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Immunity, ISSN 1074-7613, 01/2013, Volume 38, Issue 1, pp. 13 - 25
Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays pivotal roles in the immune response. Discovered as a T cell growth... 
BETA-CHAIN | SEVERE COMBINED IMMUNODEFICIENCY | CYTOKINE RECEPTOR | IN-VIVO | REGULATORY T-CELLS | GENE-EXPRESSION | RECEPTOR-ALPHA-CHAIN | MONOCLONAL-ANTIBODY | IMMUNOLOGY | IL-2 RECEPTOR | GAMMA-CHAIN | T-Lymphocyte Subsets - immunology | Humans | X-Linked Combined Immunodeficiency Diseases - genetics | Interleukin Receptor Common gamma Subunit - metabolism | X-Linked Combined Immunodeficiency Diseases - immunology | Interleukin Receptor Common gamma Subunit - immunology | Leukemia-Lymphoma, Adult T-Cell - immunology | T-Lymphocytes, Regulatory - immunology | Receptors, Interleukin-2 - genetics | Interleukin-2 - physiology | T-Lymphocytes, Helper-Inducer - immunology | Immunotherapy | T-Lymphocytes, Helper-Inducer - cytology | CD8-Positive T-Lymphocytes - metabolism | Leukemia-Lymphoma, Adult T-Cell - therapy | Interleukin-2 - metabolism | Leukemia-Lymphoma, Adult T-Cell - genetics | Immune Tolerance | Receptors, Interleukin-2 - metabolism | X-Linked Combined Immunodeficiency Diseases - therapy | Interleukin Receptor Common gamma Subunit - genetics | Cell Differentiation - immunology | Animals | T-Lymphocyte Subsets - metabolism | Interleukin-15 - metabolism | Immunologic Memory | CD8-Positive T-Lymphocytes - immunology | Interleukins | T cells | Cell growth | T cell receptors | Cytokines | Kinases | Immune system
Journal Article
Journal of immunology (Baltimore, Md, ISSN 0022-1767, 2002, Volume 169, Issue 9, pp. 4850 - 4860
We show that the lymphoid hyperplasia observed in IL-2Ralpha- and IL-2-deficient mice is due to the lack of a population of regulatory cells essential for CD4... 
GROWTH-FACTOR-BETA | INFLAMMATORY-BOWEL-DISEASE | EFFECTOR FUNCTION | IN-VIVO | IMMUNOREGULATORY CELLS | IMMUNOLOGICAL SELF-TOLERANCE | MICE | IMMUNOLOGY | AUTOIMMUNE-DISEASE | ANTIGEN RECEPTOR | LYMPHOCYTES-T | T-Lymphocyte Subsets - immunology | Interphase - immunology | Lymphopenia - pathology | CD4-Positive T-Lymphocytes - immunology | Lymphopenia - mortality | Receptors, Interleukin-2 - genetics | Interleukin-2 - physiology | Receptors, Interleukin-2 - deficiency | Bone Marrow Transplantation | Radiation Chimera - immunology | Adjuvants, Immunologic - physiology | Radiation Chimera - genetics | Receptors, Interleukin-2 - biosynthesis | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Homeostasis - immunology | T-Lymphocyte Subsets - transplantation | Mice, Knockout | Interleukin-2 - genetics | Animals | CD4-Positive T-Lymphocytes - transplantation | T-Lymphocyte Subsets - metabolism | Interleukin-2 - deficiency | Survival Analysis | Lymphocyte Count | Lymphopenia - immunology | Mice | Receptors, Interleukin-2 - physiology | Interphase - genetics | Lymphopenia - genetics | Homeostasis - genetics | T-Lymphocyte Subsets | Interleukin-2 | Adjuvants, Immunologic | Interphase | Homeostasis | Radiation Chimera | Life Sciences | Immunology | Lymphopenia | CD4-Positive T-Lymphocytes | Receptors, Interleukin-2
Journal Article