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Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 90, pp. 59 - 69
Abstract Delineation of mechanisms underlying the regulation of fibrosis-related genes in the heart is an important clinical goal as cardiac fibrosis is a... 
Cardiovascular | NF-κB | Cardiac fibroblasts | Collagen type I | Angiotensin II | p38 MAPK | Discoidin domain receptor 2 | P38 MAPK | TRANSCRIPTIONAL ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN-COUPLED RECEPTORS | DDR2 REGULATES PROLIFERATION | NECROSIS-FACTOR-ALPHA | TYROSINE KINASES | CELL BIOLOGY | NF-kappa B | HEPATIC STELLATE CELLS | MYOCARDIAL FIBROSIS | SMOOTH-MUSCLE-CELLS | NF-KAPPA-B | DEPENDENT ACTIVATION | Protein Kinase C - genetics | RNA, Small Interfering - genetics | Angiotensin II - genetics | Reactive Oxygen Species - metabolism | NADPH Oxidases - metabolism | Type C Phospholipases - metabolism | Male | NF-kappa B - metabolism | Discoidin Domain Receptors | Collagen Type I - genetics | Protein Kinase C - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Myocardium - metabolism | NADPH Oxidases - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Transcription, Genetic | p38 Mitogen-Activated Protein Kinases - metabolism | Fibroblasts - metabolism | Angiotensin II - pharmacology | Collagen Type I - metabolism | Angiotensin II - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Receptors, Mitogen - antagonists & inhibitors | Collagen Type I - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Receptors, Mitogen - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Rats, Sprague-Dawley | Myocardium - cytology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | NF-kappa B - genetics | Receptor Protein-Tyrosine Kinases - genetics | Fibroblasts - drug effects | Type C Phospholipases - genetics | Fibroblasts - cytology | Primary Cell Culture | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Receptors, Mitogen - genetics | Oxidases | Memory (Computers) | Analysis | Collagen | Genes | Angiotensin | Genetic research | Gene expression
Journal Article
Cancer and Metastasis Reviews, ISSN 0167-7659, 6/2012, Volume 31, Issue 1, pp. 295 - 321
Almost all human cancers display dysregulated expression and/or function of one or more receptor tyrosine kinases (RTKs). The strong causative association... 
Tyrosine kinase | Signaling | Biomedicine | Collagen | Oncology | Cancer Research | Extracellular matrix | Discoidin domain receptor | Metastasis | Biomedicine general | Cell migration | MATRIX-METALLOPROTEINASE | COLLAGEN-BINDING | ABL INHIBITORS IMATINIB | ACUTE MYELOID-LEUKEMIA | SOMATIC MUTATIONS | MUSCLE-CELL-MIGRATION | EPITHELIAL-MESENCHYMAL TRANSITION | LUNG-CANCER | ONCOLOGY | MAMMARY-GLAND DEVELOPMENT | COMPARATIVE GENOMIC HYBRIDIZATION | Protein Structure, Tertiary | Signal Transduction | Receptors, Mitogen - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Neoplasms - enzymology | Receptors, Mitogen - metabolism | Receptors, Mitogen - chemistry | Molecular Targeted Therapy | Receptor Protein-Tyrosine Kinases - metabolism | Disease Progression | Neoplasms - drug therapy | Collagen - metabolism | Discoidin Domain Receptors | Animals | Neoplasms - genetics | Receptor Protein-Tyrosine Kinases - genetics | Protein Binding | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Protein Processing, Post-Translational | Enzyme Activation | Mutation | Receptor Protein-Tyrosine Kinases - chemistry | Receptors, Mitogen - genetics | Tyrosine | Proteases | Oncology, Experimental | Phenols | Development and progression | Amino acids | Research | Phosphotransferases | Cells | Tumors | Cancer | discoidin domain receptor | signaling | metastasis | tyrosine kinase | collagen | cell migration | extracellular matrix
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 09/2013, Volume 73, Issue 17, pp. 5508 - 5518
The occurrence of inactivating mutations in SWI/SNF chromatin-remodeling genes in common cancers has attracted a great deal of interest. However, mechanistic... 
CELL LUNG-CANCER | ALK | ONCOLOGY | ADENOCARCINOMA | SENESCENCE | MUTATIONS | FUSIONS | DIFFERENTIATION | EXPRESSION | MEDULLOBLASTOMA | LINES | RNA, Small Interfering - genetics | Adenocarcinoma - pathology | Cell Proliferation | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Male | Immunoenzyme Techniques | Discoidin Domain Receptors | Cellular Senescence | Aged, 80 and over | Cell Differentiation | DNA Helicases - genetics | Carcinoma, Squamous Cell - therapy | Lung Neoplasms - therapy | Mutation - genetics | Blotting, Western | DNA Helicases - metabolism | Adenocarcinoma - therapy | Mice, Nude | Mice | Mice, Inbred BALB C | Carcinoma, Squamous Cell - genetics | Lung Neoplasms - pathology | Genes, Lethal | Kinesin - genetics | Adult | Female | Adenocarcinoma - genetics | Nuclear Proteins - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Transcription Factors - metabolism | Carcinoma, Non-Small-Cell Lung - therapy | Animals | Cell Cycle | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Nuclear Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | Aged | DNA Helicases - antagonists & inhibitors | Neoplasm Staging | Microscopy, Fluorescence | Apoptosis | Receptors, Mitogen - genetics
Journal Article
Immunity, ISSN 1074-7613, 04/2012, Volume 36, Issue 4, pp. 646 - 657
Journal Article
Journal Article
Matrix Biology, ISSN 0945-053X, 2007, Volume 26, Issue 3, pp. 146 - 155
Collagen-rich extracellular matrices are abundant and ubiquitous in the mammalian body. Collagens are not only essential for the mechanical stability of... 
Receptor tyrosine kinase | Integrin | Hemostasis | Collagen | Triple helix | Cell adhesion | triple helix | TYROSINE KINASE DDR1 | CRYSTAL-STRUCTURE | INTEGRIN ALPHA-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACROPHAGE MANNOSE RECEPTOR | collagen | hemostasis | HUMAN GLYCOPROTEIN-VI | VON-WILLEBRAND-FACTOR | CELL BIOLOGY | AMINO-ACID-SEQUENCE | cell adhesion | DISCOIDIN DOMAIN RECEPTOR | BINDING-SITE | receptor tyrosine kinase | integrin | I-DOMAIN | Mannose-Binding Lectins - metabolism | Receptors, Immunologic - chemistry | Integrins - chemistry | Platelet Membrane Glycoproteins - chemistry | Integrins - genetics | Collagen - chemistry | Lectins, C-Type - genetics | Integrins - metabolism | Lectins, C-Type - chemistry | Lectins, C-Type - metabolism | Discoidin Domain Receptors | Platelet Membrane Glycoproteins - metabolism | Receptors, Collagen - genetics | Receptors, Cell Surface - chemistry | Collagen - genetics | Receptors, Collagen - chemistry | Models, Molecular | Receptors, Cell Surface - metabolism | Platelet Membrane Glycoproteins - genetics | Receptors, Mitogen - metabolism | Receptors, Mitogen - chemistry | Receptor Protein-Tyrosine Kinases - metabolism | Mannose-Binding Lectins - chemistry | Collagen - metabolism | Receptors, Collagen - metabolism | Animals | Mannose-Binding Lectins - genetics | Receptor Protein-Tyrosine Kinases - genetics | Protein Conformation | Receptors, Immunologic - genetics | Receptor Protein-Tyrosine Kinases - chemistry | Receptors, Immunologic - metabolism | Receptors, Cell Surface - genetics | Receptors, Mitogen - genetics
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2011, Volume 286, Issue 15, pp. 12912 - 12923
Discoidin domain receptors (DDRs) DDR1 and DDR2 are receptor tyrosine kinases with the unique ability among receptor tyrosine kinases to respond to collagen.... 
MIGRATION | TO-MESENCHYMAL TRANSITION | STROMELYSIN-2 MMP-10 | HEPATIC STELLATE CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH-FACTORS | 2 ACTIVATION | EXTRACELLULAR-MATRIX | TYROSINE KINASES | MATRIX-METALLOPROTEINASE EXPRESSION | BETA INTEGRIN | MAP Kinase Signaling System - physiology | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Interleukin-1beta - genetics | Lung - cytology | Discoidin Domain Receptors | Collagen Type I - genetics | Interleukin-1beta - metabolism | Janus Kinase 2 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Lung - metabolism | Fibroblasts - metabolism | Matrix Metalloproteinase 10 - genetics | Collagen Type I - metabolism | Matrix Metalloproteinase 10 - biosynthesis | Mitogen-Activated Protein Kinase 3 - genetics | Janus Kinase 2 - genetics | Gene Expression Regulation - physiology | Gene Expression Regulation - drug effects | Receptors, Mitogen - biosynthesis | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Receptor Protein-Tyrosine Kinases - genetics | Lipopolysaccharides - pharmacology | Fibroblasts - cytology | Mitogen-Activated Protein Kinase 1 - metabolism | Receptors, Mitogen - genetics | Tyrosine-Protein Kinase (Tyrosine Kinase) | Primary Human Lung Fibroblasts | Polyoma Enhancer A-binding Protein | Signal Transduction | Discoidin Domain Receptor | Collagen | Fibroblast | Matrix Metalloproteinase
Journal Article