Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (2369) 2369
Book Review (415) 415
Publication (378) 378
Book Chapter (13) 13
Book / eBook (5) 5
Conference Proceeding (4) 4
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (2136) 2136
animals (1528) 1528
humans (1222) 1222
mice (714) 714
male (619) 619
female (551) 551
dinoprostone - metabolism (502) 502
receptors, prostaglandin e - metabolism (496) 496
dinoprostone - pharmacology (485) 485
receptors, prostaglandin e, ep4 subtype (446) 446
rats (422) 422
cells, cultured (380) 380
lipids (341) 341
signal transduction (333) 333
receptors, prostaglandin e, ep4 subtype - metabolism (323) 323
expression (315) 315
biochemistry & molecular biology (313) 313
cell biology (313) 313
receptors, prostaglandin e - genetics (307) 307
prostanoid receptors (305) 305
inflammation (301) 301
prostaglandin e2 (286) 286
receptors, prostaglandin e, ep2 subtype (278) 278
prostaglandins (274) 274
prostaglandin e-2 (271) 271
cyclooxygenase 2 - metabolism (249) 249
mice, inbred c57bl (237) 237
prostaglandin e (231) 231
cyclic amp - metabolism (222) 222
prostaglandins e (220) 220
gene expression (219) 219
rna, messenger - metabolism (214) 214
pharmacology & pharmacy (212) 212
mice, knockout (202) 202
rats, sprague-dawley (202) 202
cyclooxygenase-2 (196) 196
dose-response relationship, drug (194) 194
receptors (194) 194
receptors, prostaglandin e - physiology (193) 193
receptors, prostaglandin e - agonists (191) 191
signal transduction - drug effects (191) 191
article (188) 188
cell line (182) 182
endocrinology & metabolism (180) 180
immunology (179) 179
rodents (172) 172
oncology (171) 171
physiological aspects (171) 171
receptors, prostaglandin e, ep2 subtype - metabolism (166) 166
reverse transcriptase polymerase chain reaction (166) 166
cell line, tumor (164) 164
research (163) 163
abridged index medicus (158) 158
receptor (158) 158
prostaglandin (155) 155
proteins (155) 155
receptors, prostaglandin e, ep3 subtype (155) 155
activation (154) 154
physiology (152) 152
cells (151) 151
neurosciences (147) 147
immunohistochemistry (145) 145
receptors, prostaglandin e - antagonists & inhibitors (145) 145
disease models, animal (137) 137
receptors, prostaglandin e, ep4 subtype - genetics (135) 135
analysis (134) 134
cancer (134) 134
research article (134) 134
cyclooxygenase 2 - genetics (132) 132
dinoprostone - physiology (132) 132
gene-expression (132) 132
rna, messenger - genetics (130) 130
pge (126) 126
receptors, prostaglandin e, ep1 subtype (126) 126
alprostadil - pharmacology (125) 125
blotting, western (122) 122
phosphorylation (122) 122
medicine (115) 115
middle aged (114) 114
alprostadil - analogs & derivatives (112) 112
health aspects (112) 112
prostaglandin-endoperoxide synthases - metabolism (112) 112
apoptosis (110) 110
signal transduction - physiology (109) 109
in-vitro (108) 108
up-regulation (108) 108
cyclic amp-dependent protein kinases - metabolism (106) 106
receptors, prostaglandin - metabolism (106) 106
cytokines (104) 104
inhibition (103) 103
gene expression regulation - drug effects (102) 102
receptors, prostaglandin e, ep4 subtype - antagonists & inhibitors (102) 102
adult (99) 99
cox-2 (99) 99
kinases (99) 99
ep4 receptor (97) 97
multidisciplinary sciences (97) 97
time factors (96) 96
cyclooxygenase 2 (95) 95
pge2 (95) 95
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (3) 3
Dentistry (Harry R Abbott) - Stacks (1) 1
Providence Healthcare - Reference (1) 1
Providence Healthcare - Stacks (1) 1
St. Michael's Hospital - Stacks (1) 1
Toronto East General Hospital - Stacks (1) 1
UTL at Downsview - May be requested (1) 1
UofT at Scarborough - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2367) 2367
Japanese (9) 9
Chinese (4) 4
French (2) 2
German (2) 2
Spanish (2) 2
Arabic (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Mesenchymal stem cell inhibition of T-helper 17 cell- differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor
by Duffy, Michelle M and Pindjakova, Jana and Hanley, Shirley A and McCarthy, Cathal and Weidhofer, Gudrun A and Sweeney, Eva M and English, Karen and Shaw, Georgina and Murphy, J. Mary and Barry, Frank P and Mahon, Bernard P and Belton, Orina and Ceredig, Rhodri and Griffin, Matthew D
European Journal of Immunology, ISSN 0014-2980, 10/2011, Volume 41, Issue 10, pp. 2840 - 2851
Mesenchymal stem cells (MSCs) inhibit T-cell activation and proliferation but their effects on individual T-cell-effector pathways and on memory versus naive T... 
T helper cells | Immunosuppression | Stem cells | Mesenchymal stem cells | Th17 cells | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DENDRITIC CELLS | PROLIFERATION | INDUCTION | IMMUNOLOGY | ISCHEMIA-REPERFUSION INJURY | INTERFERON-GAMMA | INFLAMMATION | EXPANSION | MICE | LYMPHOCYTES | Cell Proliferation | Dinoprostone - biosynthesis | Coculture Techniques | Interleukin-2 Receptor alpha Subunit - biosynthesis | Mesenchymal Stromal Cells - immunology | Th17 Cells - drug effects | Flow Cytometry | Th17 Cells - metabolism | Polymerase Chain Reaction | Female | Cell Differentiation | Mesenchymal Stromal Cells - physiology | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Receptors, Prostaglandin E, EP4 Subtype - agonists | Mesenchymal Stromal Cells - drug effects | Cyclooxygenase 2 Inhibitors - pharmacology | Lymphocyte Activation | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Cell Communication | Interleukin-17 - biosynthesis | Blotting, Western | Indomethacin - pharmacology | Dinoprostone - metabolism | Animals | Interleukin-17 - antagonists & inhibitors | Th17 Cells - immunology | Mice | Mice, Inbred BALB C | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation
by Mo, Chenglin and Zhao, Ruonan and Vallejo, Julian and Igwe, Orisa and Bonewald, Lynda and Wetmore, Lori and Brotto, Marco
Cell Cycle, ISSN 1538-4101, 05/2015, Volume 14, Issue 10, pp. 1507 - 1516
We recently demonstrated that conditioned media (CM) from osteocytes enhances myogenic differentiation of myoblasts, suggesting that signaling from bone may be... 
EP4 | bone-muscle crosstalk | Prostaglandin E | proliferation | myogenesis | reactive oxygen species | Bone-muscle crosstalk | Reactive oxygen species | Proliferation | Myogenesis | Immunohistochemistry | Reactive Oxygen Species - metabolism | Receptors, Prostaglandin E, EP2 Subtype - metabolism | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | Alprostadil - analogs & derivatives | Myoblasts - drug effects | Muscle, Skeletal - drug effects | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Receptors, Prostaglandin E, EP4 Subtype - agonists | Receptors, Prostaglandin E, EP4 Subtype - genetics | Dinoprostone - pharmacology | Receptors, Prostaglandin E, EP3 Subtype - metabolism | Mice, Inbred C57BL | Receptors, Prostaglandin E, EP2 Subtype - genetics | Alprostadil - pharmacology | Cells, Cultured | Receptors, Prostaglandin E, EP3 Subtype - genetics | Thiophenes - pharmacology | Receptors, Prostaglandin E, EP1 Subtype - genetics | Receptors, Prostaglandin E, EP1 Subtype - metabolism | Triazoles - pharmacology | Animals | Signal Transduction - drug effects | Acetylcysteine - pharmacology | Receptors, Prostaglandin E, EP1 Subtype - agonists | Cell Proliferation - drug effects | Mice | G1 Phase Cell Cycle Checkpoints - drug effects | Receptors, Prostaglandin E, EP2 Subtype - agonists | Receptors, Prostaglandin E, EP3 Subtype - agonists | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype
by Birrell, Mark A and Maher, Sarah A and Dekkak, Bilel and Jones, Victoria and Wong, Sissie and Brook, Peter and Belvisi, Maria G
Thorax, ISSN 0040-6376, 08/2015, Volume 70, Issue 8, pp. 740 - 747
BackgroundAsthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory diseases of the airway. Current treatment options (long acting... 
Receptors, Prostaglandin E - therapeutic use | Asthma - metabolism | Lung - pathology | Humans | Mice, Inbred C57BL | Cells, Cultured | Male | Asthma - drug therapy | Animals | Lung - drug effects | Female | Lung - metabolism | Mice | Asthma - pathology | Disease Models, Animal | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Lung diseases, Obstructive | Care and treatment | Dosage and administration | Corticosteroids | Anti-inflammatory drugs | Asthma | Proteins | Studies | Disease | Cytokines | Rodents | Respiratory diseases | Chronic obstructive pulmonary disease | Inflammation | Kinases | Gene expression | Experiments | Index Medicus | Respiratory Research | Asthma Pharmacology | 1506 | Asthma Mechanisms | COPD Pharmacology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling
by Woodling, Nathaniel S and Wang, Qian and Priyam, Prachi G and Larkin, Paul and Shi, Ju and Johansson, Jenny U and Zagol-Ikapitte, Irene and Boutaud, Olivier and Andreasson, Katrin I
Journal of Neuroscience, ISSN 0270-6474, 2014, Volume 34, Issue 17, pp. 5882 - 5894
A persistent and nonresolving inflammatory response to accumulating Aβ peptide species is a cardinal feature in the development of Alzheimer's disease (AD). In... 
Neuroinflammation | Receptor | Alzheimer's disease | Peptide | Microglia | Receptors, Prostaglandin E, EP4 Subtype - agonists | Cell Survival - drug effects | Inflammation - pathology | Microglia - metabolism | Microglia - drug effects | Amyloid beta-Peptides - pharmacology | Humans | Peptide Fragments - pharmacology | Methyl Ethers - pharmacology | Alzheimer Disease - pathology | Inflammation - metabolism | Animals | Signal Transduction - drug effects | Alzheimer Disease - metabolism | Aged, 80 and over | Signal Transduction - physiology | Aged | Cell Survival - physiology | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Index Medicus | PGE2 | Aβ peptide | receptor | neuroinflammation | microglia
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text COX‐2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis
by Majumder, Mousumi and Xin, Xiping and Liu, Ling and Tutunea‐Fatan, Elena and Rodriguez‐Torres, Mauricio and Vincent, Krista and Postovit, Lynne‐Marie and Hess, David and Lala, Peeyush K
STEM CELLS, ISSN 1066-5099, 09/2016, Volume 34, Issue 9, pp. 2290 - 2305
Cancer stem‐like cells (SLC) resist conventional therapies, necessitating searches for SLC‐specific targets. We established that cyclo‐oxygenase(COX)‐2... 
EP4 | NOTCH/WNT | Breast cancer | Stem‐like cell | Cyclo‐oxygenase‐2 | Cyclo-oxygenase-2 | Stem-like cell | MIGRATION | TARGET | CYCLOOXYGENASE-2 | ANGIOGENESIS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | PROSTANOID RECEPTORS | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GROWTH | LYMPHANGIOGENESIS | INHIBITORS | HEMATOLOGY | EXPRESSION | Signal Transduction | Neoplasm Invasiveness | Receptors, Notch - metabolism | Humans | RNA, Messenger - genetics | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | Wnt Proteins - metabolism | Breast Neoplasms - enzymology | Phenotype | Animals | Breast Neoplasms - genetics | Neoplastic Stem Cells - metabolism | Breast Neoplasms - pathology | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Female | Mice | Proto-Oncogene Proteins c-akt - metabolism | Neoplasm Micrometastasis - pathology | Receptors, Prostaglandin E, EP4 Subtype - metabolism | COX-2 inhibitors | Prostaglandins | DNA microarrays | Endothelial growth factors | RNA | Analysis | Stem cells | Development and progression | Transplantation | Metastasis | Intermediate filament proteins | Genes | Rodents | Regulations | Severe combined immunodeficiency | Leukocyte migration | Mesenchyme | Oct-4 protein | Lung | Gene regulation | AKT protein | E-cadherin | Prostaglandin endoperoxide synthase | Metastases | Allografts | CD44 antigen | Animal tissues | Down-regulation | Localization | Vascular endothelial growth factor | Interleukin 2 receptors | Markers | Gene expression | Spheroids | 1-Phosphatidylinositol 3-kinase | Oxygenase | Overexpression | Inhibitors | Cell lines | Breast | Cyclooxygenase-2 | Colonization | Cell migration | Tumors | Cancer | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Prostaglandin E-2 suppresses hCAP18/LL-37 expression in human macrophages via EP2/EP4: implications for treatment of Mycobacterium tuberculosis infection
by Wan, M and Tang, X and Rekha, RS and Muvva, SSVJR and Brighenti, S and Agerberth, B and Haeggstrom, JZ
FASEB JOURNAL, ISSN 0892-6638, 05/2018, Volume 32, Issue 5, pp. 2827 - 2840
Prostaglandin (PG)E-2 is an arachidonic acid-derived lipid mediator that plays an important role in inflammation and immunity. In this study, we demonstrate... 
PROTEIN | cathelicidin | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-D-RECEPTOR | ANTIMICROBIAL PEPTIDES | cAMP | AUTOREGULATION | CUTTING EDGE | I INTERFERON | CELL BIOLOGY | eicosanoids | vitamin D-3 | innate immunity | GENE | BIOLOGY | CATHELICIDIN LL-37 | Cyclic AMP-Dependent Protein Kinases - metabolism | Receptors, Prostaglandin E, EP4 Subtype - agonists | Cell Line | Dinoprostone - pharmacology | Macrophages - pathology | Receptors, Prostaglandin E, EP2 Subtype - metabolism | Humans | Antimicrobial Cationic Peptides - biosynthesis | Autophagy - drug effects | Receptors, Calcitriol - biosynthesis | Dinoprostone - metabolism | Gene Expression Regulation - drug effects | Macrophages - metabolism | Tuberculosis - therapy | Signal Transduction - drug effects | Calcitriol - pharmacology | Mycobacterium tuberculosis - metabolism | Tuberculosis - metabolism | Macrophages - microbiology | Receptors, Prostaglandin E, EP2 Subtype - agonists | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Tuberculosis - pathology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Direct growth-inhibitory effects of prostaglandin E2 in pancreatic cancer cells in vitro through an EP4/PKA-mediated mechanism
by Schmidt, Andrea, MD and Sinnett-Smith, James, BSc and Young, Steven, PhD and Chang, Hui-Hua, PhD and Hines, O. Joe, MD and Dawson, David W., MD and Rozengurt, Enrique, PhD and Eibl, Guido, MD
Surgery: Official Journal of the Society of University Surgeons, Central Surgical Association, and the American Association of Endocrine Surgeons, ISSN 0039-6060, 2017, Volume 161, Issue 6, pp. 1570 - 1578
Background There is strong evidence linking inflammation and the development of pancreatic ductal adenocarcinoma. Cyclooxygenase-2 (COX-2) and COX-2-derived... 
Surgery | SURGERY | PROSTANOID RECEPTORS | EP4 RECEPTOR | COX-2 | SIGNALING PATHWAY | COLORECTAL-CANCER | E-2 | SELECTIVE CYCLOOXYGENASE-2 INHIBITOR | INTRAEPITHELIAL NEOPLASIA | UP-REGULATION | EXPRESSION | Intracellular Signaling Peptides and Proteins - pharmacology | Dinoprostone - pharmacology | Receptors, Prostaglandin E, EP2 Subtype - metabolism | Humans | Middle Aged | Pancreas - cytology | Pancreatic Neoplasms - pathology | Gene Expression Regulation | Male | Receptors, Prostaglandin E, EP1 Subtype - genetics | Cell Line, Tumor - drug effects | Cyclooxygenase 2 - drug effects | Carcinoma, Pancreatic Ductal - pathology | Blotting, Western | Receptors, Prostaglandin E, EP2 Subtype - drug effects | Phosphorylation - genetics | Sensitivity and Specificity | Cyclooxygenase 2 - metabolism | Female | Aged | Cell Proliferation - drug effects | Phosphorylation - drug effects | Receptors, Prostaglandin E, EP4 Subtype - drug effects | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Medical research | COX-2 inhibitors | Medical colleges | Growth | Pancreatic cancer | Analysis | Prostaglandins E | Medicine, Experimental | DNA synthesis | Rankings | Gene expression | Index Medicus | Abridged Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Roles of Prostaglandin E2–EP3/EP4 Receptor Signaling in the Enhancement of Lymphangiogenesis During Fibroblast Growth Factor-2–Induced Granulation Formation
by Hosono, Kanako and Suzuki, Tatsunori and Tamaki, Hideaki and Sakagami, Hiroyuki and Hayashi, Izumi and Narumiya, Shuh and Alitalo, Kari and Majima, Masataka
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 05/2011, Volume 31, Issue 5, pp. 1049 - 1058
OBJECTIVE—One of the hallmarks of inflammation is lymphangiogesis that drains the interstitial fluids. During chronic inflammation, angiogenesis is induced by... 
lymphangiogenesis | endothelium | prostaglandins | vascular biology | angiogenesis | Membrane Glycoproteins - metabolism | Receptors, Prostaglandin E, EP2 Subtype - metabolism | Granulation Tissue - physiopathology | Glycoproteins - metabolism | Male | Lymphatic Vessels - drug effects | Granulation Tissue - drug effects | Lymphatic Vessels - metabolism | Time Factors | Receptors, Prostaglandin E, EP4 Subtype - deficiency | Injections, Subcutaneous | Intramolecular Oxidoreductases - metabolism | Fibroblasts - metabolism | Pyrazoles - pharmacology | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Receptors, Prostaglandin E, EP4 Subtype - genetics | Receptors, Prostaglandin E, EP3 Subtype - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Mice, Inbred C57BL | Receptors, Prostaglandin E, EP2 Subtype - genetics | Cells, Cultured | Receptors, Prostaglandin E, EP3 Subtype - genetics | Receptors, Prostaglandin E, EP1 Subtype - genetics | Celecoxib | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Fibroblast Growth Factor 2 - administration & dosage | Sulfonamides - pharmacology | Granulation Tissue - metabolism | Receptors, Prostaglandin E, EP1 Subtype - metabolism | Mice, Knockout | Dinoprostone - metabolism | Lymphangiogenesis - drug effects | Macrophages - metabolism | Vascular Endothelial Growth Factor D - metabolism | Animals | Receptors, Prostaglandin E, EP3 Subtype - deficiency | Signal Transduction - drug effects | Vascular Endothelial Growth Factor C - metabolism | Fibroblasts - drug effects | Prostaglandin-E Synthases | Cyclooxygenase 2 - metabolism | Macrophages - drug effects | Mice | Lymphatic Vessels - physiopathology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Combined targeting of STAT3/NF-κB/COX-2/EP4 for effective management of pancreatic cancer
by Gong, Jingjing and Xie, Jianping and Bedolla, Roble and Rivas, Paul and Chakravarthy, Divya and Freeman, James W and Reddick, Robert and Kopetz, Scott and Peterson, Amanda and Wang, Huamin and Fischer, Susan M and Kumar, Addanki P
Clinical Cancer Research, ISSN 1078-0432, 2014, Volume 20, Issue 5, pp. 1259 - 1273
Purpose: Near equal rates of incidence and mortality emphasize the need for novel targeted approaches for better management of patients with pancreatic cancer.... 
MOUSE PROSTATE MODEL | TRANSGENIC ADENOCARCINOMA | EP4 RECEPTOR | ONCOLOGY | PATHWAY | NATURAL-PRODUCTS | STAT3 | STELLATE CELLS | GROWTH-FACTOR | NF-KAPPA-B | AMURENSE BARK EXTRACT | Immunohistochemistry | Gene Expression | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Plant Extracts - pharmacology | Humans | Pancreatic Neoplasms - pathology | NF-kappa B - metabolism | Pancreatic Neoplasms - genetics | Pancreatic Neoplasms - drug therapy | Plant Extracts - administration & dosage | Xenograft Model Antitumor Assays | Antineoplastic Agents, Phytogenic - administration & dosage | Animals | Signal Transduction - drug effects | Cyclooxygenase 2 - metabolism | Fibrosis | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | STAT3 Transcription Factor - metabolism | Disease Models, Animal | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Index Medicus | Stat3 | Prostaglandin receptor EP4 | Nexrutine | NFκB | Cox-2 | Pancreatic cancer
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury
by Zhu, Liyuan and Xu, Chuansheng and Huo, Xingyu and Hao, Huifeng and Wan, Qing and Chen, Hong and Zhang, Xu and Breyer, Richard M and Huang, Yu and Cao, Xuetao and Liu, De-Pei and FitzGerald, Garret A and Wang, Miao
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1888 - 1888
The use of nonsteroidal anti-inflammatory drugs that inhibit cyclooxygenase (COX)-1 and COX-2, increases heart failure risk. It is unknown whether microsomal... 
E-2 SYNTHASE-1 | INFARCTION | CYCLOOXYGENASE-2 | NO-REFLOW | LATE-PHASE | E SYNTHASE-1 | CARDIAC ISCHEMIA | MULTIDISCIPLINARY SCIENCES | INCREASES MORTALITY | KNOCKOUT MICE | DELETION | Myocardial Reperfusion Injury - etiology | Humans | Misoprostol - pharmacology | Male | Microcirculation - drug effects | Myocardial Reperfusion Injury - pathology | Prostaglandin-E Synthases - genetics | Membrane Proteins - metabolism | Myocardial Reperfusion Injury - drug therapy | Disease Models, Animal | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Endothelium - pathology | Receptors, Prostaglandin E, EP4 Subtype - genetics | Coronary Vessels - pathology | Cyclooxygenase 1 - genetics | Prostaglandin-E Synthases - metabolism | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | Myocardium - pathology | Mice, Knockout | Dinoprostone - metabolism | Animals | Mice | Cyclooxygenase 1 - metabolism | Misoprostol - therapeutic use
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/ PKA-and EP1/CA2+-mediated mechanism in the human pancreatic carcinoma cell line PANC-1
by Chang, Abstracthui-Hua and Young, Steven H and Sinnett-Smith, James and Ne Chou, Caroline Ei and Moro, Aune and Hertzer, Kathleen M and Hines, Oscar Joe and Rozengurt, Enrique and Eibl, Guido
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 2015, Volume 309, Issue 10, pp. 639 - 649
Obesity, a known risk factor for pancreatic cancer, is associated with inflammation and insulin resistance. Proinflammatory prostaglandin E2 (PGE(2)) and... 
Prostaglandin E2 | Obesity | Mammalian target of rapamycin complex 1 | Pancreatic cancer | PHYSIOLOGY | HIGH-FAT DIET | COUPLED RECEPTOR | COLON CARCINOGENESIS | KRAS(G12D) MOUSE MODEL | CELL BIOLOGY | CANCER GROWTH | BREAST-CANCER | INSULIN | pancreatic cancer | CYCLIC-AMP | prostaglandin E2 | PROTEIN S6 PHOSPHORYLATION | mammalian target of rapamycin complex 1 | obesity | TUMOR MICROENVIRONMENT | Cyclic AMP-Dependent Protein Kinases - metabolism | Receptors, Prostaglandin E, EP4 Subtype - genetics | Dinoprostone - pharmacology | Receptors, Prostaglandin E, EP2 Subtype - metabolism | TOR Serine-Threonine Kinases - metabolism | Calcium - metabolism | Humans | Receptors, Prostaglandin E, EP2 Subtype - genetics | Gene Expression Regulation - physiology | Multiprotein Complexes - genetics | Receptors, Prostaglandin E, EP1 Subtype - genetics | Receptors, Prostaglandin E, EP1 Subtype - metabolism | Mechanistic Target of Rapamycin Complex 1 | Dinoprostone - metabolism | Interleukin-23 Subunit p19 - metabolism | Multiprotein Complexes - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | TOR Serine-Threonine Kinases - genetics | Interleukin-23 Subunit p19 - genetics | Cell Line, Tumor | Cyclic AMP - genetics | Cyclic AMP - metabolism | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Index Medicus | Call for Papers
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2
by Jones, Victoria C and Birrell, Mark A and Maher, Sarah A and Griffiths, Mark and Grace, Megan and O'Donnell, Valerie B and Clark, Stephen R and Belvisi, Maria G
British Journal of Pharmacology, ISSN 0007-1188, 03/2016, Volume 173, Issue 6, pp. 992 - 1004
Airway microvascular leak (MVL) involves the extravasation of proteins from post-capillary venules into surrounding tissue. MVL is a cardinal sign of... 
Allergens | Asthma - metabolism | Capillary Permeability | Receptors, Prostaglandin E, EP2 Subtype - metabolism | Male | Trachea - metabolism | Azetidines - pharmacology | Receptors, Prostaglandin E, EP2 Subtype - antagonists & inhibitors | Receptors, Prostaglandin E, EP4 Subtype - antagonists & inhibitors | Bronchi - metabolism | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Receptors, Prostaglandin E, EP4 Subtype - agonists | Receptors, Prostaglandin E, EP4 Subtype - genetics | Dinoprostone - pharmacology | Ovalbumin | Guinea Pigs | Mice, Inbred C57BL | Receptors, Prostaglandin E, EP2 Subtype - genetics | Imidazoles - pharmacology | Methyl Ethers - pharmacology | Benzazepines - pharmacology | Mice, Knockout | Dinoprostone - metabolism | Animals | Dinoprostone - analogs & derivatives | Mice | Receptors, Prostaglandin E, EP2 Subtype - agonists | Proteins | Physiological aspects | Analysis | Prostaglandins E | Asthma | Lung | Prostaglandin E2 | Inflammation | Metabolism | Arachidonic acid | Inflammatory diseases | Respiratory tract | Receptors | Guinea pigs | Extravasation | Respiratory tract diseases | Microvasculature | Index Medicus | Research Papers | Research Paper
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem‐like cell functions
by Majumder, Mousumi and Xin, Xiping and Liu, Ling and Girish, Gannareddy V and Lala, Peeyush K
Cancer Science, ISSN 1347-9032, 09/2014, Volume 105, Issue 9, pp. 1142 - 1151
We previously established that COX ‐2 overexpression promotes breast cancer progression and metastasis. As long‐term use of COX ‐2 inhibitors ( COX ‐2i) can... 
macrophages | cyclooxygenase 2 | 00015986 | Cancer stem cells | 4 subtype | prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Macrophages | RQ-00015986 | Cyclooxygenase 2 | FACTOR VEGF | ANTAGONIST | prostaglandin E2 receptor EP4 subtype | HUMAN BREAST-CANCER | MURINE | PROSTANOID RECEPTORS | ONCOLOGY | GROWTH | TUMOR-ASSOCIATED MACROPHAGES | CYCLOOXYGENASE-2 EXPRESSION | UP-REGULATION | PROGRESSION | Lung Neoplasms - drug therapy | Neoplasm Transplantation | Pyrazoles - therapeutic use | Cell Proliferation | Antineoplastic Agents - therapeutic use | Vascular Endothelial Growth Factor A - metabolism | Molecular Targeted Therapy | Benzamides - therapeutic use | Lung Neoplasms - secondary | Receptors, Prostaglandin E, EP4 Subtype - antagonists & inhibitors | Mammary Neoplasms, Experimental - pathology | Female | Mammary Neoplasms, Experimental - blood supply | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Lymphangiogenesis | Lung Neoplasms - blood supply | Mammary Neoplasms, Experimental - drug therapy | Pyrazoles - pharmacology | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Lymphatic Metastasis | Neoplastic Stem Cells | Celecoxib | Tumor Burden | Sulfonamides - pharmacology | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Mice, Inbred C3H | Adenocarcinoma - blood supply | Macrophages - metabolism | Animals | Sulfonamides - therapeutic use | Neovascularization, Pathologic - drug therapy | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Mice | Apoptosis | Drug Screening Assays, Antitumor | Index Medicus | Original
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights