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Cancer Research, ISSN 0008-5472, 03/2009, Volume 69, Issue 6, pp. 2400 - 2407
Despite rapid advances in many fronts, pancreatic cancer (PC) remains one of the most difficult human malignancies to treat due, in part, to de novo and... 
TARGET | STEM-CELLS | GROWTH INHIBITION | INVASION | TUMOR PROGRESSION | ONCOLOGY | PROSTATE-CANCER | TAMOXIFEN RESISTANCE | DOWN-REGULATION | E-CADHERIN | NF-KAPPA-B | RNA, Small Interfering - genetics | Pancreatic Neoplasms - metabolism | Receptors, Notch - metabolism | Humans | Deoxycytidine - pharmacology | Drug Resistance, Neoplasm | Intercellular Signaling Peptides and Proteins - biosynthesis | NF-kappa B - metabolism | Receptor, Notch2 - genetics | Receptors, Notch - genetics | Proto-Oncogene Proteins - biosynthesis | Cell Movement - physiology | Pancreatic Neoplasms - drug therapy | Intercellular Signaling Peptides and Proteins - metabolism | Transfection | Receptors, Notch - biosynthesis | Serrate-Jagged Proteins | Antimetabolites, Antineoplastic - pharmacology | Membrane Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Calcium-Binding Proteins - biosynthesis | Signal Transduction | Membrane Proteins - genetics | Down-Regulation | Pancreatic Neoplasms - pathology | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Epithelial Cells - pathology | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Membrane Proteins - biosynthesis | Phenotype | Receptor, Notch2 - biosynthesis | Mesoderm - pathology | RNA, Messenger | Deoxycytidine - analogs & derivatives | Receptor, Notch4 | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 04/2008, Volume 58, Issue 1, pp. 52 - 64
Expression of the Notch effector gene is required for maintenance of neural progenitors in the embryonic brain, but persistent and high levels of expression... 
STEMCELL | DEVBIO | MOLNEURO | STEM-CELLS | MAMMALIAN HAIRY | DELTA-HOMOLOG | LOOP-HELIX FACTORS | NEGATIVE AUTOREGULATION | HES1 EXPRESSION | CENTRAL-NERVOUS-SYSTEM | SOMITE SEGMENTATION | PRESOMITIC MESODERM | NEUROSCIENCES | FEEDBACK LOOP | Transcription Factor HES-1 | Intercellular Signaling Peptides and Proteins - biosynthesis | Neurons - cytology | Receptors, Notch - genetics | Stem Cells - cytology | Intercellular Signaling Peptides and Proteins - physiology | Receptors, Notch - biosynthesis | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Nerve Tissue Proteins - biosynthesis | Neurons - physiology | Female | Cell Differentiation - physiology | Basic Helix-Loop-Helix Transcription Factors - physiology | Nerve Tissue Proteins - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Homeodomain Proteins - biosynthesis | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Receptors, Notch - physiology | Mice, Transgenic | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Pregnancy | Animals | Biological Clocks - physiology | Signal Transduction - physiology | Stem Cells - physiology | Mice | Homeodomain Proteins - physiology | Heparan sulfate | Proteins | Signal transduction | Rodents | Cell division | Ligands | Protein expression | Genomes | Gene expression
Journal Article
Cancer Research, ISSN 0008-5472, 09/2011, Volume 71, Issue 18, pp. 6061 - 6072
One important function of endothelial cells in glioblastoma multiforme (GBM) is to create a niche that helps promote self-renewal of cancer stem-like cells... 
INITIATING CELLS | DLL4 | ANGIOGENESIS | ONCOLOGY | VASCULAR NICHE | NEUROGENESIS | CENTRAL-NERVOUS-SYSTEM | SUBVENTRICULAR ZONE | PERIVASCULAR NICHE | INHIBITS TUMOR-GROWTH | BRAIN-TUMORS | RNA, Small Interfering - genetics | Nestin | Receptors, Notch - metabolism | Humans | Brain Neoplasms - pathology | Glycoproteins - metabolism | Cell Growth Processes - physiology | Intercellular Signaling Peptides and Proteins - biosynthesis | Receptors, Notch - genetics | Brain Neoplasms - metabolism | Antigens, CD - metabolism | Gene Knockdown Techniques | Membrane Proteins - deficiency | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Receptors, Notch - biosynthesis | Serrate-Jagged Proteins | Neoplastic Stem Cells - pathology | Glioblastoma - metabolism | Intercellular Signaling Peptides and Proteins - deficiency | Receptors, Notch - deficiency | Calcium-Binding Proteins - biosynthesis | Stem Cell Niche | Endothelial Cells - metabolism | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Calcium-Binding Proteins - deficiency | AC133 Antigen | Nerve Tissue Proteins - metabolism | Xenograft Model Antitumor Assays | Membrane Proteins - biosynthesis | Animals | Glioblastoma - pathology | Mice | Endothelial Cells - pathology | RNA, Small Interfering - administration & dosage | Intermediate Filament Proteins - metabolism | Calcium-Binding Proteins - genetics | Notch ligand | Endothelial cell | niche | glioblastoma | cancer stem cell
Journal Article
Circulation Research, ISSN 0009-7330, 05/2017, Volume 120, Issue 11, pp. 1727 - 1739
Journal Article
Journal Article
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 04/2014, Volume 25, Issue 8, pp. 1338 - 1354
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 07/2017, Volume 121, Issue 5, pp. 549 - 563
Journal Article