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The New England Journal of Medicine, ISSN 0028-4793, 03/2012, Volume 366, Issue 12, pp. 1108 - 1118
A monoclonal antibody to PCSK9 was studied in two single-dose trials in healthy volunteers and one multiple-dose trial in patients with familial or nonfamilial... 
POPULATION | MEDICINE, GENERAL & INTERNAL | STATIN | MICE | MUTATIONS | Proprotein Convertases - antagonists & inhibitors | Injections, Intravenous | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Injections, Subcutaneous | Serine Endopeptidases - immunology | Adult | Cholesterol, LDL - blood | Female | Hyperlipoproteinemia Type II - drug therapy | Drug Therapy, Combination | Pyrroles - therapeutic use | Proprotein Convertases - metabolism | Receptors, LDL - metabolism | Lipoproteins - blood | Anticholesteremic Agents - adverse effects | Proprotein Convertases - immunology | Hyperlipoproteinemia Type II - metabolism | Atorvastatin Calcium | Anticholesteremic Agents - therapeutic use | Antibodies, Monoclonal - administration & dosage | Anticholesteremic Agents - administration & dosage | Least-Squares Analysis | Serine Endopeptidases - metabolism | Receptors, LDL - drug effects | Hypercholesterolemia - metabolism | Proprotein Convertase 9 | Drugs | Dose-response relationship (Biochemistry) | Hypercholesterolemia | Monoclonal antibodies | Cholesterol, LDL | Dosage and administration | Product/Service Evaluations | Research | Drug therapy | Health aspects | Studies | Lipoproteins (low density) | Kexin | Serine | Atorvastatin | Cardiovascular disease | Subtilisin | Low density lipoprotein | Cholesterol | Index Medicus | Abridged Index Medicus
Journal Article
Lancet, The, ISSN 0140-6736, 2015, Volume 385, Issue 9965, pp. 331 - 340
Journal Article
The American Journal of Cardiology, ISSN 0002-9149, 05/2017, Volume 119, Issue 10, pp. 1576 - 1583
Journal Article
Lancet, The, ISSN 0140-6736, 2015, Volume 385, Issue 9965, pp. 341 - 350
Journal Article
Journal of Internal Medicine, ISSN 0954-6820, 06/2017, Volume 281, Issue 6, pp. 575 - 585
BackgroundThe natural farnesoid X receptor (FXR) agonist chenodeoxycholic acid (CDCA) suppresses hepatic cholesterol and bile acid synthesis and reduces... 
apolipoprotein | receptors | LDL | cholesterol | lipoprotein(a) | chenodeoxycholic acid | PCSK | PCSK9 | LDL cholesterol | LDL receptors | OBETICHOLIC ACID | GALLSTONE DISSOLUTION | CEREBROTENDINOUS XANTHOMATOSIS | MEDICINE, GENERAL & INTERNAL | MESSENGER-RNA | METABOLISM | GENE-EXPRESSION | CHOLESTEROL 7-ALPHA-HYDROXYLASE ACTIVITY | ENDOGENOUS TRIGLYCERIDE | BILE-ACIDS | HUMAN-LIVER | Liver - enzymology | Humans | Apolipoprotein C-III - blood | Receptors, LDL - metabolism | Cholesterol, LDL - drug effects | Male | Receptors, Cytoplasmic and Nuclear - agonists | Lipoprotein(a) - drug effects | Apolipoprotein C-III - drug effects | Chenodeoxycholic Acid - therapeutic use | Proprotein Convertase 9 - blood | Proprotein Convertase 9 - drug effects | Chenodeoxycholic Acid - pharmacology | Cholesterol, LDL - blood | Gallstones - drug therapy | Enzymes | Liver | Low density lipoproteins | Physiological aspects | Gallstones | Fibroblast growth factors | Triglycerides | Blood lipids | Apolipoproteins | Lipoprotein A | Trans fatty acids | Deoxycholic acid | Lipoproteins (low density) | Fibroblast growth factor | Plasma | Receptors | Reduction | Apolipoprotein C-III | Surgery | Lipoprotein (low density) receptors | Lipid metabolism | Binding | Cholecystectomy | Bile acids | Liver diseases | Secretion | Diabetes mellitus | Hydroxylase | Markers | Subtilisin | Metabolism | Insulin | Patients | Low density lipoprotein | Cholesterol | Serum levels | Lipoproteins | Kexin | Acids | Hydroxymethylglutaryl-CoA reductase | Kinetics | Chenodeoxycholic acid | Bile | Index Medicus
Journal Article
PLOS ONE, ISSN 1932-6203, 08/2008, Volume 3, Issue 8, pp. e2986 - e2986
Background: Rare mutations of the low-density lipoprotein receptor gene (LDLR) cause familial hypercholesterolemia, which increases the risk for coronary... 
POPULATION | HEART-DISEASE | METAANALYSIS | MYOCARDIAL-INFARCTION | CARDIOVASCULAR EVENTS | BIOLOGY | POLYMORPHISM | HYPERCHOLESTEROLEMIA | PREVALENCE | EPIDEMIOLOGY | GENOME-WIDE ASSOCIATION | Receptors, LDL - genetics | Oligonucleotide Array Sequence Analysis | Risk Assessment | Humans | Risk Factors | Cholesterol, LDL - drug effects | Chromosome Mapping | Random Allocation | Case-Control Studies | Genetic Variation | Cholesterol, LDL - genetics | Coronary Disease - prevention & control | Anticholesteremic Agents - therapeutic use | Coronary Disease - genetics | Cholesterol, LDL - blood | Polymorphism, Single Nucleotide | Chromosomes, Human, Pair 10 | Medical research | Hypercholesterolemia | Blood cholesterol | Low density lipoproteins | Genes | Medicine, Experimental | Genetic research | Genetics | Genetic aspects | Single nucleotide polymorphisms | Coronary heart disease | Risk factors | Lipoproteins (low density) | Risk | Lipids | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Gene polymorphism | Epidemiology | Consortia | Confidence intervals | Randomization | Population | Lipoprotein (low density) receptors | Children | Heart diseases | Statistical analysis | Mortality | Coronary artery | Health risks | Environmental health | Genetic diversity | Regression analysis | Metabolism | LDLR gene | Apolipoproteins | Coronary artery disease | Low density lipoprotein | Cholesterol | Studies | Genetic variance | Hospitals | Coronary vessels | Alleles | Biomarkers | Receptor density | Adults | Mutation | Polymorphism | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 02/2007, Volume 100, Issue 3, pp. 381 - 390
High levels of triglyceride-rich lipoproteins (TGRLs) in blood are linked to development of atherosclerosis, yet the mechanisms by which these particles... 
Vascular adhesion molecule-1 | Monocyte | NFκB | Triglyceride-rich lipoprotein | Atherosclerosis | Endothelium | atherosclerosis | ATHEROSCLEROTIC LESIONS | endothelium | CHYLOMICRON REMNANTS | CARDIAC & CARDIOVASCULAR SYSTEMS | INTERCELLULAR-ADHESION MOLECULE-1 | RECEPTOR-RELATED PROTEIN | vascular adhesion molecule-1 | triglyceride-rich lipoprotein | SIGNAL-TRANSDUCTION | FAMILY-MEMBER | METABOLISM | E-SELECTIN | monocyte | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | NF-KAPPA-B | EXPRESSION | NF kappa B | Endothelium, Vascular - cytology | LDL-Receptor Related Proteins - metabolism | Oxidative Stress | Humans | Apolipoprotein C-III - metabolism | NF-kappa B - metabolism | Endocytosis | E-Selectin - genetics | Dietary Fats - administration & dosage | E-Selectin - biosynthesis | Aorta | p38 Mitogen-Activated Protein Kinases - metabolism | Lipoproteins, VLDL - toxicity | Arteriosclerosis - etiology | Cells, Cultured - drug effects | Endothelial Cells - metabolism | Models, Cardiovascular | Receptors, LDL - metabolism | Cell Adhesion - drug effects | Cell Adhesion Molecules - metabolism | Triglycerides - toxicity | Monocytes - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Lipoproteins, LDL - toxicity | Lipoproteins, VLDL - blood | Signal Transduction - drug effects | Intercellular Adhesion Molecule-1 - genetics | Lipopolysaccharides - pharmacology | Lipoproteins, HDL - toxicity | Tumor Necrosis Factor-alpha - physiology | Leukocytes - drug effects | Vascular Cell Adhesion Molecule-1 - biosynthesis | Cells, Cultured - metabolism | Lipoproteins, HDL - blood | Monocytes - cytology | LDL-Receptor Related Proteins - drug effects | Membrane Transport Proteins - drug effects | Low Density Lipoprotein Receptor-Related Protein-1 - drug effects | LDL-Receptor Related Protein-Associated Protein - pharmacology | Intercellular Adhesion Molecule-1 - biosynthesis | Chylomicrons - blood | Membrane Transport Proteins - metabolism | Vascular Cell Adhesion Molecule-1 - genetics | Arteritis - etiology | Leukocytes - cytology | Dietary Fats - adverse effects | Rheology | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Hypoglycemia | Hypertriglyceridemia - blood | Gene Expression Regulation - drug effects | Hypertriglyceridemia - complications | Triglycerides - blood | Fat Emulsions, Intravenous - pharmacology | Receptors, LDL - drug effects | Apolipoprotein C-III - pharmacology | Aortic Diseases - etiology | Lipoproteins, LDL - blood | Endothelial Cells - drug effects | Index Medicus
Journal Article