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Development (Cambridge), ISSN 1477-9129, 2017, Volume 144, Issue 10, pp. 1743 - 1763
Notch signaling regulates a vast array of crucial developmental processes. It is therefore not surprising that mutations in genes encoding Notch receptors or ligands lead to a variety of congenital disorders in humans... 
Development | Genetics | CADASIL | Adams-Oliver syndrome | Alagille | Notch | JAGGED1 JAG1 MUTATIONS | HOMOZYGOUS CADASIL PATIENT | INTRAHEPATIC BILE-DUCTS | MATCHED HETEROZYGOUS PATIENTS | POLYCYSTIC KIDNEY SYNDROME | DEVELOPMENTAL BIOLOGY | OF-FUNCTION MUTATIONS | HAJDU-CHENEY-SYNDROME | PROMOTES VASCULAR MATURATION | AUTOSOMAL-DOMINANT ARTERIOPATHY | ADAMS-OLIVER-SYNDROME | Limb Deformities, Congenital - genetics | Genetic Diseases, Inborn - embryology | Ectodermal Dysplasia - embryology | Humans | Genetic Diseases, Inborn - genetics | Hernia, Diaphragmatic - embryology | Hernia, Diaphragmatic - genetics | Receptors, Notch - genetics | Limb Deformities, Congenital - embryology | Hajdu-Cheney Syndrome - embryology | Meningocele - embryology | Scalp Dermatoses - embryology | Abnormalities, Multiple - embryology | Alagille Syndrome - embryology | Hajdu-Cheney Syndrome - genetics | Alagille Syndrome - genetics | Animals | Ectodermal Dysplasia - genetics | Scalp Dermatoses - genetics | Developmental Biology | Meningocele - genetics | Scalp Dermatoses - congenital | Abnormalities, Multiple - genetics | Fibula | Congenital diseases | Alagille syndrome | Polycystic kidney | Developmental biology | Ligands | Dysostosis | Meninges | Genomes | Notch protein | Mutation
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 2016, Volume 127, Issue 1, pp. 137 - 152
Journal Article
Nature cell biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 278 - 285
The Notch signalling pathway has a crucial function in determining cell fates in multiple tissues within metazoan organisms(1... 
COACTIVATOR | PROTEIN | DROSOPHILA MASTERMIND | PHOSPHORYLATION | PATHWAY | HOMOLOG | DIFFERENTIATION | NLK | RECEPTORS | EXPRESSION | CELL BIOLOGY | Phosphorylation - physiology | Xenopus | RNA, Small Interfering - genetics | ELAV-Like Protein 3 | Transcription Factor HES-1 | Protein Interaction Domains and Motifs - physiology | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Humans | Embryo, Nonmammalian - metabolism | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Transfection | Basic Helix-Loop-Helix Transcription Factors - metabolism | Nuclear Proteins - genetics | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Zebrafish Proteins - metabolism | ELAV Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Gene Expression Regulation - physiology | Nuclear Proteins - metabolism | Zebrafish | DNA - metabolism | Receptor, Notch1 - metabolism | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Oligonucleotides, Antisense - genetics | Amino Acid Substitution - physiology | Models, Biological | Neurogenesis - physiology | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Signal Transduction - physiology | Mice | Zebrafish Proteins - genetics | Receptor, Notch1 - genetics | Mitogen-Activated Protein Kinases - metabolism | Protein Binding - physiology | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Genetic transcription | Protein kinases
Journal Article
Oncogene, ISSN 0950-9232, 09/2008, Volume 27, Issue 38, pp. 5115 - 5123
.... Notch signaling is an important form of direct cell-cell communication involved in cell fate determination, stem cell potential and lineage commitment... 
Epigenetics | Keratinocytes | Cancer stem cells | p63 | Rho signaling | p53 | SIGNALING PATHWAYS | RBP-J-KAPPA | HAIR FOLLICLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | keratinocytes | BETA-CATENIN | P53 HOMOLOG | epigenetics | CELL BIOLOGY | ONCOLOGY | GROWTH ARREST | CERVICAL-CANCER CELLS | GENETICS & HEREDITY | NEGATIVE TRANSCRIPTIONAL REGULATOR | KERATINOCYTE STEM-CELLS | cancer stem cells | NF-KAPPA-B | Species Specificity | Keratinocytes - radiation effects | Humans | Receptors, Notch - genetics | Tumor Suppressor Protein p53 - physiology | Neoplasms - virology | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Tumor Virus Infections - physiopathology | Tumor Suppressor Proteins - genetics | Female | Neoplasms - physiopathology | Cell Differentiation - physiology | Genes, Tumor Suppressor | Oncogene Proteins, Viral - physiology | Receptors, Notch - physiology | Uterine Cervical Neoplasms - physiopathology | Uterine Cervical Neoplasms - genetics | Ultraviolet Rays - adverse effects | Tumor Suppressor Proteins - physiology | Keratinocytes - pathology | Animals | Uterine Cervical Neoplasms - virology | Signal Transduction - physiology | Mice | Apoptosis - physiology | DNA Damage | Receptor, Notch1 - genetics | Receptor, Notch1 - physiology | Care and treatment | Tumor suppressor genes | Cellular signal transduction | Genetic aspects | Research | Health aspects | Risk factors | Cancer | Signal transduction | Gene expression | Stem cells | Cell cycle | cancer therapy | carcinogenesis
Journal Article
The EMBO Journal, ISSN 0261-4189, 2011, Volume 30, Issue 4, pp. 770 - 782
Notch signalling is important for development and tissue homeostasis and activated in many human cancers... 
miR‐200 | ZEB1 | EMT | Notch | stemness | miR-200 | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | PHENOTYPE | E-CADHERIN | MIR-200 FAMILY | REPRESSORS ZEB1 | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | COLORECTAL-CANCER | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - physiology | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasms - genetics | Membrane Proteins - physiology | Serrate-Jagged Proteins | Base Sequence | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Transcription Factors - physiology | DNA-Binding Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Models, Biological | Calcium-Binding Proteins - physiology | Homeodomain Proteins - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Signal Transduction - physiology | MicroRNAs - genetics | Feedback, Physiological - physiology | MicroRNAs - physiology | Homeodomain Proteins - physiology | Calcium-Binding Proteins - genetics | Zinc Finger E-box-Binding Homeobox 1 | Proteins | Signal transduction | Cellular biology | Molecular biology | Gene expression | Cancer
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2009, Volume 106, Issue 52, pp. 22293 - 22298
Notch signaling regulates cell specification and homeostasis of stem cell compartments, and it is counteracted by the cell fate determinant Numb... 
Messenger RNA | Lungs | Non small cell lung carcinoma | Stem cells | HeLa cells | Breast cancer | Genetic mutation | Tumors | Lung neoplasms | Cancer | NSCLC | NUMB | γ-secretase inhibitors | PROTEIN | MULTIDISCIPLINARY SCIENCES | HUMAN BREAST-CANCER | P14ARF | gamma-secretase inhibitors | SOMATIC MUTATIONS | P53 | AMPLIFICATION | GENE | CELL | EXPRESSION | Transcription Factor HES-1 | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Humans | Lung Neoplasms - metabolism | Middle Aged | Lung Neoplasms - pathology | Male | Receptors, Notch - genetics | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | DNA Mutational Analysis | Base Sequence | Female | Membrane Proteins - metabolism | Tumor Cells, Cultured | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Gene Expression | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Membrane Proteins - genetics | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Receptor, Notch1 - metabolism | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | RNA, Neoplasm - genetics | Aged | DNA, Neoplasm - genetics | Mutation | Receptor, Notch1 - genetics | Physiological aspects | Development and progression | Cellular signal transduction | Genetic aspects | Research | Lung cancer, Non-small cell | Biological Sciences
Journal Article
Journal Article
Cell stem cell, ISSN 1934-5909, 07/2014, Volume 15, Issue 1, pp. 51 - 65
Journal Article