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Neurobiology of Aging, ISSN 0197-4580, 2014, Volume 35, Issue 9, pp. 2064 - 2071
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 02/2017, Volume 176, Issue 2, pp. 413 - 422
What's already known about this topic? Pituitary adenylate cyclase‐activating polypeptide (PACAP) exhibits pleiotropic functions in the central nervous system,... 
FOCAL HYPERHIDROSIS | CELLS | PACAP | MOUSE MODEL | THORACOSCOPIC SYMPATHECTOMY | CYSTIC-FIBROSIS | VIP | SKIN IN-VIVO | EXPRESSION | AQUAPORIN-5 | DERMATOLOGY | Nerve Fibers - metabolism | Eccrine Glands - secretion | Sweat - secretion | Humans | Mice, Inbred C57BL | Receptors, Vasoactive Intestinal Peptide, Type II - metabolism | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Receptors, Vasoactive Intestinal Polypeptide, Type I - physiology | Male | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | RNA, Messenger - metabolism | Foot | Receptors, Vasoactive Intestinal Peptide, Type II - physiology | Animals | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Adult | Female | Receptors, Vasoactive Intestinal Polypeptide, Type I - metabolism | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Vasoactive intestinal peptides | Skin diseases | Skin | Neuroprotection | Sjogren's syndrome | RNA-directed DNA polymerase | Adrenal glands | Glands | Central nervous system | Lichen planus | Dermatitis | Vasodilation | Intestine | Atopic dermatitis | Vasoactive agents | Rodents | Localization | Sweat | Iodine | Sweating | Polypeptides | Psoriasis | Starch | Secretion | Fabry's disease | Exocrine glands | Polymerase chain reaction | Pituitary adenylate cyclase-activating polypeptide | Molecular modelling | Immunoreactivity | Neurotransmission | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2018, Volume 13, Issue 6, pp. e0198180 - e0198180
Pituitary adenylate cyclase-activating polypeptide (PACAP-38) is a common neuropeptide exerting a wide spectrum of functions in many fields, including... 
MULTIPLE-MYELOMA | DANIO-RERIO | OXIDATIVE STRESS | IN-VITRO | INNER-EAR | VASOACTIVE-INTESTINAL-PEPTIDE | MULTIDISCIPLINARY SCIENCES | LATERAL-LINE | TRANSCRIPTION FACTOR-3 | GENE-EXPRESSION | MACROPHAGE FUNCTIONS | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - biosynthesis | Lateral Line System - metabolism | Necrosis | RNA, Messenger - biosynthesis | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Lateral Line System - drug effects | Cytokines - genetics | Mechanoreceptors - metabolism | Receptors, Cytokine - genetics | Neutrophil Infiltration - drug effects | Activating Transcription Factor 3 - genetics | Animals, Genetically Modified | Anti-Inflammatory Agents - pharmacology | Receptors, Cytokine - biosynthesis | Neutrophils - drug effects | RNA, Messenger - genetics | Activating Transcription Factor 3 - biosynthesis | Inflammation | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Zebrafish - growth & development | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | Animals | Larva | Mechanoreceptors - drug effects | Zebrafish - metabolism | Cytokines - biosynthesis | Copper Sulfate - toxicity | Lateral Line System - cytology | Development and progression | Neuropeptides | Care and treatment | Genetic aspects | Properties | Larvae | Transcription factors | Hair cells | Multiple myeloma | Transgenic | Inflammatory response | Veterinary medicine | Interleukin 6 | Receptors | Immunology | Rodents | Pituitary adenylate cyclase-activating polypeptide receptors | Tumor necrosis factor-TNF | Interleukin 8 | Immune system | Hair | Polypeptides | Cytokines | Fertilization | Activating transcription factor 3 | Neutrophils | Zebrafish | Leukocytes (neutrophilic) | Exposure | Genetic diversity | Mammals | Gene expression | Chemical damage | Studies | Pituitary adenylate cyclase-activating polypeptide | Organic chemistry | Lateral line | In vivo methods and tests | Chemokines | Copper sulfate | Apoptosis | Index Medicus
Journal Article
Psychoneuroendocrinology, ISSN 0306-4530, 2008, Volume 34, Issue 6, pp. 833 - 843
Summary Exposure to chronic stress has been argued to produce maladaptive anxiety-like behavioral states, and many of the brain regions associated with... 
Endocrinology & Metabolism | Psychiatry | Fear | PAC 1 receptor | Corticotropin-releasing hormone | Extended amygdala | Plasticity | Vasoactive intestinal peptide | PAC | receptor | PAC receptor | RAT | PSYCHIATRY | IN-SITU HYBRIDIZATION | SYMPATHETIC NEURONS | NEUROSCIENCES | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS | RECEPTOR-DEFICIENT MICE | NEURITE OUTGROWTH | ENDOCRINOLOGY & METABOLISM | POLYPEPTIDE PACAP | GENE-EXPRESSION | AMYGDALA | Brain-Derived Neurotrophic Factor - genetics | Septal Nuclei - drug effects | Neuronal Plasticity - drug effects | Male | Receptor, trkB - genetics | RNA, Messenger - metabolism | Septal Nuclei - metabolism | Neuronal Plasticity - genetics | Time Factors | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Stress, Psychological - metabolism | Behavior, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | Anxiety - metabolism | Stress, Psychological - chemically induced | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Adaptation, Psychological - drug effects | Rats | Behavior, Animal - physiology | Up-Regulation - genetics | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Rats, Sprague-Dawley | Up-Regulation - drug effects | Stress, Psychological - genetics | Anxiety - genetics | Animals | Models, Biological | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Anxiety - chemically induced | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Chronic Disease | Receptor, trkB - metabolism | Anxiety - etiology | Tyrosine | Adenylate cyclase | Messenger RNA | Polypeptides | ACTH | Hormones | Growth factors | Index Medicus | corticotropin-releasing hormone | PAC1 receptor
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 07/2017, Volume 42, Issue 8, pp. 1679 - 1687
Chronic or repeated exposure to stressful stimuli can result in several maladaptive consequences, including increased anxiety-like behaviors and altered... 
CORTICOTROPIN-RELEASING HORMONE | EXTENDED AMYGDALA | PAC1 RECEPTOR | PSYCHIATRY | NEUROTROPHIC FACTOR | NEUROSCIENCES | BED NUCLEUS | BEHAVIORAL CONSEQUENCES | MESSENGER-RNA | STRIA TERMINALIS BNST | PEPTIDE PACAP | PHARMACOLOGY & PHARMACY | EXPRESSION | Septal Nuclei - drug effects | Microinjections | Septal Nuclei - physiology | Anxiety - physiopathology | Rats | Male | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Sex Characteristics | Vasoactive Intestinal Peptide - administration & dosage | Animals | Vasoactive Intestinal Peptide - pharmacology | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Reflex, Startle - drug effects | Female | Pituitary Adenylate Cyclase-Activating Polypeptide - administration & dosage | Corticosterone - blood | Stress, Psychological - physiopathology | Brain | Cycles | PAC1 protein | Transcription | Adrenal glands | Circuits | Corticosterone | Hypothalamus | Males | Nuclei | Infusion | Control | Startle response | Intestine | Vasoactive agents | Rodents | Anxiety | Stresses | Emotional behavior | Polypeptides | Stria terminalis | Hypothalamic-pituitary-adrenal axis | Exposure | Chemical vapor synthesis | Stress | Pituitary adenylate cyclase-activating polypeptide | Anxieties | Neural networks | Vasoactive intestinal peptide | Females | Stimuli | Index Medicus | Original
Journal Article
Neuroscience, ISSN 0306-4522, 2011, Volume 202, pp. 283 - 299
Abstract Pituitary adenylate-cyclase activating polypeptide (PACAP) has been implicated in the (patho)physiology of stress-adaptation. PACAP deficient... 
Neurology | dorsal raphe nucleus | stress | amygdala | hypothalmic paraventricular nucleus | Edinger–Westphal nucleus | bed nucleus of stria terminalis | Hypothalmic paraventricular nucleus | Amygdala | Edinger-Westphal nucleus | Bed nucleus of stria terminalis | Dorsal raphe nucleus | Stress | HORMONE CRH GENE | SEROTONERGIC SYSTEMS | RECEPTOR | CHRONIC STRESS | NEUROSCIENCES | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS | CORTICOTROPIN-RELEASING-FACTOR | MESSENGER-RNA | PEPTIDE PACAP | NEURONS | RAT-BRAIN | Immunohistochemistry | Genes, fos - physiology | Motor Activity - physiology | Anxiety - psychology | Proto-Oncogene Proteins c-fos - biosynthesis | Behavior, Animal - physiology | Male | Septum of Brain - metabolism | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Raphe Nuclei - metabolism | Ganglia, Parasympathetic - metabolism | Mice, Knockout | Septal Nuclei - metabolism | Oculomotor Nerve - metabolism | Animals | Image Processing, Computer-Assisted | Swimming - psychology | Gene Expression - physiology | Stress, Psychological - metabolism | Paraventricular Hypothalamic Nucleus - metabolism | Depression - psychology | Mice | Genes, fos - genetics | Pituitary Adenylate Cyclase-Activating Polypeptide - deficiency | Neurosciences | Goats | Animal behavior | Neurons | Depression, Mental | ACTH | Anxiety | Universities and colleges | Stress (Psychology) | Index Medicus
Journal Article
Dialogues in Clinical Neuroscience, ISSN 1294-8322, 2016, Volume 18, Issue 4, pp. 403 - 413
Trauma-related disorders, such as posttraumatic stress disorder (PTSD) are remarkably common and debilitating, and are often characterized by dysregulated... 
PTSD | ADCYAP1 | Fear | ADCYAP1R1 | Amygdala | PACAP | Estrogen | Genetic | Anxiety | Sex difference | Fear conditioning | Threat | genetic | CHILDHOOD MALTREATMENT | amygdala | estrogen | fear conditioning | sex difference | NEUROTROPHIC FACTOR | ESTROGEN-RECEPTOR INTERACTION | POSTTRAUMATIC-STRESS | NEUROSCIENCES | BED NUCLEUS | IMPAIRED FEAR INHIBITION | anxiety | FEMALE RATS | TRAUMATIZED CIVILIAN SAMPLE | POLYPEPTIDE PACAP | threat | GENDER-DIFFERENCES | fear | Adaptation, Psychological - physiology | Humans | Male | Stress Disorders, Post-Traumatic - physiopathology | Fear - physiology | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - physiology | Gene-Environment Interaction | Pituitary Adenylate Cyclase-Activating Polypeptide - blood | Female | Stress, Physiological - physiology | Estrogens - physiology | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Stress, Physiological - genetics | Risk Factors | Biomarkers - blood | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Sex Characteristics | Polymorphism, Genetic | Stress, Psychological - genetics | Stress Disorders, Post-Traumatic - blood | Animals | Sex Factors | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Stress Disorders, Post-Traumatic - genetics | Memory - physiology | Stress, Psychological - physiopathology | Index Medicus | Translational Research
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2009, Volume 106, Issue 6, pp. 2012 - 2017
Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a widely expressed neuropeptide originally discovered in the hypothalamus. It closely resembles... 
T lymphocytes | Spinal cord | Messenger RNA | Antiinflammatories | Cytokines | Disease models | Gene expression | Macrophages | Lymph nodes | Chemokines | Autoimmunity | Multiple sclerosis | Inflammation | Knock-out | Regulatory T cell | VASOACTIVE-INTESTINAL-PEPTIDE | PACAP | multiple sclerosis | REGENERATION | MULTIDISCIPLINARY SCIENCES | RECEPTOR | regulatory T cell | knock-out | IMMUNE-SYSTEM | autoimmunity | MULTIPLE-SCLEROSIS | inflammation | MICE | VIP | NEUROPEPTIDE GENE-EXPRESSION | T-CELLS | Spinal Cord - metabolism | Gene Expression Regulation - immunology | Receptors, CCR - genetics | Encephalomyelitis, Autoimmune, Experimental - etiology | Myelin-Oligodendrocyte Glycoprotein | Lymph Nodes - immunology | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Autoimmune Diseases - etiology | T-Lymphocytes, Regulatory - pathology | Mice, Knockout | Animals | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Vasoactive Intestinal Peptide - physiology | Myelin-Associated Glycoprotein | Lymphocyte Count | Myelin Proteins | Mice | Cytokines - genetics | Pituitary Adenylate Cyclase-Activating Polypeptide - deficiency | Prevention | Encephalomyelitis | Physiological aspects | Neuropeptides | Genetic aspects | Research | Suppressor cells | Health aspects | Polypeptides | Rodents | Glycoproteins | Autoimmune diseases | Cells | Brain diseases | Index Medicus | Biological Sciences
Journal Article