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Cancer and Metastasis Reviews, ISSN 0167-7659, 6/2012, Volume 31, Issue 1, pp. 295 - 321
Almost all human cancers display dysregulated expression and/or function of one or more receptor tyrosine kinases (RTKs). The strong causative association... 
Tyrosine kinase | Signaling | Biomedicine | Collagen | Oncology | Cancer Research | Extracellular matrix | Discoidin domain receptor | Metastasis | Biomedicine general | Cell migration | MATRIX-METALLOPROTEINASE | COLLAGEN-BINDING | ABL INHIBITORS IMATINIB | ACUTE MYELOID-LEUKEMIA | SOMATIC MUTATIONS | MUSCLE-CELL-MIGRATION | EPITHELIAL-MESENCHYMAL TRANSITION | LUNG-CANCER | ONCOLOGY | MAMMARY-GLAND DEVELOPMENT | COMPARATIVE GENOMIC HYBRIDIZATION | Protein Structure, Tertiary | Signal Transduction | Receptors, Mitogen - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Neoplasms - enzymology | Receptors, Mitogen - metabolism | Receptors, Mitogen - chemistry | Molecular Targeted Therapy | Receptor Protein-Tyrosine Kinases - metabolism | Disease Progression | Neoplasms - drug therapy | Collagen - metabolism | Discoidin Domain Receptors | Animals | Neoplasms - genetics | Receptor Protein-Tyrosine Kinases - genetics | Protein Binding | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Protein Processing, Post-Translational | Enzyme Activation | Mutation | Receptor Protein-Tyrosine Kinases - chemistry | Receptors, Mitogen - genetics | Tyrosine | Proteases | Oncology, Experimental | Phenols | Development and progression | Amino acids | Research | Phosphotransferases | Cells | Tumors | Cancer | discoidin domain receptor | signaling | metastasis | tyrosine kinase | collagen | cell migration | extracellular matrix
Journal Article
Immunity, ISSN 1074-7613, 04/2012, Volume 36, Issue 4, pp. 646 - 657
Journal Article
Matrix Biology, ISSN 0945-053X, 2007, Volume 26, Issue 3, pp. 146 - 155
Collagen-rich extracellular matrices are abundant and ubiquitous in the mammalian body. Collagens are not only essential for the mechanical stability of... 
Receptor tyrosine kinase | Integrin | Hemostasis | Collagen | Triple helix | Cell adhesion | triple helix | TYROSINE KINASE DDR1 | CRYSTAL-STRUCTURE | INTEGRIN ALPHA-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACROPHAGE MANNOSE RECEPTOR | collagen | hemostasis | HUMAN GLYCOPROTEIN-VI | VON-WILLEBRAND-FACTOR | CELL BIOLOGY | AMINO-ACID-SEQUENCE | cell adhesion | DISCOIDIN DOMAIN RECEPTOR | BINDING-SITE | receptor tyrosine kinase | integrin | I-DOMAIN | Mannose-Binding Lectins - metabolism | Receptors, Immunologic - chemistry | Integrins - chemistry | Platelet Membrane Glycoproteins - chemistry | Integrins - genetics | Collagen - chemistry | Lectins, C-Type - genetics | Integrins - metabolism | Lectins, C-Type - chemistry | Lectins, C-Type - metabolism | Discoidin Domain Receptors | Platelet Membrane Glycoproteins - metabolism | Receptors, Collagen - genetics | Receptors, Cell Surface - chemistry | Collagen - genetics | Receptors, Collagen - chemistry | Models, Molecular | Receptors, Cell Surface - metabolism | Platelet Membrane Glycoproteins - genetics | Receptors, Mitogen - metabolism | Receptors, Mitogen - chemistry | Receptor Protein-Tyrosine Kinases - metabolism | Mannose-Binding Lectins - chemistry | Collagen - metabolism | Receptors, Collagen - metabolism | Animals | Mannose-Binding Lectins - genetics | Receptor Protein-Tyrosine Kinases - genetics | Protein Conformation | Receptors, Immunologic - genetics | Receptor Protein-Tyrosine Kinases - chemistry | Receptors, Immunologic - metabolism | Receptors, Cell Surface - genetics | Receptors, Mitogen - genetics
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 9, pp. 4343 - 4355
A bacterial collagen-like protein Scl2 has been developed as a recombinant collagen model system to host human collagen ligand-binding sequences, with the goal... 
STREPTOCOCCUS-PYOGENES | PROTEIN | PEPTIDES | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SITES | TYROSINE KINASES | TRIPLE-HELICES | IDENTIFICATION | CLEAVAGE | DDR2 | Humans | Bacterial Proteins - chemistry | Collagen Type III - metabolism | Collagen - chemistry | Recombinant Fusion Proteins - metabolism | Discoidin Domain Receptors | HEK293 Cells | Protein Engineering | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Streptococcus pyogenes | Collagen - genetics | Protein Interaction Domains and Motifs | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Megakaryocytes - cytology | Megakaryocytes - metabolism | Binding Sites | Peptide Fragments - genetics | Peptide Fragments - metabolism | Immobilized Proteins - chemistry | Receptors, Mitogen - antagonists & inhibitors | Immobilized Proteins - genetics | Bacterial Proteins - genetics | Cells, Cultured | Collagen Type III - chemistry | Models, Molecular | Receptors, Mitogen - metabolism | Collagen Type III - genetics | Fetal Blood - cytology | Receptors, Mitogen - chemistry | Recombinant Fusion Proteins - chemistry | Receptor Protein-Tyrosine Kinases - metabolism | Collagen - metabolism | Peptide Fragments - chemistry | Receptor Protein-Tyrosine Kinases - genetics | Immobilized Proteins - metabolism | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Ligands | Receptor Protein-Tyrosine Kinases - chemistry | Cell Movement | Receptors, Mitogen - genetics | discoidin domain receptor | inhibition mechanism | triple-helix | collagen | peptides | binding | Glycobiology and Extracellular Matrices | recombinant protein expression | protein chimera
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 06/2014, Volume 426, Issue 13, pp. 2457 - 2470
The discoidin domain receptors (DDRs), DDR1 and DDR2, form a unique subfamily of receptor tyrosine kinases that are activated by the binding of triple-helical... 
crystallography | gleevec | drug design | phosphorylation | oncology | FIBROSIS | ACTIVATION | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-SURVIVAL | IDENTIFICATION | CANCER | DISCOVERY | INVASION | IMATINIB | STI-571 INHIBITION | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Molecular Sequence Data | Pyridazines - pharmacology | Discoidin Domain Receptors | Protein Kinase Inhibitors - chemistry | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Receptors, Collagen - genetics | Benzamides - pharmacology | Binding Sites | Receptors, Collagen - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Proto-Oncogene Proteins c-abl - genetics | Protein Structure, Secondary | Receptors, Mitogen - antagonists & inhibitors | Proto-Oncogene Proteins c-abl - chemistry | Models, Molecular | Imidazoles - pharmacology | Discoidin Domain Receptor 1 | Pyrimidines - pharmacology | Receptors, Mitogen - chemistry | Imatinib Mesylate | Piperazines - pharmacology | Receptors, Collagen - antagonists & inhibitors | Sequence Homology, Amino Acid | Receptor Protein-Tyrosine Kinases - genetics | Protein Kinase Inhibitors - pharmacology | Receptor Protein-Tyrosine Kinases - chemistry | Receptors, Mitogen - genetics | Memory (Computers) | Collagen | Atherosclerosis | Crystals | Development and progression | Drug resistance | Structure | Phosphotransferases | CML, chronic myeloid leukemia | KID, kinase insert domain | A-loop, activation loop | ITC, isothermal titration calorimetry | TCEP, tris(2-carboxyethyl)phosphine | DDR, discoidin domain receptor | TKI, tyrosine kinase inhibitor | RTKs, receptor tyrosine kinases | TrkB, tropomyosin-related kinase B | IGF1R, insulin-like growth factor 1 receptor
Journal Article