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Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2009, Volume 29, Issue 4, pp. 431 - 438
Journal Article
Vascular pharmacology, ISSN 1537-1891, 2012, Volume 57, Issue 1, pp. 56 - 64
... – exerts atheroprotective effects in vitro , while FTY720, a non-selective S1P mimetic inhibits atherosclerosis in LDL receptor-deficient (LDL-R... 
Cardiovascular | Sphingosine 1-phosphate (S1P) | Inflammation | High density lipoproteins (HDL) | Atherosclerosis | CHOLESTEROL | ENDOTHELIAL CELL-ADHESION | SPHINGOSINE-1-PHOSPHATE ANALOG | HYPERCHOLESTEROLEMIA | HIGH-DENSITY-LIPOPROTEIN | MACROPHAGE ACCUMULATION | INTERFERON-GAMMA | INSULIN-RESISTANCE | PHARMACOLOGY & PHARMACY | ADIPOSE-TISSUE | Spleen - immunology | Spleen - drug effects | Body Weight - immunology | Antigens, CD - metabolism | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Oxadiazoles - pharmacology | Serine Endopeptidases - immunology | CD8-Positive T-Lymphocytes - metabolism | Lymph Nodes - drug effects | Receptors, Lysosphingolipid - metabolism | Interleukin-6 - metabolism | Lymphocytes - metabolism | Propylene Glycols - pharmacology | Atherosclerosis - immunology | CD4-Positive T-Lymphocytes - metabolism | Lymph Nodes - metabolism | Receptors, LDL - metabolism | Lymph Nodes - immunology | Receptors, LDL - immunology | Atherosclerosis - metabolism | Sphingosine - pharmacology | Macrophages - metabolism | Sphingosine - analogs & derivatives | Interleukin-6 - immunology | Receptors, Lysosphingolipid - agonists | Mice | CD8-Positive T-Lymphocytes - immunology | Antigens, CD - immunology | Genes, MHC Class II - immunology | Interleukin-2 - immunology | Lymphocytes - immunology | Female | Propylene Glycols - immunology | Antigens, Differentiation, Myelomonocytic - immunology | Macrophages - immunology | Interleukin-2 - metabolism | Atherosclerosis - drug therapy | CD11b Antigen - immunology | Mice, Inbred C57BL | Proprotein Convertases - metabolism | Fingolimod Hydrochloride | Sphingosine - immunology | Proprotein Convertases - immunology | Receptors, Lysosphingolipid - immunology | Animals | Spleen - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | CD8-Positive T-Lymphocytes - drug effects | Lymphocytes - drug effects | Macrophages - drug effects | Serine Endopeptidases - metabolism | CD11b Antigen - metabolism | CD4-Positive T-Lymphocytes - drug effects | Indans - pharmacology | Hypercholesterolemia | Blood lipids | Mitogens | Low density lipoproteins | Sphingosine
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2013, Volume 62, Issue 16, pp. 1401 - 1408
.... Statin-induced lowering of low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular morbidity and mortality... 
Cardiovascular | Internal Medicine | atherosclerosis | proprotein convertase subtilisin/kexin type 9 | PCSK9 | LDL cholesterol | LDL receptor | atherosclerosis LDL cholesterol LDL receptor PCSK9 proprotein convertase subtilisin/kexin type 9 | NONHUMAN-PRIMATES | LDL-CHOLESTEROL | CARDIAC & CARDIOVASCULAR SYSTEMS | RANDOMIZED-TRIAL | MONOCLONAL-ANTIBODY | DENSITY-LIPOPROTEIN-CHOLESTEROL | SECRETED PCSK9 | RECEPTOR-MEDIATED ENDOCYTOSIS | STATIN THERAPY | HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA | SERINE-PROTEASE | Proprotein Convertases - antagonists & inhibitors | Dyslipidemias - complications | Humans | Lipoproteins, LDL - genetics | Proprotein Convertases - genetics | Molecular Targeted Therapy - trends | Serine Endopeptidases - genetics | Lipid Metabolism - genetics | Lipoproteins, LDL - metabolism | Molecular Targeted Therapy - methods | Receptors, LDL - genetics | Dyslipidemias - drug therapy | Atherosclerosis - drug therapy | Proprotein Convertases - metabolism | Risk Factors | Receptors, LDL - metabolism | Atherosclerosis - complications | Hypolipidemic Agents - pharmacology | Forecasting | Atherosclerosis - metabolism | Lipid Metabolism - drug effects | Dyslipidemias - metabolism | Serine Endopeptidases - metabolism | Mutation | Proprotein Convertase 9 | Hypertension | Hypercholesterolemia | Low density lipoproteins | Mortality | Atherosclerosis | Drug therapy | Statins | Cholesterol | Protein binding | Studies | Rodents
Journal Article
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2012, Volume 366, Issue 12, pp. 1108 - 1118
.... In all three groups, the antibody reduced levels of LDL cholesterol. In 2003, Abifadel and colleagues 1 described two families with autosomal dominant hypercholesterolemia... 
POPULATION | MEDICINE, GENERAL & INTERNAL | STATIN | MICE | MUTATIONS | Proprotein Convertases - antagonists & inhibitors | Injections, Intravenous | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Injections, Subcutaneous | Serine Endopeptidases - immunology | Adult | Cholesterol, LDL - blood | Female | Hyperlipoproteinemia Type II - drug therapy | Drug Therapy, Combination | Pyrroles - therapeutic use | Proprotein Convertases - metabolism | Receptors, LDL - metabolism | Lipoproteins - blood | Anticholesteremic Agents - adverse effects | Proprotein Convertases - immunology | Hyperlipoproteinemia Type II - metabolism | Atorvastatin Calcium | Anticholesteremic Agents - therapeutic use | Antibodies, Monoclonal - administration & dosage | Anticholesteremic Agents - administration & dosage | Least-Squares Analysis | Serine Endopeptidases - metabolism | Receptors, LDL - drug effects | Hypercholesterolemia - metabolism | Proprotein Convertase 9 | Drugs | Dose-response relationship (Biochemistry) | Hypercholesterolemia | Monoclonal antibodies | Cholesterol, LDL | Dosage and administration | Product/Service Evaluations | Research | Drug therapy | Health aspects | Studies | Lipoproteins (low density) | Kexin | Serine | Atorvastatin | Cardiovascular disease | Subtilisin | Low density lipoprotein | Cholesterol
Journal Article
Atherosclerosis, ISSN 0021-9150, 2010, Volume 214, Issue 2, pp. 345 - 349
Journal Article
Journal of lipid research, ISSN 1539-7262, 2016, Volume 57, Issue 6, pp. 1086 - 1096
Journal Article
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2013, Volume 33, Issue 7, pp. 1505 - 1512
OBJECTIVE—Sphingosine 1-phosphate (S1P) partly accounts for antiatherogenic properties of high-density lipoproteins. We previously demonstrated that FTY720, a... 
Inflammation | High-density lipoproteins | T cells | Macrophage | Murine models of disease | Sphingosine 1-phosphate | CELLS | ACTIVATION | APOLIPOPROTEIN M | SPHINGOSINE-1-PHOSPHATE ANALOG | macrophage | high-density lipoproteins | DEFICIENT MICE | HYPERLIPIDEMIC MICE | murine models of disease | HIGH-DENSITY-LIPOPROTEIN | REDUCES ATHEROSCLEROSIS | inflammation | IMMUNE-RESPONSES | FTY720 | PERIPHERAL VASCULAR DISEASE | sphingosine 1-phosphate | HEMATOLOGY | Inflammation - pathology | Sulfhydryl Compounds - pharmacology | Atherosclerosis - genetics | Dendritic Cells - immunology | Humans | Aorta - metabolism | Aortic Diseases - metabolism | CD4-Positive T-Lymphocytes - immunology | Inflammation - metabolism | U937 Cells | Lipids - blood | Inflammation Mediators - metabolism | Receptors, LDL - deficiency | Aortic Diseases - prevention & control | Dendritic Cells - drug effects | Receptors, Lysosphingolipid - metabolism | Macrophages - immunology | Aortic Diseases - pathology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Atherosclerosis - immunology | Aortic Diseases - immunology | Aorta - drug effects | Aorta - immunology | Inflammation - immunology | Biomarkers - blood | Atherosclerosis - metabolism | Cardiovascular Agents - pharmacology | Mice, Knockout | Aorta - pathology | Endothelial Cells - immunology | Aortic Diseases - genetics | Animals | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Inflammation - genetics | Receptors, Lysosphingolipid - agonists | Macrophages - drug effects | Inflammation - prevention & control | Lymphopenia - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Macrophage Activation - drug effects | Atherosclerosis - prevention & control | CD4-Positive T-Lymphocytes - drug effects | Endothelial Cells - drug effects
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 569, Issue 7757, pp. 565 - 569
Journal Article