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Biological Psychiatry, ISSN 0006-3223, 2015, Volume 79, Issue 11, pp. 917 - 927
Abstract Background GPR88 is an orphan G protein coupled receptor highly enriched in the striatum, and previous studies have focused on GPR88 function in... 
Psychiatry | Ethological scoring of anxiety | GPR88 agonist-induced GTPγS binding | Gene clustering | Medium spiny neurons | Psychiatric disorders | Spatial learning | CENTRAL EXTENDED AMYGDALA | PSYCHIATRY | DEPENDENT BEHAVIORS | PROTRACTED ABSTINENCE | NEUROSCIENCES | ADENOSINE A(2A) RECEPTORS | GPR88 agonist-induced GTP gamma S binding | C-TERMINAL DOMAINS | STRIATOPALLIDAL NEURONS | DORSAL STRIATUM | SELECTIVE INTERACTIONS | OBJECT RECOGNITION | PARKINSON-DISEASE | Naltrexone - analogs & derivatives | Receptors, Opioid, delta - metabolism | Dendrites - pathology | Male | Anxiety - drug therapy | Corpus Striatum - metabolism | Spatial Learning - physiology | Naltrexone - pharmacology | Female | Anxiety - metabolism | Corpus Striatum - pathology | Dopamine - metabolism | Dendrites - drug effects | Dendrites - metabolism | Movement Disorders - pathology | Receptors, Opioid, mu - metabolism | Mice, Inbred C57BL | Spatial Learning - drug effects | Amygdala - metabolism | Hippocampus - pathology | Amygdala - pathology | Anxiety - pathology | Mice, Knockout | Hippocampus - metabolism | Movement Disorders - metabolism | Animals | Receptors, G-Protein-Coupled - deficiency | Narcotic Antagonists - pharmacology | Serotonin - metabolism | Receptors, G-Protein-Coupled - genetics | Movement Disorders - drug therapy | Neurosciences | G proteins | Anxiety | Brain research | Genetic transcription | Neurons | Life Sciences | Human health and pathology | Other | Psychiatrics and mental health | medium spiny neurons | spatial learning | gene clustering | ethological scoring of anxiety | psychiatric disorders
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 10/2012, Volume 55, Issue 19, pp. 8350 - 8363
In the search for opioid ligands with mixed functional activity, a series of 5'-(4-chlorophenyl)-4,5 alpha-epoxypyridomorphinans possessing alkoxy or acyloxy... 
14-ALKOXYMORPHINANS | CHEMISTRY, MEDICINAL | LIGANDS | MORPHINE-TOLERANCE | DELTA | BIOLOGICAL EVALUATION | SELECTIVE MU | MICE | RECEPTOR INTERACTIONS | BINDING | ANTINOCICEPTIVE TOLERANCE
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7487, pp. 191 - 196
Journal Article
Journal Article
ACS CHEMICAL BIOLOGY, ISSN 1554-8929, 12/2011, Volume 6, Issue 12, pp. 1375 - 1381
The development of tolerance to and dependence on opioid analgesics greatly reduces their long-term usefulness. Previous studies have demonstrated that... 
RECEPTOR SELECTIVE TETRAPEPTIDE | MULTIPLE LIGANDS | POTENT | MORPHINE-TOLERANCE | SENSITIZATION | DELTA | BIOCHEMISTRY & MOLECULAR BIOLOGY | KNOCKOUT MICE | BINDING | DMT-TIC PHARMACOPHORE | DEPENDENCE
Journal Article
ACS CHEMICAL NEUROSCIENCE, ISSN 1948-7193, 09/2013, Volume 4, Issue 9, pp. 1256 - 1266
Opioid narcotics are used for the treatment of moderate-to-severe pain and primarily exert their analgesic effects through mu receptors. Although traditional... 
conformationally sampled pharmacophore | CHEMISTRY, MEDICINAL | RECEPTOR ANTAGONISTS | EFFICACY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHYSICAL-DEPENDENCE | Antinociception | FORCE-FIELDS | mu agonist | NEUROSCIENCES | opioid receptor | delta antagonist | PAIN | LIGANDS | MORPHINE-TOLERANCE | MICE | tolerance
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 03/2015, Volume 22, Issue 3, pp. 265 - 268
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 06/2019, Volume 852, pp. 265 - 273
Oxycodone, a widely prescribed and very potent oral opioid analgesic agent, is highly addictive and has many side effects, including troublesome constipation.... 
Tolerance | Naltrindole | Conditioned place preference | Delta-opioid receptor | Oxycodone | Dependence | UNITED-STATES | DOPAMINE RELEASE | ANALGESIC ABUSE | MORPHINE | MU | NUCLEUS-ACCUMBENS | GASTROINTESTINAL TRANSIT | PAIN | RELAPSE VULNERABILITY | PHARMACOLOGY & PHARMACY | Drug abuse | Liability (Law) | Constipation | Opioids
Journal Article
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