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Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7335, pp. 492 - 497
Pituitary adenylate cyclase-activating polypeptide (PACAP) is known to broadly regulate the cellular stress response. In contrast, it is unclear if the... 
SIGNAL-TRANSDUCTION | PTSD | CYCLASE-ACTIVATING POLYPEPTIDE | STRIA TERMINALIS | MULTIDISCIPLINARY SCIENCES | BRAIN-DEVELOPMENT | GENE-EXPRESSION | FEAR INHIBITION | ADENYLATE-CYCLASE | BED NUCLEUS | AMYGDALA | Septal Nuclei - drug effects | Estrogens - pharmacology | Humans | RNA, Messenger - analysis | Male | Stress Disorders, Post-Traumatic - physiopathology | Fear - physiology | RNA, Messenger - biosynthesis | Septal Nuclei - metabolism | DNA Methylation | Pituitary Adenylate Cyclase-Activating Polypeptide - blood | Female | Response Elements - genetics | Estrogens - metabolism | Genetic Predisposition to Disease - genetics | Genetic Association Studies | Pituitary Adenylate Cyclase-Activating Polypeptide - chemistry | RNA, Messenger - genetics | Amygdala - metabolism | Rats | Stress Disorders, Post-Traumatic - psychology | Sex Characteristics | Conditioning, Classical - physiology | Gene Expression Regulation - drug effects | Stress Disorders, Post-Traumatic - blood | Animals | CpG Islands - genetics | Polymorphism, Single Nucleotide - genetics | Mice | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Stress Disorders, Post-Traumatic - genetics | Psychological aspects | Physiological aspects | Causes of | Genetic aspects | Polypeptides | Post-traumatic stress disorder | Studies | Gene expression | Females | Males | Rodents | Depressive Disorders | Neuroendocrinology | Neurobiology | Survivors | Americans | Neuroendocrine Testing | Genetic Markers | Psychiatric Disorders | Reexperiencing | PTSD (DSM-IV) | Startle Reflex | Neurophysiology | Predisposition | Arousal | Adults | Stressors | Avoidance | Biologic Markers
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 11/2007, Volume 12, Issue 11, pp. 1026 - 1032
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2011, Volume 45, Issue 1, pp. 633 - 644
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2013, Volume 33, Issue 10, pp. 4614 - 4622
After G-protein-coupled receptor activation and signaling at the plasma membrane, the receptor complex is often rapidly internalized via endocytic vesicles for... 
CYCLIC-AMP | INTRACARDIAC NEURONS | AKT ACTIVATION | I-H | PACAP-INDUCED INCREASE | DYNAMICS | TRAFFICKING | PROTEIN-COUPLED RECEPTORS | BETA-ARRESTIN | ENDOCYTOSIS | NEUROSCIENCES | Temperature | Action Potentials - genetics | Electric Stimulation | Humans | Brefeldin A - pharmacology | Male | Green Fluorescent Proteins - genetics | Transfection | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Endosomes - drug effects | Neurons - physiology | Female | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | Neurons - drug effects | Thiazolidines - pharmacology | Cyclic AMP - metabolism | Action Potentials - drug effects | Animals, Newborn | Green Fluorescent Proteins - metabolism | Guinea Pigs | Drug Administration Schedule | Chlorides - pharmacology | Gene Expression Regulation - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Biophysics | Sulfonamides - pharmacology | Superior Cervical Ganglion - cytology | Barium Compounds - pharmacology | Hydrazones - pharmacology | Myocardium - cytology | Gene Expression Regulation - drug effects | Patch-Clamp Techniques | Animals | Signal Transduction - drug effects | Signal Transduction - physiology | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | In Vitro Techniques
Journal Article
Journal Article
Psychoneuroendocrinology, ISSN 0306-4530, 2008, Volume 34, Issue 6, pp. 833 - 843
Summary Exposure to chronic stress has been argued to produce maladaptive anxiety-like behavioral states, and many of the brain regions associated with... 
Endocrinology & Metabolism | Psychiatry | Fear | PAC 1 receptor | Corticotropin-releasing hormone | Extended amygdala | Plasticity | Vasoactive intestinal peptide | PAC | receptor | PAC receptor | RAT | PSYCHIATRY | IN-SITU HYBRIDIZATION | SYMPATHETIC NEURONS | NEUROSCIENCES | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS | RECEPTOR-DEFICIENT MICE | NEURITE OUTGROWTH | ENDOCRINOLOGY & METABOLISM | POLYPEPTIDE PACAP | GENE-EXPRESSION | AMYGDALA | Brain-Derived Neurotrophic Factor - genetics | Septal Nuclei - drug effects | Neuronal Plasticity - drug effects | Male | Receptor, trkB - genetics | RNA, Messenger - metabolism | Septal Nuclei - metabolism | Neuronal Plasticity - genetics | Time Factors | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Stress, Psychological - metabolism | Behavior, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | Anxiety - metabolism | Stress, Psychological - chemically induced | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Adaptation, Psychological - drug effects | Rats | Behavior, Animal - physiology | Up-Regulation - genetics | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Rats, Sprague-Dawley | Up-Regulation - drug effects | Stress, Psychological - genetics | Anxiety - genetics | Animals | Models, Biological | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Anxiety - chemically induced | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Chronic Disease | Receptor, trkB - metabolism | Anxiety - etiology | Tyrosine | Adenylate cyclase | Messenger RNA | Polypeptides | ACTH | Hormones | Growth factors | corticotropin-releasing hormone | PAC1 receptor
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e91541
Pituitary adenylate cyclase activating polypeptide (PACAP) is an important neurotrophic factor influencing differentiation of neuronal elements and exerting... 
INDUCED CELL-DEATH | PROGENITOR CELLS | CYCLIC-AMP | IN-VITRO | CARTILAGE DIFFERENTIATION | CORTICAL-NEURONS | MULTIDISCIPLINARY SCIENCES | CHICKEN PINEALOCYTES | STRESS-INDUCED APOPTOSIS | EXTRACELLULAR DOMAIN | HYDROGEN-PEROXIDE | Chondrocytes - cytology | Cell Proliferation | Oxidative Stress | Chondrogenesis - genetics | Cyclosporine - pharmacology | Limb Buds - cytology | Pituitary Adenylate Cyclase-Activating Polypeptide - chemical synthesis | Receptors, Vasoactive Intestinal Peptide, Type II - genetics | Chondrocytes - drug effects | Calcineurin - genetics | Peptides - chemical synthesis | Gene Expression Regulation, Developmental | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Cell Differentiation | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | Receptors, Vasoactive Intestinal Polypeptide, Type I - metabolism | Chondrocytes - metabolism | SOX9 Transcription Factor - metabolism | Calcineurin Inhibitors - pharmacology | Signal Transduction | Receptors, Vasoactive Intestinal Peptide, Type II - metabolism | Hydrogen Peroxide - pharmacology | Chick Embryo | Receptors, Vasoactive Intestinal Polypeptide, Type I - genetics | Peptides - pharmacology | Animals | Limb Buds - metabolism | Limb Buds - growth & development | Primary Cell Culture | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Limb Buds - drug effects | SOX9 Transcription Factor - genetics | Calcineurin - metabolism | Physiological aspects | Calcium-binding proteins | Phosphatases | Cell proliferation | Oxidative stress | Phosphorylation | Transcription factors | PAC1 protein | Adrenal glands | Downstream effects | Cyclosporins | Calcineurin | Sox9 protein | Central nervous system | Neuropeptides | Kinases | Tissues | Limb buds | Proteins | Cartilage | Receptors | Embryology | Rodents | Calcium-binding protein | Chondrogenesis | Calmodulin | Polypeptides | Pulmonary arteries | Cultures | Histology | Cartilage (articular) | Pharmacology | Inflammation | Gene expression | Medicine | Pituitary adenylate cyclase-activating polypeptide | Regeneration | Signaling | Collagen | Chondrocytes | Protein phosphatase | Differentiation | Apoptosis
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 2009, Volume 121, Issue 3, pp. 294 - 316
Vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase activating polypeptides (PACAPs) share 68% identity at the amino acid level and belong... 
Receptor variants | G-protein coupled receptor | PACAP | VIP | PACR | VPACR | CYCLASE-ACTIVATING POLYPEPTIDE | HUMAN NEUROBLASTOMA-CELLS | VASOACTIVE-INTESTINAL-PEPTIDE | WATERY-DIARRHEA SYNDROME | DIFFERENTIAL SIGNAL-TRANSDUCTION | GILA MONSTER VENOM | STIMULATES ADENYLATE-CYCLASE | PROTEIN-COUPLED-RECEPTORS | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | PHOSPHOLIPASE-C ACTIVATION | Amino Acid Sequence | Signal Transduction | Receptors, Vasoactive Intestinal Peptide, Type II - agonists | Receptors, Vasoactive Intestinal Polypeptide, Type I - physiology | Mice, Transgenic | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Organ Specificity | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - physiology | Phospholipase D - metabolism | Receptors, Vasoactive Intestinal Peptide, Type II - genetics | Receptors, Vasoactive Intestinal Polypeptide, Type I - genetics | Receptors, Vasoactive Intestinal Peptide, Type II - physiology | Animals | Vasoactive Intestinal Peptide - physiology | Receptors, Vasoactive Intestinal Polypeptide, Type I - agonists | Base Sequence | Ligands | Mice | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - agonists | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Cyclic AMP - metabolism | Hypertension | Coenzymes | Inositol | Somatotropin releasing hormone | Peptides | Guanosine | Leukemia | Inositol phosphates | Amino acids | Lipids | Cyclic adenylic acid | Hormones | Muscle proteins | Embryonic stem cells | Hamsters | Adenylate cyclase | Synthesis | Analysis | Physiological aspects | Phospholipases | Nuclear magnetic resonance | Adenylic acid | Concentration camps | Adenosine triphosphate
Journal Article