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Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3387 - 3391
Addictive diseases, including addiction to heroin, prescription opioids, or cocaine, pose massive personal and public health costs. Addictions are chronic... 
STEADY-STATE METHADONE | FREELY MOVING RATS | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VIVO MICRODIALYSIS | CORTICOTROPIN-RELEASING-FACTOR | MU-OPIOID-RECEPTOR | CHRONIC BINGE COCAINE | HPA-AXIS ACTIVATION | SINGLE-NUCLEOTIDE POLYMORPHISM | METHADONE-MAINTENANCE TREATMENT | MESSENGER-RNA LEVELS | Opioid-Related Disorders - drug therapy | Humans | Methadone - therapeutic use | Stress, Physiological | Cocaine-Related Disorders - genetics | Cocaine-Related Disorders - physiopathology | Neuropeptides - physiology | Receptors, Dopamine - drug effects | Receptors, Opioid - physiology | Dopamine - physiology | Opioid-Related Disorders - genetics | Dopaminergic Neurons - physiology | Limbic System - physiopathology | Hypothalamo-Hypophyseal System - physiopathology | Receptors, Dopamine - physiology | Limbic System - drug effects | Genetic Predisposition to Disease | Pharmacogenetics | Pituitary-Adrenal System - physiopathology | Basal Ganglia - physiopathology | Receptors, Opioid, mu - drug effects | Rats | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Cocaine-Related Disorders - drug therapy | Mice | Opioid-Related Disorders - physiopathology | Receptors, Opioid, mu - genetics | Reward | Receptors, Dopamine - genetics | Receptors, Opioid - drug effects | Basal Ganglia - drug effects | Receptors, Opioid, mu - physiology | Stress, Psychological - physiopathology | Messenger RNA | Opioids | Physiological aspects | Cocaine | Research | Health aspects | Sensory adaptation | Science in Medicine
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 2009, Volume 24, Issue 1, pp. 83 - 95
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/2008, Volume 154, Issue 2, pp. 384 - 396
A large range of neuroadaptations develop in response to chronic opioid exposure and these are thought to be more or less critical for expression of the major... 
opioid tolerance | downregulation | opioid | neuroadaptation | opioid withdrawal | synaptic plasticity | desensitization | morphine | opioid addiction | Neuroadaptation | Opioid addiction | Opioid tolerance | Desensitization | Synaptic plasticity | Opioid | Morphine | Downregulation | Opioid withdrawal | PROTEIN-KINASE-C | NEURONS IN-VITRO | CHRONIC MORPHINE TREATMENT | RAT LOCUS-CERULEUS | NUCLEUS-ACCUMBENS NEURONS | VENTRAL TEGMENTAL AREA | MIDBRAIN DOPAMINE NEURONS | PHARMACOLOGY & PHARMACY | LONG-TERM POTENTIATION | RECEPTOR DESENSITIZATION | Adaptation, Physiological | Neural Pathways - drug effects | Humans | Brain - enzymology | Neuronal Plasticity - drug effects | Opioid-Related Disorders - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Behavior, Addictive - metabolism | Brain - metabolism | Analgesics, Opioid - adverse effects | Substance Withdrawal Syndrome - metabolism | Synaptic Transmission - drug effects | Behavior, Addictive - physiopathology | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Opioid-Related Disorders - psychology | Receptors, Opioid, mu - drug effects | Receptors, Opioid, mu - metabolism | Brain - physiopathology | Drug Tolerance | Adenylyl Cyclases - metabolism | Brain - drug effects | Animals | Signal Transduction - drug effects | Neural Pathways - metabolism | Opioid-Related Disorders - physiopathology | Substance Withdrawal Syndrome - physiopathology | Substance Withdrawal Syndrome - psychology | Mitogen-Activated Protein Kinases - metabolism | Index Medicus | Focused Reviews
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2007, Volume 320, Issue 1, pp. 1 - 13
Journal Article
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 02/2008, Volume 33, Issue 3, pp. 643 - 652
Journal Article