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Science, ISSN 0036-8075, 2/2012, Volume 335, Issue 6070, pp. 851 - 855
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1379 - 1387
Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive lipid mediator that regulates many processes in vertebrate development,... 
MEDICINE, RESEARCH & EXPERIMENTAL | SPHINGOSINE 1-PHOSPHATE RECEPTOR | ENDOTHELIAL-CELLS | KINASE 1 | IN-VIVO | TRANSPORTER SPNS2 | VASCULAR LEAK | MICE | PERSISTENT STAT3 ACTIVATION | LYMPHOCYTE EGRESS | FINGOLIMOD FTY720 | Receptors, Lysosphingolipid - antagonists & inhibitors | Humans | Cell Physiological Phenomena - physiology | Lysophospholipids - agonists | Neoplasms - blood | Propylene Glycols - therapeutic use | Sphingosine - agonists | Acute Lung Injury - drug therapy | Hematopoietic Stem Cell Mobilization | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Disease Models, Animal | Influenza, Human - metabolism | Lysophospholipids - antagonists & inhibitors | Cardiovascular Diseases - metabolism | Sphingosine - antagonists & inhibitors | Sphingosine - physiology | Fingolimod Hydrochloride | Receptors, Lysosphingolipid - physiology | Sphingolipids - metabolism | Neovascularization, Physiologic - physiology | Sphingosine - analogs & derivatives | Animals | Neurogenesis - physiology | Membrane Lipids - metabolism | Sphingosine - therapeutic use | Mice | Anemia, Sickle Cell - blood | Lysophospholipids - physiology | Multiple Sclerosis - drug therapy | Cellular signal transduction | Genetic aspects | Disease susceptibility | Health aspects | Sphingosine | Plasma | Pathogenesis | Lipids | Kinases | Metabolism | Phosphatase | Endothelium | Inflammatory bowel disease | Vertebrates | Metabolites | Rodents | Atherosclerosis | Ligands | Crystal structure | Review
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2006, Volume 2, Issue 8, pp. 434 - 441
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2009, Volume 158, Issue 5, pp. 1173 - 1182
FTY720 (fingolimod) is a first-in-class sphingosine 1-phosphate (S1P) receptor modulator that was highly effective in Phase II clinical trials for Multiple... 
Multiple Sclerosis | infection | FTY720 (fingolimod) | S1P (sphingosine 1-phosphate) | autoimmunity | immunotherapy | central nervous system | S1P (sphingosine 1‐phosphate) | Autoimmunity | Infection | Multiple sclerosis | Immunotherapy | Central nervous system | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | T-CELL SUBSETS | IMMUNOMODULATOR FTY720 | PHOSPHORYLATION | AGONISM IMPAIRS | SPHINGOSINE 1-PHOSPHATE RECEPTOR-1 | S1P | ENDOTHELIAL-CELLS | EGRESS | PHARMACOLOGY & PHARMACY | SECONDARY LYMPHOID-TISSUES | T-Lymphocytes - physiology | Phosphorylation | Receptors, Lysosphingolipid - antagonists & inhibitors | Lymph Nodes - pathology | Humans | Astrocytes - pathology | Encephalomyelitis, Autoimmune, Experimental - immunology | Astrocytes - immunology | Propylene Glycols - therapeutic use | Receptors, Lysosphingolipid - genetics | Propylene Glycols - pharmacology | Sphingosine - physiology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Fingolimod Hydrochloride | Phosphotransferases (Alcohol Group Acceptor) - genetics | Receptors, Lysosphingolipid - physiology | Inflammation - immunology | Lymph Nodes - immunology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Brain - drug effects | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | Gap Junctions - physiology | Immune System - drug effects | Multiple Sclerosis - immunology | Sphingosine - therapeutic use | Lysophospholipids - physiology | Multiple Sclerosis - drug therapy | Review
Journal Article
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Journal Article
Hepatology, ISSN 0270-9139, 01/2012, Volume 55, Issue 1, pp. 267 - 276
Journal Article