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Journal Article
Nature, ISSN 0028-0836, 09/2009, Volume 461, Issue 7261, pp. 282 - 286
Phagocytic removal of apoptotic cells occurs efficiently in vivo such that even in tissues with significant apoptosis, very few apoptotic cells are detectable.... 
UTP | THYMUS | RECEPTOR SUBTYPES | EPITHELIAL-CELLS | CHEMOTAXIS | INFLAMMATION | ENGULFMENT | ELEGANS | MULTIDISCIPLINARY SCIENCES | DEATH | EXTRACELLULAR NUCLEOTIDES | Uridine Triphosphate - metabolism | Monocytes - cytology | Humans | Culture Media, Conditioned - chemistry | Culture Media, Conditioned - pharmacology | Monocytes - metabolism | Receptors, Purinergic P2Y2 | Adenosine Triphosphate - pharmacology | Chemotactic Factors - pharmacology | Chemotactic Factors - metabolism | Adenosine Triphosphate - metabolism | Receptors, Purinergic P2 - genetics | Phagocytes - cytology | Cell Line | Phagocytosis - drug effects | Jurkat Cells | Phagocytes - drug effects | Mice, Inbred C57BL | Uridine Triphosphate - pharmacology | Cells, Cultured | Phagocytosis - physiology | Thymus Gland - cytology | Purinergic P2 Receptor Antagonists | Chemotaxis - drug effects | Macrophages - cytology | Phagocytes - metabolism | Monocytes - drug effects | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Receptors, Purinergic P2 - metabolism | Macrophages - drug effects | Mice | Apoptosis - physiology | Macrophage Activation - drug effects | Receptors, Purinergic P2 - deficiency | Culture Media, Conditioned - metabolism | Phagocytes | Nucleotides | Research | Properties | Apoptosis | Rodents | Cells | Index Medicus
Journal Article
Science, ISSN 0036-8075, 10/2005, Volume 310, Issue 5745, pp. 113 - 116
To investigate the role of astrocytes in regulating synaptic transmission, we generated inducible transgenic mice that express a dominant-negative SNARE domain... 
Neuroscience | Receptors | Transmitters | Astrocytes | Synaptic transmission | Neurons | Long term potentiation | Reports | Mice | Behavioral neuroscience | Synapses | NERVOUS-SYSTEM | TRANSMISSION | ADENINE-NUCLEOTIDES | GLUTAMATE | MULTIDISCIPLINARY SCIENCES | CALCIUM WAVES | ADENOSINE | RAT HIPPOCAMPUS | RELEASE | ATP | CULTURED HIPPOCAMPAL-NEURONS | Purinergic P1 Receptor Antagonists | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Receptors, N-Methyl-D-Aspartate - metabolism | Neuronal Plasticity - drug effects | Hippocampus - drug effects | Xanthines - pharmacology | Adenosine Triphosphate - pharmacology | Long-Term Potentiation - drug effects | Excitatory Postsynaptic Potentials | Adenosine Triphosphate - metabolism | Synaptic Transmission - drug effects | Astrocytes - drug effects | Synapses - physiology | Adenosine A1 Receptor Antagonists | Cells, Cultured | Purinergic P2 Receptor Antagonists | Mice, Transgenic | Receptor, Adenosine A1 - metabolism | Adenosine Triphosphate - analogs & derivatives | Adenosine Triphosphatases - antagonists & inhibitors | Astrocytes - physiology | Animals | Receptors, Purinergic P2 - metabolism | Adenosine - metabolism | Receptors, Purinergic P1 - metabolism | Hippocampus - physiology | In Vitro Techniques | Neural transmission | Neuroglia | Research | Neurology | Adenosine | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7482, pp. 223 - 228
Traumatic brain injury (TBI) is increasingly appreciated to be highly prevalent and deleterious to neurological function(1,2). At present, no effective... 
BIOMARKERS | GREEN FLUORESCENT PROTEIN | HEAD-INJURY | INSERTION | STERILE INFLAMMATION | FLUID | CORTEX | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MICE | RELEASE | Encephalitis - prevention & control | Neuroprotective Agents - therapeutic use | Reactive Oxygen Species - metabolism | Brain Injuries - drug therapy | Humans | Astrocytes - pathology | Brain Injuries - complications | Male | Intracranial Hemorrhages - diagnosis | Microglia - physiology | Encephalitis - drug therapy | Glasgow Coma Scale | Purinergic P2 Receptor Antagonists - pharmacology | Encephalitis - complications | Cell Death - drug effects | Neuroprotective Agents - administration & dosage | Disease Models, Animal | Microglia - cytology | Glutathione - therapeutic use | Skull - metabolism | Meninges - pathology | Microglia - drug effects | Neutrophils - drug effects | Neutrophils - physiology | Encephalitis - pathology | Rats | Purinergic P2 Receptor Antagonists - therapeutic use | Meninges - drug effects | Rats, Sprague-Dawley | Brain Injuries - diagnosis | Brain - drug effects | Antioxidants - therapeutic use | Animals | Glutathione - administration & dosage | Receptors, Purinergic P2 - metabolism | Antioxidants - administration & dosage | Brain - pathology | Receptors, Purinergic P2X7 - metabolism | Purinergic P2 Receptor Antagonists - administration & dosage | Mice | Administration, Topical | Brain Injuries - pathology | Intracranial Hemorrhages - complications | Brain | Medical examination | Cell death | Physiological aspects | Skull | Models | Meninges | Observations | Injuries | Brain damage | Emergency medical care | Head injuries | Rodents | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 36, pp. 24035 - 24048
The role of endogenous inducers of inflammation is poorly understood. To produce the proinflammatory master cytokine interleukin (IL)-1β, macrophages need... 
GENE | LEUCINE-RICH PROTEOGLYCANS | CASPASE-1 | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | HYALURONAN | IL-1-BETA | SECRETION | ATP | NALP3 INFLAMMASOME | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Index Medicus | Glycobiology and Extracellular Matrices
Journal Article
Science, ISSN 0036-8075, 10/2010, Volume 330, Issue 6002, pp. 362 - 366
Neutrophils are recruited from the blood to sites of sterile inflammation, where they contribute to wound healing but may also cause tissue damage. By using... 
Liver | REPORTS | Neutrophils | Antibodies | Mice | Physical trauma | Inflammation | Sine waves | Neutrophil infiltration | Chemotaxis | Necrosis | DYING CELLS | IMMUNE-SYSTEM | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | INJURY | NLRP3 INFLAMMASOME | HEPATOTOXICITY | RELEASE | HMGB1 | IDENTIFICATION | NALP3 INFLAMMASOME | Chemotaxis, Leukocyte | Microscopy - methods | Inflammation - pathology | Liver - pathology | NLR Family, Pyrin Domain-Containing 3 Protein | Liver Diseases - pathology | Neutrophil Infiltration | Endothelium, Vascular - physiology | Inflammation - metabolism | Liver - immunology | Peptides - metabolism | Adenosine Triphosphate - metabolism | Receptors, Formyl Peptide - metabolism | Macrophage-1 Antigen - physiology | Chemokine CXCL2 - metabolism | Cues | Liver Diseases - immunology | Signal Transduction | Liver - metabolism | Neutrophils - physiology | Inflammation - immunology | Cell Adhesion | Receptors, Purinergic P2X7 | Microscopy, Confocal | Microvessels - physiology | Liver - blood supply | Animals | Carrier Proteins - metabolism | Receptors, Interleukin-8B - metabolism | Receptors, Purinergic P2 - metabolism | Chemokines - metabolism | Kinetics | Liver Diseases - metabolism | Physiological aspects | Properties | Gangrene | Molecular biology | Immune system | Cell adhesion & migration | Index Medicus
Journal Article