differentiation Factor 88 - physiology | Mice | Shock, Hemorrhagic - immunology | Life Sciences | Santé publique et épidémiologie | Pathogenesis and Immunity
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 05/2007, Volume 14, Issue 12, pp. 1279 - 1289
Interferons (IFNs) are a family of pleiotropic cytokines that typically exhibit antiviral, antiproliferative, antitumor, and immunomodulatory properties... 
Immunomodulation | Clinical applications cancer | Interferon receptor | Antiviral | Interferon | JAK/STAT signaling | Apoptosis | immunomodulation | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | RESISTANT PULMONARY TUBERCULOSIS | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | interferon receptor | interferon | HUMAN GAMMA-INTERFERON | MHC CLASS-I | ALPHA-INDUCED APOPTOSIS | MEDIATES TYROSINE PHOSPHORYLATION | clinical applications | antiviral | PHARMACOLOGY & PHARMACY | cancer | LONG-TERM TREATMENT | NF-KAPPA-B | HEPATITIS-C | Apoptosis - drug effects | Humans | Interferons - adverse effects | Interferons - therapeutic use | Interferons - immunology | Cytokines - physiology | STAT Transcription Factors - physiology | Immunity, Cellular - drug effects | Virus Diseases - drug therapy | Interleukins - physiology | Janus Kinases - physiology | Proto-Oncogene Proteins c-crk - physiology | Immunity, Cellular - physiology | Insulin Receptor Substrate Proteins | Interferon Type I - physiology | Phosphoproteins - physiology | p38 Mitogen-Activated Protein Kinases - physiology | Immunologic Factors - physiology | Interferon-gamma - physiology | Receptor, Insulin - physiology | Antibody Formation - physiology | Antibody Formation - drug effects | Signal Transduction - physiology | Cell Proliferation - drug effects | Interferons - physiology
Journal Article
Science Signaling, ISSN 1945-0877, 05/2012, Volume 5, Issue 225, pp. ra38 - ra38
Interferon-beta (IFN-beta) is widely used to treat multiple sclerosis (MS), and its efficacy was demonstrated in the setting of experimental autoimmune encephalomyelitis (EAE... 
RESPONSES | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | MECHANISM | CASPASE-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CENTRAL-NERVOUS-SYSTEM | EXPRESSION | NALP3 INFLAMMASOME | CELL BIOLOGY | Recombinant Proteins - therapeutic use | Proto-Oncogene Proteins c-vav - antagonists & inhibitors | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Encephalomyelitis, Autoimmune, Experimental - immunology | Suppressor of Cytokine Signaling 1 Protein | Male | Receptor, Interferon alpha-beta - physiology | Interleukin-1beta - genetics | Neuropeptides - physiology | Proto-Oncogene Proteins c-vav - physiology | Cytoskeletal Proteins - deficiency | Interferon-beta - therapeutic use | rac GTP-Binding Proteins - antagonists & inhibitors | Interleukin-1beta - biosynthesis | Caspase 1 - physiology | rac GTP-Binding Proteins - physiology | Disease Models, Animal | Carrier Proteins - physiology | Macrophages - physiology | Encephalomyelitis, Autoimmune, Experimental - physiopathology | Receptor, Interferon alpha-beta - deficiency | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Mice, Transgenic | Mice, Knockout | Gene Expression Regulation - drug effects | Carrier Proteins - genetics | Inflammasomes - physiology | Animals | Apoptosis Regulatory Proteins | Interferon beta-1b | CD4-Positive T-Lymphocytes - transplantation | CARD Signaling Adaptor Proteins | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Suppressor of Cytokine Signaling Proteins - physiology | Mice | Enzyme Activation | rac1 GTP-Binding Protein | Neuropeptides - antagonists & inhibitors
Journal Article