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1. Full Text DPI-289, a novel mixed delta opioid agonist / mu opioid antagonist (DAMA), has L-DOPA-sparing potential in Parkinson's disease
by Johnston, Tom H and Versi, Eboo and Howson, Patrick A and Ravenscroft, Paula and Fox, Susan H and Hill, Michael P and Reidenberg, Bruce E and Corey, Ronald and Brotchie, Jonathan M
Neuropharmacology, ISSN 0028-3908, 03/2018, Volume 131, pp. 116 - 127
Parkinson's disease | Opioids | L-DOPA | Dyskinesia | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Male | Parkinson Disease - drug therapy | Adrenergic Agents - toxicity | Dose-Response Relationship, Drug | Benzamides - therapeutic use | Dyskinesia, Drug-Induced - drug therapy | Parkinsonian Disorders - drug therapy | Female | Benzamides - pharmacology | Macaca | Narcotic Antagonists - pharmacokinetics | Vas Deferens - drug effects | Disease Models, Animal | Dyskinesia, Drug-Induced - etiology | Movement - drug effects | Parkinson Disease - pathology | Guinea Pigs | Mice, Inbred C57BL | Parkinsonian Disorders - blood | Analgesics, Opioid - therapeutic use | Piperazines - therapeutic use | Parkinson Disease - physiopathology | Receptors, Opioid, mu - antagonists & inhibitors | Piperazines - pharmacology | Rats, Sprague-Dawley | Oxidopamine - toxicity | Animals | Narcotic Antagonists - therapeutic use | Levodopa - adverse effects | Analgesics, Opioid - pharmacokinetics | Vas Deferens - metabolism | Mice | Receptors, Opioid, delta - agonists | Parkinson Disease - etiology | Phenols | Low density lipoproteins | Analysis | Movement disorders | Antiparkinsonian agents | Index Medicus
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2. Full Text Molecular control of δ-opioid receptor signalling
by Fenalti, Gustavo and Giguere, Patrick M and Katritch, Vsevolod and Huang, Xi-Ping and Thompson, Aaron A and Cherezov, Vadim and Roth, Bryan L and Stevens, Raymond C
Nature (London), ISSN 0028-0836, 2014, Volume 506, Issue 7487, pp. 191 - 196
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Naltrexone - analogs & derivatives | Receptors, Opioid, delta - metabolism | Humans | Naltrexone - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Sodium - metabolism | Arrestins - metabolism | Narcotic Antagonists - chemistry | Naltrexone - pharmacology | Narcotic Antagonists - metabolism | Receptors, Opioid, delta - genetics | Receptors, Opioid, delta - antagonists & inhibitors | Asparagine - genetics | Naltrexone - metabolism | Allosteric Regulation - drug effects | Allosteric Site - genetics | Sodium - pharmacology | Allosteric Regulation - genetics | Mutagenesis, Site-Directed | Receptors, Opioid, delta - chemistry | Allosteric Site - drug effects | Models, Molecular | Signal Transduction - drug effects | beta-Arrestins | Asparagine - metabolism | Narcotic Antagonists - pharmacology | Ligands | Receptors, Opioid, delta - agonists | Index Medicus | sodium regulation | constitutive activity | human opioid receptor | arrestin | functional selectivity | GPCR signaling | allostery
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3. Full Text Synthesis and Structure–Activity Relationships of 5′-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects
by Vekariya, Rakesh H and Lei, Wei and Ray, Abhisek and Saini, Surendra K and Zhang, Sixue and Molnar, Gabriella and Barlow, Deborah and Karlage, Kelly L and Bilsky, Edward J and Houseknecht, Karen L and Largent-Milnes, Tally M and Streicher, John M and Ananthan, Subramaniam
Journal of medicinal chemistry, ISSN 0022-2623, 07/2020, Volume 63, Issue 14, pp. 7663 - 7694
Receptors, Opioid, delta - metabolism | Analgesics, Opioid - chemical synthesis | Cricetulus | Humans | Microsomes, Liver - metabolism | Narcotic Antagonists - chemical synthesis | Male | Structure-Activity Relationship | Receptors, Opioid, mu - agonists | Morphinans - metabolism | Narcotic Antagonists - metabolism | Drug Design | Receptors, Opioid, delta - antagonists & inhibitors | Molecular Structure | CHO Cells | Morphinans - therapeutic use | Pyridines - therapeutic use | Receptors, Opioid, mu - metabolism | Pyridines - chemical synthesis | Analgesics, Opioid - therapeutic use | Morphinans - chemical synthesis | Animals | Pyridines - metabolism | Narcotic Antagonists - therapeutic use | Protein Binding | Mice | Molecular Docking Simulation | Analgesics, Opioid - metabolism | Index Medicus
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4. Full Text Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist
by Meirsman, Aura C and Le Merrer, Julie and Pellissier, Lucie P and Diaz, Jorge and Clesse, Daniel and Kieffer, Brigitte L and Becker, Jérôme A.J
Biological psychiatry (1969), ISSN 0006-3223, 2015, Volume 79, Issue 11, pp. 917 - 927
Psychiatry | Ethological scoring of anxiety | GPR88 agonist-induced GTPγS binding | Gene clustering | Medium spiny neurons | Psychiatric disorders | Spatial learning | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Naltrexone - analogs & derivatives | Receptors, Opioid, delta - metabolism | Dendrites - pathology | Male | Anxiety - drug therapy | Corpus Striatum - metabolism | Spatial Learning - physiology | Naltrexone - pharmacology | Female | Anxiety - metabolism | Corpus Striatum - pathology | Dopamine - metabolism | Dendrites - drug effects | Dendrites - metabolism | Movement Disorders - pathology | Receptors, Opioid, mu - metabolism | Mice, Inbred C57BL | Spatial Learning - drug effects | Amygdala - metabolism | Hippocampus - pathology | Amygdala - pathology | Anxiety - pathology | Mice, Knockout | Hippocampus - metabolism | Movement Disorders - metabolism | Animals | Receptors, G-Protein-Coupled - deficiency | Narcotic Antagonists - pharmacology | Serotonin - metabolism | Receptors, G-Protein-Coupled - genetics | Movement Disorders - drug therapy | G proteins | Anxiety | Brain research | Genetic transcription | Neurons | Index Medicus | Life Sciences | Human health and pathology | Other | Psychiatrics and mental health | medium spiny neurons | spatial learning | gene clustering | ethological scoring of anxiety | psychiatric disorders
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5. Full Text Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors
by Ahonen, Tiina J and Rinne, Maiju and Grutschreiber, Peter and Mätlik, Kert and Airavaara, Mikko and Schaarschmidt, Dieter and Lang, Heinrich and Reiss, David and Xhaard, Henri and Gaveriaux-Ruff, Claire and Yli-Kauhaluoma, Jari and Moreira, Vânia M
European journal of medicinal chemistry, ISSN 0223-5234, 05/2018, Volume 151, pp. 495 - 507
Morphine | Oxidation | Hydroxy ketone | Supported permanganate | Antagonist | Opioid receptor | Index Medicus
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6. Full Text Further Optimization and Evaluation of Bioavailable, Mixed-Efficacy μ‑Opioid Receptor (MOR) Agonists/δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities
by Harland, Aubrie A and Yeomans, Larisa and Griggs, Nicholas W and Anand, Jessica P and Pogozheva, Irina D and Jutkiewicz, Emily M and Traynor, John R and Mosberg, Henry I
Journal of medicinal chemistry, ISSN 0022-2623, 11/2015, Volume 58, Issue 22, pp. 8952 - 8969
Receptors, Opioid, delta - metabolism | Analgesics - pharmacology | Cricetulus | Humans | Substrate Specificity | Biological Availability | Male | Structure-Activity Relationship | Receptors, Opioid, mu - agonists | Dose-Response Relationship, Drug | Analgesics - chemical synthesis | Drug Design | Receptors, Opioid, delta - antagonists & inhibitors | Acetylation | Radioligand Assay | CHO Cells | Cricetinae | Receptors, Opioid, mu - chemistry | Receptors, Opioid, delta - chemistry | Receptors, Opioid, mu - metabolism | Mice, Inbred C57BL | Injections, Intraperitoneal | Receptors, Opioid, kappa - metabolism | Pain Measurement - drug effects | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Analgesics - chemistry | Mice | Index Medicus
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7. Full Text Structure of the δ-opioid receptor bound to naltrindole
by Granier, Sébastien and Manglik, Aashish and Kruse, Andrew C and Kobilka, Tong Sun and Thian, Foon Sun and Weis, William I and Kobilka, Brian K
Nature (London), ISSN 0028-0836, 05/2012, Volume 485, Issue 7398, pp. 400 - 404
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Cell receptors | Miscellaneous | Analytical, structural and metabolic biochemistry | Biological and medical sciences | Molecular and cellular biology | Cell structures and functions | Naltrexone - analogs & derivatives | Protein Structure, Tertiary | Receptors, Opioid, delta - metabolism | Amino Acid Sequence | Reproducibility of Results | Receptors, Opioid, delta - chemistry | Models, Molecular | Molecular Sequence Data | Naltrexone - chemistry | Substrate Specificity | Crystallography, X-Ray | Structure-Activity Relationship | Naltrexone - pharmacology | Animals | Conserved Sequence | Receptors, Opioid, delta - antagonists & inhibitors | Mice | Binding Sites | Naltrexone - metabolism | Index Medicus
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8. Full Text Non-peptidic δ opioid receptor agonists and antagonists (2000 - 2012)
by Fujii, Hideaki and Takahashi, Toshihiro and Nagase, Hiroshi
Expert opinion on therapeutic patents, ISSN 1354-3776, 09/2013, Volume 23, Issue 9, pp. 1181 - 1208
anxiolytic effect | antinociceptive effect | δ opioid receptor | convulsion | antidepressant effect | cardioprotective effect | neuroprotective effect | Neuroprotective effect | Anxiolytic effect | Convulsion | Antinociceptive effect | Antidepressant effect | Cardioprotective effect | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Receptors, Opioid, delta - metabolism | Analgesics, Opioid - adverse effects | Animals | Humans | Drug Design | Analgesics, Opioid - pharmacology | Receptors, Opioid, delta - antagonists & inhibitors | Clinical Trials as Topic | Molecular Targeted Therapy | Receptors, Opioid, delta - agonists | Patents as Topic | Index Medicus
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9. Full Text In vivo effects of μ‐opioid receptor agonist/δ‐opioid receptor antagonist peptidomimetics following acute and repeated administration
by Anand, Jessica P and Kochan, Kelsey E and Nastase, Anthony F and Montgomery, Deanna and Griggs, Nicholas W and Traynor, John R and Mosberg, Henry I and Jutkiewicz, Emily M
British journal of pharmacology, ISSN 0007-1188, 06/2018, Volume 175, Issue 11, pp. 2013 - 2027
Peptidomimetics - pharmacology | Cricetulus | Humans | Mice, Inbred C57BL | Molecular Conformation | Analgesics, Opioid - pharmacology | Rats | Male | Peptidomimetics - chemistry | Receptors, Opioid, mu - agonists | Mice, Knockout | Peptidomimetics - administration & dosage | Animals | Analgesics, Opioid - administration & dosage | Analgesics, Opioid - chemistry | Cell Line, Tumor | Female | Ligands | Receptors, Opioid, delta - antagonists & inhibitors | Mice | CHO Cells | Pain perception | Opioid receptors | Narcotics | Morphine | Naltrexone | Side effects | Receptors | Pain | Analgesics | Drug tolerance | Peptidomimetics | Dependence | Warm water | In vivo methods and tests | Conditioning | Research Papers | Research Paper
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10. Full Text Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3R)‑N‑[1R)‑1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic
by Kormos, Chad M and Ondachi, Pauline W and Runyon, Scott P and Thomas, James B and Mascarella, S. Wayne and Decker, Ann M and Navarro, Hernán A and Fennell, Timothy R and Snyder, Rodney W and Carroll, F. Ivy
Journal of medicinal chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 17, pp. 7546 - 7559
Receptors, Opioid, delta - metabolism | Receptors, Opioid, kappa - antagonists & inhibitors | Cricetulus | Receptors, Opioid, mu - metabolism | Humans | Receptors, Opioid, kappa - metabolism | Male | Structure-Activity Relationship | Rats, Sprague-Dawley | Narcotic Antagonists - chemistry | Dose-Response Relationship, Drug | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Tetrahydroisoquinolines - chemistry | Receptors, Opioid, delta - genetics | Narcotic Antagonists - pharmacology | Radioligand Assay | Receptors, Opioid, mu - genetics | Narcotic Antagonists - pharmacokinetics | Receptors, Opioid, kappa - genetics | CHO Cells | Index Medicus
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11. Full Text Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β‑Arrestin‑2
by Váradi, András and Marrone, Gina F and Palmer, Travis C and Narayan, Ankita and Szabó, Márton R and Le Rouzic, Valerie and Grinnell, Steven G and Subrath, Joan J and Warner, Evelyn and Kalra, Sanjay and Hunkele, Amanda and Pagirsky, Jeremy and Eans, Shainnel O and Medina, Jessica M and Xu, Jin and Pan, Ying-Xian and Borics, Attila and Pasternak, Gavril W and McLaughlin, Jay P and Majumdar, Susruta
Journal of medicinal chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 18, pp. 8381 - 8397
Mitragyna - chemistry | Receptors, Opioid, delta - metabolism | Cell Line | Secologanin Tryptamine Alkaloids - chemistry | Secologanin Tryptamine Alkaloids - pharmacology | Receptors, Opioid, mu - metabolism | Humans | Analgesics, Opioid - pharmacology | Male | beta-Arrestin 2 - metabolism | Receptors, Opioid, mu - agonists | Animals | Analgesics, Opioid - chemistry | Receptors, Opioid, delta - antagonists & inhibitors | Mice | Molecular Docking Simulation | Index Medicus
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