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1. Full Text A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action
by Stoeber, Miriam and Jullié, Damien and Lobingier, Braden T and Laeremans, Toon and Steyaert, Jan and Schiller, Peter W and Manglik, Aashish and von Zastrow, Mark
Neuron (Cambridge, Mass.), ISSN 0896-6273, 06/2018, Volume 98, Issue 5, pp. 963 - 976.e5
opioid receptor | ligand-induced activation | endosome | biosensor | signaling | ligand bias | GPCR | Golgi | opioid drug | subcellular location | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Dendrites - metabolism | Humans | Morphine - metabolism | Rats | Intracellular Space | Endosomes - metabolism | Narcotic Antagonists | Animals | Naloxone | Peptides - metabolism | Enkephalin, Ala-MePhe-Gly- - metabolism | Enkephalin, D-Penicillamine (2,5)- - metabolism | Enkephalin, Leucine-2-Alanine - metabolism | Biosensing Techniques | HEK293 Cells | Golgi Apparatus - metabolism | Spatio-Temporal Analysis | Cell Membrane - metabolism | Neurons - metabolism | Analgesics, Opioid - metabolism | HeLa Cells | Microscopy, Fluorescence | Receptors, Opioid - metabolism | Drugs | Neurons | Detectors | Plasma | Opioid receptors | Peptides | Narcotics | Cloning | Bias | Time series | Experiments | Neuromodulation | Golgi apparatus | Internalization | Ligands | Sensors | Biosensors | Endosomes
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2. Full Text Opioid Receptors
by Stein, Christoph
Annual review of medicine, ISSN 0066-4219, 1/2016, Volume 67, Issue 1, pp. 433 - 451
peripheral | plasticity | pain | inflammation | tolerance | addiction | Tolerance | Inflammation | Pain | Peripheral | Addiction | Plasticity | Receptors, Opioid - agonists | Chronic Pain - drug therapy | Opioid-Related Disorders - etiology | Signal Transduction | Humans | Drug Tolerance | Analgesics, Opioid - pharmacology | Analgesics, Opioid - therapeutic use | Pain - metabolism | Narcotic Antagonists - therapeutic use | Time Factors | Neuronal Plasticity | Pain - drug therapy | Ligands | Receptors, Opioid - drug effects | Receptors, Opioid - metabolism | Complications and side effects | Dosage and administration | Drug therapy | Chronic pain | Opioids | Drugs | Molecules | Side effects | Index Medicus
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3. Full Text Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum
by Atwood, Brady K and Kupferschmidt, David A and Lovinger, David M
Nature neuroscience, ISSN 1097-6256, 2014, Volume 17, Issue 4, pp. 540 - 548
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Endocannabinoids - metabolism | Receptors, Opioid, delta - metabolism | Neuronal Plasticity - drug effects | Male | Long-Term Synaptic Depression - drug effects | Corpus Striatum - metabolism | Receptors, Opioid - physiology | Female | Receptors, Opioid - metabolism | Long-Term Synaptic Depression - physiology | Oxycodone - administration & dosage | Receptors, Opioid, mu - drug effects | Receptors, Opioid, mu - metabolism | Mice, Inbred C57BL | Receptors, Opioid, kappa - metabolism | Rats | Receptors, Opioid, delta - drug effects | Opioid Peptides - metabolism | Rats, Sprague-Dawley | Receptors, Opioid, kappa - physiology | Receptors, Opioid, kappa - drug effects | Animals | Analgesics, Opioid - administration & dosage | Corpus Striatum - drug effects | Mice | Receptors, Opioid - drug effects | Receptors, Opioid, delta - physiology | Receptors, Opioid, mu - physiology | Drug abuse | Depression, Mental | Opioids | Physiological aspects | Corpus striatum | Health aspects | Risk factors | Index Medicus
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4. Full Text Molecular control of δ-opioid receptor signalling
by Fenalti, Gustavo and Giguere, Patrick M and Katritch, Vsevolod and Huang, Xi-Ping and Thompson, Aaron A and Cherezov, Vadim and Roth, Bryan L and Stevens, Raymond C
Nature (London), ISSN 0028-0836, 2014, Volume 506, Issue 7487, pp. 191 - 196
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Naltrexone - analogs & derivatives | Receptors, Opioid, delta - metabolism | Humans | Naltrexone - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Sodium - metabolism | Arrestins - metabolism | Narcotic Antagonists - chemistry | Naltrexone - pharmacology | Narcotic Antagonists - metabolism | Receptors, Opioid, delta - genetics | Receptors, Opioid, delta - antagonists & inhibitors | Asparagine - genetics | Naltrexone - metabolism | Allosteric Regulation - drug effects | Allosteric Site - genetics | Sodium - pharmacology | Allosteric Regulation - genetics | Mutagenesis, Site-Directed | Receptors, Opioid, delta - chemistry | Allosteric Site - drug effects | Models, Molecular | Signal Transduction - drug effects | beta-Arrestins | Asparagine - metabolism | Narcotic Antagonists - pharmacology | Ligands | Receptors, Opioid, delta - agonists | Index Medicus | sodium regulation | constitutive activity | human opioid receptor | arrestin | functional selectivity | GPCR signaling | allostery
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5. Full Text Synthesis and Structure–Activity Relationships of 5′-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects
by Vekariya, Rakesh H and Lei, Wei and Ray, Abhisek and Saini, Surendra K and Zhang, Sixue and Molnar, Gabriella and Barlow, Deborah and Karlage, Kelly L and Bilsky, Edward J and Houseknecht, Karen L and Largent-Milnes, Tally M and Streicher, John M and Ananthan, Subramaniam
Journal of medicinal chemistry, ISSN 0022-2623, 07/2020, Volume 63, Issue 14, pp. 7663 - 7694
Receptors, Opioid, delta - metabolism | Analgesics, Opioid - chemical synthesis | Cricetulus | Humans | Microsomes, Liver - metabolism | Narcotic Antagonists - chemical synthesis | Male | Structure-Activity Relationship | Receptors, Opioid, mu - agonists | Morphinans - metabolism | Narcotic Antagonists - metabolism | Drug Design | Receptors, Opioid, delta - antagonists & inhibitors | Molecular Structure | CHO Cells | Morphinans - therapeutic use | Pyridines - therapeutic use | Receptors, Opioid, mu - metabolism | Pyridines - chemical synthesis | Analgesics, Opioid - therapeutic use | Morphinans - chemical synthesis | Animals | Pyridines - metabolism | Narcotic Antagonists - therapeutic use | Protein Binding | Mice | Molecular Docking Simulation | Analgesics, Opioid - metabolism | Index Medicus
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6. Full Text Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies
by Volkow, Nora D and McLellan, A. Thomas
The New England journal of medicine, ISSN 0028-4793, 03/2016, Volume 374, Issue 13, pp. 1253 - 1263
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Opioid-Related Disorders - epidemiology | Chronic Pain - drug therapy | Receptors, Opioid, mu - metabolism | Humans | Drug Tolerance | Opioid-Related Disorders - diagnosis | Analgesics, Opioid - therapeutic use | Opioid-Related Disorders - prevention & control | Chronic Pain - physiopathology | Opioid-Related Disorders - physiopathology | Prevention | Care and treatment | Dosage and administration | Chronic pain | Opioids | Drug abuse | Pain | Addiction | Abuse | Narcotics | Drug tolerance | Pain management | Chronic illnesses | Index Medicus | Abridged Index Medicus
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7. Full Text Structure of the human κ-opioid receptor in complex with JDTic
by Wu, Huixian and Wacker, Daniel and Mileni, Mauro and Katritch, Vsevolod and Han, Gye Won and Vardy, Eyal and Liu, Wei and Thompson, Aaron A and Huang, Xi-Ping and Carroll, F. Ivy and Mascarella, S. Wayne and Westkaemper, Richard B and Mosier, Philip D and Roth, Bryan L and Cherezov, Vadim and Stevens, Raymond C
Nature (London), ISSN 0028-0836, 05/2012, Volume 485, Issue 7398, pp. 327 - 332
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Structure of solids and liquids; crystallography | Structure of specific crystalline solids | Physics | Exact sciences and technology | Condensed matter: structure, mechanical and thermal properties | Organic compounds | Naltrexone - analogs & derivatives | Humans | Naltrexone - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Diterpenes, Clerodane - chemistry | Receptors, Adrenergic, beta-2 - chemistry | Piperidines - pharmacology | Tetrahydroisoquinolines - chemistry | Receptors, Opioid, kappa - chemistry | Binding Sites | Receptors, Opioid, kappa - genetics | Naltrexone - metabolism | Morphinans - chemistry | Tetrahydroisoquinolines - pharmacology | Piperidines - chemistry | Receptors, Opioid, kappa - antagonists & inhibitors | Mutagenesis, Site-Directed | Receptors, Opioid, kappa - metabolism | Models, Molecular | Receptors, CXCR4 - metabolism | Guanidines - chemistry | Diterpenes, Clerodane - metabolism | Diterpenes, Clerodane - pharmacology | Protein Conformation | Receptors, CXCR4 - chemistry | Index Medicus
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