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Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2012, Volume 366, Issue 12, pp. 1108 - 1118
A monoclonal antibody to PCSK9 was studied in two single-dose trials in healthy volunteers and one multiple-dose trial in patients with familial or nonfamilial... 
POPULATION | MEDICINE, GENERAL & INTERNAL | STATIN | MICE | MUTATIONS | Proprotein Convertases - antagonists & inhibitors | Injections, Intravenous | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Injections, Subcutaneous | Serine Endopeptidases - immunology | Adult | Cholesterol, LDL - blood | Female | Hyperlipoproteinemia Type II - drug therapy | Drug Therapy, Combination | Pyrroles - therapeutic use | Proprotein Convertases - metabolism | Receptors, LDL - metabolism | Lipoproteins - blood | Anticholesteremic Agents - adverse effects | Proprotein Convertases - immunology | Hyperlipoproteinemia Type II - metabolism | Atorvastatin Calcium | Anticholesteremic Agents - therapeutic use | Antibodies, Monoclonal - administration & dosage | Anticholesteremic Agents - administration & dosage | Least-Squares Analysis | Serine Endopeptidases - metabolism | Receptors, LDL - drug effects | Hypercholesterolemia - metabolism | Proprotein Convertase 9 | Drugs | Dose-response relationship (Biochemistry) | Hypercholesterolemia | Monoclonal antibodies | Cholesterol, LDL | Dosage and administration | Product/Service Evaluations | Research | Drug therapy | Health aspects | Studies | Lipoproteins (low density) | Kexin | Serine | Atorvastatin | Cardiovascular disease | Subtilisin | Low density lipoprotein | Cholesterol | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2004, Volume 279, Issue 47, pp. 48865 - 48875
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2016, Volume 126, Issue 8, pp. 2855 - 2866
Journal Article
Science, ISSN 0036-8075, 7/2009, Volume 325, Issue 5936, pp. 100 - 104
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2015, Volume 21, Issue 11, pp. 1280 - 1288
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2012, Volume 122, Issue 8, pp. 2807 - 2816
Journal Article
Circulation Research, ISSN 0009-7330, 02/2015, Volume 116, Issue 5, pp. 789 - 796
RATIONALE:Noncoding gene variants at the SORT1 locus are strongly associated with low-density lipoprotein cholesterol (LDL-C) levels, as well as with coronary... 
Foam cell | Receptor-mediated endocytosis | Low-density lipoprotein cholesterol | Atherosclerosis | Macrophage | atherosclerosis | FAMILIAL HYPERCHOLESTEROLEMIA | CARDIAC & CARDIOVASCULAR SYSTEMS | CHOLESTEROL | VARIANTS | low-density lipoprotein cholesterol | PROSAPOSIN | macrophage | LOCI | HYPERLIPIDEMIC MICE | MOUSE MODELS | receptor-mediated endocytosis | COMPLEXITY | foam cell | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ASSOCIATION | CORONARY-ARTERY-DISEASE | Atherosclerosis - genetics | Adaptor Proteins, Vesicular Transport - deficiency | Adaptor Proteins, Vesicular Transport - genetics | Male | Aortic Diseases - metabolism | Atherosclerosis - etiology | APOBEC-1 Deaminase | Receptors, LDL - deficiency | Aortic Diseases - prevention & control | Cholesterol, LDL - blood | Female | Lipoproteins, LDL - metabolism | Foam Cells - metabolism | Receptors, LDL - genetics | Adaptor Proteins, Vesicular Transport - physiology | Cytidine Deaminase - genetics | Mice, Transgenic | Radiation Chimera | Diet, Western - adverse effects | Atherosclerosis - metabolism | Mice, Knockout | Aortic Diseases - genetics | Macrophages - metabolism | Animals | Mice | Receptors, LDL - physiology | Macrophages, Peritoneal - metabolism | Aortic Diseases - etiology | Atherosclerosis - prevention & control | Bone Marrow Cells - metabolism | Index Medicus | low density lipoprotein cholesterol
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2013, Volume 110, Issue 18, pp. 7306 - 7311
Journal Article