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1. Full Text Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: A novel regulatory role for OX40 and its comparison with GITR
by Valzasina, Barbara and Guiducci, Cristiana and Dislich, Heidrun and Killeen, Nigel and Weinberg, Andrew D and Colombo, Mario P
Blood, ISSN 0006-4971, 04/2005, Volume 105, Issue 7, pp. 2845 - 2851
Life Sciences & Biomedicine | Hematology | Science & Technology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Bone marrow, stem cells transplantation. Graft versus host reaction | Transfusions. Complications. Transfusion reactions. Cell and gene therapy | Biological and medical sciences | Immunobiology | Modulation of the immune response (stimulation, suppression) | Medical sciences | Interleukin-2 - metabolism | Receptors, Tumor Necrosis Factor - metabolism | Receptors, Nerve Growth Factor - immunology | Rats, Wistar | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Glucocorticoid-Induced TNFR-Related Protein | Rats | Receptors, Interleukin-2 - metabolism | Receptors, Nerve Growth Factor - metabolism | Graft vs Host Disease - metabolism | Receptors, OX40 | Graft vs Host Disease - immunology | CD4-Positive T-Lymphocytes - immunology | Animals | Cell Division - immunology | Mice, Mutant Strains | Bone Marrow Transplantation | Mice | Mice, Inbred BALB C | Receptors, Tumor Necrosis Factor - immunology | Lymphocyte Activation - physiology | Receptors, Tumor Necrosis Factor - genetics | Index Medicus | Abridged Index Medicus
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2. Full Text OX40 costimulation turns off Foxp3 + Tregs
by Vu, Minh Diem and Xiao, Xiang and Gao, Wenda and Degauque, Nicolas and Chen, Ming and Kroemer, Alexander and Killeen, Nigel and Ishii, Naoto and Li, Xian Chang
Blood, ISSN 0006-4971, 10/2007, Volume 110, Issue 7, pp. 2501 - 2510
Life Sciences & Biomedicine | Hematology | Science & Technology | T-Lymphocytes, Regulatory - metabolism | Lymphocyte Activation - immunology | Receptors, OX40 - metabolism | Animals | Forkhead Transcription Factors - metabolism | Mice | Forkhead Transcription Factors - genetics | Interferon-gamma - biosynthesis | Receptors, OX40 - immunology | Mice, Knockout | T-Lymphocytes, Regulatory - immunology | Index Medicus | Abridged Index Medicus | Immunobiology
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3. Full Text Control of Immunity by the TNFR-related molecule OX40 (CD134)
by Croft, Michael
Annual review of immunology, ISSN 0732-0582, 04/2010, Volume 28, Issue 1, pp. 57 - 78
Autoimmunity | Infectious disease | T cells | Costimulation | OX40L | Vaccination | Receptors, OX40 - metabolism | Animals | OX40 Ligand - immunology | Signal Transduction | T-Lymphocytes - metabolism | OX40 Ligand - metabolism | Humans | Cell Communication | Killer Cells, Natural - immunology | T-Lymphocytes - immunology | Killer Cells, Natural - metabolism | Receptors, OX40 - immunology | Care and treatment | Physiological aspects | Antigen presenting cells | Research | Properties | Identification and classification | Immune system | Cancer | Immunological research | Index Medicus | costimulation | autoimmunity | infectious disease | vaccination
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4. Full Text Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV‐1‐regulated protein gp34
by Baum, P.R and Gayle, R.B and Ramsdell, F and Srinivasan, S and Sorensen, R.A and Watson, M.L and Seldin, M.F and Baker, E and Sutherland, G.R and Clifford, K.N
The EMBO journal, ISSN 0261-4189, 09/1994, Volume 13, Issue 17, pp. 3992 - 4001
HTLV-1 | Ligand | Receptor | T cell (lymphocytes) | TNF | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Biological and medical sciences | Immunobiology | Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation | Tumor Necrosis Factor-alpha - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Tumor Necrosis Factors | Molecular Sequence Data | Receptors, OX40 | Recombinant Fusion Proteins - metabolism | Chromosomes, Human, Pair 1 | T-Lymphocytes - metabolism | Base Sequence | Cloning, Molecular | Female | Membrane Glycoproteins | Receptors, Tumor Necrosis Factor - genetics | Receptors, Tumor Necrosis Factor - metabolism | Amino Acid Sequence | Mice, Inbred C57BL | Gene Expression Regulation | Models, Molecular | OX40 Ligand | Chromosome Mapping | Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics | Membrane Proteins | Sequence Homology, Amino Acid | Animals | Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism | Human T-lymphotropic virus 1 - metabolism | Ligands | Antigens, Surface | Mice | Cytokines - biosynthesis | nucleotide sequence | infected | identification | glycoprotein gp34 | genes | human immunodeficiency virus | cDNA | man | lymphocytes T | OX40L protein | Index Medicus | AIDS/HIV
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5. Full Text Ox40+ regulatory T cells in cutaneous squamous cell carcinoma suppress effector T-cell responses and associate with metastatic potential
by Lai, Chester and August, Suzannah and Albibas, Amel and Behar, Ramnik and Cho, Shin-Young and Polak, Marta E and Theaker, Jeffrey and Macleod, Amanda S and French, Ruth R and Glennie, Martin J and Al-Shamkhani, Aymen and Healy, Eugene
Clinical cancer research, ISSN 1078-0432, 08/2016, Volume 22, Issue 16, pp. 4236 - 4248
Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | Skin Neoplasms - pathology | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Receptors, OX40 - agonists | Skin Neoplasms - immunology | Immunomodulation | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Immunophenotyping | Carcinoma, Squamous Cell - immunology | Skin Neoplasms - metabolism | T-Lymphocytes, Regulatory - immunology | Lymphocyte Activation - immunology | Neoplasm Metastasis | Phenotype | Receptors, OX40 - metabolism | T-Lymphocyte Subsets - metabolism | Biomarkers | Lymphocyte Count | Immunologic Memory | Lymphocytes, Tumor-Infiltrating - metabolism | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus
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6. Full Text OX40 and IL‐7 play synergistic roles in the homeostatic proliferation of effector memory CD4+ T cells
by Yamaki, Satoshi and Ine, Shouji and Kawabe, Takeshi and Okuyama, Yuko and Suzuki, Nobu and Soroosh, Pejman and Mousavi, Seyed Fazlollah and Nagashima, Hiroyuki and Sun, Shu‐lan and So, Takanori and Sasaki, Takeshi and Harigae, Hideo and Sugamura, Kazuo and Kudo, Hironori and Wada, Motoshi and Nio, Masaki and Ishii, Naoto
European journal of immunology, ISSN 0014-2980, 10/2014, Volume 44, Issue 10, pp. 3015 - 3025
OX40 | Memory CD4+ T cells | Th17 | Homeostatic proliferation | T cells | Memory CD4 | Life Sciences & Biomedicine | Immunology | Science & Technology | T-Lymphocyte Subsets - immunology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Cell Proliferation - physiology | Homeostasis - immunology | Mice, Transgenic | Adoptive Transfer | Receptors, OX40 - immunology | CD4-Positive T-Lymphocytes - immunology | Receptors, OX40 - metabolism | Animals | Flow Cytometry | Interleukin-7 - immunology | T-Lymphocyte Subsets - metabolism | Mice | Immunologic Memory - immunology | Interleukin-7 - metabolism | T cells | Index Medicus
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7. Full Text OX40, OX40L and Autoimmunity: a Comprehensive Review
by Webb, Gwilym J and Webb, Gwilym J and Hirschfield, Gideon M and Hirschfield, Gideon M and Lane, Peter J. L and Lane, Peter J. L
Clinical reviews in allergy & immunology, ISSN 1080-0549, 6/2016, Volume 50, Issue 3, pp. 312 - 332
Allergology | Animal models | T-regulatory cells | Immunology | Medicine & Public Health | Immunoregulation | Internal Medicine | TNF receptors | T cells | Allergy | Life Sciences & Biomedicine | Science & Technology | T-Lymphocyte Subsets - immunology | Receptors, OX40 - genetics | OX40 Ligand - genetics | OX40 Ligand - metabolism | Humans | Autoimmunity - genetics | Molecular Targeted Therapy | Cell Movement - genetics | Autoimmune Diseases - genetics | Cell Movement - immunology | Receptors, OX40 - metabolism | Transcription, Genetic | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Disease Models, Animal | Antigen-Presenting Cells - metabolism | Signal Transduction | Immunomodulation | Lymphocyte Activation | Autoimmune Diseases - immunology | Gene Expression Regulation | Cell Communication | Mice, Transgenic | Antigen-Presenting Cells - immunology | Cell Adhesion | OX40 Ligand - antagonists & inhibitors | Phenotype | Animals | T-Lymphocyte Subsets - metabolism | Protein Binding | Immunologic Memory | Mice | OX40 Ligand - blood | Receptors, OX40 - antagonists & inhibitors | Autoimmunity | Antigens | Interferon | B cells | Biological response modifiers | Health aspects | Index Medicus
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8. Full Text Small‐molecule modulators of the OX40–OX40 ligand co‐stimulatory protein–protein interaction
by Song, Yun and Margolles‐Clark, Emilio and Bayer, Allison and Buchwald, Peter
British journal of pharmacology, ISSN 0007-1188, 11/2014, Volume 171, Issue 21, pp. 4955 - 4969
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Receptors, OX40 - agonists | Receptors, OX40 - genetics | OX40 Ligand - genetics | OX40 Ligand - metabolism | Humans | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Mice, Transgenic | Forkhead Transcription Factors - genetics | Receptors, OX40 - metabolism | Animals | HEK293 Cells | Cell Line, Tumor | Receptors, OX40 - antagonists & inhibitors | Sensors | T cells | Transforming growth factors | Protein-protein interactions | Proteins | Index Medicus | Research Papers
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9. Full Text Timing of PD-1 blockade is critical to effective combination immunotherapy with anti-OX40
by Messenheimer, David J and Jensen, Shawn M and Afentoulis, Michael E and Wegmann, Keith W and Feng, Zipei and Friedman, David J and Gough, Michael J and Urba, Walter J and Fox, Bernard A
Clinical cancer research, ISSN 1078-0432, 10/2017, Volume 23, Issue 20, pp. 6165 - 6177
Life Sciences & Biomedicine | Oncology | Science & Technology | T-Lymphocyte Subsets - immunology | Immunotherapy - methods | Humans | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Receptors, OX40 - metabolism | Time Factors | T-Lymphocyte Subsets - drug effects | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Molecular Targeted Therapy - methods | Cytokines - blood | Disease Models, Animal | Cytokines - metabolism | Receptors, Antigen, T-Cell - metabolism | Programmed Cell Death 1 Receptor - metabolism | Immunophenotyping | Mice, Transgenic | Survival Rate | Treatment Outcome | Lymphocytes, Tumor-Infiltrating - drug effects | Antineoplastic Agents, Immunological - pharmacology | Xenograft Model Antitumor Assays | Animals | Antineoplastic Agents, Immunological - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | T-Lymphocyte Subsets - metabolism | Lymphocyte Count | Mice | Lymphocytes, Tumor-Infiltrating - immunology | Receptors, OX40 - antagonists & inhibitors | Cell proliferation | Animal models | PD-1 protein | CD8 antigen | Clinical trials | Antibodies | Lymphocytes T | Contraction | Anticancer properties | Receptors | CTLA-4 protein | Cell activation | Cell growth | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Immunotherapy | Medical research | Cytokines | T cell receptors | CD4 antigen | Immune checkpoint | Experimental design | Tumor necrosis factor | Exhaustion | Antitumor activity | Solid tumors | Tumors | Cancer | Index Medicus | Combination immunotherapy | T cells | Costimulation | Checkpoint blockade
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