Brain Research, ISSN 0006-8993, 2015, Volume 1621, pp. 5 - 16
Abstract N -methyl- d -aspartate receptors (NMDARs) are known for their role in the induction of long-term potentiation (LTP). Here we start by reviewing the...
Neurology | N-methyl-d-aspartate receptors, NMDARs | Long-term potentiation, LTP | Short-term potentiation, STP | N-methyl-d-aspartate, NMDA | Long-term depression, LTD | Hippocampus | N-methyl-D-aspartate receptors, NMDARs | N-methyl-D-aspartate, NMDA | PATTERNED STIMULATION | SELECTIVE ANTAGONIST | COLLATERAL-COMMISSURAL PATHWAY | SYNAPTIC-TRANSMISSION | POSTSYNAPTIC RESPONSES | AREA CA1 | NEUROSCIENCES | SPINAL-CORD NEURONS | NMDA-RECEPTOR | ACID INDUCED DEPOLARIZATIONS | RAT HIPPOCAMPAL SLICES | Animals | Synapses - physiology | Humans | Long-Term Potentiation | Hippocampus - physiology | Receptors, N-Methyl-D-Aspartate - physiology | Memory - physiology | Physiological aspects | Amino acids | Research Report
Neurology | N-methyl-d-aspartate receptors, NMDARs | Long-term potentiation, LTP | Short-term potentiation, STP | N-methyl-d-aspartate, NMDA | Long-term depression, LTD | Hippocampus | N-methyl-D-aspartate receptors, NMDARs | N-methyl-D-aspartate, NMDA | PATTERNED STIMULATION | SELECTIVE ANTAGONIST | COLLATERAL-COMMISSURAL PATHWAY | SYNAPTIC-TRANSMISSION | POSTSYNAPTIC RESPONSES | AREA CA1 | NEUROSCIENCES | SPINAL-CORD NEURONS | NMDA-RECEPTOR | ACID INDUCED DEPOLARIZATIONS | RAT HIPPOCAMPAL SLICES | Animals | Synapses - physiology | Humans | Long-Term Potentiation | Hippocampus - physiology | Receptors, N-Methyl-D-Aspartate - physiology | Memory - physiology | Physiological aspects | Amino acids | Research Report
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 2013, Volume 33, Issue 44, pp. 17290 - 17300
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels that are critical to the regulation of excitatory synaptic function in the CNS. NMDARs...
NMDA RECEPTORS | MECHANISM | STEROIDS | MEMORY | SYNAPTIC-TRANSMISSION | PREGNENOLONE SULFATE | LONG-TERM POTENTIATION | 24-HYDROXYLASE | NEUROSCIENCES | OXYSTEROLS | REVEALS | Allosteric Regulation - drug effects | Rats, Long-Evans | Rats | Male | Cholesterol - metabolism | Hydroxycholesterols - pharmacology | Norsteroids - metabolism | Rats, Sprague-Dawley | Receptors, N-Methyl-D-Aspartate - physiology | Hippocampus - metabolism | Animals | Allosteric Regulation - physiology | Female | Hydroxycholesterols - metabolism | Norsteroids - pharmacology | Mice | Action Potentials - drug effects | Organ Culture Techniques
NMDA RECEPTORS | MECHANISM | STEROIDS | MEMORY | SYNAPTIC-TRANSMISSION | PREGNENOLONE SULFATE | LONG-TERM POTENTIATION | 24-HYDROXYLASE | NEUROSCIENCES | OXYSTEROLS | REVEALS | Allosteric Regulation - drug effects | Rats, Long-Evans | Rats | Male | Cholesterol - metabolism | Hydroxycholesterols - pharmacology | Norsteroids - metabolism | Rats, Sprague-Dawley | Receptors, N-Methyl-D-Aspartate - physiology | Hippocampus - metabolism | Animals | Allosteric Regulation - physiology | Female | Hydroxycholesterols - metabolism | Norsteroids - pharmacology | Mice | Action Potentials - drug effects | Organ Culture Techniques
Journal Article
Nature Neuroscience, ISSN 1097-6256, 02/2016, Volume 19, Issue 3, pp. 432 - 442
Overactivation of neuronal N-methyl-d-aspartate receptors (NMDARs) causes excitotoxicity and is necessary for neuronal death. In the classical view, these...
DENDRITIC SPINES | MK-801 | ACTIVATION | NEURONAL DEATH | LONG-TERM DEPRESSION | ACUTE STROKE | RELEASE | BLOOD-FLOW | HIPPOCAMPAL CA1 REGION | ISCHEMIC BRAIN-DAMAGE | NEUROSCIENCES | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Nerve Tissue Proteins - physiology | Calcium - metabolism | Connexins - physiology | Rats | Magnesium - pharmacology | Membrane Potentials - physiology | Receptors, N-Methyl-D-Aspartate - physiology | Stroke - physiopathology | Connexins - metabolism | N-Methylaspartate - pharmacology | Nerve Tissue Proteins - metabolism | Stroke - metabolism | Animals | Neuroprotective Agents - pharmacology | Cell Death - physiology | Neurons - physiology | Signal Transduction - physiology | Neurons - metabolism | src-Family Kinases - physiology | Dizocilpine Maleate - pharmacology | Methyl aspartate | Cell receptors | Neural circuitry | Genetic aspects | Cellular signal transduction | Properties | Health aspects
DENDRITIC SPINES | MK-801 | ACTIVATION | NEURONAL DEATH | LONG-TERM DEPRESSION | ACUTE STROKE | RELEASE | BLOOD-FLOW | HIPPOCAMPAL CA1 REGION | ISCHEMIC BRAIN-DAMAGE | NEUROSCIENCES | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Nerve Tissue Proteins - physiology | Calcium - metabolism | Connexins - physiology | Rats | Magnesium - pharmacology | Membrane Potentials - physiology | Receptors, N-Methyl-D-Aspartate - physiology | Stroke - physiopathology | Connexins - metabolism | N-Methylaspartate - pharmacology | Nerve Tissue Proteins - metabolism | Stroke - metabolism | Animals | Neuroprotective Agents - pharmacology | Cell Death - physiology | Neurons - physiology | Signal Transduction - physiology | Neurons - metabolism | src-Family Kinases - physiology | Dizocilpine Maleate - pharmacology | Methyl aspartate | Cell receptors | Neural circuitry | Genetic aspects | Cellular signal transduction | Properties | Health aspects
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 03/2010, Volume 77, Issue 3, pp. 317 - 326
Dopamine D2 receptor blockade has been an obligate mechanism of action present in all medications that effectively treat positive symptoms of schizophrenia (e....
HEMODYNAMIC-RESPONSE | POSITIVE ALLOSTERIC MODULATOR | GENERALIZED ANXIETY DISORDER | SELECTIVE INHIBITOR | GLYCINE TRANSPORT | ANTIPSYCHOTIC-DRUGS | PREPULSE INHIBITION DEFICIT | PHARMACOLOGY & PHARMACY | CORTICAL DYSFUNCTION | HALLUCINOGENIC DRUG | RAT PREFRONTAL CORTEX | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Synaptic Potentials - physiology | Schizophrenia - metabolism | Receptors, AMPA - physiology | Humans | Nerve Net - drug effects | Nerve Net - physiology | Receptors, N-Methyl-D-Aspartate - physiology | Frontal Lobe - physiology | Interneurons - pathology | Animals | Interneurons - metabolism | Receptors, AMPA - agonists | Schizophrenia - physiopathology | Frontal Lobe - drug effects | Receptors, N-Methyl-D-Aspartate - agonists | Schizophrenia - drug therapy | Receptors, AMPA - antagonists & inhibitors
HEMODYNAMIC-RESPONSE | POSITIVE ALLOSTERIC MODULATOR | GENERALIZED ANXIETY DISORDER | SELECTIVE INHIBITOR | GLYCINE TRANSPORT | ANTIPSYCHOTIC-DRUGS | PREPULSE INHIBITION DEFICIT | PHARMACOLOGY & PHARMACY | CORTICAL DYSFUNCTION | HALLUCINOGENIC DRUG | RAT PREFRONTAL CORTEX | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Synaptic Potentials - physiology | Schizophrenia - metabolism | Receptors, AMPA - physiology | Humans | Nerve Net - drug effects | Nerve Net - physiology | Receptors, N-Methyl-D-Aspartate - physiology | Frontal Lobe - physiology | Interneurons - pathology | Animals | Interneurons - metabolism | Receptors, AMPA - agonists | Schizophrenia - physiopathology | Frontal Lobe - drug effects | Receptors, N-Methyl-D-Aspartate - agonists | Schizophrenia - drug therapy | Receptors, AMPA - antagonists & inhibitors
Journal Article
Toxicological Sciences, ISSN 1096-6080, 02/2013, Volume 131, Issue 2, pp. 548 - 557
Ketamine, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, is frequently used in pediatric general anesthesia. Accumulating evidence from...
l-Carnitine | Reactive oxygen species | Ketamine | NMDA receptor | Calcium influx | EARLY EXPOSURE | calcium influx | INDUCED CORTICAL APOPTOSIS | NICOTINIC ACETYLCHOLINE-RECEPTORS | HIPPOCAMPAL-NEURONS | CELL-DEATH | CYTOCHROME-C-OXIDASE | GLUTAMATE RECEPTORS | ketamine | reactive oxygen species | NITRIC-OXIDE | TOXICOLOGY | l-carnitine | BRAIN | Immunohistochemistry | Enzyme-Linked Immunosorbent Assay | Oxidation-Reduction | Calcium - metabolism | Rats | Comet Assay | Receptors, N-Methyl-D-Aspartate - physiology | Blotting, Western | Prosencephalon - drug effects | Animals | Prosencephalon - cytology | Ketamine - pharmacology | Neurons - drug effects | Prosencephalon - physiopathology | Index Medicus
l-Carnitine | Reactive oxygen species | Ketamine | NMDA receptor | Calcium influx | EARLY EXPOSURE | calcium influx | INDUCED CORTICAL APOPTOSIS | NICOTINIC ACETYLCHOLINE-RECEPTORS | HIPPOCAMPAL-NEURONS | CELL-DEATH | CYTOCHROME-C-OXIDASE | GLUTAMATE RECEPTORS | ketamine | reactive oxygen species | NITRIC-OXIDE | TOXICOLOGY | l-carnitine | BRAIN | Immunohistochemistry | Enzyme-Linked Immunosorbent Assay | Oxidation-Reduction | Calcium - metabolism | Rats | Comet Assay | Receptors, N-Methyl-D-Aspartate - physiology | Blotting, Western | Prosencephalon - drug effects | Animals | Prosencephalon - cytology | Ketamine - pharmacology | Neurons - drug effects | Prosencephalon - physiopathology | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 9, pp. 7558 - 7566
NMDA receptors (NMDARs), fundamental to learning and memory and implicated in certain neurological disorders, are heterotetrameric complexes composed of two...
IN-VITRO | BIOCHEMISTRY & MOLECULAR BIOLOGY | RAT CORTICAL-NEURONS | NR2D SUBUNITS | LONG-TERM POTENTIATION | SUBUNIT COMPOSITION | EPSILON-1 SUBUNIT | MICE LACKING | SYNAPTIC NMDA RECEPTORS | FUNCTIONAL-PROPERTIES | DIFFERENTIAL ROLES | Age Factors | CA1 Region, Hippocampal - physiology | Synapses - physiology | CA3 Region, Hippocampal - physiology | Mice, Inbred C57BL | Genotype | Reaction Time - physiology | Magnesium - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Receptors, N-Methyl-D-Aspartate - physiology | Receptors, N-Methyl-D-Aspartate - genetics | Excitatory Postsynaptic Potentials - physiology | Animals | Piperidines - pharmacology | Dentate Gyrus - physiology | Mice, Mutant Strains | Mice | Protein Subunits - physiology | Hippocampus - physiology | Brain | Receptor Regulation | Neuron | NMDA Receptor Subtype | Glutamate Receptors Ionotropic (AMPA, NMDA) | Postnatal Development | Neurobiology | Gene Knock-out | Triheteromeric | Kinetics | Synaptic Transmission
IN-VITRO | BIOCHEMISTRY & MOLECULAR BIOLOGY | RAT CORTICAL-NEURONS | NR2D SUBUNITS | LONG-TERM POTENTIATION | SUBUNIT COMPOSITION | EPSILON-1 SUBUNIT | MICE LACKING | SYNAPTIC NMDA RECEPTORS | FUNCTIONAL-PROPERTIES | DIFFERENTIAL ROLES | Age Factors | CA1 Region, Hippocampal - physiology | Synapses - physiology | CA3 Region, Hippocampal - physiology | Mice, Inbred C57BL | Genotype | Reaction Time - physiology | Magnesium - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Receptors, N-Methyl-D-Aspartate - physiology | Receptors, N-Methyl-D-Aspartate - genetics | Excitatory Postsynaptic Potentials - physiology | Animals | Piperidines - pharmacology | Dentate Gyrus - physiology | Mice, Mutant Strains | Mice | Protein Subunits - physiology | Hippocampus - physiology | Brain | Receptor Regulation | Neuron | NMDA Receptor Subtype | Glutamate Receptors Ionotropic (AMPA, NMDA) | Postnatal Development | Neurobiology | Gene Knock-out | Triheteromeric | Kinetics | Synaptic Transmission
Journal Article
Progress in Neurobiology, ISSN 0301-0082, 03/2012, Volume 96, Issue 3, pp. 283 - 303
â–º The water maze can detect a progressive decline in cognition during aging. â–º Dysregulation of Ca homeostasis modifies the threshold for synaptic plasticity....
Aging | Incremental learning | Episodic memory | Long-term potentiation | HIPPOCAMPAL CA1 NEURONS | NMDA RECEPTORS | MORRIS WATER MAZE | NEUROSCIENCES | AGING-RELATED CHANGES | COGNITIVE DECLINE | INDIVIDUAL-DIFFERENCES | FIMBRIA-FORNIX LESIONS | DENTATE GYRUS | WORKING-MEMORY | Memory Disorders - physiopathology | Calcium Channels - physiology | Animals | Humans | Memory Disorders - metabolism | Receptors, N-Methyl-D-Aspartate - physiology | Aging - pathology | Disease Models, Animal | episodic memory | aging | incremental learning | long-term potentiation
Aging | Incremental learning | Episodic memory | Long-term potentiation | HIPPOCAMPAL CA1 NEURONS | NMDA RECEPTORS | MORRIS WATER MAZE | NEUROSCIENCES | AGING-RELATED CHANGES | COGNITIVE DECLINE | INDIVIDUAL-DIFFERENCES | FIMBRIA-FORNIX LESIONS | DENTATE GYRUS | WORKING-MEMORY | Memory Disorders - physiopathology | Calcium Channels - physiology | Animals | Humans | Memory Disorders - metabolism | Receptors, N-Methyl-D-Aspartate - physiology | Aging - pathology | Disease Models, Animal | episodic memory | aging | incremental learning | long-term potentiation
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2015, Volume 79, Issue 9, pp. 716 - 726
Abstract N -methyl-D-aspartate receptor (NMDAR) hypofunction in parvalbumin-expressing (PV+) inhibitory neurons (INs) may contribute to symptoms in patients...
Psychiatry | Schizophrenia | Gamma oscillations | Inhibition | Parvalbumin | Computational models | NMDA hypofunction | DORSOLATERAL PREFRONTAL CORTEX | ANTERIOR CINGULATE CORTEX | FAST NETWORK OSCILLATIONS | MESSENGER-RNA EXPRESSION | INHIBITORY NEURONS | NEUROSCIENCES | PARVALBUMIN-IMMUNOREACTIVE NEURONS | AUDITORY-CORTEX | GENE-EXPRESSION | CORTICAL OSCILLATIONS | GABAERGIC NEURONS | Gamma Rhythm | Interneurons - physiology | Humans | Parvalbumins - metabolism | GABAergic Neurons - physiology | Electroencephalography | Receptors, N-Methyl-D-Aspartate - physiology | Cerebral Cortex - physiopathology | Receptors, N-Methyl-D-Aspartate - genetics | gamma-Aminobutyric Acid - physiology | Action Potentials | Animals | Interneurons - metabolism | Schizophrenia - physiopathology | GABAergic Neurons - metabolism | Models, Neurological | Methyl aspartate | Aspartate | Models | Analysis
Psychiatry | Schizophrenia | Gamma oscillations | Inhibition | Parvalbumin | Computational models | NMDA hypofunction | DORSOLATERAL PREFRONTAL CORTEX | ANTERIOR CINGULATE CORTEX | FAST NETWORK OSCILLATIONS | MESSENGER-RNA EXPRESSION | INHIBITORY NEURONS | NEUROSCIENCES | PARVALBUMIN-IMMUNOREACTIVE NEURONS | AUDITORY-CORTEX | GENE-EXPRESSION | CORTICAL OSCILLATIONS | GABAERGIC NEURONS | Gamma Rhythm | Interneurons - physiology | Humans | Parvalbumins - metabolism | GABAergic Neurons - physiology | Electroencephalography | Receptors, N-Methyl-D-Aspartate - physiology | Cerebral Cortex - physiopathology | Receptors, N-Methyl-D-Aspartate - genetics | gamma-Aminobutyric Acid - physiology | Action Potentials | Animals | Interneurons - metabolism | Schizophrenia - physiopathology | GABAergic Neurons - metabolism | Models, Neurological | Methyl aspartate | Aspartate | Models | Analysis
Journal Article
Brain Research Bulletin, ISSN 0361-9230, 2010, Volume 83, Issue 3, pp. 108 - 121
Abstract Schizophrenia is a severe mental disorder associated with a characteristic constellation of symptoms and neurocognitive deficits. At present,...
Neurology | Auditory | Schizophrenia | Review | Glutamate | NMDA receptor | Glycine | d-Serine | Visual | D-Serine | STRIATAL DOPAMINE RELEASE | GLYCINE TRANSPORT INHIBITORS | MISMATCH NEGATIVITY GENERATION | WORKING-MEMORY IMPAIRMENTS | NEUROSCIENCES | PREFRONTAL CORTEX | POSITRON-EMISSION-TOMOGRAPHY | AMINO-ACID OXIDASE | LONG-TERM POTENTIATION | HEALTHY-VOLUNTEERS | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Excitatory Amino Acid Antagonists - therapeutic use | Schizophrenia - metabolism | Humans | Sensation Disorders - etiology | Schizophrenia - complications | Schizophrenia - pathology | Learning Disorders - etiology | Receptors, N-Methyl-D-Aspartate - physiology | Brain - metabolism | Memory Disorders - etiology | Models, Biological | Cognition Disorders - etiology | Brain - pathology | Schizophrenia - drug therapy | Allosteric properties | D-serine | glycine | auditory | review | visual | glutamate
Neurology | Auditory | Schizophrenia | Review | Glutamate | NMDA receptor | Glycine | d-Serine | Visual | D-Serine | STRIATAL DOPAMINE RELEASE | GLYCINE TRANSPORT INHIBITORS | MISMATCH NEGATIVITY GENERATION | WORKING-MEMORY IMPAIRMENTS | NEUROSCIENCES | PREFRONTAL CORTEX | POSITRON-EMISSION-TOMOGRAPHY | AMINO-ACID OXIDASE | LONG-TERM POTENTIATION | HEALTHY-VOLUNTEERS | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Excitatory Amino Acid Antagonists - therapeutic use | Schizophrenia - metabolism | Humans | Sensation Disorders - etiology | Schizophrenia - complications | Schizophrenia - pathology | Learning Disorders - etiology | Receptors, N-Methyl-D-Aspartate - physiology | Brain - metabolism | Memory Disorders - etiology | Models, Biological | Cognition Disorders - etiology | Brain - pathology | Schizophrenia - drug therapy | Allosteric properties | D-serine | glycine | auditory | review | visual | glutamate
Journal Article