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1. Full Text Identification of a plant receptor for extracellular ATP
by Choi, Jeongmin and Tanaka, Kiwamu and Cao, Yangrong and Qi, Yue and Qiu, Jing and Liang, Yan and Lee, Sang Yeol and Stacey, Gary
Science, ISSN 0036-8075, 2014, Volume 343, Issue 6168, pp. 290 - 294
Extracellular adenosine 5'-triphosphate (ATP) is an essential signaling molecule that is perceived in mammals by plasma membrane P2-type purinoceptors. Similar... 
SIGNALING ROLE | PROTEIN | CLONING | MULTIDISCIPLINARY SCIENCES | GROWTH | GENES | POLLEN GERMINATION | ARABIDOPSIS | LECTINS | EXPRESSION | KINASES | Protein Kinases - metabolism | Stress, Physiological - physiology | Up-Regulation | Arabidopsis Proteins - genetics | Protein Kinases - genetics | Stress, Physiological - genetics | Receptors, Mitogen - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Adenosine Triphosphate - metabolism | Receptors, Purinergic P2 - genetics | Receptors, Purinergic P2 - metabolism | Gene Expression Regulation, Plant | Enzyme Activation | Mutation | Mitogen-Activated Protein Kinases - metabolism | Receptors, Mitogen - genetics | Signal transduction | Plasma | Plant growth | Kinases | Plant resistance | Adenosine triphosphatase
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2. Full Text C-type lectins in immunity: recent developments
by Dambuza, Ivy M and Brown, Gordon D
Current Opinion in Immunology, ISSN 0952-7915, 2016, Volume 32, pp. 21 - 27
Highlights • CLRs play an essential role in immunity to fungi and mycobacteria. • CLRs are involved in the regulation of homeostasis, autoimmunity and allergy.... 
Allergy and Immunology | FUNGAL BETA-GLUCANS | DAMAGED CELLS | CANDIDA-ALBICANS | DENDRITIC CELL-RECEPTOR | HOST-DEFENSE | AIRWAY INFLAMMATION | IMMUNOLOGY | HOUSE-DUST MITE | ANTIFUNGAL IMMUNITY | INNATE IMMUNITY | CORD FACTOR | Autoimmunity | Neoplasms - metabolism | Mycobacterium - immunology | Signal Transduction | Immunomodulation | Humans | Homeostasis | Hypersensitivity - immunology | Receptors, Mitogen - metabolism | Mycobacterium Infections - metabolism | Receptors, Mitogen - chemistry | Immunity | Mycobacterium Infections - immunology | Fungi - immunology | Lectins, C-Type - metabolism | Animals | Hypersensitivity - metabolism | Neoplasms - immunology | Mycoses - metabolism | Mycoses - immunology | Lectins
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3. Full Text The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis
by Zhang, Kun and Corsa, Callie A and Ponik, Suzanne M and Prior, Julie L and Piwnica-Worms, David and Eliceiri, Kevin W and Keely, Patricia J and Longmore, Gregory D
Nature Cell Biology, ISSN 1465-7392, 06/2013, Volume 15, Issue 6, pp. 677 - 687
Increased stromal collagen deposition in human breast tumours correlates with metastases. We show that activation of the collagen I receptor DDR2 (discoidin... 
DENSITY | CELLS | ACTIVATION | INHIBITION | PROTEIN | PHOSPHORYLATION | INTEGRIN | GSK-3-BETA | GENE-EXPRESSION | CELL BIOLOGY | Phosphorylation | Cell Proliferation | Humans | Cadherins - biosynthesis | Breast Neoplasms - metabolism | Discoidin Domain Receptors | Neoplasm Metastasis | RNA Interference | Epithelial-Mesenchymal Transition | HEK293 Cells | Carcinoma, Ductal, Breast - pathology | Female | Carcinoma, Ductal, Breast - metabolism | Snail Family Transcription Factors | Signal Transduction | Neoplasm Invasiveness | Receptors, Mitogen - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Transcription Factors - metabolism | Receptors, Collagen - metabolism | Animals | Receptor Protein-Tyrosine Kinases - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Mice | Mice, Inbred BALB C | RNA, Small Interfering | Cell Movement | Mitogen-Activated Protein Kinase 1 - metabolism | Receptors, Mitogen - genetics
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4. Full Text Molecular basis and functional significance of Angiotensin II-induced increase in Discoidin Domain Receptor 2 gene expression in cardiac fibroblasts
by George, Mereena and Vijayakumar, Anupama and Dhanesh, Sivadasan Bindu and James, Jackson and Shivakumar, K
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 90, pp. 59 - 69
Abstract Delineation of mechanisms underlying the regulation of fibrosis-related genes in the heart is an important clinical goal as cardiac fibrosis is a... 
Cardiovascular | NF-κB | Cardiac fibroblasts | Collagen type I | Angiotensin II | p38 MAPK | Discoidin domain receptor 2 | P38 MAPK | TRANSCRIPTIONAL ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN-COUPLED RECEPTORS | DDR2 REGULATES PROLIFERATION | NECROSIS-FACTOR-ALPHA | TYROSINE KINASES | CELL BIOLOGY | NF-kappa B | HEPATIC STELLATE CELLS | MYOCARDIAL FIBROSIS | SMOOTH-MUSCLE-CELLS | NF-KAPPA-B | DEPENDENT ACTIVATION | Protein Kinase C - genetics | RNA, Small Interfering - genetics | Angiotensin II - genetics | Reactive Oxygen Species - metabolism | NADPH Oxidases - metabolism | Type C Phospholipases - metabolism | Male | NF-kappa B - metabolism | Discoidin Domain Receptors | Collagen Type I - genetics | Protein Kinase C - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Myocardium - metabolism | NADPH Oxidases - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Transcription, Genetic | p38 Mitogen-Activated Protein Kinases - metabolism | Fibroblasts - metabolism | Angiotensin II - pharmacology | Collagen Type I - metabolism | Angiotensin II - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Receptors, Mitogen - antagonists & inhibitors | Collagen Type I - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Receptors, Mitogen - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Rats, Sprague-Dawley | Myocardium - cytology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | NF-kappa B - genetics | Receptor Protein-Tyrosine Kinases - genetics | Fibroblasts - drug effects | Type C Phospholipases - genetics | Fibroblasts - cytology | Primary Cell Culture | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Receptors, Mitogen - genetics | Oxidases | Memory (Computers) | Analysis | Collagen | Genes | Angiotensin | Genetic research | Gene expression
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5. Full Text Signalling through C-type lectin receptors: shaping immune responses
by Geijtenbeek, T.B.H and Gringhuis, S.I
Nature Reviews Immunology, ISSN 1474-1733, 2009, Volume 9, Issue 7, pp. 465 - 479
C-type lectin receptors (CLRs) expressed by dendritic cells are crucial for tailoring immune responses to pathogens. Following pathogen binding, CLRs trigger... 
GROWTH-FACTOR-BETA | HUMAN DENDRITIC CELLS | CYTOKINE PRODUCTION | DC-SIGN | IN-VIVO | DENGUE VIRUS-INFECTION | IMMUNOLOGY | MYELOID CELLS | NF-KAPPA-B | CD8(+) T-CELLS | CUTTING EDGE | Cytokines - metabolism | Dendritic Cells - immunology | Humans | Toll-Like Receptors - immunology | Lectins, C-Type - immunology | Receptors, Mitogen - metabolism | Antigen Presentation - immunology | Lectins, C-Type - metabolism | Signal Transduction - immunology | Animals | Receptors, Mitogen - immunology | Toll-Like Receptors - metabolism | Dendritic Cells - metabolism | Cytokines - immunology | Physiological aspects | Lectins | Cell receptors | Cellular signal transduction | Immune response | Research
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6. Full Text The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments
by Zhang, Jian-Guo and Czabotar, Peter E and Policheni, Antonia N and Caminschi, Irina and San Wan, Soo and Kitsoulis, Susie and Tullett, Kirsteen M and Robin, Adeline Y and Brammananth, Rajini and van Delft, Mark F and Lu, Jinhua and O'Reilly, Lorraine A and Josefsson, Emma C and Kile, Benjamin T and Chin, Wei Jin and Mintern, Justine D and Olshina, Maya A and Wong, Wilson and Baum, Jake and Wright, Mark D and Huang, David C.S and Mohandas, Narla and Coppel, Ross L and Colman, Peter M and Nicola, Nicos A and Shortman, Ken and Lahoud, Mireille H
Immunity, ISSN 1074-7613, 04/2012, Volume 36, Issue 4, pp. 646 - 657
The immune system must distinguish viable cells from cells damaged by physical and infective processes. The damaged cell-recognition molecule Clec9A is... 
TARGET | DOMAIN | PROTEIN | SPECTRIN | CLEC12A | CRYSTAL-STRUCTURE | MOUSE | LIGAND | IMMUNOLOGY | LECTIN-LIKE | ANTIGEN | Dendritic Cells - immunology | Humans | Actins - metabolism | Lectins, C-Type - genetics | Lectins, C-Type - chemistry | Lectins, C-Type - metabolism | Female | Cell Membrane - metabolism | Membrane Proteins - metabolism | Spectrin - metabolism | Binding Sites | Dendritic Cells - metabolism | Adaptive Immunity | Cell Line | Actin Cytoskeleton - metabolism | Protein Structure, Secondary | Mice, Inbred C57BL | Receptors, Mitogen - metabolism | Receptors, Mitogen - chemistry | Animals | Dendritic Cells - cytology | Mice | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Receptors, Mitogen - genetics | Dendritic cells | Developmental biology | Oncology, Experimental | Crystals | Cytoskeletal proteins | Research | Muscle proteins | Proteins | Stem cell research | Actin | Stem cells | Physiological aspects | Lectins | Universities and colleges | Structure | Cancer | Medical research | Cytoskeleton | Ligands | Councils | Apoptosis
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7. Full Text Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish
by Gemberling, Matthew and Gemberling, Matthew and Karra, Ravi and Karra, Ravi and Dickson, Amy L and Dickson, Amy L and Poss, Kenneth D and Poss, Kenneth D
eLife, ISSN 2050-084X, 04/2015, Volume 4, Issue 4
Heart regeneration is limited in adult mammals but occurs naturally in adult zebrafish through the activation of cardiomyocyte division. Several components of... 
cardiac hyperplasia | stem cells | heart regeneration | developmental biology | cardiomyocyte | epicardium | zebrafish | Neuregulin1 | NEUREGULIN RECEPTOR | IN-VITRO | REPAIR | CARDIAC MYOCYTES | ERBB2 | BIOLOGY | EPICARDIAL CELLS | PROLIFERATION | ADULT ZEBRAFISH | EXPRESSION | FIBROBLASTS | Cell Proliferation | Echocardiography | Signal Transduction | Zebrafish Proteins - metabolism | Heart - physiology | Hyperplasia | Mitogens - metabolism | Cardiomegaly - pathology | Myocardium - pathology | Myocytes, Cardiac - pathology | Regeneration | Animals | Myocardium - metabolism | Neuregulin-1 - metabolism | Myocytes, Cardiac - metabolism | Zebrafish - physiology | Heart Ventricles - pathology | Heart | Heart failure | Zebrafish | Cardiomyocytes | Experiments | ErbB-2 protein | Vascularization | Rodents | Stem cells | Cell cycle | Myocardium | Swimming | Heart diseases
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8. Full Text Identification of Distinct Ligands for the C-type Lectin Receptors Mincle and Dectin-2 in the Pathogenic Fungus Malassezia
by Ishikawa, Tetsuaki and Itoh, Fumie and Yoshida, Sayumi and Saijo, Shinobu and Matsuzawa, Tetsuhiro and Gonoi, Tohru and Saito, Takashi and Okawa, Yoshio and Shibata, Nobuyuki and Miyamoto, Tomofumi and Yamasaki, Sho
Cell Host & Microbe, ISSN 1931-3128, 04/2013, Volume 13, Issue 4, pp. 477 - 488
Various C-type lectin receptors (CLRs), including Mincle and Dectin-2, function as pattern recognition receptors and play a central role in immunity to fungal... 
MANNOSYLATION | PROTEIN | LIPOTEICHOIC ACID | RECOGNITION | MICROBIOLOGY | ACTIVATING RECEPTOR | CANDIDA-ALBICANS | VIROLOGY | IMMUNE-RESPONSES | INFLAMMATION | APOPTOTIC CELLS | MANNOSE | PARASITOLOGY | Mannose - immunology | Cytokines - metabolism | Mice, Inbred C57BL | Glycoproteins - metabolism | Lectins, C-Type - immunology | Membrane Proteins - immunology | Receptors, Mitogen - metabolism | Fungi - metabolism | Glycolipids - metabolism | Fungi - immunology | Lectins, C-Type - metabolism | Mannose - metabolism | Glycoproteins - immunology | Animals | Receptors, Mitogen - immunology | Glycolipids - immunology | Ligands | Membrane Proteins - metabolism | Mice | Malassezia - immunology | Malassezia - metabolism | Cytokines - immunology | Fungi | Lectins
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9. Full Text F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells
by Ahrens, Susan and Zelenay, Santiago and Sancho, David and Hanč, Pavel and Kjær, Svend and Feest, Christoph and Fletcher, Georgina and Durkin, Charlotte and Postigo, Antonio and Skehel, Mark and Batista, Facundo and Thompson, Barry and Way, Michael and Reis e Sousa, Caetano and Schulz, Oliver
Immunity, ISSN 1074-7613, 04/2012, Volume 36, Issue 4, pp. 635 - 645
Sterile inflammation can be initiated by innate immune recognition of markers of tissue injury termed damage-associated molecular patterns (DAMPs). DAMP... 
DANGER | IMMUNE-SYSTEM | C-TYPE LECTIN | DENDRITIC CELLS | MOVEMENT | CLEC9A | IMMUNOLOGY | INFLAMMATORY RESPONSE | T-Lymphocytes, Cytotoxic - immunology | Actin Cytoskeleton - metabolism | Saccharomyces cerevisiae - genetics | Humans | Actins - metabolism | Lectins, C-Type - immunology | Necrosis - metabolism | Receptors, Mitogen - metabolism | Saccharomyces cerevisiae Proteins - genetics | Immunity, Innate | Actins - genetics | Necrosis - immunology | Lectins, C-Type - metabolism | RNA Interference | Receptors, Mitogen - immunology | RNA, Small Interfering | HeLa Cells | Dendritic Cells - metabolism | Antigens | Dendritic cells | Actin | Lymphocytes | Analysis | Oncology, Experimental | Research | T cells | Cells | Cancer | Proteins | Medical research | Yeast | Insects | Microscopy | Ligands | Experiments | Immune system
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10. Full Text Discoidin domain receptor tyrosine kinases: new players in cancer progression
by Valiathan, Rajeshwari R and Marco, Marta and Leitinger, Birgit and Kleer, Celina G and Fridman, Rafael
Cancer and Metastasis Reviews, ISSN 0167-7659, 6/2012, Volume 31, Issue 1, pp. 295 - 321
Almost all human cancers display dysregulated expression and/or function of one or more receptor tyrosine kinases (RTKs). The strong causative association... 
Tyrosine kinase | Signaling | Biomedicine | Collagen | Oncology | Cancer Research | Extracellular matrix | Discoidin domain receptor | Metastasis | Biomedicine general | Cell migration | MATRIX-METALLOPROTEINASE | COLLAGEN-BINDING | ABL INHIBITORS IMATINIB | ACUTE MYELOID-LEUKEMIA | SOMATIC MUTATIONS | MUSCLE-CELL-MIGRATION | EPITHELIAL-MESENCHYMAL TRANSITION | LUNG-CANCER | ONCOLOGY | MAMMARY-GLAND DEVELOPMENT | COMPARATIVE GENOMIC HYBRIDIZATION | Protein Structure, Tertiary | Signal Transduction | Receptors, Mitogen - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Neoplasms - enzymology | Receptors, Mitogen - metabolism | Receptors, Mitogen - chemistry | Molecular Targeted Therapy | Receptor Protein-Tyrosine Kinases - metabolism | Disease Progression | Neoplasms - drug therapy | Collagen - metabolism | Discoidin Domain Receptors | Animals | Neoplasms - genetics | Receptor Protein-Tyrosine Kinases - genetics | Protein Binding | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Protein Processing, Post-Translational | Enzyme Activation | Mutation | Receptor Protein-Tyrosine Kinases - chemistry | Receptors, Mitogen - genetics | Tyrosine | Proteases | Oncology, Experimental | Phenols | Development and progression | Amino acids | Research | Phosphotransferases | Cells | Tumors | Cancer | discoidin domain receptor | signaling | metastasis | tyrosine kinase | collagen | cell migration | extracellular matrix
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