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Journal of Clinical Investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3647 - 3651
Although long considered a promising treatment option for type 1 diabetes, pancreatic islet cell transformation has been hindered by immune system rejection of... 
MEDICINE, RESEARCH & EXPERIMENTAL | RECEPTOR | TISSUE FACTOR | T-CELLS | Receptors, Interleukin-8A - antagonists & inhibitors | Diabetes Mellitus, Experimental - surgery | Diabetes Mellitus, Type 1 - surgery | Humans | Middle Aged | Diabetes Mellitus, Experimental - genetics | Interleukin-8 - physiology | Male | Chemokine CXCL1 - genetics | Receptors, Interleukin-8B - antagonists & inhibitors | Receptors, Interleukin-8B - deficiency | Diabetes Mellitus, Experimental - blood | Islets of Langerhans Transplantation - immunology | Islets of Langerhans - metabolism | Chemokine CXCL1 - physiology | Adult | Female | Diabetes Mellitus, Type 1 - immunology | Drug Evaluation, Preclinical | Receptors, Interleukin-8B - physiology | Cell Survival - drug effects | Blood Glucose - analysis | Islets of Langerhans - pathology | Graft Rejection - prevention & control | Mice, Inbred C57BL | Neutrophils - immunology | Islets of Langerhans - immunology | Chemokine CXCL1 - biosynthesis | Treatment Outcome | Sulfonamides - pharmacology | Pilot Projects | Animals | Sulfonamides - therapeutic use | Receptors, Interleukin-8B - genetics | Mice | Mice, Inbred BALB C | Graft Survival - drug effects | Natural Killer T-Cells - immunology | Receptors, Interleukin-8A - physiology | Islet cell transplantation | Care and treatment | Type 1 diabetes | Allosteric proteins | Physiological aspects | Research | Health aspects | Chemokine receptors | Brief Report
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2012, Volume 122, Issue 9, pp. 3127 - 3144
.../+)) and highly expressed by all tumors in all models. CXCR2 deficiency profoundly suppressed inflammation-driven tumorigenesis in skin and intestine as well as spontaneous... 
ATHEROSCLEROTIC LESIONS | COLON-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-NECROSIS-FACTOR | IMMUNE CELLS | INTESTINAL NEOPLASIA | PROSTATE-CANCER | SKIN CARCINOGENESIS | RECEPTOR D6 | MYELOID CELLS | BEARING MICE | Dextran Sulfate | Tetradecanoylphorbol Acetate | Adenocarcinoma - pathology | Colitis - pathology | Colonic Neoplasms - chemically induced | Mice, 129 Strain | Receptors, Interleukin-8B - antagonists & inhibitors | Receptors, Interleukin-8B - deficiency | Colonic Neoplasms - metabolism | Adenoma - metabolism | Adenocarcinoma - metabolism | Azoxymethane | Colitis - chemically induced | Statistics, Nonparametric | Papilloma - pathology | Precancerous Conditions - pathology | Neutrophils - metabolism | Papilloma - chemically induced | Papilloma - metabolism | Skin Neoplasms - pathology | Dermatitis, Contact - pathology | Gene Expression | Neutrophils - enzymology | Mice, Inbred C57BL | Skin Neoplasms - chemically induced | Tumor Burden | Chemokines, CXC - genetics | Chemokines, CXC - secretion | Mice, Knockout | Skin Neoplasms - metabolism | Animals | Cell Transformation, Neoplastic | Adenoma - secretion | Chemokines, CXC - metabolism | Receptors, Interleukin-8B - genetics | Animals, Inbred Strains | 9,10-Dimethyl-1,2-benzanthracene | Mice | Mice, Inbred BALB C | Precancerous Conditions - chemically induced | Colonic Neoplasms - secretion | Adenoma - chemically induced | Peroxidase - metabolism | Care and treatment | Cancer cells | Neutrophils | Papilloma | Genetic aspects | Diagnosis | Adenoma | Research | Gene expression
Journal Article
Journal Article
The Journal of pathology, ISSN 0022-3417, 2015, Volume 237, Issue 1, pp. 85 - 97
Pancreatitis is a significant clinical problem and the lack of effective therapeutic options means that treatment is often palliative rather than curative. A... 
pancreatitis | chemokines | inflammation | CXCR2 | ATHEROSCLEROTIC LESIONS | ACTIVATION | NEUTROPHIL | TRYPSINOGEN | KAPPA-B | PATHOLOGY | PEPTIDE | ONCOLOGY | ACINAR-CELLS | MICE | CHEMOKINE RECEPTORS | EXPRESSION | Pancreatitis, Chronic - chemically induced | Pancreatitis - prevention & control | Receptors, Interleukin-8B - antagonists & inhibitors | Receptors, Interleukin-8B - deficiency | Pancreatitis - genetics | Time Factors | Pancreatitis - immunology | Neutrophils - metabolism | Neutrophil Infiltration - drug effects | Cytoprotection | Disease Models, Animal | Pancreatitis, Chronic - immunology | Acute Disease | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Neutrophils - drug effects | Neutrophils - immunology | Pancreas - drug effects | Pancreas - pathology | Receptors, Interleukin-8B - immunology | Pancreas - metabolism | Pancreas - immunology | Pancreatitis - chemically induced | Pancreatitis, Chronic - genetics | Pancreatitis, Chronic - prevention & control | Mice, Knockout | Peptides - pharmacology | Pancreatitis, Chronic - pathology | Animals | Signal Transduction - drug effects | Receptors, Interleukin-8B - genetics | Pancreatitis - pathology | Mice, Inbred BALB C | Pancreatitis - metabolism | Ceruletide | Pancreatitis, Chronic - metabolism | Analysis | Inflammation | Pancreatitis | Original Paper | Original Papers
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2009, Volume 183, Issue 5, pp. 3332 - 3343
Journal Article
Cancer Discovery, ISSN 2159-8274, 01/2016, Volume 6, Issue 1, pp. 80 - 95
Journal Article
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2013, Volume 123, Issue 11, pp. 4836 - 4848
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 2010, Volume 30, Issue 27, pp. 9074 - 9083
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS and remyelination in MS ultimately fails. Although strategies to promote myelin... 
CHEMOKINE RECEPTOR CXCR2 | OLIGODENDROCYTE LINEAGE | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS | MOUSE | REMYELINATION | CENTRAL-NERVOUS-SYSTEM | MICE | SUBVENTRICULAR ZONE | NEUROSCIENCES | CUPRIZONE-INDUCED DEMYELINATION | Leukocyte Common Antigens - metabolism | Recovery of Function - drug effects | Microscopy, Electron, Transmission - methods | Nerve Regeneration - physiology | Encephalomyelitis, Autoimmune, Experimental - immunology | Receptors, Interleukin-8B - deficiency | Myelin Basic Protein - genetics | Oligodendroglia - drug effects | Cuprizone | Time Factors | Bone Marrow - metabolism | Demyelinating Diseases - immunology | Recovery of Function - physiology | Bone Marrow - drug effects | Disease Models, Animal | Animals, Newborn | Nerve Regeneration - genetics | Myelin Basic Protein - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Myelin-Oligodendrocyte Glycoprotein | Glycoproteins - adverse effects | Mice, Knockout | Nerve Regeneration - drug effects | Receptors, Interleukin-8B - genetics | Mice | Myelin Sheath - ultrastructure | Peptide Fragments - adverse effects | Proliferating Cell Nuclear Antigen - metabolism | Central Nervous System Stimulants - pharmacology | Cerebellum - drug effects | Lipopolysaccharides - adverse effects | Flow Cytometry | Oligodendroglia - physiology | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Freund's Adjuvant - adverse effects | Demyelinating Diseases - chemically induced | Severity of Illness Index | Encephalomyelitis, Autoimmune, Experimental - physiopathology | Myelin Sheath - physiology | Recovery of Function - genetics | Mice, Inbred C57BL | Myelin Proteolipid Protein - adverse effects | Receptors, Interleukin-8B - immunology | Antibodies - pharmacology | Animals | Neurologic Examination | Cell Differentiation - drug effects | Receptors, Interleukin-8B - metabolism | Picrotoxin - pharmacology | Stem Cells - drug effects | In Vitro Techniques
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2004, Volume 172, Issue 5, pp. 2853 - 2860
The Glu-Leu-Arg(+) (ELR+) CXC chemokines are potent promoters of angiogenesis and have been demonstrated to induce a significant portion of nonsmall cell lung... 
NONSMALL CELL | NEUTROPHIL | INTERFERON-GAMMA | INDUCED PULMONARY-FIBROSIS | PROSTATE-CANCER | IN-VIVO | PEPTIDE ENA-78 | CHEMOKINE RECEPTOR-2 LIGANDS | IMMUNOLOGY | HUMAN INTERLEUKIN-8 RECEPTOR | CARCINOMA | Transplantation, Heterotopic - pathology | Carcinoma, Lewis Lung - secondary | Molecular Sequence Data | Intercellular Signaling Peptides and Proteins - biosynthesis | Lung Neoplasms - pathology | Receptors, Interleukin-8B - deficiency | Carcinoma, Lewis Lung - blood supply | Cell Movement - genetics | Necrosis | Neovascularization, Pathologic - pathology | Cell Movement - immunology | Carcinoma, Non-Small-Cell Lung - secondary | Lung Neoplasms - secondary | Cell Division - immunology | Receptors, Chemokine - biosynthesis | Neovascularization, Pathologic - prevention & control | Neovascularization, Pathologic - immunology | Chemokines, CXC - biosynthesis | Disease Models, Animal | Endothelium, Vascular - immunology | Lung Neoplasms - blood supply | Carcinoma, Non-Small-Cell Lung - pathology | Cell Division - genetics | Receptors, Interleukin-8B - physiology | Amino Acid Sequence | Transplantation, Heterotopic - immunology | Carcinoma, Non-Small-Cell Lung - blood supply | Mice, Inbred C57BL | Carcinoma, Lewis Lung - prevention & control | Mice, Knockout | Neoplasm Transplantation - methods | Animals | Receptors, Chemokine - physiology | Receptors, Interleukin-8B - biosynthesis | Lung Neoplasms - prevention & control | Endothelium, Vascular - metabolism | Receptors, Interleukin-8B - genetics | Carcinoma, Lewis Lung - pathology | Chemokine CXCL1 | Carcinoma, Non-Small-Cell Lung - prevention & control | Mice | Receptors, CXCR3
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2011, Volume 121, Issue 10, pp. 4106 - 4117
Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal neoplasms, is characterized by an expanded stroma with marked fibrosis (desmoplasia). We... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | SIGNALING PATHWAYS | IN-VITRO | TGF-BETA | EPITHELIAL-CELLS | K-RAS | CANCER METASTASIS | II RECEPTOR | GROWTH | KAPPA-B | Protein-Serine-Threonine Kinases - deficiency | Receptors, Transforming Growth Factor beta - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Stromal Cells - pathology | Humans | Proto-Oncogene Proteins p21(ras) - physiology | Receptors, Interleukin-8B - antagonists & inhibitors | Tumor Microenvironment - physiology | Carcinoma, Pancreatic Ductal - genetics | Female | Receptors, Interleukin-8B - physiology | Gene Expression | Signal Transduction | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Protein-Serine-Threonine Kinases - genetics | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - therapy | Carcinoma, Pancreatic Ductal - pathology | Mice, Knockout | Animals | Connective Tissue Growth Factor - physiology | Mice, Nude | Chemokines, CXC - physiology | Carcinoma, Pancreatic Ductal - physiopathology | Connective Tissue Growth Factor - genetics | Mice | Pancreatic Neoplasms - physiopathology | Stromal Cells - physiology | Pancreatic Neoplasms - therapy | Receptors, Transforming Growth Factor beta - deficiency | Pancreatic cancer | Physiological aspects | Development and progression | Research | Transforming growth factors | Gene expression | Chemokine receptors
Journal Article