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2010, 1st ed., Current topics in developmental biology, ISBN 0123809142, Volume 92., xvi, 530 p., [24] p. of plates
Notch signaling is an evolutionarily conserved pathway in multicellular organisms that regulates cell-fate determination during development and in stem cells.... 
Notch proteins | Notch genes | Cellular signal transduction | Pre-clinical Medicine: Basic Sciences
Book
2014, Methods in molecular biology, ISBN 1493911384, Volume 1187.
Web Resource
2014, Methods in molecular biology, ISBN 1493911384, Volume 1187.
Web Resource
Journal Article
Circulation Research, ISSN 0009-7330, 03/2008, Volume 102, Issue 6, pp. 661 - 668
Notch signaling regulates smooth muscle cell phenotype and is critical for vascular development. One Notch target is smooth muscle α-actin (SMA), a... 
Signaling pathways | Smooth muscle α-actin | Endothelial cells | Vascular smooth muscle cells | VASCULAR DEVELOPMENT | APOPTOSIS | endothelial cells | CARDIAC & CARDIOVASCULAR SYSTEMS | RBP-J-KAPPA | smooth muscle | DEPENDENT PATHWAY | PROMOTER ANALYSIS | alpha-actin | IN-VITRO | signaling pathways | GENE | SIGNALING PATHWAY | GROWTH | CELL DIFFERENTIATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | vascular smooth muscle cells | Up-Regulation | Muscle, Smooth, Vascular - metabolism | Receptors, Notch - metabolism | Coculture Techniques | Humans | Actins - metabolism | Receptors, Notch - genetics | RNA, Messenger - metabolism | Actins - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Cell Cycle Proteins - genetics | Transcription, Genetic | Cell Differentiation | Myocytes, Smooth Muscle - drug effects | Hydroxamic Acids - pharmacology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Myocytes, Smooth Muscle - metabolism | Muscle, Smooth, Vascular - drug effects | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Promoter Regions, Genetic | Basic Helix-Loop-Helix Transcription Factors - genetics | Transduction, Genetic | Endothelial Cells - metabolism | Myocytes, Smooth Muscle - enzymology | Cell Cycle Proteins - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Receptor, Notch2 - metabolism | Histone Deacetylases - metabolism | Receptor, Notch1 - metabolism | Receptors, Notch - chemistry | Signal Transduction - drug effects | Protein Binding | Histone Deacetylase Inhibitors | Muscle, Smooth, Vascular - enzymology | Receptor, Notch4 | Index Medicus | smooth muscle α-actin
Journal Article
2010, 1st ed., Current topics in developmental biology, ISBN 9780123809148, Volume 92.
Web Resource
The EMBO Journal, ISSN 0261-4189, 10/2015, Volume 34, Issue 20, pp. 2489 - 2491
The self‐renewal and differentiation of tissue stem cells must be tightly controlled. Unrestrained self‐renewal leads to over‐proliferation of stem cells,... 
RENEWAL | STEM-CELLS | INTESTINE | LGR5 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Pyloric Antrum - cytology | Animals | Receptors, G-Protein-Coupled - metabolism | Receptors, Notch - metabolism | Homeostasis - physiology | Signal Transduction - physiology | Stem Cells - metabolism | Stem cells | Index Medicus | Views
Journal Article
Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7392, pp. 110 - 114
Developing tissues and growing tumours produce vascular endothelial growth factors (VEGFs), leading to the activation of the corresponding receptors in... 
TIP CELL-FORMATION | DLL4 | ACTIVATION | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | GROWTH | NETWORK FORMATION | KINASE INHIBITORS | TUMOR ANGIOGENESIS | EXPRESSION | Human Umbilical Vein Endothelial Cells | Neovascularization, Physiologic - drug effects | Up-Regulation | Vascular Endothelial Growth Factor Receptor-3 - biosynthesis | Receptors, Notch - metabolism | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | Intracellular Signaling Peptides and Proteins - deficiency | Membrane Proteins - deficiency | Receptors, Notch - antagonists & inhibitors | HEK293 Cells | Female | Transcription, Genetic | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Endothelial Cells - metabolism | Membrane Proteins - genetics | Vascular Endothelial Growth Factor Receptor-2 - deficiency | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Neovascularization, Physiologic - physiology | Animals | Signal Transduction - drug effects | Endothelial Cells - cytology | Models, Biological | Mice | Protein Kinase Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Cellular control mechanisms | Physiological aspects | Growth factor receptors | Neovascularization | Research | Vascular endothelial growth factor | Endothelium | Angiogenesis | Ligands | Kinases | Rodents | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7291, pp. 1052 - 1057
The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to... 
B-CELLS | ANTI-P185HER2 ANTIBODY | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | REGULATORY REGION | MALIGNANT-MELANOMA | MUTATIONS | LEUKEMIA | GAMMA-SECRETASE | CANCER-THERAPY | INHIBITS TUMOR-GROWTH | Angiogenesis Inhibitors - immunology | Neoplasms - metabolism | NIH 3T3 Cells | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Receptor, Notch2 - antagonists & inhibitors | Receptors, Notch - metabolism | Humans | Goblet Cells - drug effects | Receptors, Notch - genetics | Peptide Library | Receptors, Notch - antagonists & inhibitors | Antibody Specificity - immunology | Angiogenesis Inhibitors - therapeutic use | Antibodies - immunology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Antibodies - therapeutic use | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Angiogenesis Inhibitors - pharmacology | Receptor, Notch1 - immunology | Neoplasms - blood supply | Receptor, Notch2 - immunology | Antibodies - adverse effects | Neoplasms - drug therapy | Antibodies - pharmacology | Animals | Signal Transduction - drug effects | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Goblet Cells - pathology | Receptor, Notch1 - antagonists & inhibitors | Neoplasms - pathology | Receptors, Notch - immunology | Viral antibodies | Proteases | Proteolysis | Physiological aspects | Antibodies | Research | Properties | Membrane proteins | Cell growth | Cell cycle | Cancer | Crystal structure | Apoptosis | Receptors | Inhibitors | Toxicity | Notches | Mathematical models | Inhibition | Signalling | Diseases | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2011, Volume 121, Issue 4, pp. 1373 - 1385
Journal Article
Journal Article
Cell Stem Cell, ISSN 1934-5909, 07/2014, Volume 15, Issue 1, pp. 51 - 65
Journal Article
1994, Molecular biology intelligence unit (Unnumbered), ISBN 9781570591570, 121
Book
2012, 1. Aufl., Advances in experimental medicine and biology, ISBN 1461408989, Volume 727., xxi, 328
"The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and... 
Cellular signal transduction | Embryology | Notch proteins | Cancer | Embryology, Human
Book