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1. Full Text Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
by Levin, Aron M and Bates, Darren L and Ring, Aaron M and Krieg, Carsten and Lin, Jack T and Su, Leon and Moraga, Ignacio and Raeber, Miro E and Bowman, Gregory R and Novick, Paul and Pande, Vijay S and Fathman, C. Garrison and Boyman, Onur and Garcia, K.Christopher and SLAC National Accelerator Lab., Menlo Park, CA (United States)
Nature (London), ISSN 0028-0836, 04/2012, Volume 484, Issue 7395, pp. 529 - 533
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological and medical sciences | Medical sciences | Immunomodulators | Pharmacology. Drug treatments | Physiological aspects | Interleukin-2 | Tissue engineering | Methods | Phosphorylation | Yeast | Mutation | Engineers | Cytokines | Index Medicus | CHEM | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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2. Full Text Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy
by Liao, Wei and Lin, Jian-Xin and Leonard, Warren J
Immunity (Cambridge, Mass.), ISSN 1074-7613, 01/2013, Volume 38, Issue 1, pp. 13 - 25
Life Sciences & Biomedicine | Immunology | Science & Technology | T-Lymphocyte Subsets - immunology | Humans | X-Linked Combined Immunodeficiency Diseases - genetics | Interleukin Receptor Common gamma Subunit - metabolism | X-Linked Combined Immunodeficiency Diseases - immunology | Interleukin Receptor Common gamma Subunit - immunology | Leukemia-Lymphoma, Adult T-Cell - immunology | T-Lymphocytes, Regulatory - immunology | Receptors, Interleukin-2 - genetics | Interleukin-2 - physiology | T-Lymphocytes, Helper-Inducer - immunology | Immunotherapy | T-Lymphocytes, Helper-Inducer - cytology | CD8-Positive T-Lymphocytes - metabolism | Leukemia-Lymphoma, Adult T-Cell - therapy | Interleukin-2 - metabolism | Leukemia-Lymphoma, Adult T-Cell - genetics | Immune Tolerance | Receptors, Interleukin-2 - metabolism | X-Linked Combined Immunodeficiency Diseases - therapy | Interleukin Receptor Common gamma Subunit - genetics | Cell Differentiation - immunology | Animals | T-Lymphocyte Subsets - metabolism | Interleukin-15 - metabolism | Immunologic Memory | CD8-Positive T-Lymphocytes - immunology | Interleukins | T cells | Cell growth | T cell receptors | Cytokines | Kinases | Immune system | Index Medicus
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3. Full Text Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction
by Tang, Qizhi and Adams, Jason Y and Penaranda, Cristina and Melli, Kristin and Piaggio, Eliane and Sgouroudis, Evridiki and Piccirillo, Ciriaco A and Salomon, Benoit L and Bluestone, Jeffrey A
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2008, Volume 28, Issue 5, pp. 687 - 697
MOLIMMUNO | CELLIMMUNO | Life Sciences & Biomedicine | Immunology | Science & Technology | Autoimmunity | Interleukin-2 - metabolism | T-Lymphocytes, Regulatory - metabolism | Proto-Oncogene Proteins c-bcl-2 - immunology | Cell Survival | Lymphocyte Activation | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Diabetes Mellitus, Type 1 - metabolism | Islets of Langerhans - immunology | Lymph Nodes - metabolism | Lymph Nodes - immunology | Lymph Nodes - cytology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Interleukin-2 - immunology | Interleukin-2 Receptor alpha Subunit - metabolism | T-Lymphocytes, Regulatory - cytology | Mice, Inbred NOD | Mice | Diabetes Mellitus, Type 1 - immunology | Interleukin-2 Receptor alpha Subunit - immunology | Medical research | T cell receptors | Pancreas | Insulin | Rodents | Index Medicus
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4. Full Text Lymphopenia and interleukin-2 therapy alter homeostasis of CD4 + CD25 + regulatory T cells
by Douek, Daniel C and Chua, Kevin S and Hill, Brenna J and Carter, Charles S and Guimond, Martin and Fleisher, Thomas A and Zhang, Hua and Bernstein, Donna and Brown, Margaret V and Helman, Lee J and Kapoor, Veena and Berzofsky, Jay A and Long, Lauren M and Mackall, Crystal L and Read, E J
Nature medicine, ISSN 1078-8956, 11/2005, Volume 11, Issue 11, pp. 1238 - 1243
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Recombinant Proteins - therapeutic use | Sarcoma - complications | Humans | Middle Aged | Interleukin-2 - therapeutic use | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Interleukin-2 - immunology | Interleukin-2 - administration & dosage | Adult | Female | Lymphocyte Transfusion | Child | Mice, Inbred C57BL | Homeostasis - immunology | Receptors, Interleukin-2 - metabolism | Sarcoma - drug therapy | Receptors, Interleukin-2 - immunology | Mice, Knockout | T-Lymphocytes, Regulatory - drug effects | Animals | Lymphopenia - drug therapy | Adolescent | Forkhead Transcription Factors - analysis | Lymphopenia - immunology | Mice | CD4-Positive T-Lymphocytes - drug effects | Lymphopenia - chemically induced | Index Medicus
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5. Full Text Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7Rα-expressing cells
by Dooms, Hans and Wolslegel, Kristen and Lin, Patricia and Abbas, Abul K
The Journal of experimental medicine, ISSN 0022-1007, 03/2007, Volume 204, Issue 3, pp. 547 - 557
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Adjuvants, Immunologic - physiology | Gene Expression Regulation - immunology | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Interleukin-2 Receptor alpha Subunit - biosynthesis | Homeostasis - immunology | Mice, Transgenic | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | Cell Differentiation - genetics | Cell Differentiation - immunology | Interleukin-2 - physiology | Receptors, Interleukin-7 - genetics | Animals | Interleukin-2 Receptor alpha Subunit - genetics | Mice | Mice, Inbred BALB C | Receptors, Interleukin-7 - biosynthesis | Homeostasis - genetics | Immunologic Memory - genetics | Index Medicus
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6. Full Text Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity
by Malek, Thomas R and Castro, Iris
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2010, Volume 33, Issue 2, pp. 153 - 165
Life Sciences & Biomedicine | Immunology | Science & Technology | Animals | Signal Transduction | T-Lymphocytes - cytology | Humans | Immune Tolerance | Receptors, Interleukin-2 - metabolism | Immunologic Memory | T-Lymphocytes - immunology | Immunity | Receptors, Interleukin-2 - immunology | Interleukins | T cells | Studies | Signal transduction | T cell receptors | Lymphocytes | Immune system | Index Medicus
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