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1. Full Text Opioid Pharmacology: Developmental Effects on Opioid Metabolism
by Kopecky, Ernest A
The Clinical Journal of Pain, ISSN 0749-8047, 06/2019, Volume 35, Issue 6, pp. 481 - 486
AIMS/OBJECTIVES/BACKGROUND:Children represent a patient demographic composed of multiple, unique subpopulations differentiated by rapidly changing age-related... 
developmental | pain | TRAMADOL DISPOSITION | enzymes | CLINICAL NEUROLOGY | CANCER-PATIENTS | MORPHINE CONSUMPTION | PHARMACOKINETICS | children | CYP2D6 | pharmacology | BREAST-FED NEONATE | INFANTS | ANESTHESIOLOGY | metabolism | RECEPTOR GENE | CODEINE | opioids | Pediatric pharmacology | Pain in children | Opioids | Drug metabolism | Research | Drug therapy | Pediatric research | Health aspects
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2. Full Text Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum
by Atwood, Brady K and Kupferschmidt, David A and Lovinger, David M
Nature Neuroscience, ISSN 1097-6256, 2014, Volume 17, Issue 4, pp. 540 - 548
As prescription opioid analgesic abuse rates rise, so does the need to understand the long-term effects of opioid exposure on brain function. The dorsal... 
UNITED-STATES | LOCALIZATION | DELTA | SYNAPTIC-TRANSMISSION | RECEPTOR MESSENGER-RNA | IN-SITU HYBRIDIZATION | NEURONS | RAT-BRAIN | NEUROSCIENCES | NUCLEUS-ACCUMBENS | Endocannabinoids - metabolism | Receptors, Opioid, delta - metabolism | Neuronal Plasticity - drug effects | Male | Long-Term Synaptic Depression - drug effects | Corpus Striatum - metabolism | Receptors, Opioid - physiology | Female | Receptors, Opioid - metabolism | Long-Term Synaptic Depression - physiology | Oxycodone - administration & dosage | Receptors, Opioid, mu - drug effects | Receptors, Opioid, mu - metabolism | Mice, Inbred C57BL | Receptors, Opioid, kappa - metabolism | Rats | Receptors, Opioid, delta - drug effects | Opioid Peptides - metabolism | Rats, Sprague-Dawley | Receptors, Opioid, kappa - physiology | Receptors, Opioid, kappa - drug effects | Animals | Analgesics, Opioid - administration & dosage | Corpus Striatum - drug effects | Mice | Receptors, Opioid - drug effects | Receptors, Opioid, delta - physiology | Receptors, Opioid, mu - physiology | Drug abuse | Depression, Mental | Opioids | Physiological aspects | Corpus striatum | Health aspects | Risk factors | Index Medicus
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3. Full Text Placebo effects mediated by endogenous opioid activity on mu-opioid receptors
by Zubieta, JK and Bueller, JA and Jackson, LR and Scott, DJ and Xu, YJ and Koeppe, RA and Nichols, TE and Stohler, CS
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 08/2005, Volume 25, Issue 34, pp. 7754 - 7762
Reductions in pain ratings when administered a placebo with expected analgesic properties have been described and hypothesized to be mediated by the... 
opioid receptors | stress | pain | ANTERIOR CINGULATE CORTEX | HUMAN BRAIN | MACAQUE MONKEYS | ANTAGONIST NALOXONE | STRESS-INDUCED ANALGESIA | NEUROSCIENCES | MICE LACKING | POSITRON-EMISSION-TOMOGRAPHY | AFFECTIVE DIMENSIONS | positron emission tomography | human | placebo | MORPHINE-INDUCED ANALGESIA | PREFRONTAL CORTICAL PROJECTIONS | Opioid Peptides - physiology | Placebo Effect | Receptors, Opioid, mu - metabolism | Humans | Male | Pain Measurement - drug effects | Positron-Emission Tomography - methods | Receptors, Opioid, mu - antagonists & inhibitors | Opioid Peptides - metabolism | Brain - drug effects | Brain - metabolism | Pain Measurement - methods | Naloxone - pharmacology | Adult | Analgesics, Opioid - metabolism | Receptors, Opioid, mu - physiology | Index Medicus
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4. Full Text Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic
by Thompson, Aaron A and Liu, Wei and Chun, Eugene and Katritch, Vsevolod and Wu, Huixian and Vardy, Eyal and Huang, Xi-Ping and Trapella, Claudio and Guerrini, Remo and Calo, Girolamo and Roth, Bryan L and Cherezov, Vadim and Stevens, Raymond C
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7398, pp. 395 - 399
Members of the opioid receptor family of G-protein-coupled receptors (GPCRs) are found throughout the peripheral and central nervous system, where they have... 
CRYSTALLIZING MEMBRANE | ORPHANIN-FQ | ANTAGONIST | LIPIDIC MESOPHASES | MULTIDISCIPLINARY SCIENCES | ORL1 RECEPTOR | PROTEIN-COUPLED RECEPTORS | IDENTIFICATION | SITE-DIRECTED MUTAGENESIS | BINDING | AGONIST | Opioid Peptides - pharmacology | Humans | Substrate Specificity | Crystallography, X-Ray | Narcotic Antagonists | Piperidines - pharmacology | HEK293 Cells | Receptors, Opioid, kappa - chemistry | Binding Sites | Biomimetic Materials - chemistry | Spiro Compounds - chemistry | Receptors, Opioid - metabolism | Piperidines - chemistry | Piperidines - metabolism | Receptors, Opioid, kappa - metabolism | Models, Molecular | Opioid Peptides - metabolism | Biomimetic Materials - metabolism | Biomimetic Materials - pharmacology | Opioid Peptides - chemistry | Receptors, Opioid - chemistry | Ligands | Protein Conformation | Spiro Compounds - pharmacology | Spiro Compounds - metabolism | Chemokines | Methods | Crystal structure | Index Medicus
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5. Full Text Placebo effects on human mu-opioid activity during pain
by Wager, TD and Scott, DJ and Zubieta, JK
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 06/2007, Volume 104, Issue 26, pp. 11056 - 11061
Placebo-induced expectancies have been shown to decrease pain in a manner reversible by opioid antagonists, but little is known about the central brain... 
RAT | MULTIDISCIPLINARY SCIENCES | MECHANISMS | PERIAQUEDUCTAL GRAY-MATTER | ANTINOCICEPTION | neuroimaging | VENTROLATERAL ORBITAL CORTEX | ELECTRICAL-STIMULATION | EXPECTATION | SYSTEMS | expectancy | affective neuroscience | RECEPTORS | periaqueductal gray | ANALGESIA | Physical Stimulation | Hot Temperature - adverse effects | Placebo Effect | Receptors, Opioid, mu - metabolism | Humans | Positron-Emission Tomography | Pain - metabolism | Pain - physiopathology | Fentanyl - analogs & derivatives | Brain Chemistry | Analgesics, Opioid - metabolism | Pain Measurement | Carbon Radioisotopes | Index Medicus
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6. Full Text Phosphoproteomics Illuminates Opioid Actions
by Che, Tao and Roth, Bryan L
Biochemistry, ISSN 0006-2960, 09/2018, Volume 57, Issue 38, pp. 5505 - 5506
Opioids are widely used analgesic medications with a high potential for tolerance and dependence and represent a frequent cause of death due to overdose.... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | Phosphorylation | Animals | Signal Transduction - drug effects | Humans | Analgesics, Opioid - pharmacology | Proteomics - methods | Phosphoproteins - metabolism | Receptors, Opioid - metabolism | Index Medicus
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7. Full Text Maternal High-Fat Diet Alters Methylation and Gene Expression of Dopamine and Opioid-Related Genes
by Vucetic, Zivjena and Kimmel, Jessica and Totoki, Kathy and Hollenbeck, Emily and Reyes, Teresa M
Endocrinology, ISSN 0013-7227, 10/2010, Volume 151, Issue 10, pp. 4756 - 4764
Maternal obesity during pregnancy increases the risk of obesity in the offspring. Obesity, arising from an imbalance of energy intake and expenditure, can be... 
OBESITY | DNA METHYLATION | EARLY-LIFE | APPETITE REGULATORS | PROTEIN RESTRICTION | EPIGENETIC CONTROL | RAT | ENDOCRINOLOGY & METABOLISM | FOOD-STIMULI | RECEPTOR GENE | NUCLEUS-ACCUMBENS | Dopamine Plasma Membrane Transport Proteins - metabolism | Receptors, Opioid - genetics | Gene Expression - drug effects | Food Preferences - physiology | Dopamine - genetics | Energy Intake - genetics | Male | Maternal-Fetal Exchange - genetics | Dietary Fats - pharmacology | Opioid Peptides - genetics | Female | Mice, Inbred DBA | Maternal-Fetal Exchange - drug effects | Dopamine - metabolism | Maternal Nutritional Physiological Phenomena - physiology | Receptors, Opioid - metabolism | Animals, Newborn | Mice, Inbred C57BL | Dopamine Plasma Membrane Transport Proteins - genetics | Opioid Peptides - metabolism | Maternal Nutritional Physiological Phenomena - drug effects | Pregnancy | Animals | Hypothalamus - metabolism | Mice | Reward | DNA Methylation - drug effects | Index Medicus | Abridged Index Medicus | Brain | Animal models | Lactation | Sucrose | Opioid receptors (type mu) | epigenetics | High fat diet | Opioids | DNA methylation | Reinforcement | Dopamine transporter | Sugar | Food | Energy intake | Ventral tegmentum | Cortex (prefrontal) | Obesity | Preproenkephalin | Data processing | Gene expression | Promoters | Nucleus accumbens | Polymerase chain reaction | Progeny | Food preferences | Long-term effects
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8. Full Text The One-Two Punch of Alcoholism: Role of Central Amygdala Dynorphins/Kappa-Opioid Receptors
by Kissler, Jessica L and Sirohi, Sunil and Reis, Daniel J and Jansen, Heiko T and Quock, Raymond M and Smith, Daniel G and Walker, Brendan M
Biological Psychiatry, ISSN 0006-3223, 2014, Volume 75, Issue 10, pp. 774 - 782
Background The dynorphin (DYN)/kappa-opioid receptor (KOR) system undergoes neuroadaptations following chronic alcohol exposure that promote excessive operant... 
Psychiatry | amygdala | dynorphin | kappa opioid receptor | self-administration | Alcohol | dependence | withdrawal | CHRONIC ETHANOL-CONSUMPTION | DEPRESSION | ACTIVATION | ANTAGONIST | PSYCHIATRY | DISORDERS | NEUROSCIENCES | NUCLEUS-ACCUMBENS | KAPPA | RAT-BRAIN | Central Amygdaloid Nucleus - drug effects | Rats, Wistar | Receptors, Opioid, kappa - metabolism | Ethanol - administration & dosage | Rats | Male | Self Administration | Animals | Substance Withdrawal Syndrome - metabolism | Alcoholism - metabolism | Central Nervous System Depressants - administration & dosage | Central Amygdaloid Nucleus - metabolism | Receptors, Opioid - metabolism | Physiological aspects | Alcoholics | Neurosciences | Peptides | Alcoholism | Index Medicus | alcohol
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9. Full Text Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active
by Brown, Sarah M and Holtzman, Michael and Kim, Thomas and Kharasch, Evan D
Anesthesiology, ISSN 0003-3022, 12/2011, Volume 115, Issue 6, pp. 1251 - 1260
Background: The long-lasting high-affinity opioid buprenorphine has complex pharmacology, including ceiling effects with respect to analgesia and respiratory... 
VIVO | OPIOID RECEPTOR | RESPIRATORY DEPRESSION | MORPHINE-6-GLUCURONIDE | RATS | IN-VITRO METABOLISM | ANESTHESIOLOGY | INTRAVENOUS BUPRENORPHINE | HEALTHY-VOLUNTEERS | INHIBITORS | ANTIRETROVIRALS | Receptors, Opioid, delta - metabolism | Cricetulus | Humans | Analgesics, Opioid - pharmacology | Motor Activity - drug effects | Male | Dose-Response Relationship, Drug | Glucuronides - metabolism | Glucuronides - pharmacology | Plethysmography, Whole Body - methods | Pain - drug therapy | Buprenorphine - analogs & derivatives | Behavior, Animal - drug effects | Female | CHO Cells | Receptors, Opioid - metabolism | Cricetinae | Receptors, Opioid, mu - drug effects | Receptors, Opioid, mu - metabolism | Cells, Cultured | Receptors, Opioid, kappa - metabolism | Buprenorphine - metabolism | Receptors, Opioid, delta - drug effects | Buprenorphine - pharmacology | Respiratory Insufficiency - chemically induced | Receptors, Opioid, kappa - drug effects | Animals | Mice | Analgesics, Opioid - metabolism | Pain Measurement | Receptors, Opioid - drug effects | Tidal Volume - drug effects | Index Medicus | Abridged Index Medicus
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10. Full Text Novel Molecular Targets of Dezocine and Their Clinical Implications
by Liu, Renyu and Huang, Xi-Ping and Yeliseev, Alexei and Xi, Jin and Roth, Bryan L
Anesthesiology, ISSN 0003-3022, 03/2014, Volume 120, Issue 3, pp. 714 - 723
BACKGROUND:Although dezocine is a partial μ-opioid receptor agonist, it is not a controlled substance. Thus, the characterization of the molecular targets of... 
DEPRESSION | PAIN | INHIBITION | MORPHINE | BUPRENORPHINE | NOREPINEPHRINE TRANSPORTER | CRYSTAL-STRUCTURE | KAPPA-OPIOID RECEPTOR | ANESTHESIOLOGY | SEROTONIN | AGONIST-ANTAGONIST | Receptors, Opioid, delta - metabolism | Receptors, Opioid - agonists | Receptors, Opioid, kappa - antagonists & inhibitors | Receptors, Opioid, mu - metabolism | Humans | Receptors, Opioid, kappa - agonists | Receptors, Opioid, kappa - metabolism | Analgesics, Opioid - pharmacology | Receptors, Opioid, mu - agonists | Receptors, Opioid, mu - antagonists & inhibitors | Narcotic Antagonists | Serotonin Plasma Membrane Transport Proteins - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Tetrahydronaphthalenes - pharmacology | Receptors, Opioid, delta - antagonists & inhibitors | Norepinephrine Plasma Membrane Transport Proteins - metabolism | In Vitro Techniques | Receptors, Opioid, delta - agonists | Receptors, Opioid - metabolism | Index Medicus | Abridged Index Medicus
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11. Full Text Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions
by Shang, Yi and Lerouzic, Valerie and Schneider, Sebastian and Bisignano, Paola and Pasternak, Gavril W and Filizola, Marta
Biochemistry, ISSN 0006-2960, 08/2014, Volume 53, Issue 31, pp. 5140 - 5149
The idea of sodium ions altering G-protein-coupled receptor (GPCR) ligand binding and signaling was first suggested for opioid receptors (ORs) in the 1970s and... 
ACTIVATION | COMPLEX | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | OPIATE AGONISTS | DYNAMICS | PROTEIN-COUPLED RECEPTORS | ADENOSINE RECEPTOR | DRUG-LIKE MOLECULES | MUTATIONAL ANALYSIS | BINDING | Receptors, Opioid, delta - metabolism | Receptors, Opioid, mu - chemistry | Receptors, Opioid, delta - chemistry | Receptors, Opioid, mu - metabolism | Humans | Receptors, Opioid, kappa - metabolism | Models, Molecular | Crystallography, X-Ray | Sodium - metabolism | Molecular Dynamics Simulation | Receptors, Opioid - chemistry | Animals | Ligands | Protein Conformation | Receptors, Opioid, delta - antagonists & inhibitors | Mice | Receptors, Opioid, kappa - chemistry | Radioligand Assay | Binding Sites | Receptors, Opioid - metabolism | Research | Chemical properties | Analysis | Opioids | Drug receptors | Index Medicus
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12. Full Text Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse
by Navarro, Victor M and Gottsch, Michelle L and Chavkin, Charles and Okamura, Hiroaki and Clifton, Donald K and Steiner, Robert A
Journal of Neuroscience, ISSN 0270-6474, 09/2009, Volume 29, Issue 38, pp. 11859 - 11866
Kisspeptin is encoded by the Kiss1 gene, and kisspeptin signaling plays a critical role in reproduction. In rodents, kisspeptin neurons in the arcuate nucleus... 
MORPHOLOGIC EVIDENCE | FEMALE MOUSE | MESSENGER-RNA EXPRESSION | GENE-EXPRESSION | MEDIAN-EMINENCE | KAPPA-OPIOID RECEPTOR | ESTROGEN REGULATION | GNRH NEURONS | NEUROKININ-B | OVARIECTOMIZED RATS | NEUROSCIENCES | Receptors, Opioid - agonists | Receptors, Opioid - genetics | Dynorphins - genetics | Luteinizing Hormone - metabolism | RNA, Messenger - metabolism | Kisspeptins | In Situ Hybridization | Arcuate Nucleus of Hypothalamus - secretion | Receptors, Neurokinin-3 - metabolism | Female | Neurons - secretion | Neurons - metabolism | Dynorphins - metabolism | Luteinizing Hormone - secretion | Receptors, Opioid - metabolism | Gonadotropin-Releasing Hormone - secretion | Estradiol - metabolism | Tumor Suppressor Proteins - metabolism | Protein Precursors - genetics | Luteinizing Hormone - blood | Ovariectomy | Signal Transduction | Arcuate Nucleus of Hypothalamus - metabolism | Mice, Inbred C57BL | Receptors, Neurokinin-3 - agonists | Neurokinin B - metabolism | Mice, Knockout | Protein Precursors - metabolism | Animals | Gonadotropin-Releasing Hormone - metabolism | Mice | Models, Neurological | Index Medicus | Kisspeptin | mouse | GnRH pulses | NKB | hypothalamus | Dynorphin
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13. Full Text Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain
by Navratilova, Edita and Xie, Jennifer Yanhua and Meske, Diana and Qu, Chaoling and Morimura, Kozo and Okun, Alec and Arakawa, Naohisa and Ossipov, Michael and Fields, Howard L and Porreca, Frank
Journal of Neuroscience, ISSN 0270-6474, 05/2015, Volume 35, Issue 18, pp. 7264 - 7271
Pain is aversive, and its relief elicits reward mediated by dopaminergic signaling in the nucleus accumbens (NAc), a part of the mesolimbic reward motivation... 
Nucleus accumbens | Postsurgical pain | Affective dimension of pain | Reward | Anterior cingulate cortex | Neuropathic pain | reward | ACTIVATION | RAT | MORPHINE | PLACE PREFERENCE | nucleus accumbens | MODEL | postsurgical pain | NEUROSCIENCES | NUCLEUS-ACCUMBENS | neuropathic pain | ONGOING PAIN | BRAIN MECHANISMS | affective dimension of pain | anterior cingulate cortex | Receptors, Opioid - agonists | Microdialysis - methods | Microinjections - methods | Rats | Male | Pain Measurement - drug effects | Pain - metabolism | Rats, Sprague-Dawley | Gyrus Cinguli - metabolism | Pain Measurement - methods | Animals | Pain - drug therapy | Gyrus Cinguli - drug effects | Analgesics, Opioid - metabolism | Morphine - administration & dosage | Receptors, Opioid - metabolism | Index Medicus
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14. Full Text Placebo and Opioid Analgesia: Imaging a Shared Neuronal Network
by Predrag Petrovic and Eija Kalso and Karl Magnus Petersson and Martin Ingvar
Science, ISSN 0036-8075, 3/2002, Volume 295, Issue 5560, pp. 1737 - 1740
It has been suggested that placebo analgesia involves both higher order cognitive networks and endogenous opioid systems. The rostral anterior cingulate cortex... 
Analgesia | Neuroscience | Pain | Analgesics | Brain stem | Placebos | Stripes | Reports | Causal covariation | Transponders | Opioid analgesics | POSITRON-EMISSION-TOMOGRAPHY | ANTERIOR CINGULATE CORTEX | PERIAQUEDUCTAL GRAY | CHRONIC PAIN | ELECTRICAL-STIMULATION | THALAMIC-STIMULATION | MULTIDISCIPLINARY SCIENCES | MOTOR CORTEX | CEREBRAL ACTIVATION | C-11 DIPRENORPHINE | RECEPTOR-BINDING | Gyrus Cinguli - blood supply | Placebo Effect | Humans | Brain Stem - diagnostic imaging | Gyrus Cinguli - diagnostic imaging | Analgesics, Opioid - pharmacology | Male | Cerebrovascular Circulation | Brain Stem - physiology | Nerve Net - physiology | Brain Stem - blood supply | Piperidines - pharmacology | Adult | Gyrus Cinguli - physiology | Placebos - pharmacology | Tomography, Emission-Computed | Pain Measurement | Receptors, Opioid - metabolism | Care and treatment | Analysis | Therapeutics | Tomography | Brain | Neural networks | Index Medicus
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15. Full Text Opioid hedonic hotspot in nucleus accumbens shell: Mu, delta, and kappa maps for enhancement of sweetness "liking" and "wanting"
by Castro, Daniel C and Berridge, Kent C
Journal of Neuroscience, ISSN 0270-6474, 2014, Volume 34, Issue 12, pp. 4239 - 4250
A specialized cubic-millimeter hotspot in the rostrodorsal quadrant of medial shell in nucleus accumbens (NAc) of rats may mediate opioid enhancement of... 
Nucleus accumbens | Opioid | VENTRAL PALLIDUM | CONDITIONED PLACE PREFERENCE | FOOD-INTAKE | opioid | REWARD CIRCUITRY | OPIATE AGONISTS | nucleus accumbens | DOPAMINE TRANSPORTER | NEUROSCIENCES | INCENTIVE SALIENCE | RECEPTOR ANTAGONISM | SEEKING BEHAVIOR | CELLULAR SITES | Receptors, Opioid - agonists | Enkephalin, Ala-MePhe-Gly- - pharmacology | Nucleus Accumbens - metabolism | Analgesics, Opioid - pharmacology | Rats | Male | Taste - physiology | Rats, Sprague-Dawley | Eating - physiology | Eating - drug effects | Animals | Taste - drug effects | Brain Mapping | Reward | Nucleus Accumbens - drug effects | Receptors, Opioid - metabolism | Index Medicus
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